메뉴 건너뛰기




Volumn 1813, Issue 6, 2011, Pages 1153-1164

The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities

Author keywords

DLK1; DLK2; NOTCH canonical ligand; NOTCH signaling; Protein protein interaction

Indexed keywords

EPIDERMAL GROWTH FACTOR; LIGAND; MEMBRANE PROTEIN; NOTCH1 RECEPTOR; PROTEIN DLK1; PROTEIN DLK2; UNCLASSIFIED DRUG;

EID: 79955669250     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2011.03.004     Document Type: Article
Times cited : (76)

References (81)
  • 2
    • 0030936580 scopus 로고    scopus 로고
    • Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs
    • Moore K.A., Pytowski B., Witte L., Hicklin D., Lemischka I.R. Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA 1997, 94:4011-4016.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4011-4016
    • Moore, K.A.1    Pytowski, B.2    Witte, L.3    Hicklin, D.4    Lemischka, I.R.5
  • 3
    • 0031813294 scopus 로고    scopus 로고
    • Modulated expression of the epidermal growth factor-like homeotic protein dlk influences stromal-cell-pre-B-cell interactions, stromal cell adipogenesis, and pre-B-cell interleukin-7 requirements
    • Bauer S.R., Ruiz-Hidalgo M.J., Rudikoff E.K., Goldstein J., Laborda J. Modulated expression of the epidermal growth factor-like homeotic protein dlk influences stromal-cell-pre-B-cell interactions, stromal cell adipogenesis, and pre-B-cell interleukin-7 requirements. Mol Cell Biol 1998, 18:5247-5255.
    • (1998) Mol Cell Biol , vol.18 , pp. 5247-5255
    • Bauer, S.R.1    Ruiz-Hidalgo, M.J.2    Rudikoff, E.K.3    Goldstein, J.4    Laborda, J.5
  • 5
    • 0035181767 scopus 로고    scopus 로고
    • Dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect
    • Ohno N., Izawa A., Hattori M., Kageyama R., Sudo T. dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect. Stem Cells 2001, 19:71-79.
    • (2001) Stem Cells , vol.19 , pp. 71-79
    • Ohno, N.1    Izawa, A.2    Hattori, M.3    Kageyama, R.4    Sudo, T.5
  • 8
    • 3843100446 scopus 로고    scopus 로고
    • Overexpression of delta-like (Dlk) in a subset of myelodysplastic syndrome bone marrow trephines
    • Langer F., Stickel J., Tessema M., Kreipe H., Lehmann U. Overexpression of delta-like (Dlk) in a subset of myelodysplastic syndrome bone marrow trephines. Leuk Res 2004, 28:1081-1083.
    • (2004) Leuk Res , vol.28 , pp. 1081-1083
    • Langer, F.1    Stickel, J.2    Tessema, M.3    Kreipe, H.4    Lehmann, U.5
  • 9
    • 0033885174 scopus 로고    scopus 로고
    • Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation
    • Floridon C., Jensen C.H., Thorsen P., Nielsen O., Sunde L., Westergaard J.G., Thomsen S.G., Teisner B. Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation. Differentiation 2000, 66:49-59.
    • (2000) Differentiation , vol.66 , pp. 49-59
    • Floridon, C.1    Jensen, C.H.2    Thorsen, P.3    Nielsen, O.4    Sunde, L.5    Westergaard, J.G.6    Thomsen, S.G.7    Teisner, B.8
  • 11
    • 0033610813 scopus 로고    scopus 로고
    • Transcriptional control of the pref-1 gene in 3T3-L1 adipocyte differentiation, sequence requirement for differentiation-dependent suppression
    • Smas C.M., Kachinskas D., Liu C.M., Xie X., Dircks L.K., Sul H.S. Transcriptional control of the pref-1 gene in 3T3-L1 adipocyte differentiation, sequence requirement for differentiation-dependent suppression. J Biol Chem 1998, 273:31751-31758.
    • (1998) J Biol Chem , vol.273 , pp. 31751-31758
    • Smas, C.M.1    Kachinskas, D.2    Liu, C.M.3    Xie, X.4    Dircks, L.K.5    Sul, H.S.6
  • 12
    • 0033019684 scopus 로고    scopus 로고
    • Adipocyte differentiation is modulated by secreted delta-like (dlk) variants and requires the expression of membrane-associated dlk
    • Garces C., Ruiz-Hidalgo M.J., Bonvini E., Goldstein J., Laborda J. Adipocyte differentiation is modulated by secreted delta-like (dlk) variants and requires the expression of membrane-associated dlk. Differentiation 1999, 64:103-114.
