Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent signaling pathways

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 35669-35677

  Nakaya, Michio ^a   Chikura, Satsuki ^a   Watari, Kenji ^a   Mizuno, Natsumi ^a   Mochinaga, Koji ^a   Mangmool, Supachoke ^a   Koyanagi, Satoru ^a   Ohdo, Shigehiro ^a   Sato, Yoji ^c   Ide, Tomomi ^b   Nishida, Motohiro ^a   Kurose, Hitoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTORS; CARDIOMYOCYTES; CELLULAR RESPONSE; CELLULAR SIGNALING; G PROTEIN-COUPLED RECEPTOR KINASE; G-PROTEIN COUPLED RECEPTORS; IN-VIVO; KNOCK OUTS; METOPROLOL; SIGNALING PATHWAYS;

CARDIOLOGY; ENZYME INHIBITION; GENE EXPRESSION; HEART; LIGANDS; PHYSIOLOGY; SIGNALING;

PROTEINS;

BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ARRESTIN 1; BETA ARRESTIN 2; CARVEDILOL; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; G PROTEIN COUPLED RECEPTOR KINASE 5; GUANINE NUCLEOTIDE BINDING PROTEIN; METOPROLOL; PLACEBO; PROPRANOLOL; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COL1A GENE; CONTROLLED STUDY; CTGF GENE; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; GENE; GENE EXPRESSION; HEART DISEASE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; IN VIVO STUDY; LONG TERM CARE; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ANIMALS; ARRESTINS; FIBROSIS; G-PROTEIN-COUPLED RECEPTOR KINASE 5; HEART DISEASES; HEK293 CELLS; HUMANS; METOPROLOL; MICE; MICE, KNOCKOUT; MUSCLE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84867417643     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.357871     Document Type: Article

References (50)

