-
1
-
-
34547663626
-
The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects
-
T. Lynch, and A. Price The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects Am. Fam. Physician 76 2007 391 396 (Pubitemid 47219454)
-
(2007)
American Family Physician
, vol.76
, Issue.3
, pp. 391-396
-
-
Lynch, T.1
Price, A.2
-
3
-
-
3042587451
-
A survey of active site access channels in cytochromes P450
-
DOI 10.1016/j.jinorgbio.2004.02.007, PII S0162013404000431
-
R.C. Wade, P.J. Winn, E. Schlichting, and Sudarko A survey of active site access channels in cytochromes P450 J. Inorg. Biochem. 98 2004 1175 1182 (Pubitemid 38833595)
-
(2004)
Journal of Inorganic Biochemistry
, vol.98
, Issue.7
, pp. 1175-1182
-
-
Wade, R.C.1
Winn, P.J.2
Schlichting, I.3
Sudarko4
-
5
-
-
0034634393
-
How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms
-
S.K. Lüdemann, V. Lounnas, and R.C. Wade How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms J. Mol. Biol. 303 2000 797 811
-
(2000)
J. Mol. Biol.
, vol.303
, pp. 797-811
-
-
Lüdemann, S.K.1
Lounnas, V.2
Wade, R.C.3
-
7
-
-
18844458856
-
Ile115Leu mutation in the SRSI region of an insect cytochrome P450 (CYP6B1) compromises substrate turnover via changes in a predicted product release channel
-
DOI 10.1093/protein/gzi023
-
Z.M. Wen, and J. Baudry M.A. Schuler Ile115Leu mutation in the SRS1 region of an insect cytochrome P450 (CYP6B1) compromises substrate turnover via changes in a predicted product release channel Protein Eng. Des. Sel. 18 2005 191 199 (Pubitemid 40695124)
-
(2005)
Protein Engineering, Design and Selection
, vol.18
, Issue.4
, pp. 191-199
-
-
Wen, Z.1
Baudry, J.2
Berenbaum, M.R.3
Schuler, M.A.4
-
9
-
-
0018803839
-
Proton coupling in the cytochrome P-450 spin and redox equilibria
-
S.G. Sligar, and I.C. Gunsalus Proton coupling in the cytochrome P-450 spin and redox equilibria Biochemistry 18 1979 2290 2295
-
(1979)
Biochemistry
, vol.18
, pp. 2290-2295
-
-
Sligar, S.G.1
Gunsalus, I.C.2
-
10
-
-
0034088779
-
The catalytic pathway of cytochrome P450cam at atomic resolution
-
DOI 10.1126/science.287.5458.1615
-
I. Schlichting, and J. Berendzen S.G. Sligar The catalytic pathway of cytochrome p450cam at atomic resolution Science 287 2000 1615 1622 (Pubitemid 30127756)
-
(2000)
Science
, vol.287
, Issue.5458
, pp. 1615-1622
-
-
Schlichting, I.1
Berendzen, J.2
Chu, K.3
Stock, A.M.4
Maves, S.A.5
Benson, D.E.6
Sweet, R.M.7
Ringe, D.8
Petsko, G.A.9
Sligar, S.G.10
-
11
-
-
0032581042
-
Understanding the role of the essential Asp251 in cytochrome P450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect
-
DOI 10.1021/bi980189f
-
M. Vidakovic, and S.G. Sligar T.L. Poulos Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect Biochemistry 37 1998 9211 9219 (Pubitemid 28307674)
-
(1998)
Biochemistry
, vol.37
, Issue.26
, pp. 9211-9219
-
-
Vidakovic, M.1
Sligar, S.G.2
Li, H.3
Poulos, T.L.4
-
12
-
-
0031005499
-
Reduced oxy intermediate observed in D251N cytochrome P450(cam)
-
DOI 10.1021/bi963170q
-
D.E. Benson, K.S. Suslick, and S.G. Sligar Reduced oxy intermediate observed in D251N cytochrome P450cam Biochemistry 36 1997 5104 5107 (Pubitemid 27199724)
-
(1997)
Biochemistry
, vol.36
, Issue.17
, pp. 5104-5107
-
-
Benson, D.E.1
Suslick, K.S.2
Sligar, S.G.3
-
13
-
-
0027375275
-
Molecular recognition in cytochrome P-450: Mechanism for the control of uncoupling reactions
-
DOI 10.1021/bi00094a009
-
P.J. Loida, and S.G. Sligar Molecular recognition in cytochrome P-450: mechanism for the control of uncoupling reactions Biochemistry 32 1993 11530 11538 (Pubitemid 23341430)
-
(1993)
Biochemistry
, vol.32
, Issue.43
, pp. 11530-11538
-
-
Loida, P.J.1
Sligar, S.G.2