    • (1999) Differentiation , vol.64 , pp. 103-114
    • Garces, C.1    Ruiz-Hidalgo, M.J.2    Bonvini, E.3    Goldstein, J.4    Laborda, J.5
  • 13
    • 0027245963 scopus 로고
    • Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
    • Smas C.M., Sul H.S. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993, 73:725-734.
    • (1993) Cell , vol.73 , pp. 725-734
    • Smas, C.M.1    Sul, H.S.2
  • 15
    • 33947164677 scopus 로고    scopus 로고
    • The EGF-like protein dlk1 inhibits Notch signaling and potentiates adipogenesis of mesenchymal cells
    • Nueda M.L., Baladron V., Sanchez-Solana B., Ballesteros M.A., Laborda J. The EGF-like protein dlk1 inhibits Notch signaling and potentiates adipogenesis of mesenchymal cells. J Mol Biol 2007, 367:1281-1293.
    • (2007) J Mol Biol , vol.367 , pp. 1281-1293
    • Nueda, M.L.1    Baladron, V.2    Sanchez-Solana, B.3    Ballesteros, M.A.4    Laborda, J.5
  • 16
    • 0027467416 scopus 로고
    • Dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line
    • Laborda J., Sausville E.A., Hoffman T., Notario V. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem 1993, 268:3817-3820.
    • (1993) J Biol Chem , vol.268 , pp. 3817-3820
    • Laborda, J.1    Sausville, E.A.2    Hoffman, T.3    Notario, V.4
  • 17
    • 0028961044 scopus 로고
    • Dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily, identification of polymorphic variants of this RNA
    • Lee Y.L., Helman L., Hoffman T., Laborda J. dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily, identification of polymorphic variants of this RNA. Biochim Biophys Acta 1995, 1261:223-232.
    • (1995) Biochim Biophys Acta , vol.1261 , pp. 223-232
    • Lee, Y.L.1    Helman, L.2    Hoffman, T.3    Laborda, J.4
  • 18
    • 0037291014 scopus 로고    scopus 로고
    • Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications
    • Friedrichsen B.N., Carlsson C., Moldrup A., Michelsen B., Jensen C.H., Teisner B., Nielsen J.H. Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications. J Endocrinol 2003, 176:257-266.
    • (2003) J Endocrinol , vol.176 , pp. 257-266
    • Friedrichsen, B.N.1    Carlsson, C.2    Moldrup, A.3    Michelsen, B.4    Jensen, C.H.5    Teisner, B.6    Nielsen, J.H.7
  • 19
    • 0030457199 scopus 로고    scopus 로고
    • FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression
    • Tornehave D., Jensen C.H., Teisner B., Larsson L.I. FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression. Histochem Cell Biol 1996, 106:535-542.
    • (1996) Histochem Cell Biol , vol.106 , pp. 535-542
    • Tornehave, D.1    Jensen, C.H.2    Teisner, B.3    Larsson, L.I.4
  • 20
    • 33644749370 scopus 로고    scopus 로고
    • Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
    • Kawakami T., Chano T., Minami K., Okabe H., Okada Y., Okamoto K. Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Hum Mol Genet 2006, 15:821-830.
    • (2006) Hum Mol Genet , vol.15 , pp. 821-830
    • Kawakami, T.1    Chano, T.2    Minami, K.3    Okabe, H.4    Okada, Y.5    Okamoto, K.6
  • 22
    • 0036631089 scopus 로고    scopus 로고
    • Expression of preadipocyte factor-1(Pref-1), a delta-like protein, in healing mouse ears
    • Samulewicz S.J., Seitz A., Clark L., Heber-Katz E. Expression of preadipocyte factor-1(Pref-1), a delta-like protein, in healing mouse ears. Wound Repair Regen 2002, 10:215-221.
