메뉴 건너뛰기




Volumn 76, Issue , 2011, Pages 145-154

A new approach to an old problem: Synthetic biology tools for human disease and metabolism

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; CARBON; CHIMERIC PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE; PEGINTERFERON ALPHA2A; RECOMBINANT DNA;

EID: 84867420739     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2011.76.010686     Document Type: Article
Times cited : (7)

References (78)
  • 3
    • 29144482539 scopus 로고    scopus 로고
    • Environmentally controlled invasion of cancer cells by engineered bacteria
    • Anderson JC, Clarke EJ, Arkin AP, Voigt CA. 2006. Environmentally controlled invasion of cancer cells by engineered bacteria. J Mol Biol 355: 619-627.
    • (2006) J Mol Biol , vol.355 , pp. 619-627
    • Anderson, J.C.1    Clarke, E.J.2    Arkin, A.P.3    Voigt, C.A.4
  • 4
    • 34547916832 scopus 로고    scopus 로고
    • Environmental signal integration by a modular AND gate
    • Anderson JC, Voigt CA, Arkin AP. 2007. Environmental signal integration by a modular AND gate. Mol Syst Biol 3: 133.
    • (2007) Mol Syst Biol , vol.3 , pp. 133
    • Anderson, J.C.1    Voigt, C.A.2    Arkin, A.P.3
  • 5
    • 84859771131 scopus 로고    scopus 로고
    • Smart medication through combination of synthetic biology and cell microencapsulation
    • doi: 10.1016/j.ymben.2011.06.003.
    • Ausländer S, Wieland M, Fussenegger M. 2011. Smart medication through combination of synthetic biology and cell microencapsulation. Metab Eng doi: 10.1016/j.ymben.2011.06.003.
    • (2011) Metab Eng
    • Ausländer, S.1    Wieland, M.2    Fussenegger, M.3
  • 6
    • 42749092251 scopus 로고    scopus 로고
    • Insulin-secreting L-cells for the treatment of insulin-dependent diabetes
    • Bara H, Sambanis A. 2008. Insulin-secreting L-cells for the treatment of insulin-dependent diabetes. Biochem Biophys Res Commun 371: 39-43.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 39-43
    • Bara, H.1    Sambanis, A.2
  • 7
    • 21444457242 scopus 로고    scopus 로고
    • Programmable ligand-controlled riboregulators of eukaryotic gene expression
    • Bayer TS, Smolke CD. 2005. Programmable ligand-controlled riboregulators of eukaryotic gene expression. Nat Biotechnol 23: 337-343.
    • (2005) Nat Biotechnol , vol.23 , pp. 337-343
    • Bayer, T.S.1    Smolke, C.D.2
  • 8
    • 54949106632 scopus 로고    scopus 로고
    • Modelguided design of ligand-regulated RNAi for programmable control of gene expression
    • Beisel CL, Bayer TS, Hoff KG, Smolke CD. 2008. Modelguided design of ligand-regulated RNAi for programmable control of gene expression. Mol Syst Biol 4: 224.
    • (2008) Mol Syst Biol , vol.4 , pp. 224
    • Beisel, C.L.1    Bayer, T.S.2    Hoff, K.G.3    Smolke, C.D.4
  • 10
    • 27944464545 scopus 로고    scopus 로고
    • Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
    • Berk AJ. 2005. Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus. Oncogene 24: 7673-7685.
    • (2005) Oncogene , vol.24 , pp. 7673-7685
    • Berk, A.J.1
  • 12
    • 67650671869 scopus 로고    scopus 로고
    • Harnessing nature's toolbox: Regulatory elements for synthetic biology
    • Boyle PM, Silver PA. 2009. Harnessing nature's toolbox: Regulatory elements for synthetic biology. J R Soc Interface 6 (Suppl 4): S535-S546.
    • (2009) J R Soc Interface , vol.6 , Issue.SUPPL. 4
    • Boyle, P.M.1    Silver, P.A.2
  • 13
    • 0027465481 scopus 로고
    • A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins
    • Braselmann S, Graninger P, Busslinger M. 1993. A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins. Proc Natl Acad Sci 90: 1657-1661.