-
14
-
-
0032529586
-
Hydration energy landscape of the active site cavity in cytochrome P450cam
-
DOI 10.1002/(SICI)1097-0134(19980815)32:3<381::AID-PROT12>3.0.CO;2- 5
-
V. Helms, and R.C. Wade Hydration energy landscape of the active site cavity in cytochrome P450cam Proteins 32 1998 381 396 (Pubitemid 28360833)
-
(1998)
Proteins: Structure, Function and Genetics
, vol.32
, Issue.3
, pp. 381-396
-
-
Helms, V.1
Wade, R.C.2
-
15
-
-
34249829268
-
Dynamics of water molecules in the active-site cavity of human cytochromes P450
-
DOI 10.1021/jp070390c
-
P. Rydberg, and T.H. Rod U. Ryde Dynamics of water molecules in the active-site cavity of human cytochromes P450 J. Phys. Chem. B 111 2007 5445 5457 (Pubitemid 46854538)
-
(2007)
Journal of Physical Chemistry B
, vol.111
, Issue.19
, pp. 5445-5457
-
-
Rydberg, P.1
Rod, T.H.2
Olsen, L.3
Ryde, U.4
-
16
-
-
0033954256
-
The Protein Data Bank
-
H.M. Berman, and J. Westbrook P.E. Bourne The Protein Data Bank Nucleic Acids Res. 28 2000 235 242 (Pubitemid 30047768)
-
(2000)
Nucleic Acids Research
, vol.28
, Issue.1
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Gilliland, G.4
Bhat, T.N.5
Weissig, H.6
Shindyalov, I.N.7
Bourne, P.E.8
-
17
-
-
0022919721
-
Crystal structure of substrate-free Pseudomonas putida cytochrome P-450
-
DOI 10.1021/bi00366a049
-
T.L. Poulos, B.C. Finzel, and A.J. Howard Crystal structure of substrate-free Pseudomonas putida cytochrome P-450 Biochemistry 25 1986 5314 5322 (Pubitemid 17016546)
-
(1986)
Biochemistry
, vol.25
, Issue.18
, pp. 5314-5322
-
-
Poulos, T.L.1
Finzel, B.C.2
Howard, A.J.3
-
18
-
-
77951247090
-
P450cam visits an open conformation in the absence of substrate
-
Y.T. Lee, and R.F. Wilson D.B. Goodin P450cam visits an open conformation in the absence of substrate Biochemistry 49 2010 3412 3419
-
(2010)
Biochemistry
, vol.49
, pp. 3412-3419
-
-
Lee, Y.T.1
Wilson, R.F.2
Goodin, D.B.3
-
19
-
-
0023645035
-
High-resolution crystal structure of cytochrome P450cam
-
T.L. Poulos, B.C. Finzel, and A.J. Howard High-resolution crystal structure of cytochrome P450cam J. Mol. Biol. 195 1987 687 700
-
(1987)
J. Mol. Biol.
, vol.195
, pp. 687-700
-
-
Poulos, T.L.1
Finzel, B.C.2
Howard, A.J.3
-
20
-
-
84855757480
-
-
Chemical Computing Group version 2010. Chemical Computing Group, Montréal, Canada
-
Chemical Computing Group. 2010. Molecular Operating Environment, version 2010. Chemical Computing Group, Montréal, Canada.
-
(2010)
Molecular Operating Environment
-
-
-
22
-
-
34547931817
-
cam in quantum mechanical/molecular mechanical studies
-
DOI 10.1002/jcc.20701
-
J.J. Zheng, A. Altun, and W. Thiel Common system setup for the entire catalytic cycle of cytochrome P450(cam) in quantum mechanical/molecular mechanical studies J. Comput. Chem. 28 2007 2147 2158 (Pubitemid 47265253)
-
(2007)
Journal of Computational Chemistry
, vol.28
, Issue.13
, pp. 2147-2158
-
-
Zheng, J.1
Altun, A.2
Thiel, W.3
-
23
-
-
27344436659
-
Scalable molecular dynamics with NAMD
-
DOI 10.1002/jcc.20289
-
J.C. Phillips, and R. Braun K. Schulten Scalable molecular dynamics with NAMD J. Comput. Chem. 26 2005 1781 1802 (Pubitemid 43078511)
-
(2005)
Journal of Computational Chemistry
, vol.26
, Issue.16
, pp. 1781-1802
-
-
Phillips, J.C.1
Braun, R.2
Wang, W.3
Gumbart, J.4
Tajkhorshid, E.5
Villa, E.6
Chipot, C.7
Skeel, R.D.8
Kale, L.9
Schulten, K.10
-
24
-
-
0000217485
-
Self-consistent parameterization of biomolecules for molecular modeling and condensed phase simulations
-
A.D. Mackerell, and D. Bashford M. Karplus Self-consistent parameterization of biomolecules for molecular modeling and condensed phase simulations FASEB J. 6 1992 A143
-
(1992)
FASEB J.
