메뉴 건너뛰기




Volumn 85, Issue 8, 2011, Pages 3930-3939

The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; RAPTOR PROTEIN; RICTOR PROTEIN; S6 KINASE; UNCLASSIFIED DRUG;

EID: 79952844950     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01913-10     Document Type: Article
Times cited : (71)

References (38)
  • 2
    • 48849093563 scopus 로고    scopus 로고
    • Modulation of host cell stress responses by human cytomegalovirus
    • T. E. Shenk and M. F. Stinski (ed.), Springer, New York, NY
    • Alwine, J. C. 2008. Modulation of host cell stress responses by human cytomegalovirus, p. 263-279. In T. E. Shenk and M. F. Stinski (ed.), Current topics in microbiology and immunology, human cytomegalovirus, vol. 325. Springer, New York, NY.
    • (2008) Current Topics in Microbiology and Immunology, Human Cytomegalovirus , vol.325 , pp. 263-279
    • Alwine, J.C.1
  • 3
    • 77249151465 scopus 로고    scopus 로고
    • Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA capbinding complex and excluding 4EBP1
    • Aoyagi, M., M. Gaspar, and T. E. Shenk. 2010. Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA capbinding complex and excluding 4EBP1. Proc. Natl. Acad. Sci. U. S. A. 107:2640-2645.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 2640-2645
    • Aoyagi, M.1    Gaspar, M.2    Shenk, T.E.3
  • 5
    • 0033766453 scopus 로고    scopus 로고
    • Replication of wild type and mutant human cytomegalovirus in life-extended human diploid fibroblasts
    • Bresnahan, W. A., G. E. Hultman, and T. Shenk. 2000. Replication of wild type and mutant human cytomegalovirus in life-extended human diploid fibroblasts. J. Virol. 74:10816-10818.
    • (2000) J. Virol. , vol.74 , pp. 10816-10818
    • Bresnahan, W.A.1    Hultman, G.E.2    Shenk, T.3
  • 6
    • 37349040367 scopus 로고    scopus 로고
    • Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78 which is required for virion assembly
    • Buchkovich, N. J., T. G. Maguire, A. W. Paton, J. C. Paton, and J. C. Alwine. 2008. Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78 which is required for virion assembly. J. Virol. 82:31-39.
    • (2008) J. Virol. , vol.82 , pp. 31-39
    • Buchkovich, N.J.1    Maguire, T.G.2    Paton, A.W.3    Paton, J.C.4    Alwine, J.C.5
  • 7
    • 77957944422 scopus 로고    scopus 로고
    • Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site
    • Buchkovich, N. J., Y. Yu, F. J. Pierciey, and J. C. Alwine. 2010. Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site. J. Virol. 84:11479-11486.
    • (2010) J. Virol. , vol.84 , pp. 11479-11486
    • Buchkovich, N.J.1    Yu, Y.2    Pierciey, F.J.3    Alwine, J.C.4
  • 8
    • 40949116686 scopus 로고    scopus 로고
    • The TORrid affairs of viruses: Effects of mammalian DNA viruses on the PI3KAkt-mTOR signaling pathway
    • Buchkovich, N. J., Y. Yu, C. A. Zampieri, and J. C. Alwine. 2008. The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3KAkt-mTOR signaling pathway. Nat. Rev. Microbiol. 6:266-275.
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 266-275
    • Buchkovich, N.J.1    Yu, Y.2    Zampieri, C.A.3    Alwine, J.C.4
  • 9
    • 0346995213 scopus 로고    scopus 로고
    • Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1
    • Child, S. J., M. Hakki, K. L. De Niro, and A. P. Geballe. 2004. Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1. J. Virol. 78:197-205.
    • (2004) J. Virol. , vol.78 , pp. 197-205
    • Child, S.J.1    Hakki, M.2    De Niro, K.L.3    Geballe, A.P.4
  • 10
    • 38749132980 scopus 로고    scopus 로고
    • Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1
    • Elia, A., C. Constantinou, and M. J. Clemens. 2008. Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1. Oncogene 27:811-822.
    • (2008) Oncogene , vol.27 , pp. 811-822
    • Elia, A.1    Constantinou, C.2    Clemens, M.J.3
  • 11
    • 77956044600 scopus 로고    scopus 로고
    • Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138
    • Grainger, L., et al. 2010. Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138. J. Virol. 84:9472-9486.
    • (2010) J. Virol. , vol.84 , pp. 9472-9486
    • Grainger, L.1
  • 12
    • 33751224189 scopus 로고    scopus 로고
    • Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1
    • Hakki, M., E. E. Marshall, K. L. De Niro, and A. P. Geballe. 2006. Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1. J. Virol. 80:11817-11826.
