Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channel

American Journal of Physiology - Cell Physiology

Volumn 299, Issue 1, 2010, Pages

  Li, Tianbo ^a   Yang, Youshan ^a   Canessa, Cecilia M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acid sensing ion channel; Activation by low pH; Channel kinetics; Epithelial sodium channel degenerin; Proton sensor; Proton sensing ion channel

Indexed keywords

ACID SENSING ION CHANNEL; SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SLOW INWARD CURRENT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; KINETICS; LAMPREYS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; OOCYTES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; SODIUM CHANNELS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

CHORDATA; MAMMALIA; PETROMYZONTIDAE; RATTUS; VERTEBRATA;

EID: 77953754779     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00100.2010     Document Type: Article

References (25)

1. Alvarez de la Rosa D, Krueger SR, Kolar A, Shao D, Fitzsimonds RM, Canessa CM. Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system. J Physiol 546: 77-87, 2003.
2. Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, Welsh MJ. Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron 26: 133-141, 2000.
3. Babini E, Paukert M, Geisler HS, Grunder S. Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1). J Biol Chem 277: 41597-41603, 2002.
4. + are coactivators of acid-sensing ion channels. J Biol Chem 276: 35361-35367, 2001.
5. Chen CC, England S, Akopian AN, Wood JN. A sensory neuronspecific, proton-gated ion channel. Proc Natl Acad Sci USA 95: 10240-10245, 1998.
6. Coric T, Zhang P, Todorovic N, Canessa CM. The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1. J Biol Chem 278: 45240-45247, 2003.
7. Coric T, Zheng D, Gerstein M, Canessa CM. Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel. J Physiol 568: 725-735, 2005.
8. Coric T, Passamaneck YJ, Zhang P, Di Gregorio A, Canessa CM. Simple chordates exhibit a proton-independent function of acid-sensing ion channels. FASEB J 22: 1914-1923, 2008.
9. Cushman KA, Marsh-Haffner J, Adelman JP, McCleskey EW. A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3. J Gen Physiol 129: 345-350, 2004.
10. Diochot S, Baron A, Rash LD, Deval E, Escoubas P, Scarzello S, Salinas M, Lazdunski M. A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. EMBO J 23: 1516-1525, 2004.
11. Gonzales EB, Kawate T, Gouaux E. Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature 460: 599-604, 2009.
12. Hille B. Selective permeability: independence. In: Ionic Channels of Excitable Membranes. Sunderland, MA: Sinauer, 1992, p. 337-361.
13. Jasti J, Furukawa H, Gonzales EB, Gouaux E. Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature 449: 316-323, 2007.
14. Kapoor N, Bartoszewski R, Qadri YJ, Bebok Z, Bubien JK, Fuller CM, Benos DJ. Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration. J Biol Chem 284: 24526-24541.
15. Li T, Yang Y, Canessa CM. Interaction of the aromatics Y72/W288 in the interface of the extracellular and transmembrane domains is essential for proton-gating of ASIC. J Biol Chem 284: 4689-4694, 2008.
16. Lingueglia E, De Weille JR, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M. A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem 272: 29778-29783, 1997.
17. Molliver DC, Immke DC, Fierro L, Paré M, Rice FL, McCleskey EW. ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons. Mol Pain 1: 35, 2005.
18. + gating of acid-sensing ion channel 1a. J Biol Chem 283: 572-581, 2008.
19. Salinas M, Rash LD, Baron A, Lambeau G, Escoubas P, Lazdunski M. The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. J Physiol 570: 339-354, 2006.
20. Smith EJ, Zhang X, Cadiou H, McNaughton PA. Proton binding sites involved in the activation of acid-sensing ion channel ASIC2a. Neurosci Lett 426: 12-17, 2007. (Pubitemid 47444495)
21. Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski MA. A proton-gated cation channel involved in acid-sensing. Nature 386: 173-717, 1997.
22. Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH Jr, Welsh MJ. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron 34: 463-477, 2002.
23. +-gated currents in cultured dorsal root ganglion neurons. J Neurophysiol 89: 2459-2465, 2003.
24. Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RP. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell 118: 687-698, 2004.
25. Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Coryell MW, Wunsch AM, Lynch CM, Faraci FM 3rd, Howard MA, Welsh MJ, Wemmie JA. The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell 139: 1012-1021, 2009.