Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease

Journal of Neuroscience Research

Volumn 87, Issue 6, 2009, Pages 1462-1473

  Guan, Hanjun ^a,e   Liu, Yinxing ^a   Daily, Abigail ^a   Police, Sara ^b   Kim, Myung Hee ^a   Oddo, Salvatore ^c   LaFerla, Frank M ^c   Pauly, James R ^a   Murphy, M Paul ^a,d   Hersh, Louis B ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid clearance; Gene therapy; Peptidases

Indexed keywords

AMYLOID BETA PROTEIN; MEMBRANE METALLOENDOPEPTIDASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CELL SURFACE; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TASK PERFORMANCE; AGING; ANIMAL; BLOOD PRESSURE; BONE MARROW TRANSPLANTATION; BRAIN; COGNITIVE DEFECT; DISEASE MODEL; GENE THERAPY; GENETIC TRANSDUCTION; GENETICS; LENTIVIRINAE; MAZE TEST; METABOLISM; TRANSGENIC MOUSE;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BLOOD PRESSURE; BONE MARROW TRANSPLANTATION; BRAIN; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; GENE THERAPY; HUMANS; LENTIVIRUS; LEUKOCYTES; MAZE LEARNING; MICE; MICE, TRANSGENIC; NEPRILYSIN; TRANSDUCTION, GENETIC;

EID: 65549114145     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21944     Document Type: Article

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