Cellular stress and signal transduction responses to human cytomegalovirus infection

Microbes and Infection

Volumn 6, Issue 12, 2004, Pages 1084-1093

  Evers, David L ^a   Wang, Xin ^a   Huang, Eng Shang ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Antiviral; Cytokine; Cytomegalovirus; Signal transduction

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ACETYLSALICYLIC ACID; CELL RECEPTOR; COLCHICINE; CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GENISTEIN; INDOMETACIN; INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; NIFEDIPINE; NOCODAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; OXIPURINOL; PAPAVERINE; PROSTAGLANDIN; PROTEIN TYROSINE KINASE; RESVERATROL; ROSCOVITINE; TETRACAINE; TRANSCRIPTION FACTOR; UNINDEXED DRUG; VITRONECTIN RECEPTOR;

APOPTOSIS; CELL CYCLE; CELL GROWTH; CELL NUCLEUS; CYTOMEGALOVIRUS INFECTION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CYTOMEGALOVIRUS; HYDROLYSIS; LIFE CYCLE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; STEADY STATE; STRESS; UPREGULATION; VIRUS ADSORPTION; VIRUS INFECTIVITY; VIRUS REPLICATION;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 4544287124     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2004.05.026     Document Type: Short Survey

References (84)

1. Mocarski E.S., and Courcelle C.T. Cytomegaloviruses and their replication fourth ed Knipe D.M. Howley P.M. Fields Virology 2001 Lippincott Williams & Wilkins Philadelphia 2629 2673
2. Huang E.-S., and Kowalik T.F. The pathogenicity of human cytomegalovirus: an overview Becker Y. Darai G. Huang E.-S. Molecular aspects of human cytomegalovirus diseases 1993 Springer-Verlag Berlin 1 45
3. Speir E., Modali R., Huang E.-S., Leon M.B., Shawl F., Finkel T., and Epstein S.E. Potential role of human cytomegalovirus and p53 interaction in coronary restenosis Science 265 1994 391 394
4. Alcami A., and Koszinowski U.H. Viral mechanisms of immune evasion Immunol. Today 21 2000 447 455
5. Boyle K.A., and Compton T. Receptor-binding properties of a soluble form of human cytomegalovirus glycoprotein B J. Virol. 72 1998 1826 1833
6. Compton T., Nepomuceno R.R., and Nowlin D.M. Human cytomegalovirus penetrates host cells by pH-independent fusion at the cell surface Virology 191 1992 387 395
7. Wang X., Huong S.-M., Chiu M.L., Raab-Traub N., and Huang E.-S. Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus Nature 424 2003 456 461
8. X. Wang, D.Y. Huang, S.-M. Huong, E.-S. Huang, Integrin αvβ3 is a coreceptor for human cytomegalovirus infection, Cell (submitted).
9. Schlessinger J. Cell signaling by receptor tyrosine kinases Cell 103 2000 211 225
10. Valy-Nagy T., Bandi Z., Boldogh I., and Albrecht T. Hydrolysis of inositol phospholipids: an early signal of human cytomegalovirus infection Arch. Virol. 101 1988 199 207
11. Johnson R.A., Wang X., Ma X.L., Huong S.-M., and Huang E.-S. Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling J. Virol. 75 2001 6022 6032
12. Slobbe-van Drunen M.E., Vossen R.C., Couwenberg F.M., Hulsbosch M.M., Heemskerk J.W., van Dam-Mieras M.C., and Bruggeman C.A. Activation of protein kinase C enhances the infection of endothelial cells by human cytomegalovirus Virus Res. 48 1997 207 213
13. Jones N.L., Lewis J.C., and Kilpatrick B.A. Cytoskeletal disruption during human cytomegalovirus infection of human lung fibroblasts Eur. J. Cell Biol. 41 1986 304 312
14. Ogawa-Goto K., Tanaka K., Gibson W., Moriishi E., Miura Y., Kurata T., Irie S., and Sata T. Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid J. Virol. 77 2003 8541 8547
15. Widmann C., Gibson S., Jarpe M.B., and Johnson G.L. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human Physiol. Rev. 79 1999 143 180
16. Johnson R.A., Ma X.L., Yurochko A.D., and Huang E.-S. The role of MKK1/2 kinase activity in human cytomegalovirus infection J. Gen. Virol. 82 2001 493 497
17. Yurochko A.D., and Huang E.-S. Human cytomegalovirus binding to human monocytes induces immunoregulatory gene expression J. Immunol. 162 1999 4806 4816
