메뉴 건너뛰기




Volumn 13, Issue 9, 2012, Pages 11071-11084

The dual role of inflammation in colon carcinogenesis

Author keywords

Colitis associated colon cancer; IBD; IL 17; IL 21; IL 6; Inflammation; T cells; Tumor immunosurveillance; Ulcerative colitis

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

EID: 84866936329     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms130911071     Document Type: Review
Times cited : (80)

References (81)
  • 1
    • 47849098044 scopus 로고    scopus 로고
    • Inflammation: Gearing the journey to cancer
    • Kundu, J.K.; Surh, Y.J. Inflammation: Gearing the journey to cancer. Mutat. Res. 2008, 659, 15-30.
    • (2008) Mutat. Res , vol.659 , pp. 15-30
    • Kundu, J.K.1    Surh, Y.J.2
  • 2
    • 0035865012 scopus 로고    scopus 로고
    • Cancer risk in patients with inflammatory bowel disease: A population-based study
    • Bernstein, C.N.; Blanchard, J.F.; Kliewer, E.; Wajda, A. Cancer risk in patients with inflammatory bowel disease: A population-based study. Cancer 2001, 91, 854-862.
    • (2001) Cancer , vol.91 , pp. 854-862
    • Bernstein, C.N.1    Blanchard, J.F.2    Kliewer, E.3    Wajda, A.4
  • 3
    • 0035080617 scopus 로고    scopus 로고
    • The risk of colorectal cancer in ulcerative colitis: A meta-analysis
    • Eaden, J.A.; Abrams, K.R.; Mayberry, J.F. The risk of colorectal cancer in ulcerative colitis: A meta-analysis. Gut 2001, 48, 526-535.
    • (2001) Gut , vol.48 , pp. 526-535
    • Eaden, J.A.1    Abrams, K.R.2    Mayberry, J.F.3
  • 4
    • 0025092693 scopus 로고
    • Ulcerative colitis and colorectal cancer. A population-based study
    • Ekbom, A.; Helmick, C.; Zack, M.; Adami, H.O. Ulcerative colitis and colorectal cancer. A population-based study. N. Engl. J. Med. 1990, 323, 1228-1233.
    • (1990) N. Engl. J. Med , vol.323 , pp. 1228-1233
    • Ekbom, A.1    Helmick, C.2    Zack, M.3    Adami, H.O.4
  • 5
    • 79961047053 scopus 로고    scopus 로고
    • Intestinal inflammation and colorectal cancer: A double-edged sword?
    • Rizzo, A.; Pallone, F.; Monteleone, G.; Fantini, M.C. Intestinal inflammation and colorectal cancer: A double-edged sword? World J. Gastroenterol. 2011, 17, 3092-3100.
    • (2011) World J. Gastroenterol , vol.17 , pp. 3092-3100
    • Rizzo, A.1    Pallone, F.2    Monteleone, G.3    Fantini, M.C.4
  • 6
    • 81855166109 scopus 로고    scopus 로고
    • Tumor-associated macrophages (tam) and inflammation in colorectal cancer
    • Erreni, M.; Mantovani, A.; Allavena, P. Tumor-associated macrophages (tam) and inflammation in colorectal cancer. Cancer Microenviron. 2011, 4, 141-154.
    • (2011) Cancer Microenviron , vol.4 , pp. 141-154
    • Erreni, M.1    Mantovani, A.2    Allavena, P.3
  • 7
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes-Bipolar effects of the tumour stroma in cancer
    • Mueller, M.M.; Fusenig, N.E. Friends or foes-Bipolar effects of the tumour stroma in cancer. Nat. Rev. Cancer 2004, 4, 839-849.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 9
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S.I.; Greten, F.R.; Karin, M. Immunity, inflammation, and cancer. Cell 2010, 140, 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 12
    • 0041513275 scopus 로고    scopus 로고
    • Intestinal immune responses in wild-type and apcmin/+ mouse, a model for colon cancer
    • Kettunen, H.L.; Kettunen, A.S.; Rautonen, N.E. Intestinal immune responses in wild-type and apcmin/+ mouse, a model for colon cancer. Cancer Res. 2003, 63, 5136-5142.
