Regulation of ROS production and vascular function by carbon monoxide

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Choi, Yoon Kyung ^a   Por, Elaine D ^b   Kwon, Young Guen ^c   Kim, Young Myeong ^a  

^a Kangwon National University   (South Korea)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; BIOLOGICAL EFFECTS; BLOOD CIRCULATION; CELLULAR EVENTS; CELLULAR MECHANISMS; CELLULAR REDOX; DISEASE PREVENTION; GASEOUS MOLECULES; HEME OXYGENASES; INTRACELLULAR SIGNALS; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL ENERGY; MITOCHONDRIAL METABOLISM; NEOVASCULARIZATION; REACTIVE OXYGEN SPECIES; REDOX CASCADES; REDUCED IRON; SIGNALING MOLECULES; THERAPEUTIC APPLICATION; VASCULAR FUNCTIONS;

CARBON MONOXIDE; CARDIOVASCULAR SYSTEM; GENE EXPRESSION; METABOLISM; MOLECULES; PLANTS (BOTANY); PORPHYRINS;

MITOCHONDRIA;

CARBON MONOXIDE; CYTOCHROME C OXIDASE; GUANYLATE CYCLASE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANGIOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; DRUG DOSE ESCALATION; DRUG HALF LIFE; ENERGY METABOLISM; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PULMONARY HYPERTENSION; REPERFUSION INJURY; REVIEW; SAFETY; SMOOTH MUSCLE FIBER; STROKE; VASCULAR DISEASE; VASOCONSTRICTION; VASODILATATION; ANIMAL; BLOOD VESSEL; DRUG EFFECT; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BLOOD VESSELS; CARBON MONOXIDE; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; VASCULAR DISEASES;

EID: 84866171000     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/794237     Document Type: Review

References (150)

1. Hill-Kapturczak N., Chang S. H., Agarwal A., Heme oxygenase and the kidney. DNA and Cell Biology 2002 21 4 307 321 2-s2.0-0036266087 10.1089/104454902753759726 (Pubitemid 34594544)
2. Wu M. L., Ho Y. C., Yet S. F., A central role of heme oxygenase-1 in cardiovascular protection. Antioxidants & Redox Signaling 18352011 15 7 1835 1846
3. Kim Y. M., Bergonia H., Lancaster J. R., Nitrogen oxide-induced autoprotection in isolated rat hepatocytes. FEBS Letters 1995 374 2 228 232 2-s2.0-0028885672 10.1016/0014-5793(95)01115-U
4. Trakshel G. M., Maines M. D., Multiplicity of heme oxygenase isozymes. HO-1 and HO-2 are different molecular species in rat and rabbit. Journal of Biological Chemistry 1989 264 2 1323 1328 2-s2.0-0024494769 (Pubitemid 19038128)
5. Yoshida T., Sato M., Posttranslational and direct integration of heme oxygenase into microsomes. Biochemical and Biophysical Research Communications 1989 163 2 1086 1092 2-s2.0-0024431214 (Pubitemid 19236960)
6. Tenhunen R., Marver H. S., Schmid R., The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proceedings of the National Academy of Sciences of the United States of America 1968 61 2 748 755 2-s2.0-0014348401
7. Hwang H. W., Lee J. R., Chou K. Y., Suen C. S., Hwang M. J., Chen C., Shieh R. C., Chau L. Y., Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum. Journal of Biological Chemistry 2009 284 34 22672 22679 2-s2.0-69249128318 10.1074/jbc.M109.028001
8. Verma A., Hirsch D. J., Glatt C. E., Ronnett G. V., Snyder S. H., Carbon monoxide: a putative neural messenger. Science 1993 259 5093 381 384 2-s2.0-0027458551 (Pubitemid 23055683)
9. Ma N., Ding X., Doi M., Izumi N., Semba R., Cellular and subcellular localization of heme oxygenase-2 in monkey retina. Journal of Neurocytology 2004 33 4 407 415 2-s2.0-7744235173 10.1023/B:NEUR.0000046571.90786.6e (Pubitemid 39463163)
