Acetylation regulates the differentiation-specific functions of the retinoblastoma protein

EMBO Journal

Volumn 23, Issue 7, 2004, Pages 1609-1618

  Nguyen, Don X ^a   Baglia, Laurel A ^a   Huang, Shih Min ^a,c   Baker, Christina M ^a   McCance, Dennis J ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c Genomic Inst of the Novartis Found   (United States)

Author keywords

Acetylation; Differentiation; P CAF; Retinoblastoma protein

Indexed keywords

HISTONE ACETYLTRANSFERASE PCAF; PROTEIN P300; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; TUMOR SUPPRESSOR PROTEIN;

ACETYLATION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION;

ACETYLATION; ACETYLTRANSFERASES; ADENOVIRUS E1A PROTEINS; ANIMALS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; E1A-ASSOCIATED P300 PROTEIN; E2F TRANSCRIPTION FACTORS; FIBROBLASTS; GENE EXPRESSION REGULATION; HISTONE ACETYLTRANSFERASES; HUMANS; MICE; MICE, KNOCKOUT; MUSCLE DEVELOPMENT; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 2342569733     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600176     Document Type: Article

References (61)

1. Bannister AJ, Kouzarides T (1996) The CBP co-activator is a histone acetyltransferase. Nature 384: 641-643
2. Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T (1998) Retinoblastoma protein recruits histone deacetylase to repress transcription [see comments]. Nature 391: 597-601
3. Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58: 1097-1105
4. Chan HM, Krstic-Demonacos M, Smith L, Demonacos C, La Thangue NB (2001) Acetylation control of the retinoblastoma tumour-suppressor protein. Nat Cell Biol 3: 667-674
5. Chen PL, Scully P, Shew JY, Wang JY, Lee WH (1989) Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58: 1193-1198
6. Chen TT, Wang JY (2000) Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function. Mol Cell Biol 20: 5571-5580
7. Clarke AR, Maandag ER, van Roon M, van der Lugt NM, van der Valk M, Hooper ML, Berns A, te Riele H (1992) Requirement for a functional Rb-1 gene in murine development. Nature 359: 328-330
8. Classon M, Dyson N (2001) p107 and p130: versatile proteins with interesting pockets. Exp Cell Res 264: 135-147
9. Classon M, Salama S, Gorka C, Mulloy R, Braun P, Harlow E (2000) Combinatorial roles for PRB, p107, and p130 in E2F-mediated cell cycle control. Proc Natl Acad Sci USA 97: 10820-10825
10. Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T (1996) Shared role of the PRB-related p130 and p107 proteins in limb development. Genes Dev 10: 1633-1644
11. Dannenberg JH, van Rossum A, Schuijff L, te Riele H (2000) Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev 14: 3051-3064
12. Dignam J.D, Martin PL, Shastry BS, Roeder RG (1983) Eukaryotic gene transcription with purified components. Methods Enzymol 101:582-598
13. Dynlacht BD, Flores O, Lees JA, Harlow E (1994) Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev 8: 1772-1786
14. Dyson N (1998) The regulation of E2F by PRB-family proteins. Genes Dev 12: 2245-2262
15. Eckner R, Yao TP, Oldread E, Livingston DM (1996) Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev 10: 2478-2490
16. Goodman RH, Smolik S (2000) CBP/p300 in cell growth, transformation, and development. Genes Dev 14: 1553-1577
17. Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM (1998) p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell 2: 405-415
18. Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B (1993) Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72: 309-324
19. Guo CS, Degnin C, Fiddler TA, Stauffer D, Thayer MJ (2003) Regulation of MyoD activity and muscle cell differentiation by MDM2, Prb, and Sp1. J Biol Chem 278: 22615-22622
20. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70
21. Harbour JW, Dean DC (2000) The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 14: 2393-2409
22. Huang SM, McCance DJ (2002) Down regulation of the interleukin-8 promoter by human papillomavirus type 16 E6 and E7 through effects on CREB binding protein/p300 and P/CAF. J Virol 76: 8710-8721
23. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA (1992) Effects of an Rb mutation in the mouse. Nature 359: 295-300
24. Kawabata H, Kawahara K, Kanekura T, Araya N, Daitoku H, Hatta M, Miura N, Fukamizu A, Kanzaki T, Maruyama I, Nakajima T (2002) Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiation. J Biol Chem 277: 8099-8105
25. Kouzarides T (2000) Acetylation: a regulatory modification to rival phosphorylation? EMBO J 19: 1176-1179
26. LeCouter JE, Kablar B, Hardy WR, Ying C, Megeney LA, May LL, Rudnicki MA (1998a) Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol Cell Biol 18: 7455-7465
27. LeCouter JE, Kablar B, Whyte PF, Ying C, Rudnicki MA (1998b) Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene. Development 125: 4669-4679
28. Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K, Lee WH, Bradley A (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359: 288-294
29. Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T (1996) Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev 10: 1621-1632
