HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice

Journal of Clinical Investigation

Volumn 118, Issue 6, 2008, Pages 2025-2038

  Hisatomi, Toshio ^a,b   Nakazawa, Toru ^a   Noda, Kousuke ^a   Almulki, Lama ^a   Miyahara, Shinsuke ^a   Nakao, Shintaro ^a,b   Ito, Yasuhiro ^a   She, Haicheng ^a   Kohno, Riichiro ^b   Michaud, Norman ^a   Ishibashi, Tatsuro ^b   Hafezi Moghadam, Ali ^a   Badley, Andrew D ^c   Kroemer, Guido ^d,e,f,h   Miller, Joan W ^a,g  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c MAYO CLINIC   (United States)

^d INSERM   (France)

^e INSTITUT GUSTAVE ROUSSY   (France)

^f UNIVERSITÉ PARIS SACLAY   (France)

^g MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^h Institut Gustave Roussy   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; CYTOCHROME C; MONOCYTE CHEMOTACTIC PROTEIN 1; NELFINAVIR; RITONAVIR;

AGED; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; DISEASE MODEL; DRUG MECHANISM; ENZYME ACTIVATION; GENE MUTATION; GENE TRANSLOCATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MOUSE; NEUROPROTECTION; NONHUMAN; OUTER MEMBRANE; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN SECRETION; RETINA CELL; RETINA DETACHMENT;

ANIMALS; APOPTOSIS; CASPASE 9; CHEMOKINE CCL2; CYTOCHROMES C; HIV PROTEASE INHIBITORS; HUMANS; MICE; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MODELS, BIOLOGICAL; MUTATION; NELFINAVIR; NEUROPROTECTIVE AGENTS; RETINA;

EID: 45749103615     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34267     Document Type: Article

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