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Volumn 13, Issue 2, 2011, Pages

Therapeutic targets for bone metastases in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

BONE DISEASE; BONE MARROW; BONE TUMOR; BREAST TUMOR; DRUG EFFECT; FEMALE; HUMAN; METABOLISM; METASTASIS; METHODOLOGY; MOLECULARLY TARGETED THERAPY; OSTEOBLAST; OSTEOCLAST; PATHOLOGY; REVIEW;

EID: 80052701557     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2835     Document Type: Review
Times cited : (100)

References (56)
  • 1
    • 63049121364 scopus 로고    scopus 로고
    • The metastatic niche: adapting the foreign soil
    • 19308068
    • Psaila B, Lyden D. The metastatic niche: adapting the foreign soil. Nat Rev Cancer 2009, 9:285-293. 10.1038/nrc2621, 19308068.
    • (2009) Nat Rev Cancer , vol.9 , pp. 285-293
    • Psaila, B.1    Lyden, D.2
  • 2
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: causes, consequences and therapeutic opportunities
    • 12154351
    • Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2002, 2:584-593. 10.1038/nrc867, 12154351.
    • (2002) Nat Rev Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 3
    • 36348941863 scopus 로고    scopus 로고
    • Bone metastasis: pathogenesis and therapeutic implications
    • 18008175
    • Clézardin P, Teti A. Bone metastasis: pathogenesis and therapeutic implications. Clin Exp Metastasis 2007, 24:599-608. 10.1007/s10585-007-9112-8, 18008175.
    • (2007) Clin Exp Metastasis , vol.24 , pp. 599-608
    • Clézardin, P.1    Teti, A.2
  • 4
    • 79751472667 scopus 로고    scopus 로고
    • Tumor-derived jagged1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
    • 21295524
    • Sethi N, Dai X, Winter CG, Kang Y. Tumor-derived jagged1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 2011, 19:192-205. 10.1016/j.ccr.2010.12.022, 21295524.
    • (2011) Cancer Cell , vol.19 , pp. 192-205
    • Sethi, N.1    Dai, X.2    Winter, C.G.3    Kang, Y.4
  • 5
    • 56549098575 scopus 로고    scopus 로고
    • RANK/RANKL: regulators of immune responses and bone physiology
    • 19076348
    • Leibbrandt A, Penninger JM. RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci 2008, 1143:123-150. 10.1196/annals.1443.016, 19076348.
    • (2008) Ann N Y Acad Sci , vol.1143 , pp. 123-150
    • Leibbrandt, A.1    Penninger, J.M.2
  • 6
    • 77956504043 scopus 로고    scopus 로고
    • Activin A and bone metastasis
    • 20533297
    • Leto G. Activin A and bone metastasis. J Cell Physiol 2010, 225:302-309. 10.1002/jcp.22272, 20533297.
    • (2010) J Cell Physiol , vol.225 , pp. 302-309
    • Leto, G.1
  • 7
    • 78650304661 scopus 로고    scopus 로고
    • Bisphosphonates' antitumor activity: an unravelled side of a multifaceted drug class
    • 20655399
    • Clézardin P. Bisphosphonates' antitumor activity: an unravelled side of a multifaceted drug class. Bone 2011, 48:71-79. 10.1016/j.bone.2010.07.016, 20655399.
    • (2011) Bone , vol.48 , pp. 71-79
    • Clézardin, P.1
  • 8
    • 42049110350 scopus 로고    scopus 로고
    • Receptor of nuclear factor kB ligand and osteoprotegerin regulation of bone remodeling in health and disease
    • 2528846, 18057140
    • Kearns AE, Khosla S, Kostenuik PJ. Receptor of nuclear factor kB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev 2008, 29:155-192. 10.1210/er.2007-0014, 2528846, 18057140.
