메뉴 건너뛰기




Volumn 60, Issue 38, 2012, Pages 9609-9619

Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells

Author keywords

amylase catalyzed digestion; Citrus flavonoids; Functional foods; glucose regulating enzymes; HepG2 cell; starch Citrus flavonoid complexes

Indexed keywords

ANTIHYPERGLYCEMIC EFFECTS; DIGESTIVE ENZYMES; FUNCTIONAL FOODS; GLUCOKINASE ACTIVITY; GLUCOSE CONSUMPTION; GLUCOSE-6-PHOSPHATASE; GLUCOSIDASE; HEPATIC GLUCONEOGENESIS; HEPG2 CELLS; INHIBITORY ACTIVITY; INHIBITORY EFFECT; NARINGIN; NATURAL PRODUCTS; NOBILETIN; STARCH-CITRUS FLAVONOID COMPLEXES;

EID: 84866722274     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf3032556     Document Type: Article
Times cited : (124)

References (48)
  • 1
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • Stumvoll, M.; Goldstein, B. J.; Haeften, T. W. Type 2 diabetes: Principles of pathogenesis and therapy Lancet 2005, 365, 1333-1346
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    Haeften, T.W.3
  • 3
    • 0031853586 scopus 로고    scopus 로고
    • Postprandial hyperglycaemia and α-glucosidase inhibitors
    • Baron, A. D. Postprandial hyperglycaemia and α-glucosidase inhibitors Diabetes Res. Clin. Pract. 1998, 40, S51-S55
    • (1998) Diabetes Res. Clin. Pract. , vol.40
    • Baron, A.D.1
  • 4
    • 0035954848 scopus 로고    scopus 로고
    • Controlling postprandial hyperglycemia
    • Ratner, R. E. Controlling postprandial hyperglycemia Am. J. Cardiol. 2001, 88, 26-31
    • (2001) Am. J. Cardiol. , vol.88 , pp. 26-31
    • Ratner, R.E.1
  • 5
    • 53349152406 scopus 로고    scopus 로고
    • International Diabetes Federation guideline for management of postmeal glucose: A review of recommendations
    • Ceriello, A.; Colagiuri, S. International Diabetes Federation guideline for management of postmeal glucose: A review of recommendations Diabetic Med. 2008, 25, 1151-1156
    • (2008) Diabetic Med. , vol.25 , pp. 1151-1156
    • Ceriello, A.1    Colagiuri, S.2
  • 6
    • 57349160286 scopus 로고    scopus 로고
    • Medical management of hyperglycaemia in type 2 diabetes mellitus: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan, D. M.; Buse, J. B.; Davidson, M. B.; Ferrannini, E.; Holman, R. R.; Sherwin, R.; Zinman, B. Medical management of hyperglycaemia in type 2 diabetes mellitus: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes Diabetologia 2009, 52, 17-30
    • (2009) Diabetologia , vol.52 , pp. 17-30
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7
  • 7
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel, A. R.; Kahn, C. R. Insulin signalling and the regulation of glucose and lipid metabolism Nature 2001, 414, 799-806
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 8
    • 78649835553 scopus 로고    scopus 로고
    • Small molecules from natural sources, targeting signaling pathways in diabetes
    • Liu, Q.; Chen, L.; Hu, L.; Guo, Y.; Shen, X. Small molecules from natural sources, targeting signaling pathways in diabetes Biochim. Biophys. Acta 2010, 1799, 854-865
    • (2010) Biochim. Biophys. Acta , vol.1799 , pp. 854-865
    • Liu, Q.1    Chen, L.2    Hu, L.3    Guo, Y.4    Shen, X.5
  • 9
    • 0033933730 scopus 로고    scopus 로고
    • Inhibition of enzymic digestion of amylose by free fatty acids in vitro contributes to resistant starch formation
    • Crowe, T. C.; Seligman, S. A.; Cppeland, L. C. Inhibition of enzymic digestion of amylose by free fatty acids in vitro contributes to resistant starch formation J. Nutr. 2000, 130, 2006-2008
