-
1
-
-
70350780570
-
Nuclear CDKs drive Smad transcrip-tional activation and turnover in BMP and TGF-β pathways
-
Alarcon, C., Zaromytidou, A. I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., Sapkota, G., Pan, D., and Massagué, J. (2009). Nuclear CDKs drive Smad transcrip-tional activation and turnover in BMP and TGF-β pathways. Cell 139, 757-769.
-
(2009)
Cell
, vol.139
, pp. 757-769
-
-
Alarcon, C.1
Zaromytidou, A.I.2
Xi, Q.3
Gao, S.4
Yu, J.5
Fujisawa, S.6
Barlas, A.7
Miller, A.N.8
Manova-Todorova, K.9
Macias, M.J.10
Sapkota, G.11
Pan, D.12
Massagué, J.13
-
2
-
-
0034809804
-
Hepatic stellate cells as a target for the treatment of liver fibrosis
-
Bataller, R., and Brenner, D. A. (2001). Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin. Liver Dis. 21, 437-451.
-
(2001)
Semin. Liver Dis.
, vol.21
, pp. 437-451
-
-
Bataller, R.1
Brenner, D.A.2
-
3
-
-
73449140168
-
Molecular patho-genesis of liver fibrosis
-
Brenner, D. A. (2009). Molecular patho-genesis of liver fibrosis. Trans. Am. Clin. Climatol. Assoc. 120, 361-368.
-
(2009)
Trans. Am. Clin. Climatol. Assoc.
, vol.120
, pp. 361-368
-
-
Brenner, D.A.1
-
4
-
-
0033605559
-
MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
-
Brown, J. D., DiChiara, M. R., Anderson, K. R., Gimbrone, M. A. Jr., and Topper, J. N. (1999). MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J. Biol. Chem. 274, 8797-8805.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8797-8805
-
-
Brown, J.D.1
DiChiara, M.R.2
Anderson, K.R.3
Gimbrone Jr., M.A.4
Topper, J.N.5
-
5
-
-
12344320716
-
Thrombospondin-1 is a major activator of TGF-beta1 in vivo
-
Crawford, S. E., Stellmach, V., Murphy-Ullrich, J. E., Ribeiro, S. M., Lawler, J., Hynes, R. O., Bovin, G. P., and Bouck, N. (1998). Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell 93, 1159-1170.
-
(1998)
Cell
, vol.93
, pp. 1159-1170
-
-
Crawford, S.E.1
Stellmach, V.2
Murphy-Ullrich, J.E.3
Ribeiro, S.M.4
Lawler, J.5
Hynes, R.O.6
Bovin, G.P.7
Bouck, N.8
-
6
-
-
0031596719
-
Differential expression of transforming growth factor-β and its receptors in hepatocytes and nonparenchymal cells of rat liver after CCl4 administration
-
Date, M., Matsuzaki, K., Matsushita, M., Sakitani, K., Shibano, K., Okajima, A., Yamamoto, C., Ogata, N., Okumura, T., Seki, T., Kubota, Y., Kan, M., McKeehan, W. L., and Inoue, K. (1998). Differential expression of transforming growth factor-β and its receptors in hepatocytes and nonparenchymal cells of rat liver after CCl4 administration. J. Hepatol. 28, 572-581.
-
(1998)
J. Hepatol.
, vol.28
, pp. 572-581
-
-
Date, M.1
Matsuzaki, K.2
Matsushita, M.3
Sakitani, K.4
Shibano, K.5
Okajima, A.6
Yamamoto, C.7
Ogata, N.8
Okumura, T.9
Seki, T.10
Kubota, Y.11
Kan, M.12
McKeehan, W.L.13
Inoue, K.14
-
7
-
-
0034023752
-
Modulation of transforming growth factor β function in hepatocytes and hepatic stellate cells in rat liver injury
-
Date, M., Matsuzaki, K., Matsushita, M., Tahashi, Y., Furukawa, F., and Inoue, K. (2000). Modulation of transforming growth factor β function in hepatocytes and hepatic stellate cells in rat liver injury. Gut 46, 719-724.