    • (2008) Endocr Rev , vol.29 , pp. 155-192
    • Kearns, A.E.1    Khosla, S.2    Kostenuik, P.J.3
  • 9
    • 77954355093 scopus 로고    scopus 로고
    • Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration
    • 2896434, 20551048
    • Sabbota AL, Kim HRC, Zhe X, Fridman R, Bonfil RD, Cher ML. Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration. Cancer Res 2010, 70:5558-5566. 10.1158/0008-5472.CAN-09-4416, 2896434, 20551048.
    • (2010) Cancer Res , vol.70 , pp. 5558-5566
    • Sabbota, A.L.1    Kim, H.R.C.2    Zhe, X.3    Fridman, R.4    Bonfil, R.D.5    Cher, M.L.6
  • 14
    • 72849130461 scopus 로고    scopus 로고
    • Integrins in bone metastasis formation and potential therapeutic implications
    • 20025568
    • Clézardin P. Integrins in bone metastasis formation and potential therapeutic implications. Curr Cancer Drug Targets 2009, 9:801-806. 10.2174/156800909789760348, 20025568.
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 801-806
    • Clézardin, P.1
  • 15
    • 79952748179 scopus 로고    scopus 로고
    • Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged noninvasively using VCT, MRI and DCE-MRI in a longitudinal in vivo study
    • Bäuerle T, Komljenovic D, Merz M, Berger MR, Goodman SL, Semmler W. Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged noninvasively using VCT, MRI and DCE-MRI in a longitudinal in vivo study. Int J Cancer 2010, 128:2453-2462.
    • (2010) Int J Cancer , vol.128 , pp. 2453-2462
    • Bäuerle, T.1    Komljenovic, D.2    Merz, M.3    Berger, M.R.4    Goodman, S.L.5    Semmler, W.6
  • 16
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: biological implications and therapeutic opportunities
    • 20029421
    • Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2010, 10:9-22. 10.1038/nrc2748, 20029421.
    • (2010) Nat Rev Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 17
    • 17844399226 scopus 로고    scopus 로고
    • Effect of L-000845704, an alphaVbeta3 integrin antagonist, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women
    • 15687321
    • Murphy MG, Cerchio K, Stoch SA, Gottesdiener K, Wu M, Recker R. Effect of L-000845704, an alphaVbeta3 integrin antagonist, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. J Clin Endocrinol Metab 2005, 90:2022-2028. 10.1210/jc.2004-2126, 15687321.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2022-2028
    • Murphy, M.G.1    Cerchio, K.2    Stoch, S.A.3    Gottesdiener, K.4    Wu, M.5    Recker, R.6
  • 20
    • 0041513490 scopus 로고    scopus 로고
    • C-Src tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer bone metastasis
    • Myoui A, Nishimura R, Williams PJ, Hiraga T, Tamura D, Michigami T, Mundy GR, Yoneda T. C-Src tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer bone metastasis. Cancer Res 2003, 63:5028-5033.
    • (2003) Cancer Res , vol.63 , pp. 5028-5033
    • Myoui, A.1    Nishimura, R.2    Williams, P.J.3    Hiraga, T.4    Tamura, D.5    Michigami, T.6    Mundy, G.R.7    Yoneda, T.8
  • 21
    • 33745257077 scopus 로고    scopus 로고
    • Inhibition of protein kinase c-Src reduces the incidence of breast cancer metastases and increases survival in mice: implications for therapy
    • 16627750
    • Rucci N, Recchia I, Angelucci A, Alamanou M, Del Fattore A, Fortunati D, Susa M, Fabbro D, Bologna M, Teti A. Inhibition of protein kinase c-Src reduces the incidence of breast cancer metastases and increases survival in mice: implications for therapy. J Pharmacol Exp Ther 2006, 318:161-172. 10.1124/jpet.106.102004, 16627750.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 161-172
    • Rucci, N.1    Recchia, I.2    Angelucci, A.3    Alamanou, M.4    Del Fattore, A.5    Fortunati, D.6    Susa, M.7    Fabbro, D.8    Bologna, M.9    Teti, A.10
  • 22
    • 67649311599 scopus 로고    scopus 로고
    • Latent bone metastasis in breast cancer tied to Src-dependent survival signals
    • 2749247, 19573813
    • Zhang XH, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, Foekens JA, Massagué J. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell 2009, 16:67-78. 10.1016/j.ccr.2009.05.017, 2749247, 19573813.