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 1657-1661
    • Braselmann, S.1    Graninger, P.2    Busslinger, M.3
  • 14
    • 33644832381 scopus 로고    scopus 로고
    • In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production
    • Bro C, Regenberg B, Förster J, Nielsen J. 2006. In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production. Metab Eng 8: 102-111.
    • (2006) Metab Eng , vol.8 , pp. 102-111
    • Bro, C.1    Regenberg, B.2    Förster, J.3    Nielsen, J.4
  • 15
    • 18244390483 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
    • Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE. 2005. Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications. Ann Neurol 57: 695-703.
    • (2005) Ann Neurol , vol.57 , pp. 695-703
    • Bubber, P.1    Haroutunian, V.2    Fisch, G.3    Blass, J.P.4    Gibson, G.E.5
  • 16
    • 0242487787 scopus 로고    scopus 로고
    • Optknock: A bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
    • Burgard AP, Pharkya P, Maranas CD. 2003. Optknock: A bilevel programming framework for identifying gene knockout strategies for microbial strain optimization. Biotechnol Bioeng 84: 647-657.
    • (2003) Biotechnol Bioeng , vol.84 , pp. 647-657
    • Burgard, A.P.1    Pharkya, P.2    Maranas, C.D.3
  • 17
    • 73149084398 scopus 로고    scopus 로고
    • Making cellular memories
    • Burrill DR, Silver PA. 2010. Making cellular memories. Cell 140: 13-18.
    • (2010) Cell , vol.140 , pp. 13-18
    • Burrill, D.R.1    Silver, P.A.2
  • 18
    • 79952214973 scopus 로고    scopus 로고
    • Synthetic circuit identifies subpopulations with sustained memory of DNA damage
    • Burrill DR, Silver PA. 2011. Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev 25: 434-439.
    • (2011) Genes Dev , vol.25 , pp. 434-439
    • Burrill, D.R.1    Silver, P.A.2
  • 19
    • 43749102294 scopus 로고    scopus 로고
    • Enhancement of cell type specificity by quantitative modulation of a chimeric ligand
    • Cironi P, Swinburne IA, Silver PA. 2008. Enhancement of cell type specificity by quantitative modulation of a chimeric ligand. J Biol Chem 283: 8469-8476.
    • (2008) J Biol Chem , vol.283 , pp. 8469-8476
    • Cironi, P.1    Swinburne, I.A.2    Silver, P.A.3
  • 20
    • 78649429678 scopus 로고    scopus 로고
    • Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins
    • Culler SJ, Hoff KG, Smolke CD. 2010. Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins. Science 330: 1251-1255.
    • (2010) Science , vol.330 , pp. 1251-1255
    • Culler, S.J.1    Hoff, K.G.2    Smolke, C.D.3
  • 22
    • 34447505900 scopus 로고    scopus 로고
    • A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells
    • Deans TL, Cantor CR, Collins JJ. 2007. A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells. Cell 130: 363-372.
    • (2007) Cell , vol.130 , pp. 363-372
    • Deans, T.L.1    Cantor, C.R.2    Collins, J.J.3
  • 23
    • 23144432213 scopus 로고    scopus 로고
    • Optimality and evolutionary tuning of the expression level of a protein
    • Dekel E, Alon U. 2005. Optimality and evolutionary tuning of the expression level of a protein. Nature 436: 588-592.
    • (2005) Nature , vol.436 , pp. 588-592
    • Dekel, E.1    Alon, U.2
  • 24
    • 80052321503 scopus 로고    scopus 로고
    • Introduction to gene therapy: A clinical aftermath
    • Denèfle PP. 2011. Introduction to gene therapy: A clinical aftermath. Meth Mol Biol 737: 27-44.
    • (2011) Meth Mol Biol , vol.737 , pp. 27-44
    • Denèfle, P.P.1
  • 25
    • 77954920911 scopus 로고    scopus 로고
    • Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model
    • Duan F, March JC. 2010. Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model. Proc Natl Acad Sci 107: 11260-11264.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 11260-11264
    • Duan, F.1    March, J.C.2
  • 26
    • 57149095846 scopus 로고    scopus 로고
    • Secretion of insulinotropic proteins by commensal bacteria: Rewiring the gut to treat diabetes
    • Duan F, Curtis KL, March JC. 2008. Secretion of insulinotropic proteins by commensal bacteria: Rewiring the gut to treat diabetes. Appl Environ Microbiol 74: 7437-7438.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 7437-7438
    • Duan, F.1    Curtis, K.L.2    March, J.C.3
  • 27
    • 3843128481 scopus 로고    scopus 로고
    • Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model
    • Duarte NC, Herrga°rd MJ, Palsson BO. 2004. Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model. Genome Res 14: 1298-1309.