-
(2000)
Gut
, vol.46
, pp. 719-724
-
-
Date, M.1
Matsuzaki, K.2
Matsushita, M.3
Tahashi, Y.4
Furukawa, F.5
Inoue, K.6
-
8
-
-
2642605344
-
Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases
-
de Caestecker, M. P., Parks, W. T., Frank, C. J., Castagnino, P., Bottaro, D. P., Roberts, A. B., and Lechleider, R. J. (1998). Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev. 12, 1587-1592.
-
(1998)
Genes Dev
, vol.12
, pp. 1587-1592
-
-
de Caestecker, M.P.1
Parks, W.T.2
Frank, C.J.3
Castagnino, P.4
Bottaro, D.P.5
Roberts, A.B.6
Lechleider, R.J.7
-
9
-
-
34548329486
-
Differentiation plasticity regulated by TGF-β family proteins in development and disease
-
Derynck, R., and Akhurst, R. J. (2007). Differentiation plasticity regulated by TGF-β family proteins in development and disease. Nat. Cell Biol. 9, 1000-1004.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1000-1004
-
-
Derynck, R.1
Akhurst, R.J.2
-
11
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-β family signalling
-
Derynck, R., and Zhang, Y. E. (2003). Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425, 577-584.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
12
-
-
0034094837
-
Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts
-
Dooley, S., Delvoux, B., Lahme, B., Mangasser-Stephan, K., and Gressner, A. M. (2000). Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology 31, 1094-1106.
-
(2000)
Hepatology
, vol.31
, pp. 1094-1106
-
-
Dooley, S.1
Delvoux, B.2
Lahme, B.3
Mangasser-Stephan, K.4
Gressner, A.M.5
-
13
-
-
0037716406
-
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats
-
Dooley, S., Hamzavi, J., Breitkopf, K., Wiercinska, E., Said, H. M., Lorenzen, J., Ten Dijke, P., and Gressner, A. M. (2003). Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology 125, 178-191.
-
(2003)
Gastroenterology
, vol.125
, pp. 178-191
-
-
Dooley, S.1
Hamzavi, J.2
Breitkopf, K.3
Wiercinska, E.4
Said, H.M.5
Lorenzen, J.6
Ten Dijke, P.7
Gressner, A.M.8
-
14
-
-
84859445823
-
TGF-β in progression of liver disease
-
Dooley, S., and Ten Dijke, P. (2012). TGF-β in progression of liver disease. Cell Tissue Res. 347, 245-256.
-
(2012)
Cell Tissue Res
, vol.347
, pp. 245-256
-
-
Dooley, S.1
Ten Dijke, P.2
-
15
-
-
0033601179
-
Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription
-
Engel, M. E., McDonnell, M. A., Law, B. K., and Moses, H. L. (1999). Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J. Biol. Chem. 274, 37413-37420.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37413-37420
-
-
Engel, M.E.1
McDonnell, M.A.2
Law, B.K.3
Moses, H.L.4
-
16
-
-
77955472579
-
Evolving challenges in hepatic fibrosis
-
Friedman, S. L. (2010). Evolving challenges in hepatic fibrosis. Nat. Rev. Gastroenterol. Hepatol. 7, 425-436.
-
(2010)
Nat. Rev. Gastroenterol. Hepatol.
, vol.7
, pp. 425-436
-
-
Friedman, S.L.1
-
17
-
-
0141866937
-
p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts
-
Furukawa, F., Matsuzaki, K., Mori, S., Tahashi, Y., Yoshida, K., Sugano, Y., Yamagata, H., Matsushita, M., Seki, T., Inagaki, Y., Nishizawa, M., Fujisawa, J., and Inoue, K. (2003). p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Hepatology 38, 879-889.
