The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2

Human Molecular Genetics

Volumn 20, Issue 1, 2011, Pages 104-114

  Hallen, Linda ^a,b   Klein, Holger ^a   Stoschek, Carola ^a   Wehrmeyer, Silke ^a   Nonhoff, Ute ^a,d   Ralser, Markus ^a   Wilde, Jeannine ^a   Röhr, Christina ^a,b   Schweiger, Michal R ^a   Zatloukal, Kurt ^c   Vingron, Martin ^a   Lehrach, Hans ^a   Konthur, Zoltán ^a   Krobitsch, Sylvia ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

^d UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 2; LUCIFERASE; NUCLEIC ACID BINDING PROTEIN; UNCLASSIFIED DRUG; ZBRK1 PROTEIN; ZINC FINGER PROTEIN; NERVE PROTEIN; REPRESSOR PROTEIN; SCA2 PROTEIN; ZNF350 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; BIOINFORMATICS; CHROMATIN IMMUNOPRECIPITATION; COLON TUMOR; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING MOTIF; GENE CONTROL; GENE INTERACTION; GENE PRODUCT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; TRANSCRIPTION REGULATION; CELL STRAIN HEK293; CHROMATIN; GENETICS; HELA CELL; IMMUNOPRECIPITATION; METABOLISM; PLASMID; SPINOCEREBELLAR DEGENERATION; TRANSCRIPTION INITIATION;

BINDING SITES; CHROMATIN; COLONIC NEOPLASMS; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; NERVE TISSUE PROTEINS; PLASMIDS; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; SPINOCEREBELLAR ATAXIAS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 79956301405     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddq436     Document Type: Article

References (36)