30. Li FQ, Coonrod A, Horwitz M (2000) Selection of a dominant negative retinoblastoma protein (RB) inhibiting satellite myoblast differentiation implies an indirect interaction between MyoD and RB. Mol Cell Biol 20: 5129-5139
31. Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL (1999) p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol 19: 1202-1209
32. MacLellan WR, Xiao G, Abdellatif M, Schneider MD (2000) A novel Rb- and p300-binding protein inhibits transactivation by MyoD. Mol Cell Biol 20: 8903-8915
33. Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP, Troalen F, Trouche D, Harel-Bellan A (1998) Retinoblastoma protein represses transcription by recruiting a histone deacetylase [see comments]. Nature 391: 601-605
34. Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T (2000) Regulation of E2F1 activity by acetylation. EMBO J 19: 662-671
35. McKinsey TA, Zhang CL, Olson EN (2001) Control of muscle development by dueling HATs and HDACs. Curr Opin Genet Dev 11: 497-504
36. Miyake S, Sellers WR, Safran M, Li X, Zhao W, Grossman SR, Gan J, DeCaprio JA, Adams PD, Kaelin Jr WG (2000) Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol Cell Biol 20: 8889-8902
37. Nead MA, Baglia LA, Antinore MJ, Ludlow JW, McCance DJ (1998) Rb binds c-Jun and activates transcription. EMBO J 17: 2342-2352
38. Novitch BG, Mulligan GJ, Jacks T, Lassar AB (1996) Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol 135: 441-456
39. Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87: 953-959
40. Peschiaroli A, Figliola R, Coltella L, Strom A, Valentini A, D'Agnano I, Maione R (2002) MyoD induces apoptosis in the absence of RB function through a p21(WAF1)-dependent re-localization of cyclin/cdk complexes to the nucleus. Oncogene 21: 8114-8127
41. Polesskaya A, Duquet A, Naguibneva I, Weise C, Vervisch A, Bengal E, Hucho F, Robin P, Harel-Bellan A (2000) CREB-binding protein/p300 activates MyoD by acetylation. J Biol Chem 275: 34359-34364
42. Polesskaya A, Harel-Bellan A (2001) Acetylation of MyoD by p300 requires more than its histone acetyltransferase domain. J Biol Chem 276: 44502-44503
43. Polesskaya A, Naguibneva I, Duquet A, Bengal E, Robin P, Harel-Bellan A (2001a) Interaction between acetylated MyoD and the bromodomain of CBP and/or p300. Mol Cell Biol 21: 5312-5320
44. Polesskaya A, Naguibneva I, Fritsch L, Duquet A, Ait-Si-Ali S, Robin P, Vervisch A, Pritchard LL, Cole P, Harel-Bellan A (2001b) CBP/p300 and muscle differentiation: no HAT, no muscle. EMBO J 20: 6816-6825
45. Puri P.L, Iezzi S, Stiegler P, Chen TT, Schiltz RL, Muscat GE, Giordano A, Kedes L, Wang JY, Sartorelli V (2001) Class I histone deacetylases sequentially interact with MyoD and Prb during skeletal myogenesis. Mol Cell 8: 885-897
46. Puri PL, Sartorelli V, Yang XJ, Hamamori Y, Ogryzko VV, Howard BH, Kedes L, Wang JY, Graessmann A, Nakatani Y, Levrero M (1997) Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol Cell 1: 35-45
47. Reid JL, Bannister AJ, Zegerman P, Martinez-Balbas MA, Kouzarides T (1998) E1A directly binds and regulates the P/CAF acetyltransferase. EMBO J 17: 4469-4477
48. Ruesch MN, Laimins LA (1998) Human papillomavirus oncoproteins alter differentiation-dependent cell cycle exit on suspension in semisolid medium. Virology 250: 19-29
49. Sage J, Mulligan GJ, Attardi LD, Miller A, Chen S, Williams B, Theodorou E, Jacks T (2000) Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev 14: 3037-3050
50. Sartorelli V, Huang J, Hamamori Y, Kedes L (1997) Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol 17: 1010-1026
51. Sartorelli V, Puri PL, Hamamori Y, Ogryzko V, Chung G, Nakatani Y, Wang JY, Kedes L (1999) Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol Cell 4: 725-734
52. Schiltz RL, Nakatani Y (2000) The PCAF acetylase complex as a potential tumor suppressor. Biochem Biophys Acta 1437: M37-M53
53. -/-muscle cells. Science 264: 1467-1471
54. Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, Lassar AB, Kaelin Jr WG (1998) Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev 12: 95-106
55. Vo N, Goodman RH (2001) CREB-binding protein and p300 in transcriptional regulation. J Biol Chem 276: 13505-13508
56. Westbrook TF, Nguyen DX, Thrash BR, McCance DJ (2002) E7 abolishes raf-induced arrest via mislocalization of p21 (Cip1). Mol Cell Biol 22: 7041-7052
57. Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR, Livingston DM (1995) Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375: 694-698
58. Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T (1998) Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1 (+/-)mice. Nat Genet 18: 360-364
59. Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382: 319-324
60. Yuan W, Condorelli G, Caruso M, Felsani A, Giordano A (1996) Human p300 protein is a coactivator for the transcription factor MyoD. J Biol Chem 271: 9009-9013
61. Zacksenhaus E, Jiang Z, Chung D, Marth JD, Phillips RA, Gallie BL (1996) Prb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev 10: 3051-3064