    • (2003) Cancer Res , vol.63 , pp. 5136-5142
    • Kettunen, H.L.1    Kettunen, A.S.2    Rautonen, N.E.3
  • 13
    • 0036211286 scopus 로고    scopus 로고
    • Decreased production of interleukin-12 and type 2 immune responses are marked in cachectic patients with colorectal and gastric cancer
    • Shibata, M.; Nezu, T.; Kanou, H.; Abe, H.; Takekawa, M.; Fukuzawa, M. Decreased production of interleukin-12 and type 2 immune responses are marked in cachectic patients with colorectal and gastric cancer. J. Clin. Gastroenterol. 2002, 34, 416-420.
    • (2002) J. Clin. Gastroenterol , vol.34 , pp. 416-420
    • Shibata, M.1    Nezu, T.2    Kanou, H.3    Abe, H.4    Takekawa, M.5    Fukuzawa, M.6
  • 14
    • 51249087746 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers
    • Endo, Y.; Marusawa, H.; Kou, T.; Nakase, H.; Fujii, S.; Fujimori, T.; Kinoshita, K.; Honjo, T.; Chiba, T. Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers. Gastroenterology 2008, 135, 889-898.
    • (2008) Gastroenterology , vol.135 , pp. 889-898
    • Endo, Y.1    Marusawa, H.2    Kou, T.3    Nakase, H.4    Fujii, S.5    Fujimori, T.6    Kinoshita, K.7    Honjo, T.8    Chiba, T.9
  • 15
    • 33750321707 scopus 로고    scopus 로고
    • Interferons, immunity and cancer immunoediting
    • Dunn, G.P.; Koebel, C.M.; Schreiber, R.D. Interferons, immunity and cancer immunoediting. Nat. Rev. 2006, 6, 836-848.
    • (2006) Nat. Rev , vol.6 , pp. 836-848
    • Dunn, G.P.1    Koebel, C.M.2    Schreiber, R.D.3
  • 16
    • 34248193253 scopus 로고    scopus 로고
    • Immune surveillance of tumors
    • Swann, J.B.; Smyth, M.J. Immune surveillance of tumors. J. Clin. Investig. 2007, 117, 1137-1146.
    • (2007) J. Clin. Investig , vol.117 , pp. 1137-1146
    • Swann, J.B.1    Smyth, M.J.2
  • 17
    • 33646875285 scopus 로고    scopus 로고
    • Meta-analysis: Colorectal and small bowel cancer risk in patients with crohn's disease
    • Canavan, C.; Abrams, K.R.; Mayberry, J. Meta-analysis: Colorectal and small bowel cancer risk in patients with crohn's disease. Aliment. Pharmacol. Ther. 2006, 23, 1097-1104.
    • (2006) Aliment. Pharmacol. Ther , vol.23 , pp. 1097-1104
    • Canavan, C.1    Abrams, K.R.2    Mayberry, J.3
  • 18
    • 84860996207 scopus 로고    scopus 로고
    • Th17-related cytokines in inflammatory bowel diseases: Friends or foes
    • Monteleone, I.; Sarra, M.; Pallone, F.; Monteleone, G. Th17-related cytokines in inflammatory bowel diseases: Friends or foes? Curr. Mol. Med. 2012, 12, 592-597.
    • (2012) Curr. Mol. Med , vol.12 , pp. 592-597
    • Monteleone, I.1    Sarra, M.2    Pallone, F.3    Monteleone, G.4
  • 19
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • Dunn, G.P.; Old, L.J.; Schreiber, R.D. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004, 21, 137-148.
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 20
    • 0033909434 scopus 로고    scopus 로고
    • Immune-inflammatory mechanisms in ifngamma-mediated anti-tumor activity
    • Tannenbaum, C.S.; Hamilton, T.A. Immune-inflammatory mechanisms in ifngamma-mediated anti-tumor activity. Semin. Cancer Biol. 2000, 10, 113-123.
    • (2000) Semin. Cancer Biol , vol.10 , pp. 113-123
    • Tannenbaum, C.S.1    Hamilton, T.A.2
  • 21
    • 36148960830 scopus 로고    scopus 로고
    • Inflammatory cell infiltration of tumors: Jekyll or hyde
    • Talmadge, J.E.; Donkor, M.; Scholar, E. Inflammatory cell infiltration of tumors: Jekyll or hyde. Cancer Metastasis Rev. 2007, 26, 373-400.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 373-400
    • Talmadge, J.E.1    Donkor, M.2    Scholar, E.3
  • 22
    • 0032529466 scopus 로고    scopus 로고
    • CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer
    • Naito, Y.; Saito, K.; Shiiba, K.; Ohuchi, A.; Saigenji, K.; Nagura, H.; Ohtani, H. CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res. 1998, 58, 3491-3494.