    • (2000) J. Nutr. , vol.130 , pp. 2006-2008
    • Crowe, T.C.1    Seligman, S.A.2    Cppeland, L.C.3
  • 10
    • 0032997464 scopus 로고    scopus 로고
    • The effect of amylose-lipid complex formation on enzyme susceptibility of sago starch
    • Cui, R.; Oates, C. G. The effect of amylose-lipid complex formation on enzyme susceptibility of sago starch Food Chem. 1999, 65, 417-425
    • (1999) Food Chem. , vol.65 , pp. 417-425
    • Cui, R.1    Oates, C.G.2
  • 11
    • 80054966955 scopus 로고    scopus 로고
    • Complex formation, thermal properties, and in vitro digestibility of gelatinized potato starch-fatty acid mixtures
    • Kawai, K.; Takato, S.; Sasaki, T.; Kajiwara, K. Complex formation, thermal properties, and in vitro digestibility of gelatinized potato starch-fatty acid mixtures Food Hydrocolloids 2012, 27, 228-234
    • (2012) Food Hydrocolloids , vol.27 , pp. 228-234
    • Kawai, K.1    Takato, S.2    Sasaki, T.3    Kajiwara, K.4
  • 12
    • 68249107846 scopus 로고    scopus 로고
    • Delivery of bioactive conjugated linoleic acid with self-assembled amylose-CLA complex
    • Yang, Y.; Gu, Z.; Zhang, G. Delivery of bioactive conjugated linoleic acid with self-assembled amylose-CLA complex J. Agric. Food Chem. 2009, 57, 7125-7130
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 7125-7130
    • Yang, Y.1    Gu, Z.2    Zhang, G.3
  • 13
    • 0033833334 scopus 로고    scopus 로고
    • Amylose-lipid complex formation during cooking of rice flour
    • Kaur, K. Amylose-lipid complex formation during cooking of rice flour Food Chem. 2000, 71, 511-517
    • (2000) Food Chem. , vol.71 , pp. 511-517
    • Kaur, K.1
  • 14
    • 78649638006 scopus 로고    scopus 로고
    • Fatty acids, epicatechin-dimethylgallate, and rutin interact with buckwheat starch inhibiting its digestion by amylase: Implications for the decrease in glycemic index by buckwheat flour
    • Takahama, U.; Hirota, S. Fatty acids, epicatechin-dimethylgallate, and rutin interact with buckwheat starch inhibiting its digestion by amylase: Implications for the decrease in glycemic index by buckwheat flour J. Agric. Food Chem. 2010, 12431-12439
    • (2010) J. Agric. Food Chem. , pp. 12431-12439
    • Takahama, U.1    Hirota, S.2
  • 15
    • 47049099886 scopus 로고    scopus 로고
    • Structural and functional properties of amylose complexes with genistein
    • Cohen, R.; Orlova, Y.; Kovalev, M.; Ungar, Y.; Shimoni, E. Structural and functional properties of amylose complexes with genistein J. Agric. Food Chem. 2008, 56, 4212-4218
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 4212-4218
    • Cohen, R.1    Orlova, Y.2    Kovalev, M.3    Ungar, Y.4    Shimoni, E.5
  • 18
    • 50449111165 scopus 로고    scopus 로고
    • Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity
    • Garcia, B. O; Castillo, J. Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity J. Agric. Food Chem. 2008, 6185-6205
    • (2008) J. Agric. Food Chem. , pp. 6185-6205
    • Garcia, B.O.1    Castillo, J.2
  • 19
    • 56749179749 scopus 로고    scopus 로고
    • Neuroprotective effects of chronic hesperetin administration in mice
    • Choi, E. J.; Ahn, W. S. Neuroprotective effects of chronic hesperetin administration in mice Arch. Pharmacal Res. 2008, 31, 1457-1462
    • (2008) Arch. Pharmacal Res. , vol.31 , pp. 1457-1462