18. Rodems S.M., and Spector D.H. Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection J. Virol. 72 1998 9173 9180
19. Johnson R.A., Huong S.-M., and Huang E.-S. Activation of the mitogen activated protein kinase (MAPK) p38 by HCMV infection through two distinct pathways: a novel mechanism for activation of p38 J. Virol. 74 2000 1158 1167
20. Johnson R.A., Huong S.-M., and Huang E.-S. Inhibitory effect of 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole on HCMV DNA replication and permissive infection Antivir. Res. 41 1999 101 111
21. Baldwin A.S. Jr The NF-κB and IκB proteins: New discoveries and insights Annu. Rev. Immunol. 14 1996 649 681
22. Pahl H.L. Activators and target genes of Rel/NF-κB transcription factors Oncogene 18 1999 6853 6866
23. Cherrington J.M., and Mocarski E.S. Human cytomegalovirus IE1 transactivates the α promoter-enhancer via an 18-base-pair repeat element J. Virol. 63 1989 1435 1440
24. Kowalik T.F., Wing B., Haskill J.S., Azizkhan J.C., Baldwin A.S. Jr, and Huang E.-S. Multiple mechanisms are implicated in the regulation of NF-κB activity during human cytomegalovirus infection Proc. Natl. Acad. Sci. USA 90 1993 1107 1111
25. Speir E., Shibutani T., Yu Z.-X., Ferrans V.J., and Epstein S.E. Role of reactive oxygen intermediates in cytomegalovirus gene expression and in the response of human smooth muscle cells to viral infection Circ. Res. 79 1996 1143 1152
26. Yurochko A.D., Kowalik T.F., Huong S.-M., and Huang E.-S. Human cytomegalovirus upregulates NF-κB activity by transactivating the NF-κB p105/p50 and p65 promoters J. Virol. 69 1995 5391 5400
27. Yurochko A.D., Hwang E.S., Rasmussen L., Keay S., Periera L., and Huang E.-S. The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-κB during infection J. Virol. 71 1997 5051 5059
28. Suske G. The Sp-family of transcription factors Gene 238 1999 291 300
29. Boldogh I., AbuBakar S., and Albrecht T. Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection Science 247 1990 561 564
30. Shaulian E., and Karin M. AP-1 in cell proliferation and survival Oncogene 20 2001 2390 2400
31. Kim S., Yu S.S., Lee I.S., Ohno S., Yim J., Kim S., and Kang H.S. Human cytomegalovirus IE1 protein activates AP-1 through a cellular protein kinase(s) J. Gen. Virol. 80 1999 961 969
32. Speir E., Yu Z.-X., Ferrans V.J., Huang E.-S., and Epstein S.E. Aspirin attenuates cytomegalovirus infectivity and gene expression mediated by cyclooxygenase-2 in coronary artery smooth muscle cells Circ. Res. 83 1998 210 216
33. Tanaka J., Iida H., Sato H., and Hatano M. Inhibitors of prostaglandin synthesis inhibit growth of human cytomegalovirus and reactivation of latent virus in a productively and latently infected human cell line Virology 163 1988 205 208
34. Zhu H., Cong J.P., Yu D., Bresnahan W.A., and Shenk T.E. Inhibition of cyclooxygenase-2 blocks human cytomegalovirus replication Proc. Natl. Acad. Sci. USA. 99 2002 3932 3937
35. Funk C.D. Prostaglandins and leukotrienes: advances in eicosanoid biology Science 294 2001 1871 1875
36. AbuBakar S., Boldogh I., and Albrecht T. Human cytomegalovirus stimulates arachidonic acid metabolism through pathways that are affected by inhibitors of phospholipase A2 and protein kinase C Biochem. Biophys. Res. Comm. 166 1990 953 959
37. Shibutani T., Johnson T.M., Yu Z.-X., Ferrans V.J., Moss J., and Epstein S.E. Pertussis toxin-sensitive G proteins as mediators of the signal transduction pathways activated by cytomegalovirus infection of smooth muscle cells J. Clin. Invest. 15 1997 2054 2061
38. Zhu H., Cong J.P., Mamtora G., Gingeras T., and Shenk T. Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays Proc. Natl. Acad. Sci. USA. 95 1998 14470 14475
39. Stark G.R., Kerr I.M., Williams B.R.G., Silverman R.H., and Schreiber R.D. How cells respond to interferon Annu. Rev. Biochem. 67 1998 227 264
40. Boyle K.A., Pietropaolo R.L., and Compton T.A. Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway Mol. Cell. Biol. 19 1999 3607 3613