-
(2003)
Hepatology
, vol.38
, pp. 879-889
-
-
Furukawa, F.1
Matsuzaki, K.2
Mori, S.3
Tahashi, Y.4
Yoshida, K.5
Sugano, Y.6
Yamagata, H.7
Matsushita, M.8
Seki, T.9
Inagaki, Y.10
Nishizawa, M.11
Fujisawa, J.12
Inoue, K.13
-
18
-
-
58149216052
-
Signaling cross-talk between TGF-β/BMP and other pathways
-
Guo, X., and Wang, X. F. (2009). Signaling cross-talk between TGF-β/BMP and other pathways. Cell Res. 19, 71-88.
-
(2009)
Cell Res
, vol.19
, pp. 71-88
-
-
Guo, X.1
Wang, X.F.2
-
19
-
-
0031587828
-
The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
-
Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y.-Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A. Jr., Wrana, J. L., and Falb, D. (1997). The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89, 1165-1173.
-
(1997)
Cell
, vol.89
, pp. 1165-1173
-
-
Hayashi, H.1
Abdollah, S.2
Qiu, Y.3
Cai, J.4
Xu, Y.-Y.5
Grinnell, B.W.6
Richardson, M.A.7
Topper, J.N.8
Gimbrone Jr., M.A.9
Wrana, J.L.10
Falb, D.11
-
20
-
-
84859947735
-
Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy via TGF-β1 activation in mice
-
doi:10.1002/hep.24800 [Epub ahead of print]
-
Hayashi, H., Sakai, K., Baba, H., and Sakai, T. (2011). Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatec-tomy via TGF-β1 activation in mice. Hepatology doi:10.1002/hep.24800 [Epub ahead of print].
-
(2011)
Hepatology
-
-
Hayashi, H.1
Sakai, K.2
Baba, H.3
Sakai, T.4
-
21
-
-
0042704734
-
Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-β-dependent responses in human mesangial cells
-
Hayashida, T., Decaestecker, M., and Schnaper, H. W. (2003). Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-β-dependent responses in human mesangial cells. FASEB J. 17, 1576-1578.
-
(2003)
FASEB J
, vol.17
, pp. 1576-1578
-
-
Hayashida, T.1
Decaestecker, M.2
Schnaper, H.W.3
-
22
-
-
0031438047
-
TGF-β signalling from cell membrane to nucleus through SMAD proteins
-
Heldin, C. H., Miyazono, K., and Ten Dijke, P. (1997). TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature. 390, 465-471.
-
(1997)
Nature
, vol.390
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
Ten Dijke, P.3
-
23
-
-
0032875460
-
Mechanism of action and in vivo role of platelet-derived growth factor
-
Heldin, C. H., and Westermark, B. (1999). Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79, 1283-1316.
-
(1999)
Physiol. Rev.
, vol.79
, pp. 1283-1316
-
-
Heldin, C.H.1
Westermark, B.2
-
24
-
-
25144432973
-
The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFβ signal transduction
-
Ho, J., Cocolakis, E., Dumas, V. M., Posner, B. I., Laporte, S. A., and Lebrun, J. J. (2005). The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFβ signal transduction. EMBO J. 24, 3247-3258.
-
(2005)
EMBO J
, vol.24
, pp. 3247-3258
-
-
Ho, J.1
Cocolakis, E.2
Dumas, V.M.3
Posner, B.I.4
Laporte, S.A.5
Lebrun, J.J.6
-
25
-
-
67349254116
-
Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats
-
Hu, P. F., Chen, H., Zhong, W., Lin, Y., Zhang, X., Chen, Y. X., and Xie, W. F. (2009). Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats. J. Hepatol. 51, 102-113.
-
(2009)
J. Hepatol.
, vol.51
, pp. 102-113
-
-
Hu, P.F.1
Chen, H.2
Zhong, W.3
Lin, Y.4
Zhang, X.5
Chen, Y.X.6
Xie, W.F.7
-
26
-
-
33846951514
-
Emerging insights into transforming growth factor β Smad signal in hepatic fibrogenesis
-
Inagaki, Y., and Okazaki, I. (2007). Emerging insights into transforming growth factor β Smad signal in hepatic fibrogenesis. Gut 56, 284-292.
