Permissive role of endothelin receptors in tumor metastasis

Life Sciences

Volumn 91, Issue 13-14, 2012, Pages 522-527

  Said, Neveen ^a   Theodorescu, Dan ^b,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^c University of Colorado Comprehensive Cancer Center   (United States)

Author keywords

Endothelin; Inflammation; Metastasis

Indexed keywords

ANTINEOPLASTIC AGENT; ATRASENTAN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; FIBROBLAST GROWTH FACTOR 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTOFERRIN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; TRASTUZUMAB; UNCLASSIFIED DRUG; ZD 4045; ZIBOTENTAN;

ADVANCED CANCER; BLADDER CANCER; BONE METASTASIS; CANCER CELL; CANCER GROWTH; CANCER PATIENT; COLORECTAL CANCER; CONFERENCE PAPER; DISEASE FREE SURVIVAL; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEAD AND NECK CANCER; HUMAN; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MELANOMA; METASTASIS; NONHUMAN; OVARY CANCER; PROSTATE CANCER; PROTEIN EXPRESSION; T LYMPHOCYTE; TRIPLE NEGATIVE BREAST CANCER;

DRUG DESIGN; ENDOTHELIN-1; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN;

EID: 84867574271     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.03.040     Document Type: Conference Paper

References (77)

1. C. Arun, N.J. London, and D.M. Hemingway Prognostic significance of elevated endothelin-1 levels in patients with colorectal cancer Int J Biol Markers 19 2004 32 37
2. C. Arun, B. Swift, K.E. Porter, K.P. West, N.J. London, and D.M. Hemingway The role of big endothelin-1 in colorectal cancer Int J Biol Markers 17 2002 268 274
3. E. Asham, A. Shankar, M. Loizidou, S. Fredericks, K. Miller, and P.B. Boulos Increased endothelin-1 in colorectal cancer and reduction of tumour growth by ET(A) receptor antagonism Br J Cancer 85 2001 1759 1763
4. S. Awano, L.A. Dawson, A.R. Hunter, A.J. Turner, and B.A. Usmani Endothelin system in oral squamous carcinoma cells: specific siRNA targeting of ECE-1 blocks cell proliferation Int J Cancer 118 2006 1645 1652
5. A. Bagnato, M. Loizidou, B.R. Pflug, J. Curwen, and J. Growcott Role of the endothelin axis and its antagonists in the treatment of cancer Br J Pharmacol 163 2011 220 233
6. A. Bagnato, and L. Rosano Epithelial-mesenchymal transition in ovarian cancer progression: a crucial role for the endothelin axis Cells Tissues Organs 185 2007 85 94
7. A. Bagnato, D. Salani, V. Di Castro, J.R. Wu-Wong, R. Tecce, and M.R. Nicotra Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth Cancer Res 59 1999 720 727
8. A. Bagnato, F. Spinella, and L. Rosano Emerging role of the endothelin axis in ovarian tumor progression Endocr Relat Cancer 12 2005 761 772
9. M. Browatzki, C.A. Pfeiffer, J. Schmidt, and R. Kranzhofer Endothelin-1 induces functionally active CD40 protein via nuclear factor-kappaB in human vascular smooth muscle cells Eur J Med Res 12 2007 129 133
10. R.J. Buckanovich, A. Facciabene, S. Kim, F. Benencia, D. Sasaroli, and K. Balint Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy Nat Med 14 2008 28 36
11. J.W. Chiao, B.S. Moonga, Y.M. Yang, R. Kancherla, A. Mittelman, and J.R. Wu-Wong Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption Br J Cancer 83 2000 360 365
12. P. Clezardin Therapeutic targets for bone metastases in breast cancer Breast Cancer Res 13 2011 207
13. L.A. Dawson, N.J. Maitland, P. Berry, A.J. Turner, and B.A. Usmani Expression and localization of endothelin-converting enzyme-1 in human prostate cancer Exp Biol Med (Maywood) 231 2006 1106 1110
14. L.A. Dawson, N.J. Maitland, A.J. Turner, and B.A. Usmani Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression Br J Cancer 90 2004 1577 1582