    • (2006) J. Virol. , vol.80 , pp. 11817-11826
    • Hakki, M.1    Marshall, E.E.2    De Niro, K.L.3    Geballe, A.P.4
  • 13
    • 0031799930 scopus 로고    scopus 로고
    • Phosphorylation of the human cytomegalovirus 86-kilodalton immedicate early protein IE2
    • Harel, N. Y., and J. C. Alwine. 1998. Phosphorylation of the human cytomegalovirus 86-kilodalton immedicate early protein IE2. J. Virol. 72:5481-5492.
    • (1998) J. Virol. , vol.72 , pp. 5481-5492
    • Harel, N.Y.1    Alwine, J.C.2
  • 14
    • 40949158668 scopus 로고    scopus 로고
    • Production of infectious HCMV virions is inhibited by drugs that disrupt calcium homeostasis in the endoplasmic reticulum
    • Isler, J. A., T. G. Maguire, and J. C. Alwine. 2005. Production of infectious HCMV virions is inhibited by drugs that disrupt calcium homeostasis in the endoplasmic reticulum. J. Virol. 79:15338-15397.
    • (2005) J. Virol. , vol.79 , pp. 15338-15397
    • Isler, J.A.1    Maguire, T.G.2    Alwine, J.C.3
  • 15
    • 18844419215 scopus 로고    scopus 로고
    • Human cytomegalovirus infection activates and regulates the unfolded protein response
    • Isler, J. A., A. H. Skalet, and J. C. Alwine. 2005. Human cytomegalovirus infection activates and regulates the unfolded protein response. J. Virol. 79:6890-6899.
    • (2005) J. Virol. , vol.79 , pp. 6890-6899
    • Isler, J.A.1    Skalet, A.H.2    Alwine, J.C.3
  • 16
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto, E., et al. 2004. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6:1122-1128.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1122-1128
    • Jacinto, E.1
  • 17
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim, D. H., et al. 2002. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1
  • 18
    • 4644252994 scopus 로고    scopus 로고
    • Human cytomegalovirus infection induces rapamycin insensitive phosphorylation of downstream effectors of mTOR kinase
    • Kudchodkar, S., Y. Yu, T. Maguire, and J. C. Alwine. 2004. Human cytomegalovirus infection induces rapamycin insensitive phosphorylation of downstream effectors of mTOR kinase. J. Virol. 78:11030-11039.
    • (2004) J. Virol. , vol.78 , pp. 11030-11039
    • Kudchodkar, S.1    Yu, Y.2    Maguire, T.3    Alwine, J.C.4
  • 19
    • 33947403537 scopus 로고    scopus 로고
    • AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection
    • Kudchodkar, S. B., G. Q. Del Prete, T. G. Maguire, and J. C. Alwine. 2007. AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection. J. Virol. 81:3649-3651.
    • (2007) J. Virol. , vol.81 , pp. 3649-3651
    • Kudchodkar, S.B.1    Del Prete, G.Q.2    Maguire, T.G.3    Alwine, J.C.4
  • 20
    • 33749040235 scopus 로고    scopus 로고
    • Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes
    • Kudchodkar, S. B., Y. Yu, T. G. Maguire, and J. C. Alwine. 2006. Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Proc. Natl. Acad. Sci. U. S. A. 103:14182-14187.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 14182-14187
    • Kudchodkar, S.B.1    Yu, Y.2    Maguire, T.G.3    Alwine, J.C.4
  • 21
    • 33750068623 scopus 로고    scopus 로고
    • MTOR, translation initiation and cancer
    • DOI 10.1038/sj.onc.1209888, PII 1209888
    • Mamane, Y., E. Petroulakis, O. LeBacquer, and N. Sonenberg. 2006. mTOR, translation initiation and cancer. Oncogene 25:6416-6422. (Pubitemid 44582285)
    • (2006) Oncogene , vol.25 , Issue.48 , pp. 6416-6422
    • Mamane, Y.1    Petroulakis, E.2    LeBacquer, O.3    Sonenberg, N.4
  • 22
    • 32644446560 scopus 로고    scopus 로고
    • Phosphorylation and dephosphorylation events that regulate viral mRNA translation
    • DOI 10.1016/j.virusres.2005.10.009, PII S0168170205003229
    • Mohr, I. 2006. Phosphorylation and dephosphorylation events that regulate viral mRNA translation. Virus Res. 119:89-99. (Pubitemid 43786256)
    • (2006) Virus Research , vol.119 , Issue.1 , pp. 89-99
    • Mohr, I.1
  • 23
    • 41849101685 scopus 로고    scopus 로고
    • Human Cytomegalovirus Protein UL38 Inhibits Host Cell Stress Responses by Antagonizing the Tuberous Sclerosis Protein Complex
    • DOI 10.1016/j.chom.2008.03.002, PII S1931312808000875
    • Moorman, N. J., et al. 2008. Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe 3:253-262. (Pubitemid 351494714)
    • (2008) Cell Host and Microbe , vol.3 , Issue.4 , pp. 253-262
    • Moorman, N.J.1    Cristea, I.M.2    Terhune, S.S.3    Rout, M.P.4    Chait, B.T.5    Shenk, T.6
  • 24
    • 77951480815 scopus 로고    scopus 로고
    • Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication
    • Moorman, N. J., and T. Shenk. 2010. Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication. J. Virol. 84:5260-5269.