41. Zhu H., Cong J.P., and Shenk T. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs Proc. Natl. Acad. Sci. USA 94 1997 13985 13990
42. Browne E.P., and Shenk T. Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells Proc. Natl. Acad. Sci. USA 100 2003 11439 11444
43. Miller D.M., Zhang Y., Rahill B.M., Waldman W.J., and Sedmak D.D. Human cytomegalovirus inhibits IFN-α stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-α signal transduction J. Immunol. 162 1999 6107 6113
44. Baillie J., Sahlender D.A., and Sinclair J.H. Human cytomegalovirus infection inhibits tumor necrosis factor alpha (TNF-α) signaling by targeting the 55-kilodalton TNF-alpha receptor J. Virol. 77 2003 7007 7016
45. Carlquist J.F., Edelman L., Bennion D.W., and Anderson J.L. Cytomegalovirus induction of interleukin-6 in lung fibroblasts occurs independently of active infection and involves a G protein and the transcription factor, NF-κB J. Infect. Dis. 179 1999 1094 1100
46. Compton T., Kurt-Jones E.A., Boehme K.W., Belko J., Latz E., Golenbock D.T., and Finberg R.W. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2 J. Virol. 77 2003 4588 4596
47. Hagemeier C., Walker S.M., Sissons P.J., and Sinclair J.H. The 72K IE1 and 80K IE2 proteins of human cytomegalovirus independently trans-activate the c-fos, c-myc and hsp70 promoters via basal promoter elements J. Gen. Virol. 73 1992 2385 2393
48. Nokta M.A., Hassan M.I., Loesch K., and Pollard R.B. Human cytomegalovirus-induced immunosuppression. Relationship to tumor necrosis factor-dependent release of arachidonic acid and prostaglandin E2 in human monocytes J. Clin. Invest. 97 1996 2635 2641
49. Kline J.N., Hunninghake G.M., He B., Monick M.M., and Hunninghake G.W. Synergistic activation of the human cytomegalovirus major immediate early promoter by prostaglandin E2 and cytokines Exp. Lung. Res. 24 1998 3 14
50. Dudding L.R., Haskill S., Clark B.D., Auron P.E., Sporn S., and Huang E.-S. Cytomegalovirus infection stimulates expression of monocyte-associated mediator genes J. Immunol. 143 1989 3343 3352
51. Murayama T., Ohara Y., Obuchi M., Khabar K.A., Higashi H., Mukaida N., and Matsushima K. Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-κB-binding sites of the interleukin-8 gene J. Virol. 71 1997 5692 5695
52. Muranyi W., Haas J., Wagner M., Krohne G., and Koszinowski U.H. Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina Science 297 2002 778 779
53. Dittmer D., and Mocarski E.S. HCMV infection inhibits G1/S transition J. Virol. 71 1997 1629 1634
54. Jault F.M., Jault J.-M., Ruchti F., Fortunato E.A., Clark C., Corbeil J., Richman D.D., and Spector D.H. Cytomegalovirus infection induces high levels of cyclins, phosphorylated RB, and p53, leading to cell cycle arrest J. Virol. 69 1995 6697 6704
55. Nevins J.R. Toward an understanding of the functional complexity of the E2F and retinoblastoma families Cell Growth Differen. 9 1998 585 593
56. Poma E.E., Kowalik T.F., Zhu L., Sinclair J.H., and Huang E.-S. The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated repression of an E2F-responsive promoter J. Virol. 70 1996 7867 7877
57. Zhang Z., Huong S.-M., Wang X., Huang D.Y., and Huang E.-S. Interactions between human cytomegalovirus IE1-72 and cellular p107: functional domains and mechanisms of up-regulation of cyclin E/cdk2 kinase activity J. Virol. 77 2003 12660 12670
58. Margolis M.J., Pajovic S., Wong E.L., Wade M., Jupp R., Nelson J.A., and Azizkhan J.C. Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription J. Virol. 69 1995 7759 7767
59. Pajovic S., Wong E., Black A., and Azizkhan J.C. Identification of a viral kinase that phosphorylates specific E2Fs and pocket proteins Mol. Cell. Biol. 17 1997 6459 6464
60. Hagemeier C., Caswell R., Hayhurst G., Sinclair J., and Kouzarides T. Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein EMBO J. 13 1994 2897 2903
61. Song Y.-J., and Stinski M.F. Effect of the human cytomegalovirus IE86 protein on expression of E2F-responsive genes: a DNA microarray analysis Proc. Natl. Acad. Sci. USA 99 2002 2836 2841
