Expression of endothelin-1, endothelin-A, and endothelin-B receptor in human breast cancer and correlation with long-term follow-up

Clinical Cancer Research

Volumn 9, Issue 11, 2003, Pages 4125-4131

  Wülfing, Pia ^a   Diallo, Raihanatou ^b   Kersting, Christian ^b   Wülfing, Christian ^a   Poremba, Christopher ^b,c   Rody, Achim ^a   Greb, Robert R ^a   Böcker, Werner ^b   Kiesel, Ludwig ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1 RECEPTOR; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; ESTROGEN RECEPTOR; HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; BREAST CANCER; BREAST CARCINOMA; CANCER GRADING; CANCER GROWTH; CANCER MORTALITY; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; FOLLOW UP; GENE AMPLIFICATION; GENE EXPRESSION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONCOGENE NEU; PARACRINE SIGNALING; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS;

BREAST NEOPLASMS; DISEASE-FREE SURVIVAL; ENDOTHELIN-1; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MULTIVARIATE ANALYSIS; NEOPLASM METASTASIS; NEOPLASM STAGING; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; REPRODUCIBILITY OF RESULTS; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 17144449019     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y, Kabayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., and Masaki, Y. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (Lond.), 332: 411-415, 1988.
2. Kusuhara, M., Yamaguchi, K., Nagasaki, K., Hayashi, C., Suzaki, A., Hori, S., Handa, S., Nakamura, Y., and Abe, K. Production of endothelin in human cancer cell lines. Cancer Res., 50: 3257-3261, 1990.
3. Levin, E. R. Endothelins, N. Engl. J. Med., 333: 356-363, 1995.
4. Salani, D., Di Castro, V., Nicotra, M. R., Rosano, L., Tecce, R., Venuti, A., Natali, P. G., and Bagnato, A. Role of endothelin-1 in neovascularization of ovarian carcinoma. Am. J. Pathol., 157: 1537-1547, 2000.
5. Asham, E., Shankar, A., Loizidou, M., Fredericks, S., Miller, K., Boulos, P. B., Burnstock, G., and Taylor, I. Increased endothelin-1 in colorectal cancer and reduction of tumor growth by ET(A) receptor antagonism. Br. J. Cancer, 85: 1759-1763, 2001.
6. Nelson, B. J., Chan-Tack, K., Hedican, S. P., Magnuson, S. R., Opgenorth, T. J., Bova, G. S., and Simons, J. W. Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer. Cancer Res., 56: 663-668, 1996.
7. Yamashita, J., Ogawa, M., Inada, K., Yamashita, S., Matsuo, S., and Takano, S. A large amount of endothelin-1 is present in human breast cancer tissues. Res. Commun. Chem. Pathol. Pharmacol., 74: 363-369, 1991.
8. Alanen, K., Deng, D. X., and Chakrabarti, S. Augmented expression of endothelin-1, endothelin-3 and the endothelin-B receptor in breast carcinoma. Histopathology, 36: 161-167, 2000.
9. Kojima, K., and Nihei, Z. Expression of endothelin-1 immunoreactivity in breast cancer. Surg. Oncol., 4: 309-315, 1995.
10. Kourembanas, S., Marsden, P. A., McQuillan, L. P., and Faller, D. V. Hypoxia induces endothelin gene expression and secretion in cultured endothelium. J. Clin. Investig., 88: 1054-1057, 1991.
11. Schrey, M. P., Patel, K. V., and Tezapsidis, N. Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells. Cancer Res., 52: 1786-1790, 1992.
12. Patel, K. V., and Schrey, M. P. Human breast cancer cells contain a phosphoramidonsensitive metalloproteinase which can process exogenous big endothelin-1 to endothelin-1: a proposed mitogen for human breast fibroblasts. Br. J, Cancer, 77: 442-447, 1995.
13. Patel, K. V., Sheth, H. G., and Schrey, M. P. Stimulation of endothelin-1 secretion by human breast cancer cells through protein kinase A activation: a possible novel paracrine loop involving breast fibroblast-derived prostaglandin E2. Mol. Cell. Endocrinol., 126: 143-151, 1997.
14. Bagnato, A., Tecce, R., DiCastro, V., and Catt, K. J. Activation of mitogenic signaling by endothelin-1 in ovarian carcinoma cells. Cancer Res., 57: 1306-1311, 1997.
15. Pedram, A., Rasandi, M., Hu, R. M., and Levin, E. R. Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelin cell proliferation and invasion. J. Biol. Chem., 272: 17097-17103, 1997.
16. Rosano, L., Varmi, M., Salani, D., Di Castro, V., Spinella, F., Natali, P. G., and Bagnato, A. Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells. Cancer Res., 61: 8340-8346, 2001.
17. Cruz, A., Parnot, C., Ribatti, D., Corvol, P., and Gasc, J. M. Endothelin-1, a regulator of angiogenesis in the chick chorioallantoic membrane. J. Vasc. Res., 38: 536-545, 2001.
18. Rubanji, G. M., and Polokoff, M. A. Endothelins: molecular biology, biochemistry, pharmacology, physiology and pathophysiology. Pharmacol. Rev., 46: 325-415, 1994.
19. Morbidelli, L., Orlando, C., Maggi, C. A., Ledda, F., and Ziche, M. Proliferation and migration of endothelial cells is promoted by endothelins via activation of ETB receptors. Am. J. Physiol., 269: 4686-4695, 1995.
20. Goligorsky, M. S., Budzikowski, A. S., Tsukahara, H., and Noiri, E. Cooperation between endothelin and nitric oxide in promoting endothelial cell migration and angiogenesis. Clin. Exp. Pharmacol. Physiol., 26: 269-271, 1999.
21. Alberts, G. F., Peifly, K. A., Johns, A., Kleha, J. F., and Winkles, J. A. Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop. J. Biol. Chem., 269: 10112-10118, 1994.
22. Baley, P. A., Resnik, T. J., Eppenberger, U., and Hahn, A. W. Endothelin messenger RNA are differentially expressed in cultured human breast cancer epithelial and stromal cells. J. Clin. Investig., 85: 1320-1323, 1990.
23. Lahav, R., Heffner, G., and Patterson, P. H. An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo. Proc. Natl. Acad. Sci. USA, 96: 11496-11500, 1999.
24. Carducci, M. A., Padley, R. J., Breul, J., Vogelzang, N. J., Zonnenberg, B. A., Daliani, D. D., Schulman, C. C., Nabulsi, A. A., Humerickhouse, R. A., Weinberg, M. A., Schmitt, J. L., and Nelson, J. B. Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, Phase II, placebo-controlled trial. J. Clin. Oncol., 21: 679-689, 2003.
25. Marttunen, M. B., Hietanen, P., Tiitinen, A., Viinikka, L., and Ylikorkala, O. Antiestrogens reduce plasma levels of endothelin-1 without affecting nitrate levels in breast cancer patients. Gynecol. Endocrinol., 14: 55-59, 2000.
26. Yamashita, J., Ogawa, M., and Sakai, K. Prognostic significance of three novel biologic factors in a clinical trial of adjuvant therapy for node-negative breast cancer. Surgery (St. Louis), 117: 601-608, 1995.
27. Patel, K. V., and Schrey, M. P. Human breast cancer cells contain a phosphoramidon-sensitive metalloproteinase which can process exogenous big endothelin-1 to endothelin-1: a proposed mitogen for human breast fibroblasts. Br. J. Cancer, 71: 442-447, 1995.