10. Lin Q., Weis S., Yang G., Weng Y. H., Helston R., Rish K., Smith A., Bordner J., Polte T., Gaunitz F., Dennery P. A., Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. Journal of Biological Chemistry 2007 282 28 20621 20633 2-s2.0-34547135735 10.1074/jbc.M607954200 (Pubitemid 47100046)
11. Bindu S., Pal C., Dey S., Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal antiinflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury. Journal of Biological Chemistry 2011 286 45 39387 39402
12. Kim H. P., Wang X., Galbiati F., Ryter S. W., Choi A. M. K., Caveolae compartmentalization of hemeoxygenase-1 in endothelial cells. The FASEB Journal 2004 18 10 1080 1089 2-s2.0-3042737456 10.1096/fj.03-1391com (Pubitemid 38859216)
13. 2S Gas Biology. Antioxidants and Redox Signaling 2010 13 2 157 192 2-s2.0-77953575550 10.1089/ars.2009.2657
14. Vreman H. J., Wong R. J., Sanesi C. A., Dennery P. A., Stevenson D. K., Simultaneous production of carbon monoxide and thiobarbituric acid reactive substances in rat tissue preparations by an iron-ascorbate system. Canadian Journal of Physiology and Pharmacology 1998 76 12 1057 1065 2-s2.0-0032468407 10.1139/cjpp-76-12-1057 (Pubitemid 29254235)
15. Engel R. R., Matsen J. M., Chapman S. S., Schwartz S., Carbon monoxide production from heme compounds by bacteria. Journal of Bacteriology 1972 112 3 1310 1315 2-s2.0-0015465021
16. Jones C. I., Han Z., Presley T., Varadharaj S., Zweier J. L., Ilangovan G., Alevriadou B. R., Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite. American Journal of Physiology 2008 295 1 C180 C191 2-s2.0-52749091387 10.1152/ajpcell.00549.2007 (Pubitemid 352755805)
17. Ushio-Fukai M., Nakamura Y., Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Letters 2008 266 1 37 52 2-s2.0-44449125132 10.1016/j.canlet.2008.02.044 (Pubitemid 351753035)
18. + signaling, prolyl hydroxylases, and mTOR. Journal of Cellular Physiology 2008 217 3 674 685 2-s2.0-54049088213 10.1002/jcp.21537
19. Dulak J., Deshane J., Jozkowicz A., Agarwal A., Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation 2008 117 2 231 241 2-s2.0-38049132217 10.1161/CIRCULATIONAHA.107.698316
20. Cudmore M., Ahmad S., Al-Ani B., Fujisawa T., Coxall H., Chudasama K., Devey L. R., Wigmore S. J., Abbas A., Hewett P. W., Ahmed A., Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1. Circulation 2007 115 13 1789 1797 2-s2.0-34247247725 10.1161/CIRCULATIONAHA.106. 660134 (Pubitemid 46648616)
21. Chin B. Y., Jiang G., Wegiel B., Wang H. J., MacDonald T., Xu C. Z., Gallo D., Cszimadia E., Bach F. H., Lee P. J., Otterbein L. E., Hypoxia-inducible factor 1 α stabilization by carbon monoxide results in cytoprotective preconditioning. Proceedings of the National Academy of Sciences of the United States of America 2007 104 12 5109 5114 2-s2.0-34247571886 10.1073/pnas.0609611104 (Pubitemid 47186184)
22. Loboda A., Jazwa A., Grochot-Przeczek A., Rutkowski A. J., Cisowski J., Agarwal A., Jozkowicz A., Dulak J., Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities. Antioxidants and Redox Signaling 2008 10 10 1767 1812 2-s2.0-49849099361 10.1089/ars.2008.2043
23. Coffman L. G., Parsonage D., D'Agostino R. Jr., Torti F. M., Torti S. V., Regulatory effects of ferritin on angiogenesis. Proceedings of the National Academy of Sciences of the United States of America 2009 106 2 570 575 2-s2.0-58849163970 10.1073/pnas.0812010106
24. Bilban M., Bach F. H., Otterbein S. L., Ifedigbo E., de Costa d'Avila J., Esterbauer H., Chin B. Y., Usheva A., Robson S. C., Wagner O., Otterbein L. E., Carbon monoxide orchestrates a protective response through PPAR γ Immunity 2006 24 5 601 610 2-s2.0-33646579079 10.1016/j.immuni.2006.03.012 (Pubitemid 43728155)
