Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

Lancet

Volumn 353, Issue 9169, 1999, Pages 2001-2007

  Hjalmarson, A ^a   Goldstein, S ^a   Fagerberg, B ^a,b   Wedel, H ^a   Waagstein, F ^a   Kjekshus, J ^a   Wikstrand, J ^a   Westergren, G ^a   Thimell, M ^a   El Allaf, D ^a   Vitovec J ^a   Aldershvile, J ^a   Halinen, M ^a   Dietz, R ^a   Neuhaus, K L ^a   Janosi A ^a   Thorgeirsson, G ^a   Dunselman, P ^a   Gullestad, L ^a   Kuch, J ^a   Herlitz, J ^a   Rickenbacher, P ^a   Ball, S ^a   Gottlieb, S ^a   Deedwania, P ^a   Vandenhoven, G ^a   Novakova I ^a   Danker, S ^a   Lundstrom M ^a   Meyer Sabellek, W ^a   Balla, I ^a   Sveinsdottir, M ^a   Dorhout, B ^a   Hildebrandt, A ^a   Szczurko, I ^a   Larsson, C ^a   Bucher, E ^a   Scott, E ^a   Dwyer, D ^a   Julian, D G ^a   DeMets, D L ^a   Chatterjee, K ^a   Feyzi, J ^a   Lehto, S ^a   Karpati P ^a   Motz, W ^a   Samuelsson, O ^a   Viersma, J W ^a   Andersson, B ^a   Berthe, C ^a   Boutefeu, J M ^a   Boxho, G ^a   Decroly, P ^a   Derbaudrenghien, J P ^a   Pirlet, J ^a   Henry, P ^a   Heyndrickx, G ^a   Missault, L ^a   Nannan, M ^a   Timmermans, P ^a   Vachiery, J L ^a   Van Mieghem, W ^a   Vandenbossche, J L ^a   Dvorak K ^a   Herold, M ^a   Hradec, J ^a   Kana A ^a   Petr, P ^a   Rybka, J ^a   Smid J ^a   Svitil P ^a   Toman, J ^a   Agner, E ^a   Amtorp, O ^a   Egstrup, K ^a   Eliasen, P ^a   Gotzsche, C O ^a   Hildebrandt, P ^a   Johannesen, A ^a   Kaiser Nielsen, P ^a   Nielsen, H ^a   Nielsen, P E ^a   Pedersen, F ^a   Rokkedal Nielsen, J ^a   Skagen, K ^a   Honkanen, T ^a   Hussi, E ^a   Juvonen, J ^a   Jaaskelainen H ^a   Rinne, J ^a   Salonen, T ^a   Andresen, D ^a   Berwing, H ^a   Bethge, ^a   Beythien, ^a   Bischoff, ^a   Bundschu, ^a   Daniel, ^a   Darius, ^a   Delius, ^a   Drude, ^a   Dingerkus, ^a   Duck ^a   Eichler, ^a   Fach, ^a   Forster A ^a   Girth, ^a   Goss, ^a   Hahn, ^a   Hambrecht, ^a   Hauf, G F ^a   Heinemann, ^a   Hepp, ^a   Janka, ^a   Klocke, ^a   Konz, ^a   Krosse, B ^a   Kuhlkamp ^a   Lewek, ^a   Luderitz B ^a   Lobe ^a   Maier, ^a   Melchior, ^a   Muller ^a   Maurer ^a   Nast, ^a   Neuhaus, ^a   Obst, ^a   Odemar, ^a   von Olshausen, K E ^a   Pomykaj, ^a   Schmailzl, K J G ^a   Schrader, ^a   Schroder ^a   Schwimmbeck, P L ^a   Sigmund, M ^a   Simon, ^a   Strasser, ^a   Thilo, ^a   Vohringer ^a   Voller H ^a   Weibrodt, ^a   Wirtz, ^a   Wunderlich, ^a   Czuriga, I ^a   Hetey, M ^a   Katona, A ^a   Lengyel, M ^a   Nyaradi A ^a   Rednik, A ^a   Sandori K ^a   Szabo P ^a   Tarjan J ^a   Tenczer, J ^a   Timar S ^a   Valyi P ^a   Veress, G ^a   Zamolyi K ^a   Oze B ^a   Thorgeirsson, Ge ^a   Thorgeirsson, Gu ^a   Bernink, P J L M ^a   Bredero, A C ^a   Breedveld, R W ^a   Breuls, P N W M ^a   Bucx, J J J ^a   Cornel, J H ^a   De Milliano, P A R ^a   Dunselman, P H J M ^a   Hamer, B J B ^a   Holwerda, N L ^a   Hoogsteen, J ^a   Hoorntje, J C A ^a   Kragten, J A ^a   Liem, A H ^a   Linssen, G C M ^a   Michels, H R ^a   Ramdat