Enhancement of cell type specificity by quantitative modulation of a chimeric ligand

Journal of Biological Chemistry

Volumn 283, Issue 13, 2008, Pages 8469-8476

  Cironi, Pablo ^a   Swinburne, Ian A ^a   Silver, Pamela A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DISSOCIATION; FLOW INTERACTIONS; LIGANDS; MODULATION; PROTEINS; SIGNAL TRANSDUCTION;

CELL SURFACES; CELL TARGETING; CELL TYPES; CHIMERIC PROTEINS; DAUDI CELLS; DISSOCIATION CONSTANTS; EGF RECEPTORS; EPIDERMAL GROWTH FACTORS; MULTIDOMAIN PROTEINS; MULTISUBUNIT; PROTEIN INTERACTIONS; QUANTITATIVE APPROACHES; QUANTITATIVE CHARACTERISTICS; SPECIFIC BINDINGS; WEAK INTERACTIONS;

CELL GROWTH;

ALPHA INTERFERON RECEPTOR; ALPHA2A INTERFERON; CHIMERIC PROTEIN; EPIDERMAL GROWTH FACTOR; LIGAND; EPIDERMAL GROWTH FACTOR RECEPTOR; STAT1 PROTEIN;

ARTICLE; CELL PROLIFERATION; CELL SPECIFICITY; CELL SURFACE; CELL TYPE; CHIMERA; COMPETITIVE INHIBITION; CONTROLLED STUDY; DAUDI CELL; HELA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; MUTATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ASSAY; SIGNAL TRANSDUCTION; TARGET CELL; CELL FUNCTION; CELL LINE; GENETICS; METABOLISM; METHODOLOGY; PROTEIN ENGINEERING; SENSITIVITY AND SPECIFICITY;

CELL LINE; CELL PHYSIOLOGY; CELL PROLIFERATION; EPIDERMAL GROWTH FACTOR; HUMANS; INTERFERON ALFA-2A; LIGANDS; MUTATION; PROTEIN ENGINEERING; RECEPTOR, EPIDERMAL GROWTH FACTOR; SENSITIVITY AND SPECIFICITY; STAT1 TRANSCRIPTION FACTOR;

EID: 43749102294     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708502200     Document Type: Article

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