Secretion of insulinotropic proteins by commensal bacteria: Rewiring the gut to treat diabetes

Applied and Environmental Microbiology

Volumn 74, Issue 23, 2008, Pages 7437-7438

  Duan, Faping ^a   Curtis, Katherine L ^a   March, John C ^a,b  

^a Department of Biological and Environmental Engineering   (United States)

^b 220 Riley Robb Hall ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOLOGY; GLUCOSE; INSULIN; PROTEINS;

INTESTINAL EPITHELIAL CELLS;

HORMONES;

GLUCAGON LIKE PEPTIDE 1; INSULIN; TRANSCRIPTION FACTOR PDX 1;

BACTERIUM; COMMENSALISM; DIABETES; DIGESTIVE SYSTEM; DISEASE TREATMENT; GENETIC ENGINEERING; PROTEIN; SECRETION;

ARTICLE; BACTERIAL STRAIN; BIOENGINEERING; COMMENSAL; INSULIN RELEASE; INTESTINE EPITHELIUM; INTESTINE FLORA; NONHUMAN;

CACO-2 CELLS; EPITHELIAL CELLS; ESCHERICHIA COLI; GLUCAGON-LIKE PEPTIDE 1; HOMEODOMAIN PROTEINS; HUMANS; INCRETINS; INSULIN; RECOMBINANT PROTEINS; TRANS-ACTIVATORS;

EID: 57149095846     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.01019-08     Document Type: Article

References (15)

1. Ahmed, F. E. 2003. Genetically modified probiotics in foods. Trends Biotechnol. 21:491-497.
2. Baggio, L. L., and D. J. Drucker. 2007. Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-2157.
3. Basu, R., C. Dalla Man, M. Campioni, A. Basu, G. Klee, G. Toffolo, C. Cobelli, and R. A. Rizza. 2006. Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction. Diabetes 55:2001-2014.
4. Daniel, C., A. Repa, C. Wild, A. Pollak, B. Pot, H. Breiteneder, U. Wiedermann, and A. Mercenier. 2006. Modulation of allergic immune responses by mucosal application of recombinant lactic acid bacteria producing the major birch pollen allergen Bet v 1. Allergy 61:812-819.
5. Duan, F., and J. C. March. 2008. Interrupting Vibrio cholerae infection of human epithelial cells with engineered commensal bacterial signaling. Biotechnol. Bioeng. 101:128-134.
6. Farrar, M. D., T. R. Whitehead, J. Lan, P. Dilger, R. Thorpe, K. T. Holland, and S. R. Carding. 2005. Engineering of the gut commensal bacterium Bacteroides ovatus to produce and secrete biologically active murine interleukin-2 in response to xylan. J. Appl. Microbiol. 98:1191-1197.
7. Hansen, L., C. F. Deacon, C. Orskov, and J. J. Holst. 1999. Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 140:5356-5363.
8. Hartmann, M., A. Westendorf, J. Buer, and F. Gunzer. 2004. E-coli Nissle 1917 as a vehicle for intestinal expression of therapeutic molecules: construction of an E-coli a hemolysin based expression vector. Int. J. Med. Microbiol. 294:198.
9. Hazebrouck, S., L. Pothelune, V. Azevedo, G. Corthier, J. M. Wal, and P. Langella. 2007. Efficient production and secretion of bovine beta-lactoglobulin by Lactobacillus casei. Microb. Cell Fact. 6:6-12.
10. Koizumi, M., R. Doi, K. Fujimoto, D. Ito, E. Toyoda, T. Mori, K. Kami, Y. Kawaguchi, G. K. Gittes, and M. Imamura. 2005. Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1. Surgery 138:125-133.
11. Koizumi, M., K. Nagai, A. Kida, K. Kami, D. Ito, K. Fujimoto, Y. Kawaguchi, and R. Doi. 2006. Forced expression of PDX-1 induces insulin production in intestinal epithelia. Surgery 140:273-280.
12. Liang, J. F., and V. C. Yang. 2005. Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency. Biochem. Biophys. Res. Commun. 335:734-738.
13. Majander, K., L. Anton, J. Antikainen, H. Lang, M. Brummer, T. K. Korhonen, and B. Westerlund-Wikstrom. 2005. Extracellular secretion of polypeptides using a modified Escherichia coli flagellar secretion apparatus. Nat. Biotechnol. 23:475-481.
14. Suzuki, A., H. Nakauchi, and H. Taniguchi. 2003. Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc. Natl. Acad. Sci. USA 100:5034-5039.
15. Yoshida, S., Y. Kajimoto, T. Yasuda, H. Watada, Y. Fujitani, H. Kosaka, T. Gotow, T. Miyatsuka, Y. Umayahara, Y. Yamasaki, and M. Hori. 2002. PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. Diabetes 51:2505-2513.