3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 283-295

  Plsikova, Jana ^a   Janovec, Ladislav ^a   Koval, Jan ^a   Ungvarsky, Jan ^a   Mikes, Jaromir ^a   Jendzelovsky, Rastislav ^a   Fedorocko, Peter ^a   Imrich, Jan ^a   Kristian, Pavol ^a   Kasparkova, Jana ^b   Brabec, Viktor ^b   Kozurkova, Maria ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

^b INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

Acridine; Antitumor activity; Caspase 3; Cytotoxic; Intercalator; Molecular modeling; Topoisomerase I

Indexed keywords

(ACRIDINE 3,6 DIYLDIIMINO)BIS[(BUTYLAMINO)METHANIMINIUM]CHLORIDE; (ACRIDINE 3,6 DIYLDIIMINO)BIS[(ETHYLAMINO)METHANIMINIUM]CHLORIDE; (ACRIDINE 3,6 DIYLDIIMINO)BIS[(N HEXYLAMINO)METHANIMINIUM]CHLORIDE; (ACRIDINE 3,6 DIYLDIIMINO)BIS[(N PENTYLAMINO)METHANIMINIUM]CHLORIDE; ACRIDINE DERIVATIVE; ALKYL GROUP; ANTINEOPLASTIC AGENT; CASPASE 3; DNA; DNA TOPOISOMERASE; GUANIDINE DERIVATIVE; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CALF (BOVINE); CELL CYCLE; CELL MEMBRANE; CELL PROLIFERATION; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DNA BINDING; DNA DENATURATION; DRUG DNA BINDING; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHORESIS; ENZYME ACTIVATION; FLUORESCENCE SPECTROSCOPY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; NONHUMAN; THYMUS; ULTRAVIOLET SPECTROSCOPY;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; CASPASE 3; CATTLE; CELL CYCLE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; DNA; DNA TOPOISOMERASES, TYPE I; GUANIDINES; HL-60 CELLS; HUMANS; INTERCALATING AGENTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR DYNAMICS SIMULATION; NUCLEIC ACID DENATURATION; PHOSPHATIDYLSERINES; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867286121     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.09.020     Document Type: Article

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