A screen for inducers of p21waf1/cip1 identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties

Neurobiology of Disease

Volumn 49, Issue 1, 2013, Pages 13-21

  Ma, Thong C ^a,b   Langley, Brett ^a,b   Ko, Brian ^a,b   Wei, Na ^c   Gazaryan, Irina G ^a,b   Zareen, Neela ^c   Yamashiro, Darrell J ^c   Willis, Dianna E ^a,b   Ratan, Rajiv R ^a,b  

^a Burke Cornell Medical Research Institute   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Antitumor; Neuronal oxidative stress; Neuroprotection; P21; Prolyl hydroxylase inhibitors

Indexed keywords

CICLOPIROX; CYCLIN DEPENDENT KINASE INHIBITOR 1; DEFEROXAMINE; DIMETHYLOXALYL GLYCINE; GLYCINE; HYDROLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROLYL HYDROLASE INHIBITOR; PROTOCATECHUIC ACID; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MOLECULAR LIBRARY; NEUROPROTECTIVE AGENT; PROLYL HYDROXYLASE INHIBITOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; FOOD AND DRUG ADMINISTRATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DYNAMICS; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; CELL CULTURE; CELL DEATH; CELL LINE; DRUG EFFECTS; HIPPOCAMPUS; KNOCKOUT MOUSE; METABOLISM; MOLECULAR LIBRARY; NERVE CELL; PC12 CELL LINE; PHYSIOLOGY; RAT; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DRUG SCREENING ASSAYS, ANTITUMOR; HIPPOCAMPUS; HUMANS; MICE; MICE, KNOCKOUT; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; PROLYL-HYDROXYLASE INHIBITORS; RATS; SMALL MOLECULE LIBRARIES;

EID: 84866519432     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.08.016     Document Type: Article

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