    • (2004) Genome Res , vol.14 , pp. 1298-1309
    • Duarte, N.C.1    Herrga°rd, M.J.2    Palsson, B.O.3
  • 29
    • 0036001069 scopus 로고    scopus 로고
    • Metabolic modelling of microbes: The flux-balance approach
    • Edwards JS, Covert M, Palsson B. 2002. Metabolic modelling of microbes: The flux-balance approach. Environ Microbiol 4: 133-140.
    • (2002) Environ Microbiol , vol.4 , pp. 133-140
    • Edwards, J.S.1    Covert, M.2    Palsson, B.3
  • 33
    • 80052261503 scopus 로고    scopus 로고
    • Managing risk in developing transplant immunosuppressive agents: The new regulatory environment
    • Gabardi S, Halloran PF, Friedewald J. 2011. Managing risk in developing transplant immunosuppressive agents: The new regulatory environment. Am J Transplant 11: 1803-1809.
    • (2011) Am J Transplant , vol.11 , pp. 1803-1809
    • Gabardi, S.1    Halloran, P.F.2    Friedewald, J.3
  • 35
    • 52649173346 scopus 로고    scopus 로고
    • Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch
    • Greber D, El-Baba MD, Fussenegger M. 2008. Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch. Nucl Acids Res 36: e101.
    • (2008) Nucl Acids Res , vol.36
    • Greber, D.1    El-Baba, M.D.2    Fussenegger, M.3
  • 37
    • 74049088689 scopus 로고    scopus 로고
    • Eukaryotic systems broaden the scope of synthetic biology
    • Haynes KA, Silver PA. 2009. Eukaryotic systems broaden the scope of synthetic biology. J Cell Biol 187: 589-596.
    • (2009) J Cell Biol , vol.187 , pp. 589-596
    • Haynes, K.A.1    Silver, P.A.2
  • 38
    • 79961005102 scopus 로고    scopus 로고
    • Synthetic reversal of epigenetic silencing
    • Haynes KA, Silver PA. 2011. Synthetic reversal of epigenetic silencing. J Biol Chem 286: 27176-27182.
    • (2011) J Biol Chem , vol.286 , pp. 27176-27182
    • Haynes, K.A.1    Silver, P.A.2
  • 39
    • 77951891440 scopus 로고    scopus 로고
    • pcDNA3.1(2)-mediated ribozyme targeting of HER-2 suppresses breast cancer tumor growth
    • He P, Zhu D, Hu J-J, Peng J, Chen L-S, Lu G-X. 2010. pcDNA3.1(2)-mediated ribozyme targeting of HER-2 suppresses breast cancer tumor growth. Mol Biol Rep 37: 1597-1604.
    • (2010) Mol Biol Rep , vol.37 , pp. 1597-1604
    • He, P.1    Zhu, D.2    Hu, J.-J.3    Peng, J.4    Chen, L.-S.5    Lu, G.-X.6
  • 40
    • 0037079023 scopus 로고    scopus 로고
    • Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth
    • Ibarra RU, Edwards JS, Palsson BO. 2002. Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth. Nature 420: 186-189.
    • (2002) Nature , vol.420 , pp. 186-189
    • Ibarra, R.U.1    Edwards, J.S.2    Palsson, B.O.3
  • 41
    • 77956417789 scopus 로고    scopus 로고
    • Computational reconstruction of tissue-specific metabolic models: Application to human liver metabolism
    • Jerby L, Shlomi T, Ruppin E. 2010. Computational reconstruction of tissue-specific metabolic models: Application to human liver metabolism. Mol Syst Biol 6: 401.