-
(2007)
Gut
, vol.56
, pp. 284-292
-
-
Inagaki, Y.1
Okazaki, I.2
-
27
-
-
12544257249
-
Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-β-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo
-
Kamaraju, A. K., and Roberts, A. B. (2005). Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-β-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo. J. Biol. Chem. 280, 1024-1036.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 1024-1036
-
-
Kamaraju, A.K.1
Roberts, A.B.2
-
28
-
-
79951626443
-
Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis
-
Kawamata, S., Matsuzaki, K., Murata, M., Seki, T., Matsuoka, K., Iwao, Y., Hibi, T., and Okazaki, K. (2011). Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis. Inflamm. Bowel Dis. 17, 683-695.
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 683-695
-
-
Kawamata, S.1
Matsuzaki, K.2
Murata, M.3
Seki, T.4
Matsuoka, K.5
Iwao, Y.6
Hibi, T.7
Okazaki, K.8
-
29
-
-
38949128021
-
Mechanisms of fibrogenesis
-
(Maywood)
-
Kisseleva, T., and Brenner, D. A. (2008). Mechanisms of fibrogenesis. Exp. Biol. Med. (Maywood). 233, 109-122.
-
(2008)
Exp. Biol. Med.
, vol.233
, pp. 109-122
-
-
Kisseleva, T.1
Brenner, D.A.2
-
30
-
-
0033106484
-
A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras
-
Kretzschmar, M., Doody, J., Timokhina, I., and Massague, J. (1999). A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev. 13, 804-816.
-
(1999)
Genes Dev
, vol.13
, pp. 804-816
-
-
Kretzschmar, M.1
Doody, J.2
Timokhina, I.3
Massague, J.4
-
31
-
-
30944436222
-
Smad3 phosphoryla-tion by cyclin-dependent kinases
-
Liu, F. (2006). Smad3 phosphoryla-tion by cyclin-dependent kinases. Cytokine Growth Factor Rev. 17, 9-17.
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 9-17
-
-
Liu, F.1
-
32
-
-
76249090037
-
Pin1 promotes transforming growth factor-β-induced migration and invasion
-
Matsuura, I., Chiang, K. N., Lai, C. Y., He, D., Wang, G., Ramkumar, R., Uchida, T., Ryo, A., Lu, K., and Liu, F. (2010). Pin1 promotes transforming growth factor-β-induced migration and invasion. J. Biol. Chem. 285, 1754-1764.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 1754-1764
-
-
Matsuura, I.1
Chiang, K.N.2
Lai, C.Y.3
He, D.4
Wang, G.5
Ramkumar, R.6
Uchida, T.7
Ryo, A.8
Lu, K.9
Liu, F.10
-
33
-
-
3142546336
-
Cyclin-dependent kinases regulate the antiproliferative function of Smads
-
Matsuura, I., Denissova, N. G., Wang, G., He, D., Long, J., and Liu, F. (2004). Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430, 226-231.
-
(2004)
Nature
, vol.430
, pp. 226-231
-
-
Matsuura, I.1
Denissova, N.G.2
Wang, G.3
He, D.4
Long, J.5
Liu, F.6
-
34
-
-
33645576366
-
Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis
-
Matsuzaki, K. (2006). Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis. Histol. Histopathol. 21, 645-662.
-
(2006)
Histol. Histopathol.
, vol.21
, pp. 645-662
-
-
Matsuzaki, K.1
-
35
-
-
63849191286
-
Modulation of TGF-β signaling during progression of chronic liver diseases
-
Matsuzaki, K. (2009). Modulation of TGF-β signaling during progression of chronic liver diseases. Front. Biosci. 14, 2923-2934.
-
(2009)
Front. Biosci.
