A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)

Journal of Biological Chemistry

Volumn 287, Issue 41, 2012, Pages 34304-34315

  Mertens, Haydyn D T ^b   Kjaergaard, Magnus ^c   Mysling, Simon ^d   Gårdsvoll, Henrik ^a   Jørgensen, Thomas J D ^d   Svergun, Dmitri I ^b   Ploug, Michael ^a  

^a FINSEN LABORATORY   (Denmark)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MECHANISMS; ALLOSTERIC REGULATION; DYNAMIC PROPERTY; EXTRACELLULAR MATRICES; HIGH AFFINITY BINDING; HYDROGEN-DEUTERIUM EXCHANGE; IN-VIVO; INTERVENTION THERAPY; MULTIDOMAIN STRUCTURE; N-TERMINAL DOMAINS; PROTEOLYTIC DEGRADATION; RECEPTOR COMPLEX; SMALL ANGLE X-RAY SCATTERING; STRUCTURAL MODELS; TRANSLATIONAL RESEARCH; TUMOR IMAGING; UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTORS (UPAR); VITRONECTIN;

DEUTERIUM; HYDROGEN; MODEL STRUCTURES;

CELL ADHESION;

UROKINASE RECEPTOR;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; DIAGNOSTIC IMAGING; MOLECULAR MODEL; MOLECULARLY TARGETED THERAPY; NON INVASIVE PROCEDURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE; TRANSLATIONAL RESEARCH; TUMOR IMAGING; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ANIMALS; CELL ADHESION; CELL LINE; CELL MOVEMENT; DEUTERIUM EXCHANGE MEASUREMENT; DROSOPHILA MELANOGASTER; EXTRACELLULAR MATRIX; HUMANS; NEOPLASM INVASIVENESS; NEOPLASMS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; SCATTERING, RADIATION; STRUCTURE-ACTIVITY RELATIONSHIP; VITRONECTIN; X-RAYS;

EID: 84867242361     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.398404     Document Type: Article

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