    • (2010) Mol Syst Biol , vol.6 , pp. 401
    • Jerby, L.1    Shlomi, T.2    Ruppin, E.3
  • 42
    • 70350443611 scopus 로고    scopus 로고
    • Systems-level engineering of nonfermentative metabolism in yeast
    • Kennedy CJ, Boyle PM, Waks Z, Silver PA. 2009. Systems-level engineering of nonfermentative metabolism in yeast. Genetics 183: 385-397.
    • (2009) Genetics , vol.183 , pp. 385-397
    • Kennedy, C.J.1    Boyle, P.M.2    Waks, Z.3    Silver, P.A.4
  • 43
    • 77951107086 scopus 로고    scopus 로고
    • Synthetic biology: Applications come of age
    • Khalil AS, Collins JJ. 2010. Synthetic biology: Applications come of age. Nat Rev Genet 11: 367-379.
    • (2010) Nat Rev Genet , vol.11 , pp. 367-379
    • Khalil, A.S.1    Collins, J.J.2
  • 45
    • 35448996504 scopus 로고    scopus 로고
    • Immunomodulation by mesenchymal stem cells and clinical experience
    • Le Blanc K, Ringdèn O. 2007. Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med 262: 509-525.
    • (2007) J Intern Med , vol.262 , pp. 509-525
    • Le Blanc, K.1    Ringdèn, O.2
  • 49
    • 0033579358 scopus 로고    scopus 로고
    • Clinical Trials: Gene therapy death prompts review of adenovirus vector
    • Marshall E. 1999. Clinical Trials: Gene therapy death prompts review of adenovirus vector. Science 286: 2244-2245.
    • (1999) Science , vol.286 , pp. 2244-2245
    • Marshall, E.1
  • 50
    • 77956651992 scopus 로고    scopus 로고
    • Systems biology of the gut: The interplay of food, microbiota and host at the mucosal interface
    • Martins Dos Santos V, Müller M, de Vos WM. 2010. Systems biology of the gut: The interplay of food, microbiota and host at the mucosal interface. Curr Opin Biotechnol 21: 539-550.
    • (2010) Curr Opin Biotechnol , vol.21 , pp. 539-550
    • Martins Dos Santos, V.1    Müller, M.2    de Vos, W.M.3
  • 51
    • 65249167505 scopus 로고    scopus 로고
    • DNA binding site sequence directs glucocorticoid receptor structure and activity
    • Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR. 2009. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science 324: 407-410.
    • (2009) Science , vol.324 , pp. 407-410
    • Meijsing, S.H.1    Pufall, M.A.2    So, A.Y.3    Bates, D.L.4    Chen, L.5    Yamamoto, K.R.6
  • 54
    • 14744303077 scopus 로고
    • Cellular engineering for the treatment of metabolic disorders: Prospects for therapy in diabetes
    • Newgard CB. 1992. Cellular engineering for the treatment of metabolic disorders: Prospects for therapy in diabetes. Biotechnology (NY) 10: 1112-1120.
    • (1992) Biotechnology (NY) , vol.10 , pp. 1112-1120
    • Newgard, C.B.1
  • 55
    • 73149122136 scopus 로고    scopus 로고
    • Applications of genome-scale metabolic reconstructions
    • Oberhardt MA, Palsson BO, Papin JA. 2009. Applications of genome-scale metabolic reconstructions. Mol Syst Biol 5: 320.
    • (2009) Mol Syst Biol , vol.5 , pp. 320
    • Oberhardt, M.A.1    Palsson, B.O.2    Papin, J.A.3
  • 56
    • 53249113140 scopus 로고    scopus 로고
    • A genotoxicity test system based on p53R2 gene expression in human cells: Assessment of its reactivity to various classes of genotoxic chemicals
    • Ohno K, Ishihata K, Tanaka-Azuma Y, Yamada T. 2008. A genotoxicity test system based on p53R2 gene expression in human cells: Assessment of its reactivity to various classes of genotoxic chemicals. Mutat Res 656: 27-35.
    • (2008) Mutat Res , vol.656 , pp. 27-35
    • Ohno, K.1    Ishihata, K.2    Tanaka-Azuma, Y.3    Yamada, T.4
  • 57
    • 79751505371 scopus 로고    scopus 로고
    • Fecal matters
    • Palmer R. 2011. Fecal matters. Nat Med 17: 150-152.