    • (1998) Cancer Res , vol.58 , pp. 3491-3494
    • Naito, Y.1    Saito, K.2    Shiiba, K.3    Ohuchi, A.4    Saigenji, K.5    Nagura, H.6    Ohtani, H.7
  • 24
    • 2642706700 scopus 로고    scopus 로고
    • Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease
    • Muller, S.; Lory, J.; Corazza, N.; Griffiths, G.M.; Z'Graggen, K.; Mazzucchelli, L.; Kappeler, A.; Mueller, C. Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease. Am. J. Pathol. 1998, 152, 261-268.
    • (1998) Am. J. Pathol , vol.152 , pp. 261-268
    • Muller, S.1    Lory, J.2    Corazza, N.3    Griffiths, G.M.4    Z'Graggen, K.5    Mazzucchelli, L.6    Kappeler, A.7    Mueller, C.8
  • 27
    • 70350546309 scopus 로고    scopus 로고
    • The contrasting roles of NKT cells in tumor immunity
    • Berzofsky, J.A.; Terabe, M. The contrasting roles of NKT cells in tumor immunity. Curr. Mol. Med. 2009, 9, 667-672.
    • (2009) Curr. Mol. Med , vol.9 , pp. 667-672
    • Berzofsky, J.A.1    Terabe, M.2
  • 28
    • 0033526066 scopus 로고    scopus 로고
    • The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells
    • Kitamura, H.; Iwakabe, K.; Yahata, T.; Nishimura, S.; Ohta, A.; Ohmi, Y.; Sato, M.; Takeda, K.; Okumura, K.; van Kaer, L. et al. The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 1999, 189, 1121-1128.
    • (1999) J. Exp. Med , vol.189 , pp. 1121-1128
    • Kitamura, H.1    Iwakabe, K.2    Yahata, T.3    Nishimura, S.4    Ohta, A.5    Ohmi, Y.6    Sato, M.7    Takeda, K.8    Okumura, K.9    van Kaer, L.10
  • 30
    • 84856235126 scopus 로고    scopus 로고
    • Dysregulation of cd1d-restricted type ii natural killer t cells leads to spontaneous development of colitis in mice
    • Liao, C.M.; Zimmer, M.I.; Shanmuganad, S.; Yu, H.T.; Cardell, S.L.; Wang, C.R. Dysregulation of cd1d-restricted type ii natural killer t cells leads to spontaneous development of colitis in mice. Gastroenterology 2012, 142, 326-334.
    • (2012) Gastroenterology , vol.142 , pp. 326-334
    • Liao, C.M.1    Zimmer, M.I.2    Shanmuganad, S.3    Yu, H.T.4    Cardell, S.L.5    Wang, C.R.6
  • 32
    • 84861783871 scopus 로고    scopus 로고
    • The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in cancer: A critical review of the literature
    • Deleeuw, R.J.; Kost, S.E.; Kakal, J.A.; Nelson, B.H. The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in cancer: A critical review of the literature. Clin. Cancer Res. 2012, 18, 3022-3029.
    • (2012) Clin. Cancer Res , vol.18 , pp. 3022-3029
    • Deleeuw, R.J.1    Kost, S.E.2    Kakal, J.A.3    Nelson, B.H.4
  • 33
    • 79959742164 scopus 로고    scopus 로고
    • Prognostic role of Foxp3+ regulatory T cells infiltrating human carcinomas: The paradox of colorectal cancer
    • Ladoire, S.; Martin, F.; Ghiringhelli, F. Prognostic role of Foxp3+ regulatory T cells infiltrating human carcinomas: The paradox of colorectal cancer. Cancer Immunol. Immunother. 2011, 60, 909-918.
    • (2011) Cancer Immunol. Immunother , vol.60 , pp. 909-918
    • Ladoire, S.1    Martin, F.2    Ghiringhelli, F.3
  • 34
    • 20144375359 scopus 로고    scopus 로고
    • CD4+ CD25+ regulatory lymphocytes induce regression of intestinal tumors in Apcmin/+ mice
    • Erdman, S.E.; Sohn, J.J.; Rao, V.P.; Nambiar, P.R.; Ge, Z.; Fox, J.G.; Schauer, D.B. CD4+ CD25+ regulatory lymphocytes induce regression of intestinal tumors in Apcmin/+ mice. Cancer Res. 2005, 65, 3998-4004.
