Rational design, synthesis and biological evaluation of new 1,5-diarylpyrazole derivatives as CB1 receptor antagonists, structurally related to rimonabant

European Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2008, Pages 2627-2638

  Menozzi, Giulia ^a   Fossa, Paola ^a   Cichero, Elena ^a   Spallarossa, Andrea ^a   Ranise, Angelo ^a   Mosti, Luisa ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

1,5 Diarylpyrazoles; CB1 antagonists; Computational studies; Rimonabant analogues; Synthesis

Indexed keywords

AMIDE; CANNABINOID 1 RECEPTOR ANTAGONIST; HYDRAZIDE DERIVATIVE; PYRAZOLE DERIVATIVE; RIMONABANT;

ARTICLE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; REACTION ANALYSIS; STRUCTURE ANALYSIS;

BINDING, COMPETITIVE; DRUG DESIGN; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56949088292     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.01.043     Document Type: Article

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