ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice

PLoS Genetics

Volumn 8, Issue 8, 2012, Pages

  Damrath, Ewa ^a   Heck, Melanie V ^a   Gispert, Suzana ^a   Azizov, Mekhman ^a   Nowock, Joachim ^a   Seifried, Carola ^a   Rüb, Udo ^a   Walter, Michael ^b   Auburger, Georg ^a  

^a GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 2; BINDING PROTEIN; MESSENGER RNA; PEPTIDES AND PROTEINS; PROTEIN PABC1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIN 2 GENE; BRAIN CORTEX; CAG REPEAT; CEREBELLUM; CONTROLLED STUDY; FBXW8 GENE; FEMALE; GAIN OF FUNCTION MUTATION; GENE; GENE INDUCTION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LOSS OF FUNCTION MUTATION; MALE; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN INTERACTION; PROTEIN MICROARRAY; PROTEIN SOLUBILITY; RNA PROCESSING; RNA TRANSCRIPTION; SOLUBILITY; SPINOCEREBELLAR DEGENERATION; WEIGHT REDUCTION;

ANIMALS; CEREBELLUM; F-BOX PROTEINS; GENE KNOCK-IN TECHNIQUES; HELA CELLS; HUMANS; MICE; NERVE TISSUE PROTEINS; NEURONS; PEPTIDES; POLY(A)-BINDING PROTEIN I; SOLUBILITY;

ANIMALIA; MURINAE; MUS;

EID: 84866179163     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002920     Document Type: Article

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