    • Choi, E.J.1    Ahn, W.S.2
  • 20
    • 0035001464 scopus 로고    scopus 로고
    • Biological properties of citrus flavonoids pertaining to cancer and inflammation
    • Manthey, J. A; Grohmann, K.; Guthrie, N. Biological properties of citrus flavonoids pertaining to cancer and inflammation Curr. Med. Chem. 2001, 8, 135-153
    • (2001) Curr. Med. Chem. , vol.8 , pp. 135-153
    • Manthey, J.A.1    Grohmann, K.2    Guthrie, N.3
  • 22
    • 0037048763 scopus 로고    scopus 로고
    • Antiproliferative activities of citrus flavonoids against six human cancer cell lines
    • Manthey, J. A.; Guthrie, N. Antiproliferative activities of citrus flavonoids against six human cancer cell lines J. Agric. Food Chem. 2002, 50, 5837-5843
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 5837-5843
    • Manthey, J.A.1    Guthrie, N.2
  • 23
    • 79951938073 scopus 로고    scopus 로고
    • Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide
    • Lu, Y. H.; Su, M. Y.; Huang, H. Y.; Li, L.; Yuan, C. G. Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide Neurosci. Lett. 2010, 484, 6-11
    • (2010) Neurosci. Lett. , vol.484 , pp. 6-11
    • Lu, Y.H.1    Su, M.Y.2    Huang, H.Y.3    Li, L.4    Yuan, C.G.5
  • 25
    • 33645892889 scopus 로고    scopus 로고
    • Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice
    • Jung, U. J.; Lee, M. K.; Park, Y. B.; Kang, M. A.; Choi, M. S. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice Int. J. Biochem. Cell Biol. 2006, 38, 1134-1145
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 1134-1145
    • Jung, U.J.1    Lee, M.K.2    Park, Y.B.3    Kang, M.A.4    Choi, M.S.5
  • 26
    • 4744373549 scopus 로고    scopus 로고
    • The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice
    • Jung, U.; Lee, M.; Jeong, K. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice J. Nutr. 2004, 2499-2503
    • (2004) J. Nutr. , pp. 2499-2503
    • Jung, U.1    Lee, M.2    Jeong, K.3
  • 27
    • 74349129815 scopus 로고    scopus 로고
    • Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes
    • Akiyama, S.; Katsumata, S.; Suzuki, K.; Nakaya, Y.; Ishimi, Y.; Uehara, M. Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin- clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes Biosci. Biotechnol., Biochem. 2009, 73, 2779-2782
    • (2009) Biosci. Biotechnol., Biochem. , vol.73 , pp. 2779-2782
    • Akiyama, S.1    Katsumata, S.2    Suzuki, K.3    Nakaya, Y.4    Ishimi, Y.5    Uehara, M.6
  • 28
    • 77249151607 scopus 로고    scopus 로고
    • Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats
    • Akiyama, S.; Katsumata, S.; Suzuki, K. Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats J. Clin. Biochem. Nutr. 2010, 46, 87-92
    • (2010) J. Clin. Biochem. Nutr. , vol.46 , pp. 87-92
    • Akiyama, S.1    Katsumata, S.2    Suzuki, K.3
  • 30
    • 33746253640 scopus 로고    scopus 로고
    • Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China
    • Lu, Y. H.; Zhang, C. W.; Bucheli, P.; Wei, D. Z. Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China Plant Food Hum. Nutr. 2006, 61, 57-65
    • (2006) Plant Food Hum. Nutr. , vol.61 , pp. 57-65
    • Lu, Y.H.1    Zhang, C.W.2    Bucheli, P.3    Wei, D.Z.4
  • 31
    • 79958006212 scopus 로고    scopus 로고
    • Inhibition of buckwheat starch digestion by the formation of starch/bile salt complexes: Possibility of its occurrence in the intestine