25. Suliman H. B., Carraway M. S., Tatro L. G., Piantadosi C. A., A new activating role for CO in cardiac mitochondrial biogenesis. Journal of Cell Science 2007 120 2 299 308 2-s2.0-33846993042 10.1242/jcs.03318
26. Lancel S., Hassoun S. M., Favory R., Decoster B., Motterlini R., Neviere R., Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis. Journal of Pharmacology and Experimental Therapeutics 2009 329 2 641 648 2-s2.0-65649135789 10.1124/jpet.108.148049
27. Brune B., Ullrich V., Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Molecular Pharmacology 1987 32 4 497 504 2-s2.0-0023490534 (Pubitemid 18006150)
28. Basuroy S., Tcheranova D., Bhattacharya S., Leffler C. W., Parfenova H., Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF- α -induced apoptosis. American Journal of Physiology 2011 300 2 C256 C265 2-s2.0-79251589339 10.1152/ajpcell.00272.2010
29. Petersen L. C., The effect of inhibitors on the oxygen kinetics of cytochrome c oxidase. Biochimica et Biophysica Acta 1977 460 2 299 307 2-s2.0-0017353388
30. Pankow D., Ponsold W., Effect of carbon monoxide exposure on heart cytochrome c oxidase activity of rats. Biomedica Biochimica Acta 1984 43 10 1185 1189 2-s2.0-0021749064 (Pubitemid 15221726)
31. Bilban M., Haschemi A., Wegiel B., Chin B. Y., Wagner O., Otterbein L. E., Heme oxygenase and carbon monoxide initiate homeostatic signaling. Journal of Molecular Medicine 2008 86 3 267 279 2-s2.0-39849088049 10.1007/s00109-007- 0276-0
32. Bilban M., Haschemi A., Wegiel B., Chin B. Y., Wagner O., Otterbein L. E., Heme oxygenase and carbon monoxide initiate homeostatic signaling. Journal of Molecular Medicine 2008 86 3 267 279 2-s2.0-39849088049 10.1007/s00109-007- 0276-0
33. Veal E. A., Day A. M., Morgan B. A., Hydrogen peroxide sensing and signaling. Molecular Cell 2007 26 1 1 14 2-s2.0-34147210988 10.1016/j.molcel. 2007.03.016 (Pubitemid 46578115)
34. Taillé C., El-Benna J., Lanone S., Boczkowski J., Motterlini R., Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle. Journal of Biological Chemistry 2005 280 27 25350 25360 2-s2.0-21844468521 10.1074/jbc.M503512200 (Pubitemid 40962237)
35. Motterlini R., Otterbein L. E., The therapeutic potential of carbon monoxide. Nature Reviews Drug Discovery 2010 9 9 728 743 2-s2.0-77956323967 10.1038/nrd3228
36. Yachie A., Niida Y., Wada T., Igarashi N., Kaneda H., Toma T., Ohta K., Kasahara Y., Koizumi S., Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. Journal of Clinical Investigation 1999 103 1 129 135 2-s2.0-0032893958 (Pubitemid 29031171)
37. Ushio-Fukai M., VEGF signaling through NADPH oxidase-derived ROS. Antioxidants and Redox Signaling 2007 9 6 731 739 2-s2.0-34249071326 10.1089/ars.2007.1556 (Pubitemid 46799105)
38. Takac I., Schroder K., Brandes R. P., The Nox family of NADPH oxidases: friend or foe of the vascular system? Current Hypertension Reports 2012 14 1 70 78
39. Nakahira K., Hong P. K., Xue H. G., Nakao A., Wang X., Murase N., Drain P. F., Wang X., Sasidhar M., Nabel E. G., Takahashi T., Lukacs N. W., Ryter S. W., Morita K., Choi A. M. K., Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. Journal of Experimental Medicine 2006 203 10 2377 2389 2-s2.0-33749322644 10.1084/jem.20060845 (Pubitemid 44498371)
40. Desouki M. M., Kulawiec M., Bansal S., Das G. M., Singh K. K., Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors. Cancer Biology and Therapy 2005 4 12 1367 1373 2-s2.0-31144469322 (Pubitemid 43131182)
