Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia

Journal of Leukocyte Biology

Volumn 62, Issue 1, 1997, Pages 100-106

  Persidsky, Yuri ^a   Gendelman, Howard E ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Blood brain barrier; Macrophage

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM INFECTION; DEMENTIA; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MONOCYTE; MOUSE; NEUROLOGICAL COMPLICATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030838827     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.62.1.100     Document Type: Article

References (62)

1. Navia, B. A., Cho, E.-S., Petito, C. K., Price, R. W. (1986) The AIDS dementia complex: II. Neuropathology. Ann. Neurol. 19, 525-535.
2. Berger, J. R., Kaderman, R. (1995) HIV encephalopathy: clinical and diagnostic considerations. In Technical Advances in AIDS Research in the Human Nervous System (E. O. Major and J. A. Levy, eds.), New York: Plenum, 3-25.
3. Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C., Pezeshkpour, G. M., Yungbluth, M., Janotta, F., Aksamit, A., Martin, M. A., Fauci, A. S. (1986) Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233, 1089-1093.
4. Gabuzda, D. H., Ho, D. D., De La Monte, S. M., Hirsh, M. S., Rota, T. R., Sobel, R. A. (1986) Immunohistochemical identification of HTLV-III antigen in the brains of patients with AIDS. Ann. Neurol. 20, 289-295.
5. Wiley, C. A., Schrier, R. D., Nelson, J. A., Lampert, P. W., Oldstone, M. B. A. (1986) Cellular localization of human immunodeficiency virus infection within the brains of acquired immunodeficiency syndrome patients. Proc. Natl. Acad. Sci. USA 83, 7089-7093.
6. Budka, H. (1986) Multinucleated giant cells in brain: a hallmark of the acquired immune deficiency syndrome (AIDS). Acta Neuropathol. 69, 253-258.
7. Petito, C. K., Cho, E.-S., Lemann, W., Navia, B. A., Price, R. W. (1986) Neuropathology of acquired immunodeficiency syndrome (AIDS): an autopsy review. J. Neuropathol. Exp. Neurol. 45, 635-646.
8. Kure, K., Lyman, W. D., Weidenheim, K. M., Dickson, D. W. (1990) Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method. Am. J. Pathol. 136, 1085-1092.
9. Glass, J. D., Fedor, H., Wesselingh, S. L., McArthur, J. C. (1995) Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann. Neurol. 38, 755-762.
10. Nottet, H. S. L. M., Gendelman, H. E. (1995) Unraveling the neuroimmune mechanisms for HIV-1 encephalitis. Immunol. Today 16, 441-448.
11. Brew, B. B., Rosenblum, M., Cronin, K., Price, R. W. (1995) AIDS dementia complex and HIV-1 brain infection: Clinical-virological correlations. Ann. Neurol. 38, 563-570.
12. Wiley, C. A., Achim, C. (1994) Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency disease syndrome. Ann. Neurol. 36, 673-676.
13. Guilian, D., Vaca, K., Noonan, C. (1990) Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 250, 1593-1596.
14. Pulliam, L., Herndier, B. G., Tang, N. M., McGrath, M. S. (1991) HIV-infected-macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J. Clin. Invest. 87, 503-512.
15. Genis, P., Jett, M., Berton, E. W., Gelbard, H. A., Dzenko, K., Keane, R., Resnick, L., Volsky, D. J., Epstein, L. G., Gendelman, H. E. (1992) Cytokines and arachidonic acid metabolites produced during HIV-1 infected macrophage-astroglial interactions: implications for the neuropathogenesis of HIV disease. J. Exp. Med. 176, 1703-1718.
16. Gelbard, H. A., Nottet, H. S. L. M., Swindells, S., Jett, M., Dzenko, K. A., Genis, P., White, R., Wang, L., Choi, Y.-B., Zhang, D., Lipton, S. A., Tourtellotte, W., Epstein, L. G., Gendelman, H. E. (1994) Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J. Virol. 68, 4628-4635.
17. Bukrinsky, M. I., Nottet, H. S. L. M., Schmidtmayerova, H., Dubrovsky, L., Flanagan, C. R., Mullins, M. E., Lipton, S. A., Gendelman, H. E. (1995) Regulation of nitric oxide synthase in HIV-1-infected monocytes: implications for HIV-associated neurological disease. J. Exp. Med. 181, 735-745.
18. Wesselingh, S. L., Power, C., Glass, J. D., Tyor, W. R., McArthur, J. C., Farber, J. M., Griffin, J. W., Griffin, D. E. (1993) Intracerebral cytokine mRNA expression in AIDS. Ann. Neurol. 33, 576-582.
19. Tyor, W. R., Glass, J. D., Griffin, J. W., Becker, P. S., McArthur, J. C., Bezman, L., Griffin, D. E. (1992) Cytokine expression in the brain during the acquired immunodeficiency disease syndrome. Ann. Neurol. 31, 349-360.