    • (2009) Cancer Cell , vol.16 , pp. 67-78
    • Zhang, X.H.1    Wang, Q.2    Gerald, W.3    Hudis, C.A.4    Norton, L.5    Smid, M.6    Foekens, J.A.7    Massagué, J.8
  • 24
    • 70349758510 scopus 로고    scopus 로고
    • SRC kinases as therapeutic targets for cancer
    • 19787002
    • Kim LC, Song L, Haura EB. SRC kinases as therapeutic targets for cancer. Nat Rev Clin Oncol 2009, 6:587-595. 10.1038/nrclinonc.2009.129, 19787002.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 587-595
    • Kim, L.C.1    Song, L.2    Haura, E.B.3
  • 25
    • 54049123792 scopus 로고    scopus 로고
    • Cathepsin K inhibitors as treatment of bone metastasis
    • 18685424
    • Le Gall C, Bonnelye E, Clézardin P. Cathepsin K inhibitors as treatment of bone metastasis. Curr Opin Support Palliat Care 2008, 2:218-222. 10.1097/SPC.0b013e32830baea9, 18685424.
    • (2008) Curr Opin Support Palliat Care , vol.2 , pp. 218-222
    • Le Gall, C.1    Bonnelye, E.2    Clézardin, P.3
  • 26
    • 37349065426 scopus 로고    scopus 로고
    • Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts
    • 17962093
    • Fuller K, Lawrence KM, Ross JL, Grabowska UB, Shiroo M, Samuelsson B, Chambers TJ. Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts. Bone 2008, 42:200-211. 10.1016/j.bone.2007.09.044, 17962093.
    • (2008) Bone , vol.42 , pp. 200-211
    • Fuller, K.1    Lawrence, K.M.2    Ross, J.L.3    Grabowska, U.B.4    Shiroo, M.5    Samuelsson, B.6    Chambers, T.J.7
  • 28
    • 79952278967 scopus 로고    scopus 로고
    • The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: results of a 4-week, double-blind, randomized, controlled trial
    • 21147688
    • Jensen AB, Wynne C, Ramirez G, He W, Song Y, Berd Y, Wang H, Mehta A, Lombardi A. The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: results of a 4-week, double-blind, randomized, controlled trial. Clin Breast Cancer 2010, 10:452-458. 10.3816/CBC.2010.n.059, 21147688.
    • (2010) Clin Breast Cancer , vol.10 , pp. 452-458
    • Jensen, A.B.1    Wynne, C.2    Ramirez, G.3    He, W.4    Song, Y.5    Berd, Y.6    Wang, H.7    Mehta, A.8    Lombardi, A.9
  • 29
    • 70349964679 scopus 로고    scopus 로고
    • Promising bone-related therapeutic targets for rheumatoid arthritis
    • 2797318, 19798028
    • Choi Y, Arron JR, Townsend MJ. Promising bone-related therapeutic targets for rheumatoid arthritis. Nat Rev Rheumatol 2009, 5:543-548. 10.1038/nrrheum.2009.175, 2797318, 19798028.
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 543-548
    • Choi, Y.1    Arron, J.R.2    Townsend, M.J.3
  • 30
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • 14695408
    • Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B, Shaughnessy JD. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003, 349:2483-2494. 10.1056/NEJMoa030847, 14695408.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3    Rasmussen, E.4    Ma, Y.5    Barlogie, B.6    Shaughnessy, J.D.7
  • 32
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • 1801040, 17068150
    • Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy JD. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 2007, 109:2106-2111. 10.1182/blood-2006-09-047712, 1801040, 17068150.