, vol.14
, pp. 2923-2934
-
-
Matsuzaki, K.1
-
36
-
-
80755187843
-
Smad phosphoisoform signaling specificity: the right place at the right time
-
Matsuzaki, K. (2011). Smad phosphoisoform signaling specificity: the right place at the right time. Carcinogenesis 32, 1578-1588.
-
(2011)
Carcinogenesis
, vol.32
, pp. 1578-1588
-
-
Matsuzaki, K.1
-
37
-
-
84859441977
-
Smad phospho-isoform signals in acute and chronic liver injury: similarities and differences between epithelial and mes-enchymal cells
-
Matsuzaki, K. (2012). Smad phospho-isoform signals in acute and chronic liver injury: similarities and differences between epithelial and mes-enchymal cells. Cell Tissue Res. 347, 225-243.
-
(2012)
Cell Tissue Res
, vol.347
, pp. 225-243
-
-
Matsuzaki, K.1
-
38
-
-
67650466368
-
Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-β signal in later stages of human colorectal cancer
-
Matsuzaki, K., Kitano, C., Murata, M., Sekimoto, G., Yoshida, K., Uemura, Y., Seki, T., Taketani, S., Fujisawa, J., and Okazaki, K. (2009). Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-β signal in later stages of human colorectal cancer. Cancer Res. 69, 5321-5330.
-
(2009)
Cancer Res
, vol.69
, pp. 5321-5330
-
-
Matsuzaki, K.1
Kitano, C.2
Murata, M.3
Sekimoto, G.4
Yoshida, K.5
Uemura, Y.6
Seki, T.7
Taketani, S.8
Fujisawa, J.9
Okazaki, K.10
-
39
-
-
34347232205
-
Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor βsignaling,promoting cirrhosis and hepatocellular carcinoma
-
Matsuzaki, K., Murata, M., Yoshida, K., Sekimoto, G., Uemura, Y., Sakaida, N., Kaibori, M., Kamiyama, Y., Nishizawa, M., Fujisawa, J., Okazaki, K., and Seki, T. (2007). Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor βsignaling,promoting cirrhosis and hepatocellular carcinoma. Hepatology 46, 48-57.
-
(2007)
Hepatology
, vol.46
, pp. 48-57
-
-
Matsuzaki, K.1
Murata, M.2
Yoshida, K.3
Sekimoto, G.4
Uemura, Y.5
Sakaida, N.6
Kaibori, M.7
Kamiyama, Y.8
Nishizawa, M.9
Fujisawa, J.10
Okazaki, K.11
Seki, T.12
-
40
-
-
6044261233
-
TGF-β and HGF transmit the signals through JNK-dependent Smad2/3 phosphoryla-tion at the linker regions
-
Mori, S., Matsuzaki, K., Yoshida, K., Furukawa, F., Tahashi, Y., Yamagata, H., Sekimoto, G., Seki, T., Matsui, H., Nishizawa, M., Fujisawa, J., and Okazaki,K. (2004). TGF-β and HGF transmit the signals through JNK-dependent Smad2/3 phosphoryla-tion at the linker regions. Oncogene 23, 7416-7429.
-
(2004)
Oncogene
, vol.23
, pp. 7416-7429
-
-
Mori, S.1
Matsuzaki, K.2
Yoshida, K.3
Furukawa, F.4
Tahashi, Y.5
Yamagata, H.6
Sekimoto, G.7
Seki, T.8
Matsui, H.9
Nishizawa, M.10
Fujisawa, J.11
Okazaki, K.12
-
41
-
-
79955444776
-
A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling
-
Moriya, K., Bae, E., Honda, K., Sakai, K., Sakaguchi, T., Tsujimoto, I., Kamisoyama, H., Keene, D. R., Sasaki, T., and Sakai, T. (2011). A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling. Gastroenterology 140, 1653-1663.