20. Griffin, D. E., Wesselingh, S. L., McArthur, J. C. (1994) Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia. Ann. Neurol. 35, 592-599.
21. Shakaskan, E. G., Brew, B. J., Rosenblum, R. M., Thompson, R. M., Price, R. W. (1991) Increased neopterin levels in brain of patients with human immunodeficiency virus 1 infection. J. Neurochem. 59, 1541-1548.
22. Giulian, D., Yu, J., Xia, L., Tom, D., Li, J., Lin, S-N., Schwarz, R., Noonan, C. (1996) Study of receptor-mediated neurotoxins released by HIV-1 infected mononuclear phagocytes found in human brain. J. Neurosci. 16, 3139-3153.
23. Ketzler, S., Weis, S., Haug, H., Budka, H. (1990) Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol. 80, 92-94.
24. Everall, I. P., Luthert, P. J., Lantos, P. L. (1991) Neuronal loss in the frontal cortex in HIV infection. Lancet 337, 1119-1121.
25. Wiley, C. A., Masliah, E., Morey, M., Lemere, C., De Teresa, R., Grafe, M., Hansen, L., Terry, R. (1991) Neocortical damage during HIV infection. Ann. Neurol. 29, 651-657.
26. Masliah, E., Ge, N., Achim, C., Hansen, L. A., Wiley, C. A. (1992) Selective neuronal vulnerability in HIV encephalitis. J. Neuropathol. Exp. Neurol. 51, 585-593.
27. Masliah, E., Ge, N., Achim, C., Wiley, C. A. (1995) Differential vulnerability of calbindin-immunoreactive neurons in HIV encephalitis. J. Neuropathol. Exp. Neurol. 54, 350-357.
28. Petito, C. K., Roberts, B. (1995) Evidence of apoptotic cell death in HIV encephalitis. Am. J. Pathol. 146, 1121-1130.
29. Seilhean, D., Duyckaerts, C., Vazeux, R., Bolgert, F., Brunet, P., Katlama, C., Gentilini, M., Hauw, J.-J. (1993) HIV-1-associated cognitive/motor complex: absence of neuronal loss in the cerebral neocortex. Neurology 43, 1492-1499.
30. Masliah, E. (1996) In vivo modeling of HIV-1 mediated neurodegeneration. Am. J. Pathol. 149, 745-750.
31. Masliah, E., Ge, N., Morey, M., De Teresa, R., Terry, R. D., Wiley, C. A. (1992) Cortical dendritic pathology in human immunodeficiency virus encephalitis. Lab. Invest. 66, 285-291.
32. Nottet, H. S. L. M., Jett, M., Flanagan, C. R., Zhai, Q. H., Persidsky, Y., Rizzino, A., Bernton, E. W., Genis, P., Baldwin, T., Schwartz, J., LaBenz, C. J., Gendelman, H. E. (1995) A regulatory role for astrocytes in HIV-1 encephalitis. An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-α by activated HIV-1-infected monocytes is attenuated by primary human astrocytes. J. Immunol. 154, 3567-3581.
33. Dickson, D. W., Lee, S. S., Mattiace, L. A., Yen, S.-H. C., Brosnan, C. F. (1993) Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7, 75-83.
34. Gendelman, H. E., Lipton, S. A., Tardieu, M., Bukrinsky, M., Nottet, H. S. L. M. (1994) The neuropathogenesis of HIV-1 infection. J. Leukoc. Biol. 56, 389-398.
35. Adamson, C. D., Wildemann, B., Sasaki, M., Glass, J. D., McArthur, J., Christov, V. I., Dawson, T. M., Dawson, V. L. (1996) Immunologic NO synthase: Elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 274, 1917-1921.
36. Gelman, B. B. (1992) Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndrome. Ann. Neurol. 34, 65-70.
37. Lee, S. C., Liu, W., Dickson, D. W., Brosnan, C. F., Berman, J. W. (1993) Cytokine production by human fetal microglia and astrocytes: differential induction by lipopolysaccharide and IL-1β. J. Immunol. 150, 2659-2667.
38. Wilt, S. G., Milward, E., Zhou, J. M., Nagasato, K., Patton, H., Rusten, R., Griffin, D. E., O'Connor, M., Dubois-Dalq, M. (1995) In vitro evidence for dual role of tumor necrosis facror-α in human immunodeficiency virus type 1 encephalopathy. Ann. Neurol. 37, 381-394.
39. Moses, A. V., Bloom, F. E., Pauza, D., Nelson, J. A. (1993) Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc. Natl. Acad. Sci. USA 90, 10474-10478.
40. Peluso, R., Haase, A. T., Stowring, L., Edwards, M., Ventura, P. (1986) A Trojan horse mechanism for the spread of visna in monocytes. Virol. 147, 231-236.
41. Basarga, O., Lavi, E., Bobroski, L., Khalili, K., Pestaner, J. P., Tawadros, R., Pomerantz, R. J. (1996) Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry. AIDS 10, 573-585.
42. Takahashi, K., Wesselingh, S. L., Griffin, D. E., McArthur, J. C., Johnson, R. T., Glass, J. D. (1996) Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunohistochemistry. Ann. Neurol. 39, 705-711.