    • (2005) Cancer Res , vol.65 , pp. 3998-4004
    • Erdman, S.E.1    Sohn, J.J.2    Rao, V.P.3    Nambiar, P.R.4    Ge, Z.5    Fox, J.G.6    Schauer, D.B.7
  • 35
    • 79958027367 scopus 로고    scopus 로고
    • Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation
    • Sugai, M.; Aoki, K.; Osato, M.; Nambu, Y.; Ito, K.; Taketo, M.M.; Shimizu, A. Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation. J. Immunol. 2011, 186, 6515-6520.
    • (2011) J. Immunol , vol.186 , pp. 6515-6520
    • Sugai, M.1    Aoki, K.2    Osato, M.3    Nambu, Y.4    Ito, K.5    Taketo, M.M.6    Shimizu, A.7
  • 36
    • 77954176180 scopus 로고    scopus 로고
    • What are Toll-like receptors and what role may they have in IBD?
    • Fukata, M.; Abreu, M.T. What are Toll-like receptors and what role may they have in IBD? Inflamm. Bowel Dis. 2008, 14, S90-S92.
    • (2008) Inflamm. Bowel Dis , vol.14
    • Fukata, M.1    Abreu, M.T.2
  • 37
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • Cario, E.; Podolsky, D.K. Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect. Immun. 2000, 68, 7010-7017.
    • (2000) Infect. Immun , vol.68 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 38
    • 37849033136 scopus 로고    scopus 로고
    • Role of Toll-like receptors in gastrointestinal malignancies
    • Fukata, M.; Abreu, M.T. Role of Toll-like receptors in gastrointestinal malignancies. Oncogene 2008, 27, 234-243.
    • (2008) Oncogene , vol.27 , pp. 234-243
    • Fukata, M.1    Abreu, M.T.2
  • 40
    • 69449102284 scopus 로고    scopus 로고
    • Innate immune signaling by toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors
    • Fukata, M.; Hernandez, Y.; Conduah, D.; Cohen, J.; Chen, A.; Breglio, K.; Goo, T.; Hsu, D.; Xu, R.; Abreu, M.T. Innate immune signaling by toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm. Bowel Dis. 2009, 15, 997-1006.
    • (2009) Inflamm. Bowel Dis , vol.15 , pp. 997-1006
    • Fukata, M.1    Hernandez, Y.2    Conduah, D.3    Cohen, J.4    Chen, A.5    Breglio, K.6    Goo, T.7    Hsu, D.8    Xu, R.9    Abreu, M.T.10
  • 42
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein Myd88
    • Rakoff-Nahoum, S.; Medzhitov, R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein Myd88. Science 2007, 317, 124-127.
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 43
    • 67650299380 scopus 로고    scopus 로고
    • Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
    • Uronis, J.M.; Muhlbauer, M.; Herfarth, H.H.; Rubinas, T.C.; Jones, G.S.; Jobin, C. Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One 2009, 4, e6026.
    • (2009) PLoS One , vol.4
    • Uronis, J.M.1    Muhlbauer, M.2    Herfarth, H.H.3    Rubinas, T.C.4    Jones, G.S.5    Jobin, C.6
  • 44
    • 77957735624 scopus 로고    scopus 로고
    • Role of tumour-associated macrophages in cancer-related inflammation
    • Sica, A. Role of tumour-associated macrophages in cancer-related inflammation. Exp. Oncol. 2010, 32, 153-158.
    • (2010) Exp. Oncol , vol.32 , pp. 153-158
    • Sica, A.1
  • 45
    • 41149164902 scopus 로고    scopus 로고
    • The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    • Allavena, P.; Sica, A.; Garlanda, C.; Mantovani, A. The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol. Rev. 2008, 222, 155-161.
    • (2008) Immunol. Rev , vol.222 , pp. 155-161
    • Allavena, P.1    Sica, A.2    Garlanda, C.3    Mantovani, A.4
  • 48
    • 77957969757 scopus 로고    scopus 로고
    • The dual role of tumor necrosis factor (TNF) in cancer biology
    • Bertazza, L.; Mocellin, S. The dual role of tumor necrosis factor (TNF) in cancer biology. Curr. Med. Chem. 2010, 17, 3337-3352.
    • (2010) Curr. Med. Chem , vol.17 , pp. 3337-3352
    • Bertazza, L.1    Mocellin, S.2
  • 49
    • 2442560241 scopus 로고    scopus 로고
    • Optimizing anti-TNF treatment in inflammatory bowel disease
    • Rutgeerts, P.; van Assche, G.; Vermeire, S. Optimizing anti-TNF treatment in inflammatory bowel disease. Gastroenterology 2004, 126, 1593-1610.