    • (2002) Wound Repair Regen , vol.10 , pp. 215-221
    • Samulewicz, S.J.1    Seitz, A.2    Clark, L.3    Heber-Katz, E.4
  • 24
    • 0036295562 scopus 로고    scopus 로고
    • The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system
    • Baladron V., Ruiz-Hidalgo M.J., Bonvini E., Gubina E., Notario V., Laborda J. The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system. Biochem Biophys Res Commun 2002, 291:193-204.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 193-204
    • Baladron, V.1    Ruiz-Hidalgo, M.J.2    Bonvini, E.3    Gubina, E.4    Notario, V.5    Laborda, J.6
  • 25
    • 0035511616 scopus 로고    scopus 로고
    • Specific regions of the extracellular domain of dlk, an EGF-like homeotic protein involved in differentiation, participate in intramolecular interactions
    • Baladron V., Ruiz-Hidalgo M.J., Gubina E., Bonvini E., Laborda J. Specific regions of the extracellular domain of dlk, an EGF-like homeotic protein involved in differentiation, participate in intramolecular interactions. Front Biosci 2001, 6:A25-A32.
    • (2001) Front Biosci , vol.6
    • Baladron, V.1    Ruiz-Hidalgo, M.J.2    Gubina, E.3    Bonvini, E.4    Laborda, J.5
  • 27
    • 43449099439 scopus 로고    scopus 로고
    • Dlk1 specifically interacts with insulin-like growth factor binding protein 1 to modulate adipogenesis of 3T3-L1 cells
    • Nueda M.L., Garcia-Ramirez J.J., Laborda J., Baladron V. dlk1 specifically interacts with insulin-like growth factor binding protein 1 to modulate adipogenesis of 3T3-L1 cells. J Mol Biol 2008, 379:428-442.
    • (2008) J Mol Biol , vol.379 , pp. 428-442
    • Nueda, M.L.1    Garcia-Ramirez, J.J.2    Laborda, J.3    Baladron, V.4
  • 28
    • 0036343728 scopus 로고    scopus 로고
    • Dlk modulates mitogen-activated protein kinase signaling to allow or prevent differentiation
    • Ruiz-Hidalgo M.J., Gubina E., Tull L., Baladron V., Laborda J. dlk modulates mitogen-activated protein kinase signaling to allow or prevent differentiation. Exp Cell Res 2002, 274:178-188.
    • (2002) Exp Cell Res , vol.274 , pp. 178-188
    • Ruiz-Hidalgo, M.J.1    Gubina, E.2    Tull, L.3    Baladron, V.4    Laborda, J.5
  • 29
    • 33745866965 scopus 로고    scopus 로고
    • Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation
    • Wang Y., Sul H.S. Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation. Mol Cell Biol 2006, 26:5421-5435.
    • (2006) Mol Cell Biol , vol.26 , pp. 5421-5435
    • Wang, Y.1    Sul, H.S.2
  • 30
    • 40949124822 scopus 로고    scopus 로고
    • The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila
    • Bray S.J., Takada S., Harrison E., Shen S.C., Ferguson-Smith A.C. The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev Biol 2008, 8:11.
    • (2008) BMC Dev Biol , vol.8 , pp. 11
    • Bray, S.J.1    Takada, S.2    Harrison, E.3    Shen, S.C.4    Ferguson-Smith, A.C.5
  • 31
    • 1642382833 scopus 로고    scopus 로고
    • Notch signaling: control of cell communication and cell fate
    • Lai E.C. Notch signaling: control of cell communication and cell fate. Development 2004, 131:965-973.
    • (2004) Development , vol.131 , pp. 965-973
    • Lai, E.C.1
  • 33
    • 0023996419 scopus 로고
    • The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila
    • Artavanis-Tsakonas S. The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila. Trends Genet 1988, 4:95-100.
    • (1988) Trends Genet , vol.4 , pp. 95-100
    • Artavanis-Tsakonas, S.1
  • 35
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: cell fate control and signal integration in development
    • Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 1999, 284:770-776.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 36
    • 0026075015 scopus 로고
    • Choosing a cell fate: a view from the Notch locus
    • Artavanis-Tsakonas S., Simpson P. Choosing a cell fate: a view from the Notch locus. Trends Genet 1991, 7:403-408.
    • (1991) Trends Genet , vol.7 , pp. 403-408
    • Artavanis-Tsakonas, S.1    Simpson, P.2
  • 37
    • 0031405415 scopus 로고    scopus 로고
    • Comparative aspects of Notch signaling in lower and higher eukaryotes
    • Blaumueller C.M., Artavanis-Tsakonas S. Comparative aspects of Notch signaling in lower and higher eukaryotes. Perspect Dev Neurobiol 1997, 4:325-343.