43. Nottet, H. S. L. M., Persidsky, Y., Sasseville, V. G., Nukuna, A. N., Bock, P., Zhai, Q.-H., Sharer, L. R., McComb, R., Swindells, S., Soderland, C., Gendelman, H. E. (1996) Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. J. Immunol. 156, 1284-1295.
44. Sasseville, V. G., Newman, W. A., Lackner, A. W., Smith, M. O., Lausen, N. C. G., Beall, D., Ringler, D. J. (1992) Elevated vascular cell adhesion molecule-1 in AIDS encephalitis induced by simian immunodeficiency virus. Am. J. Pathol. 141, 1021-1030.
45. 1 integrin interactions. Am. J. Pathol. 144, 27-40.
46. Simmonds, P. (1996) Neurotropism of HIV type? AIDS Res. Hum. Retrovir. 12, 469-470.
47. Peudenier, S., Hery, C., Montagnier, L., Tardieu, M. (1991) Human microglia cells: Characterization in cerebral tissue and in primary culture, and study of their susceptibility to HIV-1 infection. Ann. Neurol. 29, 152-161.
48. Watkins, B. A., Dorn, H. H., Kelly, W. B., Armstrong, R. C., Potts, B. J., Michaels, F., Kufta, C. V., Dubois-Dalq, M. (1990) Specific tropism of HIV-1 for microglial cells in primary human brain cultures. Science 249, 549-553.
49. Strizki, J. M., Albright, A. V., Sheng, H., O'Conner, M., Perrin, L., Gonzales-Scarano, F. (1996) Infection of primary human microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: Evidence of differential tropism. J. Virol. 70, 7654-7662.
50. Lee, S. C., Hatch, W. C., Liu, W., Kress, Y., Lyman, W. D., Dickson, D. W. (1993) Productive infection of human fetal microglia by HIV-1. Am. J. Pathol. 143, 1032-1039.
51. Power, C., McArthur, J. C., Johnson, R. T., Griffin, D. E., Glass, J. D., Perryman, S., Chesebro, B. (1994) Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences. J. Virol. 68, 4643-4649.
52. Korber, B. T. M., Kunstman, K. J., Patterson, B. K., Furtado, M., McEvilly, M. M., Levy, R., Wolinsky, S. M. (1994) Genetic differences between blood-and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: Evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences. J. Virol. 68, 7467-7481.
53. Reddy, T. R., Achim, C. L., Sirko, D. A., Tehranchi, S., Kraus, F. G., Wong-Staal, F., Wiley, C. A., and the HIV Neurobehavioral Research Group. (1996) Sequence analysis of the V3 loop in brain and spleen of patients with HIV encephalitis. AIDS Res. Hum. Retrovir. 12, 477-482.
54. DiStefano, M., Wilt, S., Gray, F., Dubois-Dalq, M., Chiodi, F. (1996) HIV type 1 V3 sequence and the development of dementia during AIDS. AIDS Res. Hum. Retrovir. 12, 471-476.
55. Epstein, L. G., Kuiken, C., Blumberg, B. M., Hartman, S., Sharer, L. R., Clement, M., Goudsmit, J. (1991) HIV-1 V3 domain variation in brain and spleen of children with AIDS: Tissue-specific evolution within host-determined quasispecies. Virol. 180, 583-590.
56. Dubois-Dalq, M., Altmeyer, R., Chiron, M., Wilt, S. (1995) HIV interactions with cells of the nervous system. Curr. Op. Neurobiol. 5, 647-655.
57. Johnson, R. T., Glass, J. D., McArthur, J. C., Chesebro, B. W. (1995) Quantitation of human immunodeficiency virus in brain of demented and nondemented patients with acquired immunodeficiency syndrome. Ann. Neurol. 39, 392-395.
58. Persidsky, Y., Stins, M., Way, D., Witte, M. H., Weinand, M., Kim, K. S., Bock, P., Gendelman, H. E., Fiala, M. (1997) A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J. Immunol. 158, 3499-3510.
59. Persidsky, Y., Nottet, H. S. L. M., Sasseville, V. G., Epstein, L. G., Gendelman, H. E. (1995) The development of animal model systems for HIV-1 encephalitis and associated dementia. J. Neurovirol. 1, 229-243.
60. Hurtrel, M., Ganiere, J. P., Guelfi, J. F., Chakrabarti, L., Maire, M. A., Gray, F., Montagnier, L., Hurtrel, B. (1992) Comparison of early and late feline immunodeficiency virus encephalopathies. AIDS 6, 399-406.
61. Tyor, W. R., Power, C., Gendelman, H. E., Markham, R. B. (1993) A model of human immunodeficiency virus encephalitis in scid mice. Proc. Natl. Acad. Sci. USA 90, 8658-8662.
62. Persidsky, Y., Limoges, J., McComb, R., Bock, P., Baldwin, T., Tyor, W., Patil, A., Nottet, H. S. M. M., Epstein, L., Gelbard, H., Flanagan, E., Reinhard, J., Pirruccello, S. J., Gendelman, H. E. (1996) Human immunodeficiency virus encephalitis in SCID mice. Am. J. Pathol. 149, 1027-1053.