    • (2004) Gastroenterology , vol.126 , pp. 1593-1610
    • Rutgeerts, P.1    van Assche, G.2    Vermeire, S.3
  • 51
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappab transcription factors in the immune system
    • Vallabhapurapu, S.; Karin, M. Regulation and function of NF-kappab transcription factors in the immune system. Annu. Rev. Immunol. 2009, 27, 693-733.
    • (2009) Annu. Rev. Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 52
    • 4043088499 scopus 로고    scopus 로고
    • Ikkbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F.R.; Eckmann, L.; Greten, T.F.; Park, J.M.; Li, Z.W.; Egan, L.J.; Kagnoff, M.F.; Karin, M. Ikkbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004, 118, 285-296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.W.5    Egan, L.J.6    Kagnoff, M.F.7    Karin, M.8
  • 54
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: Role in inflammation and cancer
    • Rose-John, S.; Scheller, J.; Elson, G.; Jones, S.A. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: Role in inflammation and cancer. J. Leukoc. Biol. 2006, 80, 227-236.
    • (2006) J. Leukoc. Biol , vol.80 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 58
    • 84861567294 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (Stat3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (Snai) protein stability
    • Lee, J.; Kim, J.C.; Lee, S.E.; Quinley, C.; Kim, H.; Herdman, S.; Corr, M.; Raz, E. Signal transducer and activator of transcription 3 (Stat3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (Snai) protein stability. J. Biol. Chem. 2012, 287, 18182-18189.
    • (2012) J. Biol. Chem , vol.287 , pp. 18182-18189
    • Lee, J.1    Kim, J.C.2    Lee, S.E.3    Quinley, C.4    Kim, H.5    Herdman, S.6    Corr, M.7    Raz, E.8
  • 59
    • 0027313034 scopus 로고
    • Relationship of functional and antigenic interleukin 6 to disease activity in inflammatory bowel disease
    • Hyams, J.S.; Fitzgerald, J.E.; Treem, W.R.; Wyzga, N.; Kreutzer, D.L. Relationship of functional and antigenic interleukin 6 to disease activity in inflammatory bowel disease. Gastroenterology 1993, 104, 1285-1292.
    • (1993) Gastroenterology , vol.104 , pp. 1285-1292
    • Hyams, J.S.1    Fitzgerald, J.E.2    Treem, W.R.3    Wyzga, N.4    Kreutzer, D.L.5
  • 60
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo
    • Atreya, R.; Mudter, J.; Finotto, S.; Mullberg, J.; Jostock, T.; Wirtz, S.; Schutz, M.; Bartsch, B.; Holtmann, M.; Becker, C.; et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo. Nat. Med. 2000, 6, 583-588.
    • (2000) Nat. Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3    Mullberg, J.4    Jostock, T.5    Wirtz, S.6    Schutz, M.7    Bartsch, B.8    Holtmann, M.9    Becker, C.10
  • 62
    • 77949326158 scopus 로고    scopus 로고
    • Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
    • Matsumoto, S.; Hara, T.; Mitsuyama, K.; Yamamoto, M.; Tsuruta, O.; Sata, M.; Scheller, J.; Rose-John, S.; Kado, S.; Takada, T. Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J. Immunol. 2010, 184, 1543-1551.
    • (2010) J. Immunol , vol.184 , pp. 1543-1551
    • Matsumoto, S.1    Hara, T.2    Mitsuyama, K.3    Yamamoto, M.4    Tsuruta, O.5    Sata, M.6    Scheller, J.7    Rose-John, S.8    Kado, S.9    Takada, T.10
  • 63
    • 77149155643 scopus 로고    scopus 로고
    • Disease-related expression of the IL6/Stat3/Socs3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis
    • Li, Y.; de Haar, C.; Chen, M.; Deuring, J.; Gerrits, M.M.; Smits, R.; Xia, B.; Kuipers, E.J.; van der Woude, C.J. Disease-related expression of the IL6/Stat3/Socs3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut 2010, 59, 227-235.
    • (2010) Gut , vol.59 , pp. 227-235
    • Li, Y.1    de Haar, C.2    Chen, M.3    Deuring, J.4    Gerrits, M.M.5    Smits, R.6    Xia, B.7    Kuipers, E.J.8    van der Woude, C.J.9
  • 64
    • 34447629700 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (Socs3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon
    • Rigby, R.J.; Simmons, J.G.; Greenhalgh, C.J.; Alexander, W.S.; Lund, P.K. Suppressor of cytokine signaling 3 (Socs3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene 2007, 26, 4833-4841.