62. Bresnahan W.A., Albrecht T., and Thompson E.A. The cyclin E promoter is activated by human cytomegalovirus 86-kDa immediate early protein J. Biol. Chem. 273 1998 22075 22082
63. Wiebusch L., and Hagemeier C. Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G1 J. Virol. 73 1999 9274 9283
64. Sinclair J., Baillie J., Bryant L., and Caswell R. Human cytomegalovirus mediates cell cycle progression through G(1) into early S phase in terminally differentiated cells J. Gen. Virol. 81 2000 1553 1565
65. Levine A.J. p53, the cellular gatekeeper for growth and division Cell 88 1997 323 331
66. Muganda P., Mendoza O., Hernandez J., and Qian Q. Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts J. Virol. 68 1994 8028 8034
67. Fortunato E.A., and Spector D.H. p53 and RPA are sequestered in viral replications centers in the nuclei of cells infected with human cytomegalovirus J. Virol. 72 1998 2033 2039
68. Tsai H.L., Kou G.H., Chen S.C., Wu C.W., and Lin Y.S. Human cytomegalovirus immediate-early protein IE2 tethers a transcriptional repression domain to p53 J. Biol. Chem. 271 1996 3534 3540
69. Kovacs A., Weber M.L., Burns L.J., Jacob H.S., and Vercellotti G.M. Cytoplasmic sequestration of p53 in cytomegalovirus-infected human endothelial cells Am. J. Pathol. 149 1996 1531 1539
70. Bresnahan W.A., Boldogh I., Chi P., Thompson E.A., and Albrecht T. Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication Virology 231 1997 239 247
71. Zhu H., Shen Y., and Shenk T. Human cytomegalovirus IE1 and IE2 proteins block apoptosis J. Virol. 69 1995 7960 7970
72. Yu Y., and Alwine J.C. Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3′-OH kinase pathway and the cellular kinase Akt J. Virol. 76 2002 3731 3738
73. Sabbatini P., and McCormick F. Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis J. Biol. Chem. 274 1999 24263 24269
74. Brune W., Nevels M., and Shenk T. Murine cytomegalovirus m41 open reading frame encodes a Golgi-localized antiapoptotic protein J. Virol. 77 2003 11633 11643
75. Goldmacher V.S., Bartle L.M., Skaletskaya A., Dionne C.A., Kedersha N.L., Vater C.A., Han J.W., Lutz R.J., Watanabe S., McFarland Cahir E.D., Kieff E.D., Mocarski E.S., and Chittenden T. A cytomegalovirus-encoded mitochondria- localized inhibitor of apoptosis structurally unrelated to Bcl-2 Proc. Natl. Acad. Sci. USA 96 1999 12536 12541
76. Skaletskaya A., Bartle L.M., Chittenden T., McCormick A.L., Mocarski E.S., and Goldmacher V.S. A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation Proc. Natl. Acad. Sci. USA 98 2001 7829 7834
77. Penfold M.E.T., Dairaghi D.J., Duke G.M., Saederup N., Mocarski E.S., Kemble G.W., and Schall T.J. Cytomegalovirus encodes a potent alpha chemokine Proc. Natl. Acad. Sci. USA 96 1999 9839 9844
78. Bodaghi B., Jones T.R., Zipeto D., Vita C., Sun L., Laurent L., Arenzana-Seisdedos F., Virelizier J.L., and Michelson S. Chemokine sequestration by viral chemoreceptors as a novel viral escape strategy: withdrawal of chemokines from the environment of cytomegalovirus-infected cells J. Exp. Med. 188 1998 855 866
79. Neote K., DiGregorio D., Mak J.Y., Horuk R., and Schall T.J. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor Cell 72 1993 415 425
80. Streblow D.N., Soderberg-Naucler C., Vieira J., Smith P., Wakabayashi E., Ruchti F., Mattison K., Altschuler Y., and Nelson J.A. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration Cell 99 1999 511 520
81. Cinatl J. Jr, Margraf S., Vogel J.U., Scholz M., Cinatl J., and Doerr H.W. Human cytomegalovirus circumvents NF-κB dependence in retinal pigment epithelial cells J. Immunol. 167 2001 1900 1908
82. X. Wang, E.-S. Huang, unpublished results.
83. Marschall M., Stein-Gerlach M., Freitag M., Kupfer R., van Den Bogaard M., and Stamminger T. Inhibitors of human cytomegalovirus replication drastically reduce the activity of the viral protein kinase pUL97 J. Gen. Virol. 82 2001 1439 1450
84. Albrecht T., Boldogh I., Fons M., AbuBakar S., and Deng C.Z. Cell activation signals and the pathogenesis of human cytomegalovirus Intervirology 3 1990 68 75