The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal model

Journal of Neuroimmune Pharmacology

Volumn 7, Issue 2, 2012, Pages 412-423

  Lan, Xiqian ^a   Kiyota, Tomomi ^a   Hanamsagar, Richa ^a   Huang, Yunlong ^a   Andrews, Scott ^a   Peng, Hui ^a   Zheng, Jialin C ^a   Swindells, Susan ^b   Carlson, George A ^c   Ikezu, Tsuneya ^a,d  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c MCLAUGHLIN RESEARCH INSTITUTE   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid peptide; Animal model; Antiretroviral therapy; Macrophage; Neuron

Indexed keywords

AMPRENAVIR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; ATAZANAVIR; BETA SECRETASE 1; DARUNAVIR; GAMMA SECRETASE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INDINAVIR; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; RITONAVIR; SAQUINAVIR; TIPRANAVIR; OLIGOPEPTIDE; PYRIDINE DERIVATIVE;

ALLELE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; ANIMAL; DISEASE MODEL; IMMUNOBLOTTING; METABOLISM; MOUSE MUTANT; NERVE CELL; PATHOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV PROTEASE INHIBITORS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LOPINAVIR; MACROPHAGES; MICE; MICE, SCID; MICE, TRANSGENIC; NELFINAVIR; NEURONS; OLIGOPEPTIDES; PYRIDINES; RITONAVIR; SAQUINAVIR;

EID: 84866505826     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-011-9304-5     Document Type: Article

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