15. D. Dreau, A. Karaa, C. Culberson, H. Wyan, I.H. McKillop, and M.G. Clemens Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis Clin Exp Metastasis 23 2006 41 53
16. M.M. Elahi, and N.W. Everson Prognosis of colorectal cancer patients with elevated endothelin-1 concentrations Asian J Surg 27 2004 4 9
17. J. Fischgrabe, M. Gotte, K. Michels, L. Kiesel, and P. Wulfing Targeting endothelin A receptor enhances anti-proliferative and anti-invasive effects of the HER2 antibody trastuzumab in HER2-overexpressing breast cancer cells Int J Cancer 127 2010 696 706
18. A. Giaid, Q.A. Hamid, D.R. Springall, M. Yanagisawa, O. Shinmi, and T. Sawamura Detection of endothelin immunoreactivity and mRNA in pulmonary tumours J Pathol 162 1990 15 22
19. M.J. Grimshaw Endothelins in breast tumour cell invasion Cancer Lett 222 2005 129 138
20. M.J. Grimshaw, T. Hagemann, A. Ayhan, C.E. Gillett, C. Binder, and F.R. Balkwill A role for endothelin-2 and its receptors in breast tumor cell invasion Cancer Res 64 2004 2461 2468
21. M.J. Grimshaw, J.L. Wilson, and F.R. Balkwill Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors Eur J Immunol 32 2002 2393 2400
22. T.A. Guise, J.J. Yin, and K.S. Mohammad Role of endothelin-1 in osteoblastic bone metastases Cancer 97 2003 779 784
23. G.P. Gupta, and J. Massague Cancer metastasis: building a framework Cell 127 2006 679 695
24. G.P. Gupta, D.X. Nguyen, A.C. Chiang, P.D. Bos, J.Y. Kim, and C. Nadal Mediators of vascular remodelling co-opted for sequential steps in lung metastasis Nature 446 2007 765 770
25. N.H. Ha, V.S. Nair, D.N. Reddy, P. Mudvari, K. Ohshiro, and K.S. Ghanta Lactoferrin-Endothelin-1 Axis Contributes to the Development and Invasiveness of Triple-Negative Breast Cancer Phenotypes Cancer Res 71 2011 7259 7269
26. A. Hachiya, A. Kobayashi, Y. Yoshida, T. Kitahara, Y. Takema, and G. Imokawa Biphasic expression of two paracrine melanogenic cytokines, stem cell factor and endothelin-1, in ultraviolet B-induced human melanogenesis Am J Pathol 165 2004 2099 2109
27. T. Hagemann, F. Balkwill, and T. Lawrence Inflammation and cancer: a double-edged sword Cancer Cell 12 2007 300 301
28. T. Hagemann, C. Binder, L. Binder, T. Pukrop, L. Trumper, and M.J. Grimshaw Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells DNA Cell Biol 24 2005 766 776
29. V. Hearnden, H. Lomas, S. Macneil, M. Thornhill, C. Murdoch, and A. Lewis Diffusion studies of nanometer polymersomes across tissue engineered human oral mucosa Pharm Res 26 2009 1718 1728
30. E. Herrmann, M. Bogemann, S. Bierer, E. Eltze, M.I. Toma, and T. Kopke The role of the endothelin axis and microvessel density in bladder cancer - correlation with tumor angiogenesis and clinical prognosis Oncol Rep 18 2007 133 138
31. E. Herrmann, A. Tiemann, E. Eltze, C. Bolenz, C. Bremer, and T. Persigehl Endothelin-A-receptor antagonism with atrasentan exhibits limited activity on the KU-19-19 bladder cancer cell line in a mouse model J Cancer Res Clin Oncol 135 2009 1455 1462
32. E.E. Hinsley, S. Hunt, K.D. Hunter, S.A. Whawell, and D.W. Lambert Endothelin-1 stimulates motility of head and neck squamous carcinoma cells by promoting stromal-epithelial interactions Int J Cancer 130 2012 40 47
33. M.M. Hoosein, M.R. Dashwood, K. Dawas, H.M. Ali, K. Grant, and F. Savage Altered endothelin receptor subtypes in colorectal cancer Eur J Gastroenterol Hepatol 19 2007 775 782
34. G. Imokawa, Y. Yada, and M. Miyagishi Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes J Biol Chem 267 1992 24675 24680
35. S. Jamal, and R.J. Schneider UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells J Clin Invest 110 2002 443 452
