Human cytomegalovirus induces the activity and expression of acetyl-coenzyme a carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication

Journal of Virology

Volumn 85, Issue 12, 2011, Pages 5814-5824

  Spencer, Cody M ^a   Schafer, Xenia L ^a   Moorman, Nathaniel J ^b   Munger, Joshua ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FUROIC ACID DERIVATIVE; 5 TETRADECYLOXY 2 FUROIC ACID; ACETYL COENZYME A CARBOXYLASE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; FIBROBLAST; GENE EXPRESSION; HUMAN CYTOMEGALOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; RNA INTERFERENCE; VIRUS ATTENUATION; VIRUS GENE; VIRUS REPLICATION;

ACETYL-COA CARBOXYLASE; CELL LINE; CYTOMEGALOVIRUS; DNA REPLICATION; FATTY ACIDS; FIBROBLASTS; HOST-PATHOGEN INTERACTIONS; HUMANS; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; VIRUS REPLICATION;

HUMAN HERPESVIRUS 5;

EID: 79958108811     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02630-10     Document Type: Article

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