Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 2, 2011, Pages 615-622

  Baliraine, Frederick N ^a   Nsobya, Samuel L ^b   Achan, Jane ^b   Tibenderana, James K ^c   Talisuna, Ambrose O ^d   Greenhouse, Bryan ^a   Rosenthal, Philip J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAKERERE UNIVERSITY   (Uganda)

^c MALARIA CONSORTIUM   (United Kingdom)

^d Medicines for Malaria Venture   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; CARRIER PROTEIN; MICROSATELLITE DNA; MULTIDRUG RESISTANCE PROTEIN 1; PFCRT PROTEIN; QUININE; SODIUM PROTON EXCHANGE PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; CHILD; CLINICAL EFFECTIVENESS; CODON; DRUG RESISTANCE; DRUG RESPONSE; DRUG SENSITIVITY; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFANT; MAJOR CLINICAL STUDY; MALARIA; NONHUMAN; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; UGANDA;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE; HUMANS; INFANT; MALARIA, FALCIPARUM; MEMBRANE TRANSPORT PROTEINS; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; PROTOZOAN PROTEINS; QUININE; SEQUENCE ANALYSIS, DNA; SODIUM-HYDROGEN ANTIPORTER; TREATMENT OUTCOME; UGANDA;

EID: 78751692553     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00954-10     Document Type: Article

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