P2Y6 receptor-Gα12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis

EMBO Journal

Volumn 27, Issue 23, 2008, Pages 3104-3115

  Nishida, Motohiro ^a   Sato, Yoji ^b   Uemura, Aya ^a   Narita, Yusuke ^a   Tozaki Saitoh, Hidetoshi ^a   Nakaya, Michio ^a   Ide, Tomomi ^c   Suzuki, Kazuhiro ^b   Inoue, Kazuhide ^a   Nagao, Taku ^b   Kurose, Hitoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Fibrosis; G protein; Purine receptor

Indexed keywords

2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; 8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE TRIPHOSPHATE; ANGIOTENSIN II; BETA,GAMMA DIBROMOMETHYLENE 6 N,N DIETHYLADENOSINE TRIPHOSPHATE; CANGRELOR; CARBENOXOLONE; CONNECTIVE TISSUE GROWTH FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HEPTANOL; MEMBRANE PROTEIN; MRS 2578; PANNEXIN 1; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; RHO FACTOR; SURAMIN; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ACE PROTEIN, HUMAN; CELL ADHESION MOLECULE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; POSTN PROTEIN, HUMAN; PURINERGIC P2 RECEPTOR; URIDINE DIPHOSPHATE;

ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GENE EXPRESSION; HEART FAILURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HEMODYNAMICS; HISTOLOGY; MOUSE; MUSCLE STRETCHING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BLOOD PRESSURE; C57BL MOUSE; DRUG ANTAGONISM; FIBROSIS; HEART MUSCLE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD PRESSURE; CELL ADHESION MOLECULES; CONNECTIVE TISSUE GROWTH FACTOR; FIBROSIS; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; PEPTIDYL-DIPEPTIDASE A; RATS; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; URIDINE DIPHOSPHATE;

EID: 57149085654     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.237     Document Type: Article

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