Targeting multiple conformations leads to small molecule inhibitors of the uPAR•uPA protein-protein interaction that block cancer cell invasion

ACS Chemical Biology

Volumn 6, Issue 11, 2011, Pages 1232-1243

  Khanna, May ^a   Wang, Fang ^a   Jo, Inha ^a   Knabe, W Eric ^a   Wilson, Sarah M ^a   Li, Liwei ^a   Bum Erdene, Khuchtumur ^a   Li, Jing ^a   W Sledge, George ^a,b   Khanna, Rajesh ^a   Meroueh, Samy O ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; UROKINASE; UROKINASE RECEPTOR;

ARTICLE; BINDING AFFINITY; CANCER CELL; CELL ADHESION; CELL ENERGY; CELL INVASION; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE; METASTASIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

ANTINEOPLASTIC AGENTS; BENZOIC ACIDS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MOLECULAR CONFORMATION; MOLECULAR WEIGHT; NEOPLASM INVASIVENESS; PIPERIDINES; PROTEIN BINDING; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; STRUCTURE-ACTIVITY RELATIONSHIP; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 81555208984     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb200180m     Document Type: Article

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