-
(2011)
Gastroenterology
, vol.140
, pp. 1653-1663
-
-
Moriya, K.1
Bae, E.2
Honda, K.3
Sakai, K.4
Sakaguchi, T.5
Tsujimoto, I.6
Kamisoyama, H.7
Keene, D.R.8
Sasaki, T.9
Sakai, T.10
-
42
-
-
0025343641
-
Physiology of thrombospondin
-
Mosher, D. F. (1990). Physiology of thrombospondin. Annu. Rev. Med. 41, 85-97.
-
(1990)
Annu. Rev. Med.
, vol.41
, pp. 85-97
-
-
Mosher, D.F.1
-
43
-
-
65449159717
-
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-β signaling from tumor suppression to onco-genesis in early chronic hepatitis B
-
Murata, M., Matsuzaki, K., Yoshida, K., Sekimoto, G., Tahashi, Y., Mori, S., Uemura, Y., Sakaida, N., Fujisawa, J., Seki, T., Kobayashi, K., Yokote, K., Koike, K., and Okazaki, K. (2009). Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-β signaling from tumor suppression to onco-genesis in early chronic hepatitis B. Hepatology 49, 1203-1217.
-
(2009)
Hepatology
, vol.49
, pp. 1203-1217
-
-
Murata, M.1
Matsuzaki, K.2
Yoshida, K.3
Sekimoto, G.4
Tahashi, Y.5
Mori, S.6
Uemura, Y.7
Sakaida, N.8
Fujisawa, J.9
Seki, T.10
Kobayashi, K.11
Yokote, K.12
Koike, K.13
Okazaki, K.14
-
44
-
-
0033584854
-
Regulation of Smad7 promoter by direct association with Smad3 and Smad4
-
Nagarajan, R. P., Zhang, J., Li, W., and Chen, Y. (1999). Regulation of Smad7 promoter by direct association with Smad3 and Smad4. J. Biol. Chem. 274, 33412-33418.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33412-33418
-
-
Nagarajan, R.P.1
Zhang, J.2
Li, W.3
Chen, Y.4
-
45
-
-
67650377329
-
Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor-suppression in rat hepa-tocellular carcinoma
-
Nagata, H., Hatano, E., Tada, M., Murata,M., Kitamura, K., Asechi, H., Narita, M., Yanagida, A., Tamaki, N., Yagi, S., Ikai, I., Matsuzaki, K., and Uemoto, S. (2009). Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepa-tocellular carcinoma. Hepatology 49, 1944-1953.
-
(2009)
Hepatology
, vol.49
, pp. 1944-1953
-
-
Nagata, H.1
Hatano, E.2
Tada, M.3
Murata, M.4
Kitamura, K.5
Asechi, H.6
Narita, M.7
Yanagida, A.8
Tamaki, N.9
Yagi, S.10
Ikai, I.11
Matsuzaki, K.12
Uemoto, S.13
-
46
-
-
0030611757
-
Identification of Smad7 a TGFβ-inducible antagonist of TGF-β signalling
-
Nakao, A., Afrakhte, M., Moren, A., Nakayama, T., Christian, J. L., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N. E., Heldin, C. H., and Ten Dijke, P. (1997). Identification of Smad7,a TGFβ-inducible antagonist of TGF-β signalling. Nature 389, 631-635.
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
Afrakhte, M.2
Moren, A.3
Nakayama, T.4
Christian, J.L.5
Heuchel, R.6
Itoh, S.7
Kawabata, M.8
Heldin, N.E.9
Heldin, C.H.10
Ten Dijke, P.11
-
47
-
-
0033361039
-
Liver fibrosis Springer Semin
-
Pinzani, M. (1999). Liver fibrosis. Springer Semin. Immunopathol. 21, 475-490.
-
(1999)
Immunopathol
, vol.21
, pp. 475-490
-
-
Pinzani, M.1
-
49
-
-
0030898417
-
Mitogen-activated protein kinase pathways
-
Robinson, M. J., and Cobb, M. H. (1997). Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9, 180-186.