1. Pierce, K. L., Premont, R. T., and Lefkowitz, R. J. (2002) Seven-transmembrane receptors. Nat. Rev. Mol. Cell Biol. 3, 639-650 (Pubitemid 34987785)
2. Reiter, E., and Lefkowitz, R. J. (2006) GRKs and β-arrestins. Roles in receptor silencing, trafficking, and signaling. Trends Endocrinol. Metab. 17, 159-165
3. DeFea, K. A. (2011) β-Arrestins as regulators of signal termination and transduction. How do they determine what to scaffold? Cell. Signal. 23, 621-629
4. DeWire, S. M., Ahn, S., Lefkowitz, R. J., and Shenoy, S. K. (2007) β-Arrestins and cell signaling. Annu. Rev. Physiol. 69, 483-510
5. Premont, R. T., and Gainetdinov, R. R. (2007) Physiological roles of G protein-coupled receptor kinases and arrestins. Annu. Rev. Physiol. 69, 511-534 (Pubitemid 46457653)
6. Moore, C. A., Milano, S. K., and Benovic, J. L. (2007) Regulation of receptor trafficking by GRKs and arrestins. Annu. Rev. Physiol. 69, 451-482 (Pubitemid 46457651)
7. Hanyaloglu, A. C., and von Zastrow, M. (2008) Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu. Rev. Pharmacol. Toxicol. 48, 537-568 (Pubitemid 351738163)
8. 2-adrenergic receptor and β-arrestin. Science 294, 1307-1313
9. 2-adrenergic receptor. Nature 401, 286-290
10. Ribas, C., Penela, P., Murga, C., Salcedo, A., Garcíia-Hoz, C., Jurado-Pueyo, M., Aymerich, I., and Mayor, F., Jr. (2007) The G protein-coupled receptor kinase (GRK) interactome. Role of GRKs in GPCR regulation and signaling. Biochim. Biophys. Acta 1768, 913-922 (Pubitemid 46452540)
11. Rajagopal, S., Rajagopal, K., and Lefkowitz, R. J. (2010) Teaching old receptors new tricks. Biasing seven-transmembrane receptors. Nat. Rev. Drug. Discov. 9, 373-386
12. Rockman, H. A., Koch, W. J., and Lefkowitz, R. J. (2002) Seven-transmembrane- spanning receptors and heart function. Nature 415, 206-212 (Pubitemid 34059526)
13. Brodde, O. E. (1993) β-Adrenoceptors in cardiac disease. Pharmacol. Ther. 60, 405-430
14. Metra, M., Cas, L. D., di Lenarda, A., and Poole-Wilson, P. (2004) β-Blockers in heart failure. Are pharmacological differences clinically important? Heart Fail. Rev. 9, 123-130 (Pubitemid 39485473)
15. Leimbach, W. N., Jr., Wallin, B. G., Victor, R. G., Aylward, P. E., Sundlöf, G., and Mark, A. L. (1986) Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure. Circulation 73, 913-919 (Pubitemid 16102181)
16. Thomas, J. A., and Marks, B. H. (1978) Plasma norepinephrine in congestive heart failure. Am. J. Cardiol. 41, 233-243 (Pubitemid 8318642)
17. Bristow, M. R. (2000) β-Adrenergic receptor blockade in chronic heart failure. Circulation 101, 558-569
18. Cruickshank, J. M. (2007) Are we misunderstanding β-blockers. Int. J. Cardiol. 120, 10-27
19. Azzi, M., Charest, P. G., Angers, S., Rousseau, G., Kohout, T., Bouvier, M., and Piñeyro, G. (2003) β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc. Natl. Acad. Sci. U.S.A. 100, 11406-11411 (Pubitemid 37205948)
20. Kim, I. M., Tilley, D. G., Chen, J., Salazar, N. C., Whalen, E. J., Violin, J. D., and Rockman, H. A. (2008) β-Blockers alprenolol and carvedilol stimulate β-arrestin-mediated EGFR transactivation. Proc. Natl. Acad. Sci. U.S.A. 105, 14555-14560
21. Wisler, J. W., DeWire, S. M., Whalen, E. J., Violin, J. D., Drake, M. T., Ahn, S., Shenoy, S. K., and Lefkowitz, R. J. (2007) A unique mechanism of β-blocker action. Carvedilol stimulates β-arrestin signaling. Proc. Natl. Acad. Sci. U.S.A. 104, 16657-16662 (Pubitemid 350211072)
22. Kim, J., Ahn, S., Ren, X. R., Whalen, E. J., Reiter, E., Wei, H., and Lefkowitz, R. J. (2005) Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 102, 1442-1447 (Pubitemid 40209189)
23. Ren, X. R., Reiter, E., Ahn, S., Kim, J., Chen, W., and Lefkowitz, R. J. (2005) Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor. Proc. Natl. Acad. Sci. U.S.A. 102, 1448-1453 (Pubitemid 40209190)
24. Shukla, A. K., Violin, J. D., Whalen, E. J., Gesty-Palmer, D., Shenoy, S. K., and Lefkowitz, R. J. (2008) Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors. Proc. Natl. Acad. Sci. U.S.A. 105, 9988-9993
25. Wei, H., Ahn, S., Shenoy, S. K., Karnik, S. S., Hunyady, L., Luttrell, L. M., and Lefkowitz, R. J. (2003) Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proc. Natl. Acad. Sci. U.S.A. 100, 10782-10787 (Pubitemid 37140105)