    • (1997) Perspect Dev Neurobiol , vol.4 , pp. 325-343
    • Blaumueller, C.M.1    Artavanis-Tsakonas, S.2
  • 39
  • 41
    • 0031213641 scopus 로고    scopus 로고
    • Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12
    • Oda T., Elkahloun A.G., Meltzer P.S., Chandrasekharappa S.C. Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12. Genomics 1997, 43:376-379.
    • (1997) Genomics , vol.43 , pp. 376-379
    • Oda, T.1    Elkahloun, A.G.2    Meltzer, P.S.3    Chandrasekharappa, S.C.4
  • 43
    • 21444451993 scopus 로고    scopus 로고
    • Notch in vertebrates-molecular aspects of the signal
    • Katsube K., Sakamoto K. Notch in vertebrates-molecular aspects of the signal. Int J Dev Biol 2005, 49:369-374.
    • (2005) Int J Dev Biol , vol.49 , pp. 369-374
    • Katsube, K.1    Sakamoto, K.2
  • 44
    • 0033816140 scopus 로고    scopus 로고
    • Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
    • Shimizu K., Chiba S., Hosoya N., Kumano K., Saito T., Kurokawa M., Kanda Y., Hamada Y., Hirai H. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol 2000, 20:6913-6922.
    • (2000) Mol Cell Biol , vol.20 , pp. 6913-6922
    • Shimizu, K.1    Chiba, S.2    Hosoya, N.3    Kumano, K.4    Saito, T.5    Kurokawa, M.6    Kanda, Y.7    Hamada, Y.8    Hirai, H.9
  • 45
    • 0032724977 scopus 로고    scopus 로고
    • Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods
    • Shimizu K., Chiba S., Kumano K., Hosoya N., Takahashi T., Kanda Y., Hamada Y., Yazaki Y., Hirai H. Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem 1999, 274:32961-32969.
    • (1999) J Biol Chem , vol.274 , pp. 32961-32969
    • Shimizu, K.1    Chiba, S.2    Kumano, K.3    Hosoya, N.4    Takahashi, T.5    Kanda, Y.6    Hamada, Y.7    Yazaki, Y.8    Hirai, H.9
  • 46
    • 0034675218 scopus 로고    scopus 로고
    • Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
    • Shimizu K., Chiba S., Saito T., Kumano K., Hirai H. Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. Biochem Biophys Res Commun 2000, 276:385-389.
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 385-389
    • Shimizu, K.1    Chiba, S.2    Saito, T.3    Kumano, K.4    Hirai, H.5
  • 47
    • 55449135598 scopus 로고    scopus 로고
    • The molecular logic of Notch signaling-a structural and biochemical perspective
    • Gordon W.R., Arnett K.L., Blacklow S.C. The molecular logic of Notch signaling-a structural and biochemical perspective. J Cell Sci 2008, 121:3109-3119.
    • (2008) J Cell Sci , vol.121 , pp. 3109-3119
    • Gordon, W.R.1    Arnett, K.L.2    Blacklow, S.C.3
  • 49
    • 0026086474 scopus 로고
    • Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor
    • Rebay I., Fleming R.J., Fehon R.G., Cherbas L., Cherbas P., Artavanis-Tsakonas S. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 1991, 67:687-699.
    • (1991) Cell , vol.67 , pp. 687-699
    • Rebay, I.1    Fleming, R.J.2    Fehon, R.G.3    Cherbas, L.4    Cherbas, P.5    Artavanis-Tsakonas, S.6
  • 51
    • 0035839458 scopus 로고    scopus 로고
    • Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain
    • Ohtsuka T., Sakamoto M., Guillemot F., Kageyama R. Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain. J Biol Chem 2001, 276:30467-30474.
    • (2001) J Biol Chem , vol.276 , pp. 30467-30474
    • Ohtsuka, T.1    Sakamoto, M.2    Guillemot, F.3    Kageyama, R.4
  • 52
    • 0037363922 scopus 로고    scopus 로고
    • HES and HERP families: multiple effectors of the Notch signaling pathway
    • Iso T., Kedes L., Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003, 194:237-255.