    • (2007) Blood , vol.109 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3    Walker, R.4    Barlogie, B.5    Shaughnessy, J.D.6
  • 34
    • 47249149740 scopus 로고    scopus 로고
    • Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases
    • 18546262
    • Bu G, Lu W, Liu CC, Selander K, Yoneda T, Hall C, Keller ET, Li Y. Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. Int J Cancer 2008, 123:1034-1042. 10.1002/ijc.23625, 18546262.
    • (2008) Int J Cancer , vol.123 , pp. 1034-1042
    • Bu, G.1    Lu, W.2    Liu, C.C.3    Selander, K.4    Yoneda, T.5    Hall, C.6    Keller, E.T.7    Li, Y.8
  • 35
    • 79551610971 scopus 로고    scopus 로고
    • Emerging therapeutic opportunities for skeletal restoration
    • 21283108
    • Kawai M, Mödder UI, Khosla S, Rosen CJ. Emerging therapeutic opportunities for skeletal restoration. Nat Rev Drug Discov 2011, 10:141-156. 10.1038/nrd3299, 21283108.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 141-156
    • Kawai, M.1    Mödder, U.I.2    Khosla, S.3    Rosen, C.J.4
  • 36
    • 77956504043 scopus 로고    scopus 로고
    • Activin A and bone metastasis
    • 20533297
    • Leto G. Activin A and bone metastasis. J Cell Physiol 2010, 225:302-309. 10.1002/jcp.22272, 20533297.
    • (2010) J Cell Physiol , vol.225 , pp. 302-309
    • Leto, G.1
  • 39
    • 0037317520 scopus 로고    scopus 로고
    • The endothelin axis: emerging role in cancer
    • 12563310
    • Nelson J, Bagnato A, Battistini B, Nisen P. The endothelin axis: emerging role in cancer. Nat Rev Cancer 2003, 3:110-116. 10.1038/nrc990, 12563310.
    • (2003) Nat Rev Cancer , vol.3 , pp. 110-116
    • Nelson, J.1    Bagnato, A.2    Battistini, B.3    Nisen, P.4
  • 41
    • 33750075185 scopus 로고    scopus 로고
    • Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis
    • 16826430
    • Dréau D, Karaa A, Culberson C, Wyan H, McKillop IH, Clemens MG. Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis. Clin Exp Metastasis 2006, 23:41-53. 10.1007/s10585-006-9016-z, 16826430.
    • (2006) Clin Exp Metastasis , vol.23 , pp. 41-53
    • Dréau, D.1    Karaa, A.2    Culberson, C.3    Wyan, H.4    McKillop, I.H.5    Clemens, M.G.6
  • 42
    • 1942538390 scopus 로고    scopus 로고
    • A role for endothelin-2 and its receptors in breast tumor cell invasion
    • 15059899
    • Grimshaw MJ, Hagemann T, Ayhan A, Gillett CE, Binder C, Balkwill FR. A role for endothelin-2 and its receptors in breast tumor cell invasion. Cancer Res 2004, 64:2461-2468. 10.1158/0008-5472.CAN-03-1069, 15059899.
    • (2004) Cancer Res , vol.64 , pp. 2461-2468
    • Grimshaw, M.J.1    Hagemann, T.2    Ayhan, A.3    Gillett, C.E.4    Binder, C.5    Balkwill, F.R.6
  • 43
    • 77955758944 scopus 로고    scopus 로고
    • Novel bone-targeted strategies in oncology
    • 20643782
    • Vallet S, Smith MR, Raje N. Novel bone-targeted strategies in oncology. Clin Cancer Res 2010, 16:4084-4093. 10.1158/1078-0432.CCR-10-0600, 20643782.
