Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 14, 2009, Pages 5497-5502

  Broaders, Kyle E ^a   Cohen, Joel A ^a   Beaudette, Tristan T ^a   Bachelder, Eric M ^a   Fréchet, Jean M J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acid sensitive; Biocompatible; Encapsulation; Polymer; Vaccine

Indexed keywords

ACETAL; DEXTRAN; IRON OXIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; POLYGLACTIN;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENCAPSULATION; FEMALE; IMMUNOTHERAPY; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGEN PRESENTATION; BIOCOMPATIBLE MATERIALS; DEXTRANS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOTHERAPY;

EID: 65249187336     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0901592106     Document Type: Article

References (32)

1. Reddy ST, Swartz MA, Hubbell JA (2006) Targeting dendritic cells with biomaterials: developing the next generation of vaccines. Trends Immunol 27:573-579.
2. Jiang WL, Gupta RK, Deshpande MC, Schwendeman SP (2005) Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable del ivery of vaccine antigens. Adv Drug Deliver Rev 57:391-410.
3. Fong L, Engleman EG (2000) Dendritic cells in cancer immunotherapy. Annu Rev Immunol 18:245-273.
4. Rock KL,Shen L (2005) Cross-presentation: Underlying mechanisms and role in immune surveillance. Immunol Rev 207:166-183.
5. Howland SW,Wittrup KD (2008) Antigen release kinetics in the phagosome are critical to cross-presentation efficiency. J Immunol 180:1576-1583.
6. Shen LJ, Rock KL (2006) Priming of T cells by exogenous antigen cross-presented on MHC class I molecules. Curr Opin Immunol 18:85-91.
7. Falo LD, Kovacsovics-Bankowski M, Thompson K, Rock KL (1995) Targeting antigen into the phagocytic pathway in-vivo induces protective tumor-immunity. Nat Med 1:649-653.
8. Egilmez NK, et al. (2000) In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: Induction of tumor regression and potent antitumor immunity. Cancer Res 60:3832-3837.
9. Solbrig CM, Saucier-Sawyer JK, Cody V, Saltzman WM, Hanlon DJ (2007) Polymer nanoparticles for immunotherapy from encapsulated tumor-associated antigens and whole tumor cells. Mol Pharm 4:47-57.
10. Murthy N, Thng YX, Schuck S, Xu MC, Frechet JMJ (2002) A novel strategy for encapsulation and release of proteins: Hydrogels and microgels with acid-labile acetal cross-linkers. J Am Chem Soc 124:12398-12399.
11. Murthy N, et al. (2003) A macromolecular delivery vehicle for protein-based vaccines: Acid-degradable protein-loaded microgels. Proc Natl Acad Sci USA 100:4995-5000.
12. Standley SM, et al. (2004) Acid-degradable particles for protein-based vaccines: Enhanced survival rate for tumor-challenged mice using ovalbumin model. Bioconjugate Chem 15:1281-1288.
13. Bachelder EM, Beaudette TT, Broaders KE, Dashe J, Frechet JMJ (2008) Acetal derivitized dextran: An acid-responsive biodegradable material for therapeutic applications. J Am Chem Soc 130:10494-10495.
14. Cai JQ, Davison BE, Ganellin CR, Thaisrivongs S (1995) New 3,4-O-isopropylidene derivatives of D-glucopyranosides and L-glucopyranosides. Tetrahedron Lett 36:6535-6536.
15. Debost JL, Gelas J, Horton D, Mols O (1984) Preparative acetonation of pyranoid, vicinal trans-glycols under kinetic control. Carbohyd Res 125:329-335.
16. Udenfriend S,et al. (1972) Fluorescamine: A reagent for assay of ami no-acids, peptides, proteins, and primary amines in picomole range. Science 178:871-872.
17. Karttunen J, Shastri N (1991) Measurement of ligand-induced activation in single viable t-cells using the lacz reporter gene. Proc Natl Acad Sci USA 88:3972-3976.
18. Karttunen J, Sanderson S, Shastri N (1992) Detection of rare antigen-presenting cells by the Lacz T-cell activation assay suggests an expression cloning strategy for T-cell antigens. Proc Natl Acad Sci USA 89:6020-6024.
19. Fife TH, Jao LK (1965) Substituent effects in acetal hydrolysis. J Org Chem 30(5):1492-1495.
20. Doner LW, Irwin PL (1992) Assay of reducing end-groups in oligosaccharide homologs with 2,2'-bicinchoninate. Anal Biochem 202:50-53.
21. Kreevoy MM, Taft RW (1955) Acid-catalyzed hydrolysis of acetal and chloroacetal. JAm Chem Soc 77:3146-3148.
22. Sanderson S, Frauwirth K, Shastri N (1995) Expression of endogenous peptide major histocompatibility complex class-ll complexes derived from invariant chain-antigen fusion proteins. Proc Natl Acad Sci USA 92:7217-7221.
23. Cui CJ, Stevens VC, Schwendeman SP (2007) Injectable polymer microspheres enhance immunogenicity of a contraceptive peptide vaccine. Vaccine 25:500-509.
24. Kirby DJ, et al. (2008) PLGA microspheres for the del ivery of a novel subunit TB vaccine. J Drug Target 16:282-293.
25. Kovacsovics-Bankowski M, Rock KL (1995) A Phagosome-to-cytosol pathway for exogenous antigens presented on MHC class-l molecules. Science 267:243-246.
26. Shen LJ, Sigal LJ, Boes M, Rock KL (2004) Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity 21:155-165.
27. Yoshida M, Babensee JE (2004) Poly(lactic-co-glycolic acid) enhances maturation of human monocyte-derived dendritic cells. J Biomed Mater Res A 71A:45-54.
28. Yoshida M, Mata J, Babensee JE (2007) Effect of poly(lactic-co-glycolic acid) contact on maturation of murine bone marrow-derived dendritic cells. J Biomed Mater Res A 80A:7-12.
29. Naessens M, Cerdobbel A, Soetaert W, Vandamme EJ (2005) Leuconostoc dextransucrase and dextran: Production, properties and applications. J Chem Technol Biot 80:845-860.
30. Bilati U, Allemann E, Doelker E (2003) Sonication parameters for the preparation of biodegradable nanocapsules of controlled size by the double emulsion method. Pharm Dev Technol 8:1-9.
31. Standley SM, et al. (2007) Incorporation of CpG oligonucleotide ligand into proteinloaded particle vaccines promotes antigen-specific CD8 T-cell immunity. Bioconjugate Chem 18:77-83.
32. Lorenzen A, Kennedy SW (1993) A fluorescence-based protein assay for use with a microplate reader. Anal Biochem 214:346-348.