    • (2007) Oncogene , vol.26 , pp. 4833-4841
    • Rigby, R.J.1    Simmons, J.G.2    Greenhalgh, C.J.3    Alexander, W.S.4    Lund, P.K.5
  • 66
    • 58149296036 scopus 로고    scopus 로고
    • Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens
    • Curtis, M.M.; Way, S.S. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 2009, 126, 177-185.
    • (2009) Immunology , vol.126 , pp. 177-185
    • Curtis, M.M.1    Way, S.S.2
  • 67
    • 84860238945 scopus 로고    scopus 로고
    • IL-17/IL-17 receptor system in autoimmune disease: Mechanisms and therapeutic potential
    • Zhu, S.; Qian, Y. IL-17/IL-17 receptor system in autoimmune disease: Mechanisms and therapeutic potential. Clin. Sci. 2012, 122, 487-511.
    • (2012) Clin. Sci , vol.122 , pp. 487-511
    • Zhu, S.1    Qian, Y.2
  • 68
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17a monoclonal antibody, for moderate to severe crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • doi:10.1136/gutjnl-2011-301668
    • Hueber, W.; Sands, B.E.; Lewitzky, S.; Vandemeulebroecke, M.; Reinisch, W.; Higgins, P.D.; Wehkamp, J.; Feagan, B.G.; Yao, M.D.; Karczewski, M., et al. Secukinumab, a human anti-IL-17a monoclonal antibody, for moderate to severe crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial. Gut 2012, doi:10.1136/gutjnl-2011-301668.
    • (2012) Gut
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3    Vandemeulebroecke, M.4    Reinisch, W.5    Higgins, P.D.6    Wehkamp, J.7    Feagan, B.G.8    Yao, M.D.9    Karczewski, M.10
  • 72
    • 67651094058 scopus 로고    scopus 로고
    • Endogenous IL-17 contributes to reduced tumor growth and metastasis
    • Kryczek, I.; Wei, S.; Szeliga, W.; Vatan, L.; Zou, W. Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood 2009, 114, 357-359.
    • (2009) Blood , vol.114 , pp. 357-359
    • Kryczek, I.1    Wei, S.2    Szeliga, W.3    Vatan, L.4    Zou, W.5
  • 75
    • 84859602743 scopus 로고    scopus 로고
    • Role of IL-17a in the development of colitis-associated cancer
    • Hyun, Y.S.; Han, D.S.; Lee, A.R.; Eun, C.S.; Youn, J.; Kim, H.Y. Role of IL-17a in the development of colitis-associated cancer. Carcinogenesis 2012, 33, 931-936.
    • (2012) Carcinogenesis , vol.33 , pp. 931-936
    • Hyun, Y.S.1    Han, D.S.2    Lee, A.R.3    Eun, C.S.4    Youn, J.5    Kim, H.Y.6
  • 76
    • 67849120058 scopus 로고    scopus 로고
    • Interleukin-21 as a new therapeutic target for immune-mediated diseases
    • Monteleone, G.; Pallone, F.; Macdonald, T.T. Interleukin-21 as a new therapeutic target for immune-mediated diseases. Trends Pharmacol. Sci. 2009, 30, 441-447.
    • (2009) Trends Pharmacol. Sci , vol.30 , pp. 441-447
    • Monteleone, G.1    Pallone, F.2    Macdonald, T.T.3
  • 77
    • 70449334555 scopus 로고    scopus 로고
    • IL-21: Roles in immunopathology and cancer therapy
    • Sondergaard, H.; Skak, K. IL-21: Roles in immunopathology and cancer therapy. Tissue antigens 2009, 74, 467-479.
    • (2009) Tissue Antigens , vol.74 , pp. 467-479
    • Sondergaard, H.1    Skak, K.2
  • 81
    • 80655125038 scopus 로고    scopus 로고
    • Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice
    • Jauch, D.; Martin, M.; Schiechl, G.; Kesselring, R.; Schlitt, H.J.; Geissler, E.K.; Fichtner-Feigl, S. Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice. Gut 2011, 60, 1678-1686.
    • (2011) Gut , vol.60 , pp. 1678-1686
    • Jauch, D.1    Martin, M.2    Schiechl, G.3    Kesselring, R.4    Schlitt, H.J.5    Geissler, E.K.6    Fichtner-Feigl, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.