, vol.6
, pp. 143
-
-
MacKerell, A.D.1
Bashford, D.2
Karplus, M.3
-
25
-
-
0041784950
-
All-atom empirical potential for molecular modeling and dynamics studies of proteins
-
A.D. MacKerell, and D. Bashford M. Karplus All-atom empirical potential for molecular modeling and dynamics studies of proteins J. Phys. Chem. B 102 1998 3586 3616 (Pubitemid 128576688)
-
(1998)
Journal of Physical Chemistry B
, vol.102
, Issue.18
, pp. 3586-3616
-
-
MacKerell Jr., A.D.1
Bashford, D.2
Bellott, M.3
Dunbrack Jr., R.L.4
Evanseck, J.D.5
Field, M.J.6
Fischer, S.7
Gao, J.8
Guo, H.9
Ha, S.10
Joseph-McCarthy, D.11
Kuchnir, L.12
Kuczera, K.13
Lau, F.T.K.14
Mattos, C.15
Michnick, S.16
Ngo, T.17
Nguyen, D.T.18
Prodhom, B.19
Reiher III, W.E.20
Roux, B.21
Schlenkrich, M.22
Smith, J.C.23
Stote, R.24
Straub, J.25
Watanabe, M.26
Wiorkiewicz-Kuczera, J.27
Yin, D.28
Karplus, M.29
more..
-
26
-
-
0004016501
-
Comparison of simple potential functions for simulating liquid water
-
W.L. Jorgensen, and J. Chandrasekhar M.L. Klein Comparison of simple potential functions for simulating liquid water J. Chem. Phys. 79 1983 926 935
-
(1983)
J. Chem. Phys.
, vol.79
, pp. 926-935
-
-
Jorgensen, W.L.1
Chandrasekhar, J.2
Klein, M.L.3
-
27
-
-
0037055032
-
The elusive oxidant species of cytochrome P450 enzymes: Characterization by combined quantum mechanical/molecular mechanical (QM/MM) calculations
-
DOI 10.1021/ja026279w
-
J.C. Schöneboom, and H. Lin S. Shaik The elusive oxidant species of cytochrome P450 enzymes: characterization by combined quantum mechanical/molecular mechanical (QM/MM) calculations J. Am. Chem. Soc. 124 2002 8142 8151 (Pubitemid 34755533)
-
(2002)
Journal of the American Chemical Society
, vol.124
, Issue.27
, pp. 8142-8151
-
-
Schoneboom, J.C.1
Lin, H.2
Reuter, N.3
Thiel, W.4
Cohen, S.5
Ogliaro, F.6
Shaik, S.7
-
28
-
-
33646940952
-
Numerical integration of the cartesian equations of motion of a system with constraints: Molecular dynamics of n-alkanes
-
J.-P. Ryckaert, G. Ciccotti, and H.J.C. Berendsen Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes J. Comput. Phys. 23 1977 327 341
-
(1977)
J. Comput. Phys.
, vol.23
, pp. 327-341
-
-
Ryckaert, J.-P.1
Ciccotti, G.2
Berendsen, H.J.C.3
-
29
-
-
33847142225
-
CAVER: A new tool to explore routes from protein clefts, pockets and cavities
-
M. Petrek, and M. Otyepka J. Damborský CAVER: a new tool to explore routes from protein clefts, pockets and cavities BMC Bioinformatics 7 2006 316
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 316
-
-
Petrek, M.1
Otyepka, M.2
Damborský, J.3
-
30
-
-
33846406882
-
A comparison of methods to compute the potential of mean force
-
D. Trzesniak, A.P.E. Kunz, and W.F. van Gunsteren A comparison of methods to compute the potential of mean force ChemPhysChem 8 2007 162 169
-
(2007)
ChemPhysChem
, vol.8
, pp. 162-169
-
-
Trzesniak, D.1
Kunz, A.P.E.2
Van Gunsteren, W.F.3
-
31
-
-
41049115037
-
Computation of binding free energy with molecular dynamics and grand canonical Monte Carlo simulations
-
Y.Q. Deng, and B. Roux Computation of binding free energy with molecular dynamics and grand canonical Monte Carlo simulations J. Chem. Phys. 128 2008 115103
-
(2008)
J. Chem. Phys.
, vol.128
, pp. 115103
-
-
Deng, Y.Q.1
Roux, B.2
-
32
-
-
0025092326
-
Effect of the tyrosine 96 hydrogen bond on the inactivation of cytochrome P-450(cam) induced by hydrostatic pressure
-
C. Di Primo, and G. Hui Bon Hoa S. Sligar Effect of the tyrosine 96 hydrogen bond on the inactivation of cytochrome P-450cam induced by hydrostatic pressure Eur. J. Biochem. 193 1990 383 386 (Pubitemid 20344911)
-
(1990)
European Journal of Biochemistry
, vol.193
, Issue.2
, pp. 383-386
-
-
Di Primo, C.1
Hui Bon Hoa, G.2
Douzou, P.3
Sligar, S.4
-
34
-
-
0034693705
-
Interactions between redox partners in various cytochrome P450 systems: Functional and structural aspects
-
D.F.V. Lewis, and P. Hlavica Interactions between redox partners in various cytochrome P450 systems: functional and structural aspects Biochim. Biophys. Acta 1460 2000 353 374
-
(2000)
Biochim. Biophys. Acta
, vol.1460
, pp. 353-374
-
-
Lewis, D.F.V.1
Hlavica, P.2
|