Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins

Science

Volumn 330, Issue 6008, 2010, Pages 1251-1255

  Culler, Stephanie J ^a   Hoff, Kevin G ^a   Smolke, Christina D ^a,b  

^a California Institute of Technology   (United States)

^b Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; RNA; WNT PROTEIN;

BIOMARKER; CELL ORGANELLE; GENE EXPRESSION; GENETIC ANALYSIS; PROTEIN; RNA; SIGNALING;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL FUNCTION; DEVICE; DISEASE MARKER; GENE EXPRESSION; GENETIC ENGINEERING; MOLECULAR SENSOR; PRIORITY JOURNAL;

ALTERNATIVE SPLICING; APOPTOSIS; APTAMERS, NUCLEOTIDE; BETA CATENIN; CAPSID PROTEINS; CELL LINE; CELL NUCLEUS; EXONS; GANCICLOVIR; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENETIC ENGINEERING; GREEN FLUORESCENT PROTEINS; HUMANS; INTRONS; LIGANDS; MUTATION; NF-KAPPA B P50 SUBUNIT; PROTEIN BINDING; SIGNAL TRANSDUCTION; SURVIVAL OF MOTOR NEURON 1 PROTEIN; TRANSCRIPTION FACTOR RELA; TRANSFECTION; WNT PROTEINS;

EID: 78649429678     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1192128     Document Type: Article

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32. We thank K. Hertel for providing the pHis-BIVT-MS2-RSp55 construct, M. Jensen for providing pCD19t-Tk-T2A-IL15op-epHIV7, L. J. Maher for providing pGAD24, and B. Stewart for laboratory assistance. This work was supported by the Caltech Joseph Jacobs Institute for Molecular Engineering for Medicine (grant to C.D.S.), the NIH (fellowship to K.G.H., grant to C.D.S.), the U.S. Department of Defense (grant to C.D.S.), the Alfred P. Sloan Foundation (fellowship to C.D.S.), and the Bill and Melinda Gates Foundation (grant to C.D.S.). The authors have filed for a patent related to this work.