A review of immunomodulators with reference to Canova®

Homeopathy

Volumn 98, Issue 3, 2009, Pages 169-176

  Smit, E ^a   Oberholzer, H M ^a   Pretorius, E ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX VACCINE; ANTIINFECTIVE AGENT; BENZNIDAZOLE; CANOVA; CYTOKINE; HEPATITIS B VACCINE; HEPATITIS C VACCINE; HOMEOPATHIC AGENT; IMIQUIMOD; IMMUNOMODULATING AGENT; INFLUENZA VACCINE; MELAN A; METHOTREXATE; OKT 4; POLYPEPTIDE ANTIBIOTIC AGENT; PROBIOTIC AGENT; RECOMBINANT ALPHA2B INTERFERON; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT INTERLEUKIN 6; RITUXIMAB; TOCILIZIMAB; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ANTIBODY; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ACTINIC KERATOSIS; AUTOIMMUNITY; B CELL LYMPHOMA; BASAL CELL CARCINOMA; BONE MARROW; BRAZIL; CELL ACTIVATION; CHAGAS DISEASE; CONDYLOMA ACUMINATUM; CROHN DISEASE; DRUG PROTEIN BINDING; HEMATOPOIESIS; HOMEOPATHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MELANOMA; MONOCYTE; NONHUMAN; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; SARCOMA; THROMBOCYTE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-HIV AGENTS; BLOOD PLATELETS; BONE MARROW CELLS; CROTALID VENOMS; HOMEOPATHY; HUMANS; IMMUNOLOGIC FACTORS; LYMPHOCYTES; PLANT EXTRACTS;

EID: 67651177756     PISSN: 14754916     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.homp.2009.05.001     Document Type: Review

References (45)

