Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

Neurobiology of Aging

Volumn 33, Issue 12, 2012, Pages 2903-2919

  Durairajan, Siva Sundara Kumar ^a   Liu, Liang Feng ^a   Lu, Jia Hong ^a   Chen, Lei Lei ^a   Yuan, Qiuju ^b   Chung, Sookja K ^c   Huang, Ling ^d   Li, Xing Shu ^d   Huang, Jian Dong ^c   Li, Min ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

amyloid; Alzheimer's disease; Amyloid precursor protein; Berberine; Glycogen synthase kinase; Tau phosphorylation; TgCRND8 mice

Indexed keywords

BERBERINE; GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TAU PROTEIN;

ALZHEIMER DISEASE; AMYLOID NEUROPATHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN HOMOGENATE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG MECHANISM; DRUG MEGADOSE; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GLIOSIS; IN VITRO STUDY; LEARNING DISORDER; LONG TERM MEMORY; LOW DRUG DOSE; MEMORY CONSOLIDATION; MOUSE; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SPATIAL MEMORY; TRANSGENIC MOUSE;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BERBERINE; BRAIN; CELL LINE, TUMOR; CHROMONES; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MAZE LEARNING; MEMBRANE PROTEINS; MEMORY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MORPHOLINES; MUTATION; PEPTIDE FRAGMENTS; TRANSFECTION;

EID: 84866744899     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.02.016     Document Type: Article

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