Reduction of in vitro invasion and in vivo cartilage degradation in a SCID mouse model by loss of function of the fibrinolytic system of rheumatoid arthritis synovial fibroblasts

Arthritis and Rheumatism

Volumn 63, Issue 9, 2011, Pages 2584-2594

  Serrataĩ, Simona ^a   Margheri, Francesca ^a   Chillà, Anastasia ^a   Neumann, Elena ^b,c   Müller Ladner, Ulf ^b,c   Benucci, Maurizio ^d   Fibbi, Gabriella ^a   Del Rosso, Mario ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c KERCKHOFF HEART CENTER   (Germany)

^d SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MATRIGEL; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; UROKINASE; UROKINASE RECEPTOR; WX 340;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTISENSE THERAPY; ARTICLE; CARTILAGE; CELL COUNT; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRINOLYSIS; FIBROBLAST; GENE EXPRESSION; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MEMBRANE FILTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSORIATIC ARTHRITIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SCID MOUSE; SYNOVIAL FIBROBLAST; SYNOVIUM; ZYMOGRAPHY;

ANIMALS; ARTHRITIS, RHEUMATOID; CARTILAGE, ARTICULAR; CELL COUNT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FIBROBLASTS; HUMANS; MICE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; SYNOVIAL MEMBRANE; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 80052314684     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30439     Document Type: Article

References (34)