Misier, A R ^a   Schaafsma, H J ^a   Sijbring, P ^a   Taverne, R J T ^a   Van Kempen, L H J ^a   Van Stralen, R ^a   Van Veldhuisen, P J ^a   Veerhoek, M J ^a   Werter, C J P J ^a   Wesdorp, J C L ^a   Willems, A R ^a   Withagen, A J A M ^a   Zwart, P A G ^a   Bjornerheim, R ^a   Dahle, M ^a   Dickstein, K ^a   Froland, G S ^a   Gundersen, T ^a   Hofsoy, K ^a   Hole, T L ^a   Johansen, T ^a   Mannsverk, J ^a   Nesje, P ^a   Omland, T M ^a   Sjodin C ^a   Smith, P ^a   Tjonndal, H A ^a   Vikesdal, O ^a   Waage, K ^a   Adamus, ^a   Jaworska, K ^a   Kolodziej, P ^a   Kornacewicz Jach, Z ^a   Krzeminska Pakula M ^a   Piotrowski, J W ^a   Piwowarska, W ^a   Stogowski, A ^a   Wodniecki, J ^a   Wrabec, K ^a   Ahlstrom P ^a   Ekdahl, S ^a   Hemmingson, L O ^a   Holmberg, L ^a   Lernfelt, B ^a   Nilsson B Widgren, H ^a   Angman K ^a   Erne, P ^a   Mohacsi, P ^a   Polikar, R ^a   Schlapfer H ^a   Batin, P ^a   Berkin, K E ^a   Callaghan, T S ^a   Forfar, J ^a   Frenneaux, M ^a   Greenbaum, R A ^a   Maltz, M ^a   Murdoch, D ^a   Reynolds, G ^a   Stephens, J ^a   Struthers, A ^a   Swan, J ^a   Tildesley, G ^a   Abbasi, A ^a   Alagona, P ^a   Alderman, J ^a   Alipour, M ^a   Anderson, J L ^a   Ansari, Z ^a   Ashraf, M ^a   Beanblossom, B T ^a   Bennett, S ^a   Benvenuti, D ^a   Berk, M R ^a   Bhalla, R ^a   Bilazarian, S D ^a   Browne, K F ^a   MBuchter, C ^a   Carlson, R ^a   Carlson, C J ^a   Danisa, K ^a   Dauber, I ^a   DeWood, M A ^a   Dennish, G ^a   Denny, D M ^a   DiBianco, R ^a   Diller, P M ^a   Dunlap, M ^a   Dowd, K ^a   Edmiston, A ^a   El Shahawy, M ^a   Elkayam, U ^a   Farnham, J ^a   Fenster, P ^a   Friedman, S ^a   Heywood, T ^a   Galichia, J P ^a   Geller, M ^a   Ghali, J K ^a   Gheorghiade, M ^a   Giles, T ^a   Gillespe, R ^a   Goldberg, G ^a   Goldberg, M C ^a   Goldscher, D A ^a   Gooden, G P ^a   Goodman, M ^a   Goodman, L ^a   Gorwit, J ^a   Gottlieb, S S ^a   Gradman, A ^a   Grech, D ^a   Hack, T ^a   Hall, J H ^a   Hattenhauer, M T ^a   Higginbotham, M B ^a   Hutchins, S ^a   Imburgia, M ^a   Iteld, B J ^a   Jackson, B ^a   Jafri, S ^a   Jauch, W ^a   Jennison, S ^a   Kahn, B H ^a   Kao, W ^a   Kaplan, K ^a   Karlsberg, R ^a   Kennedy, H L ^a   Kennedy, J J ^a   Kirkegaard, L ^a   Kraus, D H ^a   LaBresh, K ^a   Lalonde, L ^a   Lesser, M F ^a   Levites, R ^a   Levy, M ^a   Lewis, R K ^a   Loh, I K ^a   Madyoon, H ^a   Maislos, F ^a   Mann, D ^a   Maurice, G L ^a   Nisar, A ^a   Old, W ^a   Pappas, J D ^a   Phadke, K ^a   Promisloff, S ^a   Rashkow, A M ^a   Reeves, B ^a   Rosen, J H ^a   Rotman, M ^a   Saleem, T ^a   Savran, S V ^a   Shah, R ^a   Shalev, Y ^a   Shanes, J G ^a   O'Shaughnessy, M ^a   Silverman, B ^a   Steingart, R M ^a   Swenson, L ^a   Syed, K ^a   Thadani, U ^a   Thorsen, R D ^a   Tonkon, M J ^a   Touchon, R ^a   Uhl, G ^a   Vaska, K J ^a   Wagner, S G ^a   Weaver, C J ^a   Weiss, R J ^a   Wickemeyer, W J ^a   Willens, H J ^a   Wilson, J R ^a   Wright, R ^a   Yellen, L ^a   more..