41. +]i through the mitochondrial ROS-PKCe{open} signaling axis in pulmonary artery smooth muscle cells. Free Radical Biology and Medicine 2008 45 9 1223 1231 2-s2.0-53449086013 10.1016/j.freeradbiomed.2008.06.012
42. Lamon B. D., Zhang F. F., Puri N., Brodsky S. V., Goligorsky M. S., Nasjletti A., Dual pathways of carbon monoxide-mediated vasoregulation: modulation by redox mechanisms. Circulation Research 2009 105 8 775 783 2-s2.0-70350134020 10.1161/CIRCRESAHA.109.197434
43. Brüne B., Zhou J., Hypoxia-inducible factor-1 α under the control of nitric oxide. Methods in Enzymology 2007 435 463 478 2-s2.0-39749124246 10.1016/S0076-6879(07)35024-6
44. Thom S. R., Xu Y. A., Ischiropoulos H., Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure. Chemical Research in Toxicology 1997 10 9 1023 1031 2-s2.0-0030876302 10.1021/tx970041h (Pubitemid 27418019)
45. Thorup C., Jones C. L., Gross S. S., Moore L. C., Goligorsky M. S., Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS. American Journal of Physiology 1999 277 6 F882 F889 2-s2.0-0033372937 (Pubitemid 30046063)
46. Kim Y. M., Bergonia H. A., Muller C., Pitt B. R., Watkins W. D., Lancaster J. R., Loss and degradation of enzyme-bound heme induced by cellular nitric oxide synthesis. Journal of Biological Chemistry 1995 270 11 5710 5713 2-s2.0-0028957038 10.1074/jbc.270.11.5710
47. Albakri Q. A., Stuehr D. J., Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability. Journal of Biological Chemistry 1996 271 10 5414 5421 2-s2.0-0029935269 10.1074/jbc.271.10.5414 (Pubitemid 26084448)
48. White K. A., Marletta M. A., Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry 1992 31 29 6627 6631 2-s2.0-0026735580
49. Suematsu M., Goda N., Sano T., Kashiwagi S., Egawa T., Shinoda Y., Ishimura Y., Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. Journal of Clinical Investigation 1995 96 5 2431 2437 2-s2.0-0028856163
50. Imai T., Morita T., Shindo T., Nagai R., Yazaki Y., Kurihara H., Suematsu M., Katayama S., Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice. Circulation Research 2001 89 1 55 62 2-s2.0-0035816734 (Pubitemid 34135492)
51. Foresti R., Hammad J., Clark J. E., Johnson T. R., Mann B. E., Friebe A., Green C. J., Motterlini R., Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. British Journal of Pharmacology 2004 142 3 453 460 2-s2.0-3042826932 10.1038/sj.bjp.0705825 (Pubitemid 38869858)
52. Morita T., Perrella M. A., Lee M. E., Kourembanas S., Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proceedings of the National Academy of Sciences of the United States of America 1995 92 5 1475 1479 2-s2.0-0028928004 10.1073/pnas.92.5.1475
53. Ryter S. W., Morse D., Choi A. M., Carbon monoxide: to boldly go where NO has gone before. Science's STKE 2004 2004 230 RE6 2-s2.0-2542461143
54. Foresti R., Motterlini R., The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis. Free Radical Research 1999 31 6 459 475 2-s2.0-0032757252
55. Zuckerbraun B. S., Billiar T. R., Otterbein S. L., Kim P. K. M., Liu F., Choi A. M. K., Bach F. H., Otterbein L. E., Carbon monoxide protects against liver failure through Nitric oxide-induced heme Oxygenase 1. Journal of Experimental Medicine 2003 198 11 1707 1716 2-s2.0-0344737602 10.1084/jem.20031003 (Pubitemid 37494163)
56. Semenza G. L., Targeting HIF-1 for cancer therapy. Nature Reviews Cancer 2003 3 10 721 732 2-s2.0-0142166332 (Pubitemid 37328811)
57. Choi Y. K., Kim C. K., Lee H., Jeoung D., Ha K. S., Kwon Y. G., Kim K. W., Kim Y. M., Carbon monoxide promotes VEGF expression by increasing HIF-1 α protein level via two distinct mechanisms, translational activation and stabilization of HIF-1 α protein. Journal of Biological Chemistry 2010 285 42 32116 32125 2-s2.0-77957802876 10.1074/jbc.M110.131284