    • Takahama, U.; Hirota, S. Inhibition of buckwheat starch digestion by the formation of starch/bile salt complexes: Possibility of its occurrence in the intestine J. Agric. Food. Chem. 2011, 59, 6277-6283
    • (2011) J. Agric. Food. Chem. , vol.59 , pp. 6277-6283
    • Takahama, U.1    Hirota, S.2
  • 32
    • 0033910618 scopus 로고    scopus 로고
    • Total and pancreatic amylase measured with 2-chloro-4-nitrophenyl-4- O -β- d -galactopyranosylmaltoside
    • Morishita, Y.; Iinuma, Y.; Nakashima, N. Total and pancreatic amylase measured with 2-chloro-4-nitrophenyl-4- O -β- d -galactopyranosylmaltoside Clin. Chem. 2000, 46, 928-933
    • (2000) Clin. Chem. , vol.46 , pp. 928-933
    • Morishita, Y.1    Iinuma, Y.2    Nakashima, N.3
  • 33
    • 80052566344 scopus 로고    scopus 로고
    • Inhibitory effects of muscadine anthocyanins on α-glucosidase and pancreatic lipase activities
    • You, Q.; Chen, F.; Wang, X.; Luo, P. G.; Jiang, Y. Inhibitory effects of muscadine anthocyanins on α-glucosidase and pancreatic lipase activities J. Agric. Food. Chem. 2011, 59, 9506-9511
    • (2011) J. Agric. Food. Chem. , vol.59 , pp. 9506-9511
    • You, Q.1    Chen, F.2    Wang, X.3    Luo, P.G.4    Jiang, Y.5
  • 34
    • 78651395097 scopus 로고    scopus 로고
    • Antihyperglycemic activity of Selaginella tamariscina (Beauv.) Spring
    • Zheng, X. K.; Li, Y. J.; Zhang, L.; Feng, W. S.; Zhang, X. Antihyperglycemic activity of Selaginella tamariscina (Beauv.) Spring J. Ethnopharmacol. 2011, 133, 531-537
    • (2011) J. Ethnopharmacol. , vol.133 , pp. 531-537
    • Zheng, X.K.1    Li, Y.J.2    Zhang, L.3    Feng, W.S.4    Zhang, X.5
  • 36
    • 0023683758 scopus 로고
    • Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction
    • Alegre, M.; Ciudad, C. J.; Fillat, C.; Guinovart, J. J. Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction Anal. Biochem. 1988, 173, 185-189
    • (1988) Anal. Biochem. , vol.173 , pp. 185-189
    • Alegre, M.1    Ciudad, C.J.2    Fillat, C.3    Guinovart, J.J.4
  • 37
    • 69249105583 scopus 로고    scopus 로고
    • Electrochemical investigations of antioxidant interactions with radical anion and dianion of 1,3-dinitrobenzene
    • Arshad, N.; Janjua, N. K.; Ahmed, S.; Khan, A. Y.; Skibsted, L. H. Electrochemical investigations of antioxidant interactions with radical anion and dianion of 1,3-dinitrobenzene Electrochim. Acta 2009, 54, 6184-6189
    • (2009) Electrochim. Acta , vol.54 , pp. 6184-6189
    • Arshad, N.1    Janjua, N.K.2    Ahmed, S.3    Khan, A.Y.4    Skibsted, L.H.5
  • 38
    • 78649272229 scopus 로고    scopus 로고
    • A novel triple-wavelength colorimetric method for measuring amylose and amylopectin contents
    • Wang, J.; Li, Y.; Tian, Y.; Xu, X.; Ji, X.; Cao, X.; Jin, Z. A novel triple-wavelength colorimetric method for measuring amylose and amylopectin contents Starch/Staerke 2010, 62, 508-516
    • (2010) Starch/Staerke , vol.62 , pp. 508-516
    • Wang, J.1    Li, Y.2    Tian, Y.3    Xu, X.4    Ji, X.5    Cao, X.6    Jin, Z.7
  • 39
    • 0029842468 scopus 로고    scopus 로고
    • The complex of amylose and iodine
    • Yu, X.; Houtman, C.; Atalla, R. H. The complex of amylose and iodine Carbohydr. Res. 1996, 292, 129-141
    • (1996) Carbohydr. Res. , vol.292 , pp. 129-141
    • Yu, X.1    Houtman, C.2    Atalla, R.H.3
  • 40
    • 33645826979 scopus 로고    scopus 로고
    • Evaluation of variations in amylose-iodine absorbance spectra