1. Patwardhan B., and Gautam M. Botanical immunodrugs: scope and opportunities. Drug Discov Today 10 7 (2005) 495-502
2. Levy M.N., Koeppen B.M., and Stanton B.A. Nonrespiratory functions of the lung. In: Schmitt W.R., and Hall A. (Eds). Principles of Physiology (2006), Mosby, Elsevier, Philadelphia 417-428
3. Kierszenbaum A.L. Immune-lymphatic system. In: Ozols I., and Hall A. (Eds). Histology and Cell Biology. An Introduction to Pathology (2007), Elsevier, Philadelphia, Mosby 291-322
4. Dutta R.C. Peptide immunomodulators versus infection; an analysis. Immunol Lett 83 3 (2002) 153-161
5. Ballas Z.K. Immunomodulators: a brave new world. J Allergy Clin Immunol 121 2 (2008) 331-333
6. Piemonte M., and Buchi D. Analysis of IL-2, IFN-γ and TNF-α production, α5β1 integrins and actin filaments distribution in peritoneal mouse macrophages treated with homeopathic medicament. J Submicrosc Cytol Pathol 34 3 (2002) 255-263
7. Casale T.B., and Stokes J.R. Immunomodulators for allergic respiratory disorders. J Allergy Clin Immunol 121 2 (2008) 288-296
8. Pirofski L., and Casadevall A. Immunomodulators as an antimicrobial tool. Curr Opin Microbiol 9 (2006) 489-495
9. Abbas A.K., and Lichtman A.H. Antigen capture and presentation to lymphocytes. In: Schmitt W.R., Hacker H.N., and Bellus M.A. (Eds). Basic Immunology. Functions and Disorders of the Immune System (2001), WB Saunders Company, Philadelphia, Pennsylvania, USA 43-64
10. Randolph G.J., Jakubzick C., and Qu C. Antigen presentation by monocytes and monocyte-derived cells. Curr Opin Immunol 20 (2008) 52-60
11. Peakman M., and Vergani D. Cellular immune responses: macrophages, dendritic cells and B lymphocytes. In: Ward J. (Ed). Basic and Clinical Immunology (1997), Churchill Livingstone, Edinburgh 67-80
12. Todd I., and Spickett G. Antigen recognition. In: Noyes V., and Misina M. (Eds). Immunology (Lecture Notes). 5th edn (2005), Blackwell Publishing Ltd, Massachusetts, USA 14-27
13. Mahnke K., Bedke T., and Enk A.H. Regulatory conversation between antigen presenting cells and regulatory T cells enhance immune suppression. Cell Immunol 250 (2007) 1-13
14. Dabbagh K., and Lewis D.B. Toll-like receptors and T-helper-1/T-helper-2 responses. Curr Opin Infect Dis 16 (2003) 199-204
15. Delneste Y., Beauvillain C., and Jeannin P. Innate immunity: structure and function of TLRs. Méd Sci 23 1 (2007) 67-73
16. Atkinson T.J. Toll-like receptors, transduction effector pathways, and disease diversity: evidence of an immunobiological paradigm explaining all human illness?. Int Rev Immunol 27 (2008) 255-281
17. Majewska M., and Szczepanik M. The role of Toll-like receptors (TLR) in innate and adaptive immune responses and their function in immune response regulation. Postepy Hig Med Dosw 60 (2006) 52-63
18. Berinstein N.L. Enhancing cancer vaccines with immunomodulators. Vaccine 25 (2007) 27-88
19. Meyer T., and Stockfleth E. Clinical investigations of Toll-like receptor agonists. Expert Opin Investig Drugs 17 7 (2008) 1051-1065
20. Pollard T.D., and Earnshaw W.C. Signalling mechanisms: plasma membrane receptors. In: Schmitt W., and Mahon J. (Eds). Cell Biology (2004), Saunders-Elsevier, Philadelphia 427-442
21. Adorini L. Cytokine-based immunointervention in the treatment of autoimmune diseases. Clin Exp Immunol 132 (2003) 185-192
22. Spelman K., Burns J., Nichols D., Winters N., Ottersberg S., and Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev 11 2 (2006) 128-150
23. Blanco P., Palucka A.K., Pascual V., and Banchereau J. Dendritic cells and cytokines in human inflammatory and autoimmune disease. Cytokine Growth Factor Rev 19 (2008) 41-52
24. Finckh A., and Gabay C. At the horizon of innovative therapy in rheumatology: new biologic agents. Curr Opin Rheumatol 20 (2008) 269-275
25. Okamoto H., Hoshi D., Kiire A., Yamanaka H., and Kamatani N. Molecular targets of rheumatoid arthritis. Inflamm Allergy Drug Targets 7 1 (2008) 53-66
26. Kirkwood J.M., Tarhini A.A., Panellini M.C., et al. Next generation of immunotherapy for melanoma. J Clin Oncol 26 20 (2008) 3445-3455
27. Brandenburg S., Takahasi T., de la Rosa M., et al. IL-2 induces in vivo suppression by CD4+CD25+Fox3+ regulatory T cells. Eur J Immunol 38 (2008) 1643-1653
28. Tsitoura D.C., and Tassios Y. Immunomodulation: the future cure for allergic diseases. Ann NY Acad Sci 1088 (2006) 100-115
29. Reichenberg-Ullman J. Transformational homeopathy (2007), The Towshend Letter Group
30. Jobst K.A. Homeopathy, Hahnemann and the Lancet and 250 years on: a case of the Emperor's new clothes?. J Altern Complement Med 11 5 (2005) 751-754
31. Seligmann I.C., Lima P.D.L., Cardoso P.C.S., et al. The Canova method homeopathic compound is not genotoxic to the in vitro human lymphocytes. Genet Mol Res 2 (2003) 223-228
32. Lopes L., Godoy L.M.F., de Oliveira C.C., et al. Phagocytosis, endosomal/lysosomal system and other cellular aspects of macrophage activation by Canova medication. Micron 37 (2006) 277-287
33. Pereira W.K.V., Lonardoni M.V.C., Grespan R., Caparroz-Assef S.M., Cuman R.K.N., and Bersani-Amado C.A. Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection. J Infect 51 (2005) 157-168
34. Takahachi G., Maluf M.L.F., Svidzinkski T.I.E., Dalalio M.M.O., Bersani-Amado C.A., and Cuman R.K.N. In vitro and in vivo effects of the Canova medicine on experimental infection with Paracoccidioides brasiliensis in mice. Indian J Pharmacol 28 5 (2006) 350-354
35. Cummings S., and Dana U. Everybody's guide to homeopathic medicines (1997), Jeremy P. Tarcher/Putnam, New York
36. Kent J.T. Lectures on Materia Medica (1996), B. Jain Publishers, Delhi, India
37. De Oliveira C.C., De Oliveira S.M., Godoy L.M.F., Gabardo J., and De Freitas Buchi D. Canova, a Brazilian medical formulation, alters oxidative metabolism of mice macrophages. J Infect 52 (2006) 420-432
38. Sato D., Wal R., de Oliveira C.C., et al. Histopathological and immunophenotyping studies on normal and sarcoma 180-bearing mice treated with a complex homeopathic medication. Homeopathy 94 (2005) 26-32
39. Burbano R.R., Leal M.F., da Costa J.B., et al. Lymphocyte proliferation stimulated by activated human macrophages treated with Canova. Homeopathy 98 1 (2009) 45-48
40. Abud A.P.R., Cesar B., Cavazzani L.F.M., de Oliveira C.C., Gabardo J., and Buchi D. Activation of bone marrow cells treated with Canova in vitro. Cell Biol Int (2006) 1-9
41. Smit E., Pretorius E., Anderson R., Oomen J., and Potjo M. Differentiation of human monocytes in vitro following exposure to Canova in the absence of cytokines. Ultrastruct Pathol 32 (2008) 147-152
42. Pretorius E., Oberholzer H.M., Smit E., et al. Ultrastructural changes in platelet aggregates of HIV patients: a scanning electron microscopy study. Ultrastruct Pathol 32 (2008) 1-5
43. Aleixo D.L., Ferraz F.N., de Melo C.S., et al. Changes of RAPD profile of Trypanosoma cruzi II with Canova and Benznidazole. Homeopathy 97 2 (2008) 59-64