    • (2003) J Cell Physiol , vol.194 , pp. 237-255
    • Iso, T.1    Kedes, L.2    Hamamori, Y.3
  • 53
    • 33645976866 scopus 로고    scopus 로고
    • Notch-1 up-regulation and signaling following macrophage activation modulates gene expression patterns known to affect antigen-presenting capacity and cytotoxic activity
    • Monsalve E., Perez M.A., Rubio A., Ruiz-Hidalgo M.J., Baladron V., Garcia-Ramirez J.J., Gomez J.C., Laborda J., Diaz-Guerra M.J. Notch-1 up-regulation and signaling following macrophage activation modulates gene expression patterns known to affect antigen-presenting capacity and cytotoxic activity. J Immunol 2006, 176:5362-5373.
    • (2006) J Immunol , vol.176 , pp. 5362-5373
    • Monsalve, E.1    Perez, M.A.2    Rubio, A.3    Ruiz-Hidalgo, M.J.4    Baladron, V.5    Garcia-Ramirez, J.J.6    Gomez, J.C.7    Laborda, J.8    Diaz-Guerra, M.J.9
  • 55
    • 84883840386 scopus 로고
    • Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
    • Todaro G.J., Green H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol 1963, 17:299-313.
    • (1963) J Cell Biol , vol.17 , pp. 299-313
    • Todaro, G.J.1    Green, H.2
  • 57
    • 0025778925 scopus 로고
    • 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO
    • Laborda J. 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res 1991, 19:3998.
    • (1991) Nucleic Acids Res , vol.19 , pp. 3998
    • Laborda, J.1
  • 58
    • 47549092021 scopus 로고    scopus 로고
    • The serum levels of the EGF-like homeotic protein dlk1 correlate with different metabolic parameters in two hormonally different children populations in Spain
    • Hermida C., Garces C., de Oya M., Cano B., Martinez-Costa O.H., Rivero S., Garcia-Ramirez J.J., Laborda J., Aragon J.J. The serum levels of the EGF-like homeotic protein dlk1 correlate with different metabolic parameters in two hormonally different children populations in Spain. Clin Endocrinol Oxf 2008, 69:216-224.
    • (2008) Clin Endocrinol Oxf , vol.69 , pp. 216-224
    • Hermida, C.1    Garces, C.2    de Oya, M.3    Cano, B.4    Martinez-Costa, O.H.5    Rivero, S.6    Garcia-Ramirez, J.J.7    Laborda, J.8    Aragon, J.J.9
  • 61
    • 0027192017 scopus 로고
    • Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila
    • de Celis J.F., Barrio R., del Arco A., Garcia-Bellido A. Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila. Proc Natl Acad Sci USA 1993, 90:4037-4041.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4037-4041
    • de Celis, J.F.1    Barrio, R.2    del Arco, A.3    Garcia-Bellido, A.4
  • 62
    • 0035854693 scopus 로고    scopus 로고
    • Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation
    • Shimizu K., Chiba S., Saito T., Kumano K., Takahashi T., Hirai H. Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. J Biol Chem 2001, 276:25753-25758.
    • (2001) J Biol Chem , vol.276 , pp. 25753-25758
    • Shimizu, K.1    Chiba, S.2    Saito, T.3    Kumano, K.4    Takahashi, T.5    Hirai, H.6
  • 63
    • 77954364477 scopus 로고    scopus 로고
    • Pref-1 interacts with fibronectin to inhibit adipocyte differentiation, Mol Cell Biol
    • Y. Wang, L. Zhao, C. Smas, H.S. Sul, Pref-1 interacts with fibronectin to inhibit adipocyte differentiation, Mol Cell Biol 30 3480-3492.
    • , vol.30 , pp. 3480-3492
    • Wang, Y.1    Zhao, L.2    Smas, C.3    Sul, H.S.4
  • 64
    • 12944255642 scopus 로고    scopus 로고
    • Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
    • Yang L.T., Nichols J.T., Yao C., Manilay J.O., Robey E.A., Weinmaster G. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell 2005, 16:927-942.
    • (2005) Mol Biol Cell , vol.16 , pp. 927-942
    • Yang, L.T.1    Nichols, J.T.2    Yao, C.3    Manilay, J.O.4    Robey, E.A.5    Weinmaster, G.6
  • 65
    • 0346505185 scopus 로고    scopus 로고
    • An O-fucose site in the ligand binding domain inhibits Notch activation
    • Lei L., Xu A., Panin V.M., Irvine K.D. An O-fucose site in the ligand binding domain inhibits Notch activation. Development 2003, 130:6411-6421.