36. A.L. Kadekaro, R. Kavanagh, H. Kanto, S. Terzieva, J. Hauser, and N. Kobayashi alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes Cancer Res 65 2005 4292 4299
37. L.E. Kandalaft, A. Facciabene, R.J. Buckanovich, and G. Coukos Endothelin B Receptor, a New Target in Cancer Immune Therapy Clin Cancer Res 15 2009 4521 4528
38. R.M. Kedzierski, and M. Yanagisawa ENDOTHELIN SYSTEM: The Double-Edged Sword in Health and Disease Annu Rev Pharmacol Toxicol 41 2001 851 876
39. T.H. Kim, H. Xiong, Z. Zhang, and B. Ren [beta]-Catenin activates the growth factor endothelin-1 in colon cancer cells Oncogene 24 2004 597 604
40. K. Kojima, and Z. Nihei Expression of endothelin-1 immunoreactivity in breast cancer Surg Oncol 4 1995 309 315
41. B.R. Konety, and J.B. Nelson Nonandrogenic mediators of prostatic growth Hematol Oncol Clin North Am 15 2001 459 476
42. G. Le Brun, P. Aubin, H. Soliman, F. Ropiquet, J.M. Villette, and P. Berthon Upregulation of endothelin 1 and its precursor by IL-1beta, TNF-alpha, and TGF-beta in the PC3 human prostate cancer cell line Cytokine 11 1999 157 162
43. G.M. Lloyd, C.P. Neal, C. Arun, N.J. London, and D.M. Hemingway The prognostic value of circulating big endothelin-1 in patients undergoing potentially curative resection for colorectal cancer Colorectal Dis 13 2011 290 295
44. H.-Q. Mai, Z.-Y. Zeng, K.-T. Feng, Y.-L. Ye, C.-Q. Zhang, and W.-J. Liang Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma Cancer Sci 97 2006 1388 1395
45. C.R. Mangahas, G.V. dela Cruz, G. Friedman-Jimenez, and S. Jamal Endothelin-1 induces CXCL1 and CXCL8 secretion in human melanoma cells J Invest Dermatol 125 2005 307 311
46. C.R. Mangahas, G.V. dela Cruz, R.J. Schneider, and S. Jamal Endothelin-1 upregulates MCAM in melanocytes J Invest Dermatol 123 2004 1135 1139
47. A. Mantovani Cancer: Inflaming metastasis Nature 457 2009 36 37
48. J. Nelson, A. Bagnato, B. Battistini, and P. Nisen The endothelin axis: emerging role in cancer Nat Rev Cancer 3 2003 110 116
49. J.B. Nelson, K. Chan-Tack, S.P. Hedican, S.R. Magnuson, T.J. Opgenorth, and G.S. Bova Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer Cancer Res 56 1996 663 668
50. J.B. Nelson, K. Fizazi, K. Miller, C.S. Higano, J.W. Moul, and T. Morris Phase III study of the efficacy and safety of zibotentan (ZD4054) in patients with bone metastatic castration-resistant prostate cancer (CRPC) J Clin Oncol 29 2011 abstr 117
51. J.B. Nelson, S.P. Hedican, D.J. George, A.H. Reddi, S. Piantadosi, and M.A. Eisenberger Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate Nat Med 1 1995 944 949
52. J.B. Nelson, W. Love, J.L. Chin, F. Saad, C.C. Schulman, and D.J. Sleep Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer Cancer 113 2008 2478 2487
53. C.-H. Ohlmann, A. Merseburger, H. Suttmann, D. Schilling, L. Trojan, and C. Kempkensteffen Novel options for the treatment of castration-resistant prostate cancer World J Urol 2011 1 9
54. C.F. Peeters, C.M. Thomas, F.C. Sweep, P.N. Span, T. Wobbes, and T.M. Ruers Elevated serum endothelin-1 levels in patients with colorectal cancer; relevance for prognosis Int J Biol Markers 15 2000 288 293
55. B. Qian, Y. Deng, J.H. Im, R.J. Muschel, Y. Zou, and J. Li A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth PLoS One 4 2009 e6562
56. L. Rosano, V. Di Castro, F. Spinella, M.R. Nicotra, P.G. Natali, and A. Bagnato ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo Mol Cancer Ther 6 2007 2003 2011
57. L. Rosano, V. Di Castro, F. Spinella, G. Tortora, M.R. Nicotra, and P.G. Natali Combined Targeting of Endothelin A Receptor and Epidermal Growth Factor Receptor in Ovarian Cancer Shows Enhanced Antitumor Activity Cancer Res 67 2007 6351 6359