^a Sahlgrenska University Hospital ^*

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

METOPROLOL; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG TOLERANCE; FEMALE; FOLLOW UP; HEART EJECTION FRACTION; HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UNITED STATES;

EID: 0033549290     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(99)04440-2     Document Type: Article

References (29)

1. Consensus recommendations for the management of chronic heart failure. Am J Cardiol. 83:1999;2-38A.
2. Garg R.G., Yusuf S. Overview of randomised trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA. 273:1995;1450-1456.
3. Effect of enalapril on survival in patients with reduced left ventricular ejections fraction and congestive heart failure. N Engl J Med. 325:1991;293-302.
4. Pfeffer M.A., Braunwald E., Moyé L.A.et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the survival and ventricular enlargement trial. N Engl J Med. 327:1992;669-677.
5. Waagstein F., Hjalmarson Å., Varnauskas X., Wallentin I. Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy. Br Heart J. 37:1975;1022-1036.
6. Swedberg K., Hjalmarson Å., Waagstein F., Wallentin I. Prolongation of survival in congestive cardiomyopathy by β-receptor blockade. Lancet. i:1979;1374-1376.
7. Gundersen T. Influence of heart size on mortality and reinfarction in patients treated with timolol after myocardial infarction. Br Heart J. 50:1983;135-139.
8. Chadda K., Goldstein S., Byington R., Curb J.D. Effect of propranolol after acute myocardial infarction in patients with congestive heart failure. Circulation. 73:1986;503-510.
9. Waagstein F., Bristow M.R., Swedberg K.et al. Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Lancet. 342:1993;1441-1446.
10. A randomized trial of β-blockade in heart failure: the cardiac insufficiency bisoprolol study (CIBIS). Circulation. 90:1994;1765-1773.
11. Packer M., Bristow M.R., Cohn J.N.et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med. 334:1996;1349-1355.
12. Randomised, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischaemic heart disease. Lancet. 349:1997;375-380.
13. Waagstein F., Wahlqvist I., Andersson B.et al. Metoprolol prevents left ventricular dilatation and increase exercise ejection fraction to the same extent in idiopathic and ischemic cardiomyopathy. Eur Heart J. 19(suppl):1998;307. abstr.
14. Rationale, design, and organisation of the metoprolol CR/XL randomized trial in heart failure (MERIT-HF). Am J Cardiol. 80:1997;54-58J.
15. Narang R., Cleland J.G.F., Erhardt L.et al. Mode of death in chronic heart failure. a request and proposition for more accurate classification. Eur Heart J. 17:1996;1390-1403.
16. Cleland J.G.F., Bristow M.R., Erdmann E., Remme W.J., Swedberg K., Waagstein F. Beta-blocking agents in heart failure: should they be used and how? Eur Heart J. 17:1996;1629-1639.
17. Doughty R.N., Rodgers A., Sharpe N., MacMahon S. Effects of beta-blocker therapy on mortality in patients with heart failure. Eur Heart J. 18:1997;560-565.
18. Heydenrich P.A., Lee T.T., Massie B.M. Effect of beta-blockade on mortality in patients with heart failure: a meta-analysis of randomized clinical trials. J Am Coll Cardiol. 30:1997;27-34.
19. The cardiac insufficiency bisoprolol study II (CIBIS II). Lancet. 353:1999;9-13.
20. Rankin A.C., Cobbe S.M. Arrhytmias and sudden death in heart failure: can we prevent them? McMurray J.J.V., Cleland J.G.F. Heart failure in clinical practice. 1996;189-205 Martin Dunitz Ltd, London.
21. Olsson G., Wikstrand J., Warnold I.et al. Metoprolol-induced reduction in postinfarction mortality: pooled results from five double-blind randomized trials. Eur Heart J. 13:1992;28-32.
22. Olsson G., Tuomilehto J., Berglund G.et al. Primary prevention of sudden cardiovascular death in hypertensive patients: mortality results from the MAPHY study. Am J Hypertens. 4:1991;151-158.
23. Wikstrand J., Kendall M. The role of beta receptor blockade in preventing sudden death. Eur Heart J. 13(suppl D):1992;111-120.
24. Goldstein S., Kennedy H.L., Hall C.et al. Extended release metoprolol CR/XL in patients with heart failure: a pilot study examining the tolerability, safety and effect on left ventricular ejection fraction. Am Heart J. 1999;. in press.
25. 3-year follow-up of patients randomised in the metoprolol in dilated cardiomyopathy trial. Lancet. 351:1998;1180-1181.
26. Sandberg A., Ragnarsson G., Jonsson U.E., Sjögren J. Design of a new multiple-unit controlled-release formulation of metoprolol: metoprolol CR/XL. Eur J Clin Pharmacol. 33(suppl):1988;S3-7.
27. Andersson B., Åberg J. The effect on heart rate of immediate and slow-release metoprolol in patients with chronic heart failure. J Am Coll Cardiol. 33:1999;183-184A. abstr.
28. Herlitz J., Waagstein F., Lindqvist J., Swedberg K., Hjalmarson Å. Effect of metoprolol on the prognosis for patients with suspected acute myocardial infarction and indirect signs of congestive heart failure (A subgroup analysis of the Göteborg Metoprolol Trial). Am J Cardiol. 80:1997;40-44J.
29. Herlitz J., Dellborg M., Karlson B.W.et al. Similar risk reducing effect of extended release metoprolol once daily and immediate release metoprolol twice daily during 5 years after myocardial infarction. Cardiovasc Drugs Ther. 1999;. in press.