    • (2010) J. Virol. , vol.84 , pp. 5260-5269
    • Moorman, N.J.1    Shenk, T.2
  • 26
    • 10744225986 scopus 로고    scopus 로고
    • Coding potential of laboratory and clinical strains of human cytomegalovirus
    • Murphy, E., et al. 2003. Coding potential of laboratory and clinical strains of human cytomegalovirus. Proc. Natl. Acad. Sci. U. S. A. 25:14976-14981.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.25 , pp. 14976-14981
    • Murphy, E.1
  • 27
    • 78650074979 scopus 로고    scopus 로고
    • Translational control of the abundance of cytoplasmic poly(A) binding protein in human cytomegalovirus-infected cells
    • Perez, C., C. McKinney, U. Chulunbaatar, and I. Mohr. 2011. Translational control of the abundance of cytoplasmic poly(A) binding protein in human cytomegalovirus-infected cells. J. Virol. 85:156-164.
    • (2011) J. Virol. , vol.85 , pp. 156-164
    • Perez, C.1    McKinney, C.2    Chulunbaatar, U.3    Mohr, I.4
  • 28
    • 33750044112 scopus 로고    scopus 로고
    • Stress and mTORture signaling
    • Reiling, J. H., and D. M. Sabatini. 2006. Stress and mTORture signaling. Oncogene 25:6373-6383.
    • (2006) Oncogene , vol.25 , pp. 6373-6383
    • Reiling, J.H.1    Sabatini, D.M.2
  • 29
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D. D., et al. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14:1296-1302.
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1
  • 31
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D. D., D. A. Guertin, S. M. Ali, and D. M. Sabatini. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 32
    • 0346373732 scopus 로고    scopus 로고
    • Herpes Simplex Virus Virion Host Shutoff Protein: Immune Evasion Mediated by a Viral RNase?
    • DOI 10.1128/JVI.78.3.1063-1068.2004
    • Smiley, J. R. 2004. Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase? J. Virol. 78:1063-1068. (Pubitemid 38095816)
    • (2004) Journal of Virology , vol.78 , Issue.3 , pp. 1063-1068
    • Smiley, J.R.1
  • 33
    • 67650228579 scopus 로고    scopus 로고
    • Rapamycin inhibits mTORC1, but not completely
    • Thoreen, C. C., and D. M. Sabatini. 2009. Rapamycin inhibits mTORC1, but not completely. Autophagy 5:725-726.
    • (2009) Autophagy , vol.5 , pp. 725-726
    • Thoreen, C.C.1    Sabatini, D.M.2
  • 34
    • 1842831274 scopus 로고    scopus 로고
    • Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells
    • DOI 10.1101/gad.1185304
    • Walsh, D., and I. Mohr. 2004. Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells. Genes Dev. 18:660-672. (Pubitemid 38489934)
    • (2004) Genes and Development , vol.18 , Issue.6 , pp. 660-672
    • Walsh, D.1    Mohr, I.2
  • 35
    • 20744448501 scopus 로고    scopus 로고
    • Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells
    • DOI 10.1128/JVI.79.13.8057-8064.2005
    • Walsh, D., C. Perez, J. Notary, and I. Mohr. 2005. Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells. J. Virol. 79:8057-8064. (Pubitemid 40853509)
    • (2005) Journal of Virology , vol.79 , Issue.13 , pp. 8057-8064
    • Walsh, D.1    Perez, C.2    Notary, J.3    Mohr, I.4
  • 36
    • 64049088651 scopus 로고    scopus 로고
    • Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death
    • Xuan, B., Z. Qian, E. Torigoi, and D. Yu. 2009. Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death. J. Virol. 83:3463-3474.
    • (2009) J. Virol. , vol.83 , pp. 3463-3474
    • Xuan, B.1    Qian, Z.2    Torigoi, E.3    Yu, D.4
  • 37
    • 42449090225 scopus 로고    scopus 로고
    • Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt
    • Yu, Y., and J. C. Alwine. 2008. Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. J. Virol. 82:4521-4526.
    • (2008) J. Virol. , vol.82 , pp. 4521-4526
    • Yu, Y.1    Alwine, J.C.2
  • 38
    • 18744382485 scopus 로고    scopus 로고
    • Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin (mTOR) signaling: Small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection
    • Yu, Y., S. B. Kudchodkar, and J. C. Alwine. 2005. Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin (mTOR) signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection. J. Virol. 79:6882-6889.
    • (2005) J. Virol. , vol.79 , pp. 6882-6889
    • Yu, Y.1    Kudchodkar, S.B.2    Alwine, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.