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 180-186
-
-
Robinson, M.J.1
Cobb, M.H.2
-
50
-
-
0027366398
-
Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo
-
Rockey, D. C., Housset, C. N., and Friedman, S. L. (1993). Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J. Clin. Invest. 92, 1795-1804.
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 1795-1804
-
-
Rockey, D.C.1
Housset, C.N.2
Friedman, S.L.3
-
51
-
-
33845970267
-
Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phos-phatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways
-
Sapkota, G., Knockaert, M., Alarcon, C., Montalvo, E., Brivanlou, A. H., and Massague, J. (2006). Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phos-phatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways. J. Biol. Chem. 281, 40412-40419.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 40412-40419
-
-
Sapkota, G.1
Knockaert, M.2
Alarcon, C.3
Montalvo, E.4
Brivanlou, A.H.5
Massague, J.6
-
52
-
-
34347235524
-
Reversible Smad-dependent signaling between tumor suppression and oncogenesis
-
Sekimoto, G., Matsuzaki, K.,Yoshida, K., Mori, S., Murata, M., Seki, T., Matsui, H., Fujisawa, J., and Okazaki, K. (2007). Reversible Smad-dependent signaling between tumor suppression and oncogenesis. Cancer Res. 67, 5090-5096.
-
(2007)
Cancer Res
, vol.67
, pp. 5090-5096
-
-
Sekimoto, G.1
Matsuzaki, K.2
Yoshida, K.3
Mori, S.4
Murata, M.5
Seki, T.6
Matsui, H.7
Fujisawa, J.8
Okazaki, K.9
-
53
-
-
0038682002
-
Mechanisms of TGF-β signaling from cell membrane to the nucleus
-
Shi, Y., and Massague, J. (2003). Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
54
-
-
0034703087
-
Participation of Smad2, Smad3, and Smad4 in transforming growth factor β (TGF-β)-induced activation of Smad7 THE TGF-beta response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation
-
Stopa, M., Anhuf, D., Terstegen, L., Gatsios, P., Gressner, A. M., and Dooley, S. (2000). Participation of Smad2, Smad3, and Smad4 in transforming growth factor β (TGF-β)-induced activation of Smad7. THE TGF-beta response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation. J. Biol. Chem. 275, 29308-29317.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29308-29317
-
-
Stopa, M.1
Anhuf, D.2
Terstegen, L.3
Gatsios, P.4
Gressner, A.M.5
Dooley, S.6
-
55
-
-
18244401140
-
Differential regulation of TGF-β signal in hepatic stellate cells between acute and chronic rat liver injury
-
Tahashi, Y., Matsuzaki, K., Date, M., Yoshida, K., Furukawa, F., Sugano, Y., Matsushita, M., Himeno, Y., Inagaki, Y., and Inoue, K. (2002). Differential regulation of TGF-β signal in hepatic stellate cells between acute and chronic rat liver injury. Hepatology. 35, 49-61.
-
(2002)
Hepatology
, vol.35
, pp. 49-61
-
-
Tahashi, Y.1
Matsuzaki, K.2
Date, M.3
Yoshida, K.4
Furukawa, F.5
Sugano, Y.6
Matsushita, M.7
Himeno, Y.8
Inagaki, Y.9
Inoue, K.10
-
56
-
-
0034646674
-
Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β
-
von Gersdorff, G., Susztak, K., Rezvani, F., Bitzer, M., Liang, D., and Böttinger, E. P. (2000). Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β. J. Biol. Chem. 275, 11320-11326.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 11320-11326
-
-
von Gersdorff, G.1
Susztak, K.2
Rezvani, F.3
Bitzer, M.4
Liang, D.5
Böttinger, E.P.6
-
57
-
-
65649084845
-
Transforming growth factor-β-inducible phosphorylation of Smad3
-
Wang, G., Matsuura, I., He, D., and Liu, F. (2009). Transforming growth factor-β-inducible phosphorylation of Smad3. J. Biol. Chem. 284, 9663-9673.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 9663-9673
-
-
Wang, G.1
Matsuura, I.2
He, D.3
Liu, F.4
-
58
-
-
67651165609
-
The etiology of liver damage imparts cytokines transforming growth factor β1 or interleukin-13 as driving forces in fibrogenesis
-
Weng, H. L., Liu, Y., Chen, J. L., Huang, T., Xu, L. J., Godoy, P., Hu, J. H., Zhou, C., Stickel, F., Marx, A., Bohle, R. M., Zimmer, V., Lammert, F., Mueller, S., Gigou, M., Samuel, D., Mertens, P. R., Singer, M. V., Seitz, H. K., and Dooley, S. (2009). The etiology of liver damage imparts cytokines transforming growth factor β1 or interleukin-13 as driving forces in fibrogenesis. Hepatology 50, 230-243.
