Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase

Science

Volumn 316, Issue 5822, 2007, Pages 288-290

  Leibundgut, Marc ^a   Jenni, Simon ^a   Frick, Christian ^a   Ban, Nenad ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEIN; FATTY ACID SYNTHASE;

ENZYME ACTIVITY; FATTY ACID; YEAST;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; STRUCTURE ANALYSIS; YEAST;

ACYL CARRIER PROTEIN; ACYLTRANSFERASES; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; FATTY ACID SYNTHETASE COMPLEX; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 34247353309     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1138249     Document Type: Article

References (31)

1. S. W. White, J. Zheng, Y. M. Zhang, C. O. Rock, Annu. Rev. Biochem. 74, 791 (2005).
2. K. J. Weissman, Philos. Trons. A Moth. Phys. Eng. Sci. 362, 2671 (2004).
3. R. Finking, M. A. Marahiel, Annu. Rev. Microbiol. 58, 453 (2004).
4. T. Maier, S. Jenni, N. Ban, Science 311, 1258 (2006).
5. S. Smith, A. Witkowski, A. K. Joshi, Prog. Lipid Res. 42, 289 (2003).
6. E. Schweizer, J. Hofmann, Microbiol. Mol. Biol. Rev. 68, 501 (2004).
7. F. Lynen, Eur. J. Biochem. 112, 431 (1980).
8. S. Jenni, M. Leibundgut, T. Maier, N. Ban, Science 311, 1263 (2006).
9. T. A. Holak, M. Nilges, J. H. Prestegard, A. M. Gronenborn, G. M. Clore, Eur. J. Biochem. 175, 9 (1988).
10. G. Y. Xu et al., Structure 9, 277 (2001).
11. H. C. Wong, G. Liu, Y. M. Zhang, C. O. Rock, J. Zheng, J. Biol. Chem. 277, 15874 (2002).
12. G. A. Zornetzer, B. G. Fox, J. L. Markley, Biochemistry 45, 5217 (2006).
13. M. P. Crump et al., Biochemistry 36, 6000 (1997).
14. S. C. Findlow, C. Winsor, T. J. Simpson, J. Crosby, M. P. Crump, Biochemistry 42, 8423 (2003).
15. A. Koglin et al., Science 312, 273 (2006).
16. A. Roujeinikova et al., J. Mol. Biol. 365, 135 (2007).
17. P. Bhaumik, M. K. Koski, T. Glumoff, J. K. Hiltunen, R. K. Wierenga, Curr. Opin. Struct. Biol. 15, 621 (2005).
18. Y. M. Zhang et al., J. Biol. Chem. 276, 8231 (2001).
19. Y. M. Zhang, B. Wu, J. Zheng, C. O. Rock, J. Biol. Chem. 278, 52935 (2003).
20. K. D. Parris et al., Structure 8, 883 (2000).
21. S. Rafi et al., J. Biol. Chem. 281, 39,285 (2006).
22. S. Jenni et ol., Science 316, 254 (2007).
23. Materials and methods are described in the supporting material on Science Online.
24. H. Schuster, B. Rautenstrauss, M. Mittag, D. Stratmann, E. Schweizer, Eur. J. Biochem. 228, 417 (1995).
25. F. Fichtlscherer, C. Wellein, M. Mittag, E. Schweizer, Eur. J. Biochem. 267, 2666 (2000).
26. A. H. Mohamed, S. S. Chirala, N. H. Mody, W. Y. Huang, S. J. Wakil, J. Biol. Chem. 263, 12315 (1988).
27. T. Schreckenbach, H. Wobser, F. Lynen, Eur. J. Biochem. 80, 13 (1977).
28. G. B. Kresze, L. Steber, D. Oesterhelt, F. Lynen, Eur. J. Biochem. 79, 181 (1977).
29. P. von Wettstein-Knowles, J. G. Olsen, K. A. McGuire, A. Henriksen, FEBS J. 273, 695 (2006).
30. R. N. Perham, Annu. Rev. Biochem. 69, 961 (2000).
31. All data were collected at the Swiss Light Source (SLS, Paul Scherrer Institute, Villigen). We are grateful to C. Schulze-Briese, S. Gutmann, E. Pohl, S. Russo, and T. Tomizaki for their outstanding support at the SLS. We thank T. Maier and J. Erzberger for critically reading the manuscript and all members of the Ban laboratory for suggestions and discussions; R. Grosse-Kunstleve, P. Afonine, and P. Adams for providing a prerelease version of the PHENIX refinement program and advice regarding structure refinement; A. Jones for a prerelease version of the program O; D. Sargent for technical assistance. Yeast cells were kindly provided by F. Hepfer of Hefe Schweiz AG. This work was supported by the Swiss National Science Foundation (SNSF) and the National Center of Excellence in Research (NCCR) Structural Biology program of the SNSF. Coordinates and structure factors of the S. cerevisiae structure have been deposited in the Protein Data Bank with the accession code 2UV8.