    • (2011) Nat Med , vol.17 , pp. 150-152
    • Palmer, R.1
  • 58
    • 8744224466 scopus 로고    scopus 로고
    • OptStrain: A computational framework for redesign of microbial production systems
    • Pharkya P, Burgard AP, Maranas CD. 2004. OptStrain: A computational framework for redesign of microbial production systems. Genome Res 14: 2367-2376.
    • (2004) Genome Res , vol.14 , pp. 2367-2376
    • Pharkya, P.1    Burgard, A.P.2    Maranas, C.D.3
  • 61
    • 0033564230 scopus 로고    scopus 로고
    • How aneuploidy affects metabolic control and causes cancer
    • Rasnick D, Duesberg PH. 1999. How aneuploidy affects metabolic control and causes cancer. Biochem J 340 (Pt 3): 621-630.
    • (1999) Biochem J , vol.340 , Issue.PART 3 , pp. 621-630
    • Rasnick, D.1    Duesberg, P.H.2
  • 64
    • 84934438895 scopus 로고    scopus 로고
    • Systems biology approaches and tools for analysis of interactomes and multitarget drugs
    • Schrattenholz A, Groebe K, Soskic V. 2010. Systems biology approaches and tools for analysis of interactomes and multitarget drugs. Meth Mol Biol 662: 29-58.
    • (2010) Meth Mol Biol , vol.662 , pp. 29-58
    • Schrattenholz, A.1    Groebe, K.2    Soskic, V.3
  • 65
    • 0037069467 scopus 로고    scopus 로고
    • Analysis of optimality in natural and perturbed metabolic networks
    • Segrè D, Vitkup D, Church GM. 2002. Analysis of optimality in natural and perturbed metabolic networks. Proc Natl Acad Sci 99: 15112-15117.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 15112-15117
    • Segrè, D.1    Vitkup, D.2    Church, G.M.3
  • 67
    • 84867435330 scopus 로고    scopus 로고
    • Regulating gene expression through engineered RNA technologies
    • CRC Press, San Diego.
    • Smolke CD, Win MN. 2010. Regulating gene expression through engineered RNA technologies. In The metabolic pathway engineering hand book. CRC Press, San Diego.
    • (2010) The metabolic pathway engineering hand book
    • Smolke, C.D.1    Win, M.N.2
  • 69
    • 1842324170 scopus 로고
    • A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression
    • Strähle U, Klock G, Schütz G. 1987. A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression. Proc Natl Acad Sci 84: 7871-7875.
    • (1987) Proc Natl Acad Sci , vol.84 , pp. 7871-7875
    • Strähle, U.1    Klock, G.2    Schütz, G.3
  • 71
    • 0037628628 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulinproducing cells
    • Suzuki A, Nakauchi H, Taniguchi H. 2003. Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulinproducing cells. Proc Natl Acad Sci 100: 5034-5039.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 5034-5039
    • Suzuki, A.1    Nakauchi, H.2    Taniguchi, H.3
  • 72
    • 51149102891 scopus 로고    scopus 로고
    • Intron length increases oscillatory periods of gene expression in animal cells
    • Swinburne IA, Miguez DG, Landgraf D, Silver PA. 2008. Intron length increases oscillatory periods of gene expression in animal cells. Genes Dev 22: 2342-2346.
    • (2008) Genes Dev , vol.22 , pp. 2342-2346
    • Swinburne, I.A.1    Miguez, D.G.2    Landgraf, D.3    Silver, P.A.4
  • 75
    • 0030574067 scopus 로고    scopus 로고
    • Design of metabolic control for large flux changes
    • Thomas S, Fell DA. 1996. Design of metabolic control for large flux changes. J Theor Biol 182: 285-298.
    • (1996) J Theor Biol , vol.182 , pp. 285-298
    • Thomas, S.1    Fell, D.A.2
  • 77
    • 79957902145 scopus 로고    scopus 로고
    • Gut microbiome, obesity, and metabolic dysfunction
    • Tilg H, Kaser A. 2011. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest 121: 2126-2132.
    • (2011) J Clin Invest , vol.121 , pp. 2126-2132
    • Tilg, H.1    Kaser, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.