Notch3 and kidney injury: Never two without three

Journal of Pathology

Volumn 228, Issue 3, 2012, Pages 266-273

  Sanchez Niño, Maria Dolores ^a   Ortiz, Alberto ^b  

^a HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

chronic kidney disease; fibrosis; inflammation; kidney; Notch

Indexed keywords

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ANGIOTENSIN II; BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GAMMA SECRETASE; NEPHRIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; NOTCH4 RECEPTOR; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; WNT PROTEIN;

ACUTE KIDNEY FAILURE; APOPTOSIS; CADASIL; CELL CULTURE; CELL PROLIFERATION; CHRONIC KIDNEY DISEASE; DIABETIC NEPHROPATHY; ENDOCYTOSIS; ENZYME INHIBITION; FIBROBLAST; FIBROSING ALVEOLITIS; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GLOMERULOSCLEROSIS; GLOMERULUS; HUMAN; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KIDNEY CELL; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY TUBULE CELL; LIGAND BINDING; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; URETER OBSTRUCTION; WESTERN BLOTTING;

ANIMALS; FEMALE; HUMANS; INFLAMMATION; KIDNEY; NEPHRITIS, INTERSTITIAL; RECEPTORS, NOTCH; URETERAL OBSTRUCTION;

EID: 84867570635     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4101     Document Type: Review

References (55)