    • (2003) Development , vol.130 , pp. 6411-6421
    • Lei, L.1    Xu, A.2    Panin, V.M.3    Irvine, K.D.4
  • 66
    • 35549010538 scopus 로고    scopus 로고
    • Regulation of Notch signaling by glycosylation
    • Stanley P. Regulation of Notch signaling by glycosylation. Curr Opin Struct Biol 2007, 17:530-535.
    • (2007) Curr Opin Struct Biol , vol.17 , pp. 530-535
    • Stanley, P.1
  • 69
    • 0025971830 scopus 로고
    • The choice of cell fate in the epidermis of Drosophila
    • Heitzler P., Simpson P. The choice of cell fate in the epidermis of Drosophila. Cell 1991, 64:1083-1092.
    • (1991) Cell , vol.64 , pp. 1083-1092
    • Heitzler, P.1    Simpson, P.2
  • 71
    • 0031046071 scopus 로고    scopus 로고
    • Cleavage of membrane-associated pref-1 generates a soluble inhibitor of adipocyte differentiation
    • Smas C.M., Chen L., Sul H.S. Cleavage of membrane-associated pref-1 generates a soluble inhibitor of adipocyte differentiation. Mol Cell Biol 1997, 17:977-988.
    • (1997) Mol Cell Biol , vol.17 , pp. 977-988
    • Smas, C.M.1    Chen, L.2    Sul, H.S.3
  • 72
    • 0028142406 scopus 로고
    • Structural characterization and alternate splicing of the gene encoding the preadipocyte EGF-like protein pref-1
    • Smas C.M., Green D., Sul H.S. Structural characterization and alternate splicing of the gene encoding the preadipocyte EGF-like protein pref-1. Biochemistry 1994, 33:9257-9265.
    • (1994) Biochemistry , vol.33 , pp. 9257-9265
    • Smas, C.M.1    Green, D.2    Sul, H.S.3
  • 73
    • 0344813763 scopus 로고    scopus 로고
    • Molecular mechanisms of adipocyte differentiation and inhibitory action of pref-1
    • Smas C.M., Sul H.S. Molecular mechanisms of adipocyte differentiation and inhibitory action of pref-1. Crit Rev Eukaryot Gene Expr 1997, 7:281-298.
    • (1997) Crit Rev Eukaryot Gene Expr , vol.7 , pp. 281-298
    • Smas, C.M.1    Sul, H.S.2
  • 74
    • 0033694589 scopus 로고    scopus 로고
    • Function of pref-1 as an inhibitor of adipocyte differentiation
    • Sul H.S., Smas C., Mei B., Zhou L. Function of pref-1 as an inhibitor of adipocyte differentiation. Int J Obes Relat Metab Disord 2000, 24(Suppl 4):S15-S19.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , Issue.SUPPL. 4
    • Sul, H.S.1    Smas, C.2    Mei, B.3    Zhou, L.4
  • 75
    • 0033971947 scopus 로고    scopus 로고
    • The role of the epidermal growth factor-like protein dlk in cell differentiation
    • Laborda J. The role of the epidermal growth factor-like protein dlk in cell differentiation. Histol Histopathol 2000, 15:119-129.
    • (2000) Histol Histopathol , vol.15 , pp. 119-129
    • Laborda, J.1
  • 76
    • 0037093526 scopus 로고    scopus 로고
    • Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing
    • Mei B., Zhao L., Chen L., Sul H.S. Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing. Biochem J 2002, 364:137-144.
    • (2002) Biochem J , vol.364 , pp. 137-144
    • Mei, B.1    Zhao, L.2    Chen, L.3    Sul, H.S.4
  • 80
    • 33751351093 scopus 로고    scopus 로고
    • Identification of a novel gene family involved in osmotic stress response in Caenorhabditis elegans
    • Wheeler J.M., Thomas J.H. Identification of a novel gene family involved in osmotic stress response in Caenorhabditis elegans. Genetics 2006, 174:1327-1336.
    • (2006) Genetics , vol.174 , pp. 1327-1336
    • Wheeler, J.M.1    Thomas, J.H.2
  • 81
    • 33747083190 scopus 로고    scopus 로고
    • Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression
    • Lamitina T., Huang C.G., Strange K. Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression. Proc Natl Acad Sci USA 2006, 103:12173-12178.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12173-12178
    • Lamitina, T.1    Huang, C.G.2    Strange, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.