    • Knutson, C. Evaluation of variations in amylose-iodine absorbance spectra Carbohydr. Polym. 1999, 42, 65-72
    • (1999) Carbohydr. Polym. , vol.42 , pp. 65-72
    • Knutson, C.1
  • 41
    • 54449083443 scopus 로고    scopus 로고
    • Iodine binding property of a ternary complex consisting of starch, protein, and free fatty acids
    • Liu, J.; Fei, L.; Maladen, M.; Hamaker, B. R.; Zhang, G. Iodine binding property of a ternary complex consisting of starch, protein, and free fatty acids Carbohydr. Polym. 2009, 75, 351-355
    • (2009) Carbohydr. Polym. , vol.75 , pp. 351-355
    • Liu, J.1    Fei, L.2    Maladen, M.3    Hamaker, B.R.4    Zhang, G.5
  • 42
    • 38849201011 scopus 로고    scopus 로고
    • Slowly digestible waxy maize starch prepared by octenyl succinic anhydride esterification and heat-moisture treatment: Glycemic response and mechanism
    • He, J.; Liu, J.; Zhang, G. Slowly digestible waxy maize starch prepared by octenyl succinic anhydride esterification and heat-moisture treatment: Glycemic response and mechanism Biomacromolecules 2008, 9, 175-184
    • (2008) Biomacromolecules , vol.9 , pp. 175-184
    • He, J.1    Liu, J.2    Zhang, G.3
  • 44
    • 45749116594 scopus 로고    scopus 로고
    • Flavonoids for controlling starch digestion: Structural requirements for inhibiting human α-amylase
    • Piparo, L. E.; Scheib, H.; Frei, N.; Williamson, G.; Grigorov, M.; Chou, C. J. Flavonoids for controlling starch digestion: Structural requirements for inhibiting human α-amylase J. Med. Chem. 2008, 51, 3555-3561
    • (2008) J. Med. Chem. , vol.51 , pp. 3555-3561
    • Piparo, L.E.1    Scheib, H.2    Frei, N.3    Williamson, G.4    Grigorov, M.5    Chou, C.J.6
  • 45
    • 16344384538 scopus 로고    scopus 로고
    • Different polyphenolic components of soft fruits inhibit α-amylase and α-glucosidase
    • McDougall, G. J.; Shpiro, F.; Dobson, P.; Smith, P.; Blake, A.; Stewart, D. Different polyphenolic components of soft fruits inhibit α-amylase and α-glucosidase J. Agric. Food. Chem. 2005, 53, 2760-2766
    • (2005) J. Agric. Food. Chem. , vol.53 , pp. 2760-2766
    • McDougall, G.J.1    Shpiro, F.2    Dobson, P.3    Smith, P.4    Blake, A.5    Stewart, D.6
  • 46
    • 33144478510 scopus 로고    scopus 로고
    • The inhibitory effects of berry polyphenols on digestive enzymes
    • Mcdougall, G. J.; Stewart, D. The inhibitory effects of berry polyphenols on digestive enzymes Life Sci. 2005, 23, 189-195
    • (2005) Life Sci. , vol.23 , pp. 189-195
    • McDougall, G.J.1    Stewart, D.2
  • 47
    • 79957932584 scopus 로고    scopus 로고
    • Inhibition of key digestive enzymes by cocoa extracts and procyanidins
    • Gu, Y.; Hurst, W. J.; Stuart, D. A.; Lambert, J. D. Inhibition of key digestive enzymes by cocoa extracts and procyanidins J. Agric. Food. Chem. 2011, 59, 5305-5311
    • (2011) J. Agric. Food. Chem. , vol.59 , pp. 5305-5311
    • Gu, Y.1    Hurst, W.J.2    Stuart, D.A.3    Lambert, J.D.4
  • 48
    • 67349232382 scopus 로고    scopus 로고
    • Antioxidant and antidiabetic activity of Dangyuja (Citrus grandis Osbeck) extract treated with Aspergillus saitoi
    • Kim, G. N.; Shin, J. G.; Jang, H. D. Antioxidant and antidiabetic activity of Dangyuja (Citrus grandis Osbeck) extract treated with Aspergillus saitoi Food Chem. 2009, 117, 35-41
    • (2009) Food Chem. , vol.117 , pp. 35-41
    • Kim, G.N.1    Shin, J.G.2    Jang, H.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.