Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling

Genes and Development

Volumn 26, Issue 20, 2012, Pages 2271-2285

  Stoyanova, Tanya ^a   Goldstein, Andrew S ^a,b   Cai, Houjian ^a,c   Drake, Justin M ^a   Huang, Jiaoti ^a   Witte, Owen N ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

catenin; Regulated intramembrane proteolysis; Self renewal; Transformation; Trop2

Indexed keywords

BETA CATENIN; MEMBRANE PROTEIN; MICRORNA; PRESENILIN 1; PRESENILIN 2; PROTEIN TROP2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL PROLIFERATION; CELL RENEWAL; CELL TRANSFORMATION; CONTROLLED STUDY; EPITHELIUM HYPERPLASIA; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEM CELL; TISSUE REGENERATION;

ANIMALS; ANTIGENS, NEOPLASM; BETA CATENIN; CELL ADHESION MOLECULES; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; HYPERPLASIA; L-SELECTIN; MALE; MICE; PROSTATIC NEOPLASMS; PROTEOLYSIS; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84867702118     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.196451.112     Document Type: Article

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