Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins

British Journal of Pharmacology

Volumn 135, Issue 7, 2002, Pages 1685-1694

  Hooiveld, Guido J E J ^a,b,d   Heegsma, Janette ^a,b   Van Montfoort, Jessica E ^b,c   Jansen, Peter L M ^a   Meijer, Dirk K F ^b   Müller, Michael ^a,d  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

ABC transporter; ATP dependent drug transport; Baculovirus expression system; Drug secretion; Enzyme kinetics; Human MDR1; P glycoprotein; Rat Mdr1b; Rat Mdr2; Stereoisomers

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1B; MULTIDRUG RESISTANCE PROTEIN 2; QUINIDINE; QUININE; UNCLASSIFIED DRUG; VALSPODAR; VINCRISTINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG CLEARANCE; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; DRUG UPTAKE; HUMAN; METHYLATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUATERNARY; RAT; STEREOCHEMISTRY; STEREOISOMERISM;

ADENOSINE TRIPHOSPHATE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CATIONS; DRUG DESIGN; HUMANS; IMMUNOBLOTTING; INSECTS; MUSCARINIC ANTAGONISTS; P-GLYCOPROTEIN; P-GLYCOPROTEINS; QUINIDINE; QUININE; RATS; RECOMBINANT PROTEINS;

EID: 0036965593     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704620     Document Type: Article

References (44)

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