-
(2009)
Hepatology
, vol.50
, pp. 230-243
-
-
Weng, H.L.1
Liu, Y.2
Chen, J.L.3
Huang, T.4
Xu, L.J.5
Godoy, P.6
Hu, J.H.7
Zhou, C.8
Stickel, F.9
Marx, A.10
Bohle, R.M.11
Zimmer, V.12
Lammert, F.13
Mueller, S.14
Gigou, M.15
Samuel, D.16
Mertens, P.R.17
Singer, M.V.18
Seitz, H.K.19
Dooley, S.20
more..
-
59
-
-
0034695511
-
Regulation of Smad activity
-
Wrana, J. L. (2000). Regulation of Smad activity. Cell 100, 189-192.
-
(2000)
Cell
, vol.100
, pp. 189-192
-
-
Wrana, J.L.1
-
60
-
-
58149239730
-
Phospho-control of TGF-β superfamily signaling
-
Wrighton, K. H., Lin, X., and Feng, X. H. (2009). Phospho-control of TGF-β superfamily signaling. Cell Res. 19, 8-20.
-
(2009)
Cell Res
, vol.19
, pp. 8-20
-
-
Wrighton, K.H.1
Lin, X.2
Feng, X.H.3
-
61
-
-
19944429743
-
Acceleration of Smad2 and Smad3 phospho-rylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis
-
Yamagata, H., Matsuzaki, K., Mori, S., Yoshida, K., Tahashi, Y., Furukawa, F., Sekimoto, G., Watanabe, T., Uemura, Y., Sakaida, N., Yoshioka, K., Kamiyama, Y., Seki, T., and Okazaki, K. (2005). Acceleration of Smad2 and Smad3 phospho-rylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis. Cancer Res. 65, 157-165.
-
(2005)
Cancer Res
, vol.65
, pp. 157-165
-
-
Yamagata, H.1
Matsuzaki, K.2
Mori, S.3
Yoshida, K.4
Tahashi, Y.5
Furukawa, F.6
Sekimoto, G.7
Watanabe, T.8
Uemura, Y.9
Sakaida, N.10
Yoshioka, K.11
Kamiyama, Y.12
Seki, T.13
Okazaki, K.14
-
62
-
-
20244376914
-
Transforming growth factor-β and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphoryla-tion in rat hepatic stellate cells after acute liver injury
-
Yoshida, K., Matsuzaki, K., Mori, S., Tahashi, Y., Yamagata, H., Furukawa, F., Seki, T., Nishizawa, M., Fujisawa, J., and Okazaki, K. (2005). Transforming growth factor-β and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphoryla-tion in rat hepatic stellate cells after acute liver injury. Am. J. Pathol. 166, 1029-1039.
-
(2005)
Am. J. Pathol.
, vol.166
, pp. 1029-1039
-
-
Yoshida, K.1
Matsuzaki, K.2
Mori, S.3
Tahashi, Y.4
Yamagata, H.5
Furukawa, F.6
Seki, T.7
Nishizawa, M.8
Fujisawa, J.9
Okazaki, K.10
|