1. Del Rosso M, Fibbi G, Matucci-Cerinic M,. The urokinase-type plasminogen activator system and inflammatory joint diseases. Clin Exp Rheumatol 1999; 17: 485-98. (Pubitemid 29343639)
2. Ludwig T,. Local proteolytic activity in tumor cell invasion and metastasis. Bioessays 2005; 27: 1181-91. (Pubitemid 43076144)
3. Van Hinsbergh VW, Engelse MA, Quax PH,. Pericellular proteases in angiogenesis and vasculogenesis. Arterioscler Thromb Vasc Biol 2006; 26: 716-28. (Pubitemid 43732143)
4. Del Rosso M, Fibbi G, Pucci M, D'Alessio S, Del Rosso A, Magnelli L, et al. Multiple pathways of cell invasion are regulated by multiple families of serine proteases. Clin Exp Metastasis 2002; 19: 193-207. (Pubitemid 34553521)
5. Dano K, Behrend N, Hoyer-Hansen G, Johnsen N, Lund LR, Ploug M, et al. Plasminogen activation and cancer. Thromb Haemost 2005; 93: 676-81. (Pubitemid 40485402)
6. Whitelock JM, O'Grady RL, Gibbins JR,. Interstitial collagenase (matrix metalloproteinase 1) associated with the plasma membrane of both neoplastic and nonneoplastic cells. Invasion Metastasis 1991; 11: 139-48.
7. Guiducci S, Del Rosso A, Cinelli M, Margheri F, D'Alessio S, Fibbi G, et al. Rheumatoid synovial fibroblasts constitutively express the fibrinolytic pattern of invasive tumor-like cells. Clin Exp Rheumatol 2005; 23: 364-72. (Pubitemid 40823545)
8. Okamoto H, Cujec TP, Yamanaka H, Kamatani N,. Molecular aspects of rheumatoid arthritis: role of transcription factors. FEBS J 2008; 257: 4463-70.
9. Busso N, Hamilton JA,. Extravascular coagulation and the plasminogen activator/plasmin system in rheumatoid arthritis [review]. Arthritis Rheum 2002; 46: 2268-79.
10. Judex MO, Mueller BM,. Plasminogen activation/plasmin in rheumatoid arthritis: matrix degradation and more. Am J Pathol 2005; 166: 645-7. (Pubitemid 40315621)
11. Ronday HK, Smits HH, Van Muijen GN, Pruszczynski MS, Dohlain RJ, Van Langelaan EJ, et al. Difference in expression of plasminogen activation system in synovial tissue of patients with rheumatoid arthritis and osteoarthritis. Br J Rheumatol 1996; 35: 416-23.
12. Matucci Cerinic M, Generini S, Partsch G, Pignone A, Dini G, Konttinen YT, et al. Synoviocytes from osteoarthritis and rheumatoid arthritis produce plasminogen activators and plasminogen activator inhibitor-1 and display u-PA receptor on their surface. Life Sci 1998; 63: 441-53. (Pubitemid 28358108)
13. Busso N, Peclat V, So A, Sappino AP,. Plasminogen activation in synovial tissues: differences between normal, osteoarthritis, and rheumatoid arthritis joints. Ann Rheum Dis 1997; 56: 550-7. (Pubitemid 27428478)
14. Watanabe N, Ando K, Yoshida S, Inuzuka S, Kobayashi M, Matsui N, et al. Gene expression prolife analysis of RA-SF cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium. Biochem Biophys Res Commun 2002; 294: 1121-9. (Pubitemid 34687166)
15. Li J, Ny A, Leonardsson G, Nandakumar KS, Holmdahl R, Ny T,. The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis. Am J Pathol 2005; 166: 783-92. (Pubitemid 40315635)
16. Jin T, Tarkowski A, Carmeliet P, Bokarewa M,. Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis. Arthritis Res Ther 2003; 5: R9-17.
17. Fibbi G, Ziche M, Morbidelli L, Magnelli L, Del Rosso M,. Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells. Exp Cell Res 1988; 179: 385-95. (Pubitemid 19002930)
18. Del Rosso M, Fibbi G, Schmitt M,. Non-enzymatic activities of proteases: from scepticism to reality. Biol Chem 2002; 383: 1-4. (Pubitemid 34224023)
19. Fibbi G, Pucci M, Serni U, Matucci Cerinic M, Del Rosso M,. Antisense targeting of the urokinase receptor blocks urokinase-dependent proliferation, chemoinvasion, and chemotaxis of human synovial cells and chondrocytes in vitro. Proc Assoc Am Phys 1998; 110: 340-50. (Pubitemid 28345904)
20. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson AT, Bingham CO, et al. 2010 rheumatoid arthritis classification criteria. Arthritis Rheum 2010; 2: 2569-81.
21. Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H,. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum 2006; 54: 2665-73. (Pubitemid 44205029)
22. Serrati S, Margheri F, Fibbi G, Di Cara G, Minafra L, Pucci-Minafra I, et al. Endothelial cells and normal breast epithelial cells enhance invasion of breast carcinoma cells by CXCR-4-dependent up-regulation of urokinase-type plasminogen activator receptor (uPAR, CD87) expression. J Pathol 2008; 214: 545-54. (Pubitemid 351492460)
23. Jankun J, Skrzypczak-Jankun E,. Molecular basis of specific inhibition of urokinase plasminogen activator by amiloride. Cancer Biochem Biophys 1999; 17: 109-23. (Pubitemid 29475251)
24. Stoppelli MP, Tacchetti C, Cubellis MV, Corti A, Hearing VJ, Cassani G, et al. Autocrine saturation of pro-urokinase receptors on human A431 cells. Cell 1986; 45: 675-84.
25. D'Alessio S, Fibbi G, Cinelli M, Guiducci S, Del Rosso A, Margheri F, et al. Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis. Arthritis Rheum 2004; 50: 3275-85. (Pubitemid 39372005)
26. Quattrone A, Fibbi G, Anichini E, Pucci M, Zamperini A, Capaccioli S, et al. Reversion of the invasive phenotype of transformed human fibroblasts by anti-messenger oligonucleotide inhibition of urokinase receptor gene expression. Cancer Res 1995; 55: 90-5.
27. Margheri F, D'Alessio S, Serrati S, Pucci M, Annunziato F, Liotta F, et al. Effects of block urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases. Gene Ther 2005; 12: 702-14. (Pubitemid 40575610)
28. Serrati S, Margheri F, Pucci M, Cantelmo AR, Cammarota R, Dotor J, et al. TGFβ1 antagonistic peptides inhibit TGFβ1-dependent angiogenesis. Biochem Pharmacol 2009; 77: 813-25.
29. Judex M, Neumann E, Fleck M, Pap T, Mountz JD, Gay RE, et al. "Inverse wrap": an improved implantation technique for virus-transduced synovial fibroblasts in the SCID mouse model for rheumatoid arthritis. Mod Rheumatol 2001; 11: 145-50.
30. Lefevre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 2009; 15: 1414-20.
31. Hamilton JA, Slyvka J,. Stimulation of human synovial fibroblast plasminogen activator production by mononuclear cell supernatants. J Immunol 1981; 126: 851-5. (Pubitemid 11136876)
32. Hart PH, Vitti GF, Burgess DR, Whitty GA, Royston K, Hamilton JA,. Activation of human monocytes by granulocyte-macrophage colony-stimulating factor: increased urokinase-type plasminogen activator activity. Blood 1991; 77: 841-8.
33. Vitti G, Hamilton JA,. Modulation of urokinase-type plasminogen activator messenger RNA levels in human synovial fibroblasts by interleukin-1, retinoic acid, and a glucocorticoid. Arthritis Rheum 1988; 31: 1046-51.
34. Wolley DE, Tetlow LC,. Observations on the microenvironmental nature of cartilage degradation in rheumatoid arthritis. Ann Rheum Dis 1997; 56: 151-61. (Pubitemid 27144197)