1. Zeisberg M, Neilson EG,. Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 2010; 21: 1819-1834.
2. Sanz AB, Sanchez-Nino MD, Ramos AM, et al,. NF-kappaB in renal inflammation. J Am Soc Nephrol 2010; 21: 1254-1262.
3. Bielesz B, Sirin Y, Si H, et al,. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest 2010; 120: 4040-4054.
4. Wynn TA,. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199-210.
5. Djudjaj S, Chatziantoniou C, Raffetseder U, et al,. Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury. J Pathol 2012; 228: 286-299.
6. Pancewicz J, Nicot C,. Current views on the role of Notch signaling and the pathogenesis of human leukemia. BMC Cancer 2011; 11: 502.
7. Chillakuri CR, Sheppard D, Lea SM, et al,. Notch receptor-ligand binding and activation: insights from molecular studies. Semin Cell Dev Biol 2012; 23: 421-428.
8. Borggrefe T, Liefke R,. Fine-tuning of the intracellular canonical Notch signaling pathway. Cell Cycle 2012; 11: 264-276.
9. Eiraku M, Tohgo A, Ono K, et al,. DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nature Neurosci 2005; 8: 873-880.
10. Sanchez-Solana B, Nueda ML, Ruvira MD, et al,. The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities. Biochim Biophys Acta 2011; 1813: 1153-1164.
11. Rauen T, Raffetseder U, Frye BC, et al,. YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation. J Biol Chem 2009; 284: 26928-26940.
12. Wang MM,. Notch signaling and Notch signaling modifiers. Int J Biochem Cell Biol 2011; 43: 1550-1562.
13. Kopan R, Ilagan MX,. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009; 137: 216-233.
14. Ilagan MX, Kopan R,. SnapShot: notch signaling pathway. Cell 2007; 128: 1246.
15. Andersen P, Uosaki H, Shenje LT, et al,. Non-canonical Notch signaling: emerging role and mechanism. Trends Cell Biol 2012; 22: 257-265.
16. Nyhan KC, Faherty N, Murray G, et al,. Jagged/Notch signalling is required for a subset of TGFbeta1 responses in human kidney epithelial cells. Biochim Biophys Acta 2010; 1803: 1386-1395.
17. Johnson EA,. HIF takes it up a notch. Sci Signal 2011; 4: e33.
18. Ong CT, Cheng HT, Chang LW, et al,. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem 2006; 281: 5106-5119.
19. Schwanbeck R, Martini S, Bernoth K, et al,. The Notch signaling pathway: molecular basis of cell context dependency. Eur J Cell Biol 2011; 90: 572-581.
20. del Alamo D, Rouault H, Schweisguth F,. Mechanism and significance of cis-inhibition in Notch signalling. Curr Biol 2011; 21: R40-R47.
21. Sirin Y, Susztak K,. Notch in the kidney: development and disease. J Pathol 2012; 226: 394-403.
22. Barak H, Surendran K, Boyle SC,. The role of Notch signaling in kidney development and disease. Adv Exp Med Biol 2012; 727: 99-113.
23. Niranjan T, Bielesz B, Gruenwald A, et al,. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nature Med 2008; 14: 290-298.
24. Purow B,. Notch inhibition as a promising new approach to cancer therapy. Adv Exp Med Biol 2012; 727: 305-319.
25. Gupta S, Li S, Abedin MJ, et al,. Effect of Notch activation on the regenerative response to acute renal failure. Am J Physiol Renal Physiol 2010; 298: F209-F215.
26. Kobayashi T, Terada Y, Kuwana H, et al,. Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury. Kidney Int 2008; 73: 1240-1250.
27. Sharma M, Callen S, Zhang D, et al,. Activation of Notch signaling pathway in HIV-associated nephropathy. AIDS 2010; 24: 2161-2170.
28. Murea M, Park JK, Sharma S, et al,. Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function. Kidney Int 2010; 78: 514-522.
29. Waters AM, Wu MY, Huang YW, et al,. Notch promotes dynamin-dependent endocytosis of nephrin. J Am Soc Nephrol 2012; 23: 27-35.
30. Surendran K, Selassie M, Liapis H, et al,. Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol 2010; 21: 819-832.
31. McDaniell R, Warthen DM, Sanchez-Lara PA, et al,. NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet 2006; 79: 169-173.
32. Uyttendaele H, Marazzi G, Wu G, et al,. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 1996; 122: 2251-2259.
33. Cummins TD, Mendenhall MD, Lowry MN, et al,. Elongin C is a mediator of Notch4 activity in human renal tubule cells. Biochim Biophys Acta 2011; 1814: 1748-1757.
34. Penton AL, Leonard LD, Spinner NB,. Notch signaling in human development and disease. Semin Cell Dev Biol 2012; 23: 450-457.
35. Arboleda-Velasquez JF, Manent J, Lee JH, et al,. Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A 2011; 108: E128-E135.
36. Kusaba T, Hatta T, Kimura T, et al,. Renal involvement in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Clin Nephrol 2007; 67: 182-187.
37. Guerrot D, Francois A, Boffa JJ, et al,. Nephroangiosclerosis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: is NOTCH3 mutation the common culprit? Am J Kidney Dis 2008; 52: 340-345.
38. Wallays G, Nuyens D, Silasi-Mansat R, et al,. Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Arterioscler Thromb Vasc Biol 2011; 31: 2881-2888.
39. Wang Q, Zhao N, Kennard S, et al,. Notch2 and Notch3 function together to regulate vascular smooth muscle development. PLoS One 2012; 7: e37365.
40. Domenga V, Fardoux P, Lacombe P, et al,. Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev 2004; 18: 2730-2735.
41. Boulos N, Helle F, Dussaule JC, et al,. Notch3 is essential for regulation of the renal vascular tone. Hypertension 2011; 57: 1176-1182.
42. Esteban V, Lorenzo O, Ruperez M, et al,. Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. J Am Soc Nephrol 2004; 15: 1514-1529.
43. Ishidoya S, Morrissey J, McCracken R, et al,. Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction. Kidney Int 1995; 47: 1285-1294.
44. Clement N, Gueguen M, Glorian M, et al,. Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk. J Cell Sci 2007; 120: 3352-3361.
45. Lavoz C, Rodrigues-Diez R, Benito-Martin A, et al,. Angiotensin II contributes to renal fibrosis independently of Notch pathway activation. PLoS One 2012; 7: e40490.
46. Rodrigues-Diez R, Carvajal-Gonzalez G, Sanchez-Lopez E, et al,. Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways. Pharm Res 2008; 25: 2447-2461.
47. Nixon C, Vertucci FJ, Swindle R. The effect of post space preparation on the apical seal of root canal obturated teeth. Todays FDA 1991; 3:1C, 6C.
48. Carvajal G, Rodriguez-Vita J, Rodrigues-Diez R, et al,. Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation. Kidney Int 2008; 74: 585-595.
49. Ruiz-Ortega M, Ruperez M, Lorenzo O, et al,. Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney. Kidney Int Suppl 2002; 82: S12-S22.
50. Wu Y, Cain-Hom C, Choy L, et al,. Therapeutic antibody targeting of individual Notch receptors. Nature 2010; 464: 1052-1057.
51. Li K, Li Y, Wu W, et al,. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem 2008; 283: 8046-8054.
52. Cheng HT, Kim M, Valerius MT, et al,. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 2007; 134: 801-811.
53. Kitamoto T, Takahashi K, Takimoto H, et al,. Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice. Biochem Biophys Res Commun 2005; 331: 1154-1162.
54. Krebs LT, Xue Y, Norton CR, et al,. Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis 2003; 37: 139-143.
55. Murphy PA, Lam MT, Wu X, et al,. Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice. Proc Natl Acad Sci U S A 2008; 105: 10901-10906.