58. L. Rosano, F. Spinella, and A. Bagnato The importance of endothelin axis in initiation, progression, and therapy of ovarian cancer Am J Physiol Regul Integr Comp Physiol 299 2010 R395 404
59. L. Rosano, F. Spinella, D. Salani, V. Di Castro, A. Venuti, and M.R. Nicotra Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma Cancer Res 63 2003 2447 2453
60. L. Rosano, M. Varmi, D. Salani, V. Di Castro, F. Spinella, and P.G. Natali Endothelin-1 Induces Tumor Proteinase Activation and Invasiveness of Ovarian Carcinoma Cells Cancer Res 61 2001 8340 8346
61. N. Said, S. Smith, M. Sanchez-Carbayo, and D. Theodorescu Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer J Clin Invest 121 2011 132 147
62. A. Shankar, M. Loizidou, G. Aliev, S. Fredericks, D. Holt, and P.B. Boulos Raised endothelin 1 levels in patients with colorectal liver metastases Br J Surg 85 1998 502 506
63. R.A. Simpson, T. Dickinson, K.E. Porter, N.J. London, and D.M. Hemingway Raised levels of plasma big endothelin 1 in patients with colorectal cancer Br J Surg 87 2000 1409 1413
64. M. Smollich, M. Gotte, J. Fischgrabe, L.F. Macedo, A. Brodie, and S. Chen ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole Breast Cancer Res Treat 123 2010 345 357
65. F. Spinella, L. Rosano, V. Di Castro, S. Decandia, M.R. Nicotra, and P.G. Natali Endothelin-1 and Endothelin-3 Promote Invasive Behavior via Hypoxia-Inducible Factor-1{alpha} in Human Melanoma Cells Cancer Res 67 2007 1725 1734
66. F. Spinella, L. Rosano, V. Di Castro, P.G. Natali, and A. Bagnato Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion J Biol Chem 279 2004 46700 46705
67. F. Spinella, L. Rosano, V. Di Castro, M.R. Nicotra, P.G. Natali, and A. Bagnato Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells Clin Cancer Res 10 2004 4670 4679
68. A.M. Sutcliffe, D.L. Clarke, D.A. Bradbury, L.M. Corbett, J.A. Patel, and A.J. Knox Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1 Br J Pharmacol 157 2009 436 450
69. B. Titus, H.F. Frierson Jr., M. Conaway, K. Ching, T. Guise, and J. Chirgwin Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2 Cancer Res 65 2005 7320 7327
70. Y. Wang, J. Chen, Q. Li, H. Wang, G. Liu, and Q. Jing Identifying novel prostate cancer associated pathways based on integrative microarray data analysis Comput Biol Chem 35 2011 151 158
71. Y.-F. Wen, B. Qi, H. Liu, H.-Y. Mo, Q.-Y. Chen, and J. Li Polymorphisms in the Endothelin-1 and Endothelin A Receptor Genes and Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma Clin Cancer Res 17 2011 2451 2458
72. J.L. Wilson, J. Burchell, and M.J. Grimshaw Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1 Cancer Res 66 2006 11802 11807
73. P. Wulfing Expression of endothelin-1, endothelin-A, and endothelin-B receptor in human breast cancer and correlation with long-term follow-up Clin Cancer Res 9 11 2003 4125 4131
74. C. Wulfing, E. Eltze, H. Piechota, H. Abol-Enein, P. Wulfing, and M.E. Bode Expression of endothelin-1 and endothelin-A and -B receptors in invasive bladder cancer Oncol Rep 13 2005 223 228
75. C. Wulfing, E. Eltze, J. Yamini, P. Wulfing, S. Bierer, and W. Bocker Expression of the endothelin axis in bladder cancer: relationship to clinicopathologic parameters and long-term survival Eur Urol 47 2005 593 600
76. J. Yamashita, M. Ogawa, and K. Sakai Prognostic significance of three novel biologic factors in a clinical trial of adjuvant therapy for node-negative breast cancer Surgery 117 6 1995 601 608
77. J.J. Yin A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases Proc Natl Acad Sci U S A 100 19 2003 10954 10959