Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol

Acta Paediatrica, International Journal of Paediatrics

Volumn 90, Issue 6, 2001, Pages 652-657

  Lutjohann D ^a   Bjorkhem I ^a   Locatelli, S ^a   Dame, C ^a   Schmolling, J ^a   Von Bergmann, K ^a   Fahnenstich, H ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Central nervous system; Cytochrome P450; Lipoproteins; Neonates

Indexed keywords

26 HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; CYTOCHROME P450; OXYSTEROL; STEROID;

AGE; ARTICLE; BRAIN METABOLISM; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; FETUS; GAS CHROMATOGRAPHY; GESTATIONAL AGE; HUMAN; HYDROXYLATION; ISOTOPE DILUTION ASSAY; MASS SPECTROMETRY; NEWBORN; NEWBORN HEMOLYTIC DISEASE; PREMATURITY; PRIORITY JOURNAL; UMBILICAL CORD BLOOD;

BRAIN; CHOLESTEROL; ERYTHROBLASTOSIS, FETAL; FETUS; HUMANS; HYDROXYCHOLESTEROLS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, SMALL FOR GESTATIONAL AGE; LONGITUDINAL STUDIES;

EID: 0034955877     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2001.tb02429.x     Document Type: Article

References (29)

1. Cholesterol and the cell membrane
2. Lipoproteins and cellular cholesterol homeostasis
3. Cholesterol biosynthesis and metabolism
4. Inborn errors of cholesterol biosynthesis
5. Cholesterol and myelin
6. Studies on the synthesis of cholesterol in the brain of the human fetus
7. Cholesterol for synthesis of myelin is made locally, not imported into brain
8. Sterol metabolism in fetal, newborn, and suckled lambs and their response to cholesterol after weaning
9. Placental transfer of cholesterol into the human fetus
10. A receptor-mediated pathway for cholesterol homeostasis
11. Regulation of bile acid biosynthesis
12. The constitution of cerebrosterol, a hydroxycholesterol isolated from horse brain
13. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
14. Cholesterol homeostasis in human brain: Turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
15. Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
16. Importance of a novel oxidative mechanism for elimination of brain cholesterol
17. Atherosclerosis and sterol 27-hydroxylase: Evidence for a role of this enzyme in elimination of cholesterol from human macrophages
18. Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport
19. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans
20. Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: Evidence that most of this steroid in the circulation is of pulmonary origin
21. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry
22. Fetal and maternal lipoprotein metabolism in human pregnancy
23. Sources of cholesterol during development of the rat fetus and fetal organs
24. Transport of side-chain oxidized oxysterols in the human circulation
25. Plasma cholesterol and lipoprotein levels during fetal development and infancy
26. High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease
27. Identification of a new inborn error in bile acid synthesis: Mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease
28. Expression of CYP3A in the human liver - Evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth