Molecular basis for Bcl-2 homology 3 domain recognition in the Bcl-2 protein family: Identification of conserved hot spot interactions

Journal of Biological Chemistry

Volumn 284, Issue 26, 2009, Pages 17499-17511

  Moroy, Gautier ^a   Martin, Elyette ^a   Dejaegere, Annick ^a   Stote, Roland H ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-APOPTOTIC PROTEIN; APOPTOSIS; APOPTOTIC; APOPTOTIC PROTEINS; BCL-2 FAMILY; BINDING FREE ENERGY; BIOLOGICAL PROCESS; BOLTZMANN; HETERODIMERS; HOT SPOT; MIMETICS; MOLECULAR BASIS; MOLECULAR DYNAMICS SIMULATIONS; PEPTIDE COMPLEX; PROGRAMMED CELL DEATHS; PROTEIN COMPLEXES; PROTEIN FAMILY; RECOGNITION MECHANISM; RECOGNITION PROCESS; SURFACE AREA;

AMINATION; AMINES; AMINO ACIDS; BINDING ENERGY; CELL DEATH; CELL MEMBRANES; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; ORGANIC ACIDS;

PROTEINS;

AMINO ACID; BH3 PROTEIN; BIM PROTEIN; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL;

AMINO ACID ANALYSIS; ARTICLE; CONTROLLED STUDY; HUMAN; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; COMPUTER SIMULATION; CONSERVED SEQUENCE; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 67650558416     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805542200     Document Type: Article

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