Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines

Nature Materials

Volumn 3, Issue 3, 2004, Pages 190-196

  Wang, Chun ^a   Ge, Qing ^b   Ting, David ^a,d   Nguyen, David ^a,d   Shen, Hui Rong ^c   Chen, Jianzhu ^b   Eisen, Herman N ^b   Heller, Jorge ^c   Langer, Robert ^a   Putnam, David ^a,e  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c AP Pharma   (United States)

^d HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^e Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CELLS; DEGRADATION; DNA; HYDROLYSIS; IMMUNIZATION; PROTONS; TUMORS; VACCINES;

GENETIC VACCINATION; PLASMIDS;

POLYESTERS;

DNA VACCINE; ESTER; IMMUNOLOGICAL ADJUVANT; MICROSPHERE;

ARTICLE; DENDRITIC CELL; DRUG EFFECT; HUMAN; IMMUNOLOGY; LYMPH NODE; METABOLISM;

ADJUVANTS, IMMUNOLOGIC; DENDRITIC CELLS; ESTERS; HUMANS; LYMPH NODES; MICROSPHERES; VACCINES, DNA;

EID: 1542333716     PISSN: 14761122     EISSN: None     Source Type: Journal    
DOI: 10.1038/nmat1075     Document Type: Article

References (39)

1. Liu, M. A. DNA vaccines: a review. J. Internal Med. 253, 402-410 (2003).
2. Ulmer, J. B. et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745-1749 (1993).
3. Barouch, D. H. et al. Control of viremia and prevention of clinical AIDS in Rhesus monkeys by cytokine-augmented DNA vaccination. Science 290, 486-492 (2000).
4. Wang, R. et al. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282, 476-480 (1998).
5. Cho, H. J. et al. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism. Nature Biotechnol. 18, 509-514 (2000).
6. Dubensky, T. W., Liu, M. A. & Ulmer, J. B. Delivery systems for gene-based vaccines. Mol. Med. 6, 723-732 (2000).
7. Singh, M. & O'Hagan, D. Advances in vaccine adjuvants. Nature Biotechnol. 17, 1075-1081 (1999).
8. Zhao, Z. & Leong, K. W. Controlled delivery of antigens and adjuvants In vaccine development. J. Pharm. Sci. 85, 1261-1270 (1996).
9. Hanes, J., Cleland, J. L. & Langer, R. New advances in microsphere-based singledose vaccines. Adv. Drug Delivery Rev. 28, 97-119 (1997).
10. Luo, D. & Saltzman, W. M. Synthetic DNA delivery systems. Nature Biotechnol. 18, 33-37 (2000).
11. Mathiowitz, E. et al. Biologically erodable microspheres as potential oral drug delivery systems. Nature 386, 410-414 (1997).
12. Tabata, I. & Ikada, Y. Phagocytosis of polymer microspheres by macrophages. Adv. Polym. Sci. 94, 107-141 (1990).
13. Donnelly, J. J., Liu, M. A. & Ulmer, J. B. Antigen presentation and DNA vaccines. Am. J. Respir. Crit. Care 162, S190-S193 (2000).
14. Jones, D., Corris, S., McDonald, S., Clegg, J. & Farrar, G. Poly (DL-lactide-co-glycolide) -encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Vaccine 15, 814-817 (1997).
15. Hedley, M. L., Curley, J. & Urban, R. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses. Nature Med 4, 365-368 (1998).
16. Singh, M., Briones, M., Ott, G. & O'Hagan D. Cationic microparticles: A potent delivery system for DMA vaccines. Proc. Natl. Acad. Sci. USA 97, 811-816 (2000).
17. Walter, E. et al Hydrophilic poly(DL-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells. J. Control. Release 76, 149-168 (2001).
18. Wang, D., Robinson, D. R., Kwon, G. S. & Samuel, J. Encapsulation of plasmid DNA in biodegradable poly(D,L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. J. Control. Release 57, 9-18 (1999).
19. Anderson, J. M. & Shive, M. S. Biodegradation and biocompatibuity of PLA and PLGA microspheres. Adv. Drug Deliv. Rev. 28, 5-24 (1997).
20. Fu, K., Pack, D. W., Klibanov, A. M. & Langer, R. Visual evidence of acidic environment within degradingpoly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm. Res. 17, 100-106 (2000).
21. Kaech, S. M. & Ahmed, R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a development program in naïve cells. Nature Immunol. 2, 415-422 (2001).
22. Princiotta, M. F. et al. Quantitating protein synthesis, degradation, and endogenous antigen processing. Immunity 18, 343-354 (2003).
23. Denis-Mize, K. S. et al. Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells. Gene Ther. 7, 2105-2112 (2000).
24. OHagan, D. et al. Induction of potent immune responses by cationic microparticles with adsorbed human immunodeficiency virus DNA vaccines. J. Virol. 75, 9037-9043 (2001).
25. Lunsford, L., McKeever, U., Eckstein, V. & Hedley, M. L. Tissue distribution and persistence in mice of plasmid DNA encapsulated in a PLGA-based microsphere delivery vehicle. J. Drug Target, 8, 39-50 (2000).
26. McKeever, U. et al. Protective immune responses elicited in mice by immunization with formulations of poly(lactide-co-glycolide) microparticles. Vaccine 20, 1524-1531 (2002).
27. Luo, Y. et al. Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice. Vaccine 21, 1938-1947 (2003).
28. Klencke, B. et al. Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: aphase I study of ZYC101 Chin. Cancer Res. 8, 1028-1037 (2002).
29. Zhu, G., Mallery, S. R. & Schwendamen, S. P. Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide). Nature Biotechnol. 18, 52-57 (2000).
30. Tan Y. & Huang L. Overcoming the inflammatory toxicity of cationic gene vectors. J. Drug Target. 10, 153-60 (2002).
31. Heller, J., Barr, J., Ng, S. Y., Schwach-Abdellaoui, K. & Gurny, R. Poly(ortho esters): synthesis, characterization, properties and uses. Adv. Drug Deliv. Rev. 54, 1015-1039(2002).
32. Schwach-Abbellaoui, K., Heller, J. & Gurny, R. Hydrolysis and erosion studies of autocatalyzed poly(ortho esters) containing lactoyl-lactyl acid aimers. Macromolecules 32, 301-307 (1999).
33. Heller, J. Development of poly(ortho esters): a historical overview. Biomaterials 11, 659-665 (1990).
34. Chen, J., Eisen, H. N. & Kranz, D. M. A model T-cell receptor system for studying memory T-cell development. Microbes Infect. 5, 233-240 (2003).
35. Cho, B. K. et al. A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins. Immunity 12, 263-272 (2000).
36. Behr, J. P. The proton sponge: a trick to enter cells the viruses did not exploit. Chimia 51, 34-36 (1997).
37. Mellman, I. & Steinman, R. M. Dendritic cells: specialized and regulated antigen processing machines. Cell 106, 255-258 (2001).
38. Probst, H. C., Langel, J., Kollias, G. Sevan den Broek, M. Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity 18, 713-720 (2003).
39. Hansen, M. B., Nielsen, S. I. & Berg, K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119, 203-210 (1989).