Druggability of dynamic protein-protein interfaces

Current Pharmaceutical Design

Volumn 18, Issue 30, 2012, Pages 4599-4606

  Ulucan, Ozlem ^a   Eyrisch, Susanne ^a,b   Helms, Volkhard ^a  

^a Center for Bioinformatics   (Germany)

^b Priaxon AG   (Germany)

Author keywords

Binding pocket; EPOS; MDpocket; Molecular dynamics simulation; Protein cavity; Transient pocket

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADRENODOXIN; CASPASE 3; CD47 ANTIGEN; INTERLEUKIN 2; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MDM2;

BINDING SITE; BIOLOGY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG PROTEIN BINDING; FOLLOW UP; HYDROPHOBICITY; MOLECULAR DOCKING; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIMULATION;

BINDING SITES; DRUG DISCOVERY; MOLECULAR DYNAMICS SIMULATION; PROTEIN INTERACTION MAPPING; PROTEIN-SERINE-THREONINE KINASES;

EID: 84866388293     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212802651652     Document Type: Review

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