26. 12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis. EMBO J. 27, 3104-3115
27. 12/13- mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts. J. Biol. Chem. 280, 23041-23047
28. Charest, P. G., Terrillon, S., and Bouvier, M. (2005) Monitoring agonist-promoted conformational changes of β-arrestin in living cells by intramolecular BRET. EMBO Rep. 6, 334-340 (Pubitemid 40561625)
29. 2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2). J. Biol. Chem. 281, 31940-31949
30. 2-adrenergic receptormediated signaling. Circ. Res. 99, 1084-1091
31. Daniels, A., van Bilsen, M., Goldschmeding, R., van der Vusse, G. J., and van Nieuwenhoven, F. A. (2009) Connective tissue growth factor and cardiac fibrosis. Acta Physiol. 195, 321-338
32. Ruiz-Ortega, M., Rodríguez-Vita, J., Sanchez-Lopez, E., Carvajal, G., and Egido, J. (2007) TGF-β signaling in vascular fibrosis. Cardiovasc. Res. 74, 196-206
33. Yamamoto, K., Masuyama, T., Sakata, Y., Nishikawa, N., Mano, T., Yoshida, J., Miwa, T., Sugawara, M., Yamaguchi, Y., Ookawara, T., Suzuki, K., and Hori, M. (2002) Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart. Cardiovasc. Res. 55, 76-82 (Pubitemid 34615941)
34. Varma, D. R., Shen, H., Deng, X. F., Peri, K. G., Chemtob, S., and Mulay, S. (1999) Inverse agonist activities of β-adrenoceptor antagonists in rat myocardium. Br. J. Pharmacol. 127, 895-902 (Pubitemid 29295348)
35. 1-receptor transgenic mice. Mol. Pharmacol. 60, 712-717
36. Rakesh, K., Yoo, B., Kim, I. M., Salazar, N., Kim, K. S., and Rockman, H. A. (2010) β-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. Sci. Signal. 3, ra46
37. 1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J. Clin. Invest. 117, 2445-2458
38. Gesty-Palmer, D., Flannery, P., Yuan, L., Corsino, L., Spurney, R., Lefkowitz, R. J., and Luttrell, L. M. (2009) A β-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci. Transl. Med. 1, 1ra1
39. Tzingounis, A. V., von Zastrow, M., and Yudowski, G. A. (2010) β-Blocker drugs mediate calcium signaling in native central nervous system neurons by β-arrestin-biased agonism. Proc. Natl. Acad. Sci. U.S.A. 107, 21028-21033
40. Bristow, M. R. (2011) Treatment of chronic heart failure with β-adrenergic receptor antagonists. A convergence of receptor pharmacology and clinical cardiology. Circ. Res. 109, 1176-1194
41. Gustafsson, A. B., Brunton, L. L. (2000) β-Adrenergic stimulation of rat cardiac fibroblasts enhances induction of nitric-oxide synthase by interleukin-1β via message stabilization. Mol. Pharmacol. 58, 1470-1478
42. Butcher, A. J., Prihandoko, R., Kong, K. C., McWilliams, P., Edwards, J. M., Bottrill, A., Mistry, S., and Tobin, A. B. (2011) Differential G proteincoupled receptor phosphorylation provides evidence for a signaling bar code. J. Biol. Chem. 286, 11506-11518
43. Torrecilla, I., Spragg, E. J., Poulin, B., McWilliams, P. J., Mistry, S. C., Blaukat, A., and Tobin, A. B. (2007) Phosphorylation and regulation of a G protein-coupled receptor by protein kinase CK2. J. Cell Biol. 177, 127-137 (Pubitemid 46588407)
44. 2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci. Signal. 4, ra51
45. Zidar, D. A., Violin, J. D., Whalen, E. J., and Lefkowitz, R. J. (2009) Selective engagement of G protein-coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc. Natl. Acad. Sci. U.S.A. 106, 9649-9654
46. Bokoch, M. P., Zou, Y., Rasmussen, S. G., Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H. J., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L., and Kobilka, B. K. (2010) Ligand-specific regulation of the extracellular surface of a G protein-coupled receptor. Nature 463, 108-112
47. 1-adrenergic receptor. Proc. Natl. Acad. Sci. U.S.A. 108, 8228-8232
48. Group, M. H. S. (1999) Effect of metoprolol CR/XL in chronic heart failure. Metoprolol CR/XL randomized intervention trial in congestive heart failure (MERIT-HF). Lancet 353, 2001-2007
49. Waagstein, F., Caidahl, K., Wallentin, I., Bergh, C. H., and Hjalmarson, A. (1989) Long-term β-blockade in dilated cardiomyopathy. Effects of shortand long-term metoprolol treatment followed by withdrawal and readministration of metoprolol. Circulation 80, 551-563 (Pubitemid 19231389)
50. Reiter, M. J. (2004) Cardiovascular drug class specificity, β-blockers. Prog. Cardiovasc. Dis. 47, 11-33