1. Bellefroid, E.J., Lecocq, P.J., Benhida, A., Poncelet, D.A., Belayew, A. and Martial, J.A. (1989) The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. DNA., 8, 377-387.
2. Tadepally, H.D., Burger, G. and Aubry, M. (2008) Evolution of C2H2-zinc finger genes and subfamilies in mammals: species-specific duplication and loss of clusters, genes and effector domains. BMC Evol. Biol., 8, 176.
3. Urrutia, R. (2003) KRAB-containing zinc-finger repressor proteins. Genome Biol., 4, 231.
4. Zheng, L., Pan, H., Li, S., Flesken-Nikitin, A., Chen, P.L., Boyer, T.G. and Lee, W.H. (2000) Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol. Cell., 6, 757-768.
5. Vissing, H., Meyer, W.K., Aagaard, L., Tommerup, N. and Thiesen, H.J. (1995) Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. FEBS Lett.., 369, 153-157.
6. Tan, W., Zheng, L., Lee, W.H. and Boyer, T.G. (2004) Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression. J. Biol. Chem.., 279, 6576-6587.
7. Tan, W., Kim, S. and Boyer, T.G. (2004) Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1. J. Biol. Chem.., 279, 55153-55160.
8. Yun, J. and Lee, W.H. (2003) Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage. Mol. Cell. Biol.., 23, 7305-7314.
9. Furuta, S., Wang, J.M., Wei, S., Jeng, Y.M., Jiang, X., Gu, B., Chen, P.L., Lee, E.Y. and Lee, W.H. (2006) Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell., 10, 13-24.
10. Garcia, V., Dominguez, G., Garcia, J.M., Silva, J., Pena, C., Silva, J.M., Carcereny, E., Menendez, J., Espana, P. and Bonilla, F. (2004) Altered expression of the ZBRK1 gene in human breast carcinomas. J. Pathol.., 202, 224-232.
11. Garcia, V., Garcia, J.M., Pena, C., Silva, J., Dominguez, G., Rodriguez, R., Maximiano, C., Espinosa, R., Espana, P. and Bonilla, F. (2005) The GADD45, ZBRK1 and BRCA1 pathway: quantitative analysis of mRNA expression in colon carcinomas. J. Pathol.., 206, 92-99.
12. Lin, L.F., Chuang, C.H., Li, C.F., Liao, C.C., Cheng, C.P., Cheng, T.L., Shen, M.R., Tseng, J.T., Chang, W.C., Lee, W.H. et al. (2010) ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. Cancer Res.., 70, 192-201.
13. Lastres-Becker, I., Rub, U. and Auburger, G. (2008) Spinocerebellar ataxia 2 (SCA2). Cerebellum., 7, 115-124.
14. Nonhoff, U., Ralser, M., Welzel, F., Piccini, I., Balzereit, D., Yaspo, M.L., Lehrach, H. and Krobitsch, S. (2007) Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. Mol. Biol. Cell., 18, 1385-1396.
15. Nonis, D., Schmidt, M.H., van de Loo, S., Eich, F., Dikic, I., Nowock, J. and Auburger, G. (2008) Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking. Cell Signal.., 20, 1725-1739.
16. Ralser, M., Albrecht, M., Nonhoff, U., Lengauer, T., Lehrach, H. and Krobitsch, S. (2005) An integrative approach to gain insights into the cellular function of human ataxin-2. J. Mol. Biol.., 346, 203-214.
17. Ralser, M., Nonhoff, U., Albrecht, M., Lengauer, T., Wanker, E.E., Lehrach, H. and Krobitsch, S. (2005) Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. Hum. Mol. Genet.., 14, 2893-2909.
18. Aprelikova, O., Pace, A.J., Fang, B., Koller, B.H. and Liu, E.T. (2001) BRCA1 is a selective co-activator of 14-3-3 sigma gene transcription in mouse embryonic stem cells. J. Biol. Chem.., 276, 25647-25650.
19. Harkin, D.P., Bean, J.M., Miklos, D., Song, Y.H., Truong, V.B., Englert, C., Christians, F.C., Ellisen, L.W., Maheswaran, S., Oliner, J.D. et al. (1999) Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell., 97, 575-586.
20. MacLachlan, T.K., Somasundaram, K., Sgagias, M., Shifman, Y., Muschel, R.J., Cowan, K.H. and El-Deiry, W.S. (2000) BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. J. Biol. Chem.., 275, 2777-2785.
21. Welcsh, P.L., Lee, M.K., Gonzalez-Hernandez, R.M., Black, D.J., Mahadevappa, M., Swisher, E.M., Warrington, J.A. and King, M.C. (2002) BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc. Natl Acad. Sci. USA., 99, 7560-7565.
22. Frietze, S., Lan, X., Jin, V.X. and Farnham, P.J. (2010) Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263. J. Biol. Chem.., 285, 1393-1403.
23. Wiedemeyer, R., Westermann, F., Wittke, I., Nowock, J. and Schwab, M. (2003) Ataxin-2 promotes apoptosis of human neuroblastoma cells. Oncogene., 22, 401-411.
24. Reddy, P.S. and Housman, D.E. (1997) The complex pathology of trinucleotide repeats. Curr. Opin. Cell Biol.., 9, 364-372.
25. Schols, L., Bauer, P., Schmidt, T., Schulte, T. and Riess, O. (2004) Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis. Lancet Neurol.., 3, 291-304.
26. Stevanin, G., Durr, A. and Brice, A. (2002) Spinocerebellar ataxias caused by polyglutamine expansions. Adv. Exp. Med. Biol.., 516, 47-77.
27. Huynh, D.P., Del Bigio, M.R., Ho, D.H. and Pulst, S.M. (1999) Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2. Ann. Neurol.., 45, 232-241.
28. Goehler, H., Lalowski, M., Stelzl, U., Waelter, S., Stroedicke, M.,Worm,U., Droege, A., Lindenberg, K.S., Knoblich, M., Haenig, C. et al. (2004) A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Mol. Cell., 15, 853-865.
29. Flicek, P., Aken, B.L., Ballester, B., Beal, K., Bragin, E., Brent, S., Chen, Y., Clapham, P., Coates, G., Fairley, S. et al. (2010) Ensembl's 10th year. Nucleic Acids Res., 38, D557-562.
30. Sultan, M., Schulz, M.H., Richard, H., Magen, A., Klingenhoff, A., Scherf, M., Seifert, M., Borodina, T., Soldatov, A., Parkhomchuk, D. et al. (2008) A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome. Science., 321, 956-960.
31. de Kok, J.B., Roelofs, R.W., Giesendorf, B.A., Pennings, J.L., Waas, E.T., Feuth, T., Swinkels, D.W. and Span, P.N. (2005) Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genes. Lab. Invest.., 85, 154-159.
32. Holt, L.J., Bussow, K., Walter, G. and Tomlinson, I.M. (2000) By-passing selection: direct screening for antibody-antigen interactions using protein arrays. Nucleic Acids Res., 28, E72.
33. Rhyner, C., Konthur, Z., Blaser, K. and Crameri, R. (2003) High-throughput isolation of recombinant antibodies against recombinant allergens. Biotechniques., 35, 672-674.
34. Walter, G., Konthur, Z. and Lehrach, H. (2001) High-throughput screening of surface displayed gene products. Comb. Chem. High Throughput Screen.., 4, 193-205.
35. Rhead, B., Karolchik, D., Kuhn, R.M., Hinrichs, A.S., Zweig, A.S., Fujita, P.A., Diekhans, M., Smith, K.E., Rosenbloom, K.R., Raney, B.J. et al. (2010) The UCSC Genome Browser database: update 2010. Nucleic Acids Res., 38, D613-619.
36. Gardiner-Garden, M. and Frommer, M. (1987) CpG islands in vertebrate genomes. J. Mol. Biol.., 196, 261-282.