    • (2010) Clin Cancer Res , vol.16 , pp. 4084-4093
    • Vallet, S.1    Smith, M.R.2    Raje, N.3
  • 44
    • 84873072048 scopus 로고    scopus 로고
    • AstraZeneca halts phase III trial of ZIBOTENTAN in non-metastatic castrate resistant prostate cancer
    • AstraZeneca halts phase III trial of ZIBOTENTAN in non-metastatic castrate resistant prostate cancer. , http://www.astrazeneca.com/Media/Press-releases/Article/0022011AstraZeneca-halts-phase-III-trial-of-ZIBOTENTAN
  • 45
    • 77950878893 scopus 로고    scopus 로고
    • TGFb pathway as a therapeutic target in bone metastases
    • 20166977
    • Juárez P, Guise TA. TGFb pathway as a therapeutic target in bone metastases. Curr Pharm Des 2010, 16:1301-1312. 10.2174/138161210791034049, 20166977.
    • (2010) Curr Pharm Des , vol.16 , pp. 1301-1312
    • Juárez, P.1    Guise, T.A.2
  • 46
    • 70249108848 scopus 로고    scopus 로고
    • Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment
    • 2731927, 19727403
    • Dunn LK, Mohammad KS, Fournier PG, McKenna CR, Davis HW, Niewolna M, Peng XH, Chirgwin JM, Guise TA. Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. PLoS One 2009, 4:e6896. 10.1371/journal.pone.0006896, 2731927, 19727403.
    • (2009) PLoS One , vol.4 , pp. e6896
    • Dunn, L.K.1    Mohammad, K.S.2    Fournier, P.G.3    McKenna, C.R.4    Davis, H.W.5    Niewolna, M.6    Peng, X.H.7    Chirgwin, J.M.8    Guise, T.A.9
  • 47
    • 77953765387 scopus 로고    scopus 로고
    • Doxorubicin in combination with a small TGFb inhibitor: a potential novel therapy for metastatic breast cancer in mouse models
    • 2860989, 20442777
    • Bandyopadhyay A, Wang L, Agyin J, Tang Y, Lin S, Yeh IT, De K, Sun LZ. Doxorubicin in combination with a small TGFb inhibitor: a potential novel therapy for metastatic breast cancer in mouse models. PloS One 2010, 5:e10365. 10.1371/journal.pone.0010365, 2860989, 20442777.
    • (2010) PloS One , vol.5 , pp. e10365
    • Bandyopadhyay, A.1    Wang, L.2    Agyin, J.3    Tang, Y.4    Lin, S.5    Yeh, I.T.6    De, K.7    Sun, L.Z.8
  • 48
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • 19945376
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890. 10.1016/j.cell.2009.11.007, 19945376.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 51
    • 77950882020 scopus 로고    scopus 로고
    • The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases?
    • 20166978
    • Hirbe AC, Morgan EA, Weilbaecher KN. The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases?. Curr Pharm Des 2010, 16:1284-1290. 10.2174/138161210791034012, 20166978.
    • (2010) Curr Pharm Des , vol.16 , pp. 1284-1290
    • Hirbe, A.C.1    Morgan, E.A.2    Weilbaecher, K.N.3
  • 53
    • 58149332686 scopus 로고    scopus 로고
    • Translating an antagonist of chemokine receptor CXCR4: from bench to bedside
    • 19088012
    • Wong D, Korz W. Translating an antagonist of chemokine receptor CXCR4: from bench to bedside. Clin Cancer Res 2008, 14:7975-7980. 10.1158/1078-0432.CCR-07-4846, 19088012.
    • (2008) Clin Cancer Res , vol.14 , pp. 7975-7980
    • Wong, D.1    Korz, W.2
  • 55
    • 84885094093 scopus 로고    scopus 로고
    • Servier Medical Art
    • Servier Medical Art. , http://www.servier.com/Smart/ImageBank.aspx?id_=729
  • 56
    • 37249013214 scopus 로고    scopus 로고
    • ClinicalTrials.gov
    • ClinicalTrials.gov. , http://www.clinicaltrials.gov/


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.