Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 14, 2006, Pages 3755-3760

  Fevig, John M ^a   Cacciola, Joseph ^a   Buriak Jr , Joseph ^a   Rossi, Karen A ^a   Knabb, Robert M ^a   Luettgen, Joseph M ^a   Wong, Pancras C ^a   Bai, Stephen A ^a   Wexler, Ruth R ^a   Lam, Patrick Y S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Anticoagulants; Antithrombotic agents; Bicyclic core; Factor Xa inhibitors; Pyrazole; Pyrazolo 4,3 d pyrimidin 7(6H) ones

Indexed keywords

BLOOD CLOTTING FACTOR 10A; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; THROMBOSIS;

ADMINISTRATION, ORAL; ANIMALS; ANTITHROMBIN III; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DOGS; FACTOR XA; FIBRINOLYTIC AGENTS; PYRAZOLES; PYRIMIDINONES; THROMBOSIS;

EID: 33745154028     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.044     Document Type: Article

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