58. Ceradini D. J., Kulkarni A. R., Callaghan M. J., Tepper O. M., Bastidas N., Kleinman M. E., Capla J. M., Galiano R. D., Levine J. P., Gurtner G. C., Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nature Medicine 2004 10 8 858 864 2-s2.0-4043184065 10.1038/nm1075 (Pubitemid 39070860)
59. Poss K. D., Tonegawa S., Heme oxygenase 1 is required for mammalian iron reutilization. Proceedings of the National Academy of Sciences of the United States of America 1997 94 20 10919 10924 2-s2.0-0030886381 10.1073/pnas.94.20. 10919 (Pubitemid 27430836)
60. Cisowski J., oboda A., Józkowicz A., Chen S., Agarwal A., Dulak J., Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: effect of HO-1 knockout. Biochemical and Biophysical Research Communications 2005 326 3 670 676 2-s2.0-10444266581 10.1016/j.bbrc.2004.11.083 (Pubitemid 39642777)
61. Bussolati B., Ahmed A., Pemberton H., Landis R. C., Di Carlo F., Haskard D. O., Mason J. C., Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration. Blood 2004 103 3 761 766 2-s2.0-1642581763 10.1182/blood-2003-06-1974 (Pubitemid 38129530)
62. Jözkowicz A., Huk I., Nigisch A., Weigel G., Dietrich W., Motterlini R., Dulak J., Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX. Antioxidants and Redox Signaling 2003 5 2 155 162 2-s2.0-1642531778 (Pubitemid 36457591)
63. Lin H. H., Chen Y. H., Yet S. F., Chau L. Y., After vascular injury, heme oxygenase-1/carbon monoxide enhances re-endothelialization via promoting mobilization of circulating endothelial progenitor cells. Journal of Thrombosis and Haemostasis 2009 7 8 1401 1408 2-s2.0-67949099048 10.1111/j.1538-7836.2009. 03478.x
64. Nakao A., Kaczorowski D. J., Zuckerbraun B. S., Lei J., Faleo G., Deguchi K., McCurry K. R., Billiar T. R., Kanno S., Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. Biochemical and Biophysical Research Communications 2008 367 3 674 679 2-s2.0-38649131957 10.1016/j.bbrc.2007.12.152
65. Dulak J., Motterlini R., Józkowicz A., Foresti R., Kasza A., Frick M., Huk I., Green C. J., Pachinger O., Weidinger F., Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells. Antioxidants and Redox Signaling 2002 4 2 229 240 2-s2.0-0036090780 (Pubitemid 34517174)
66. Marti H. H., Risau W., Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. Proceedings of the National Academy of Sciences of the United States of America 1998 95 26 15809 15814 2-s2.0-0032431037 10.1073/pnas.95.26.15809 (Pubitemid 29018782)
67. Bruick R. K., McKnight S. L., A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001 294 5545 1337 1340 2-s2.0-0035834409 10.1126/science.1066373 (Pubitemid 33063099)
68. Hirsilä M., Koivunen P., Günzler V., Kivirikko K. I., Myllyharju J., Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. Journal of Biological Chemistry 2003 278 33 30772 30780 2-s2.0-0043234538 10.1074/jbc.M304982200 (Pubitemid 36994584)
69. Pan Y., Mansfield K. D., Bertozzi C. C., Rudenko V., Chan D. A., Giaccia A. J., Simon M. C., Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Molecular and Cellular Biology 2007 27 3 912 925 2-s2.0-33846630894 10.1128/MCB.01223-06 (Pubitemid 46174556)
70. Counts D. F., Cardinale G. J., Udenfriend S., Prolyl hydroxylase half reaction: peptidyl prolyl-independent decarboxylation of α -ketoglutarate. Proceedings of the National Academy of Sciences of the United States of America 1978 75 5 2145 2149 2-s2.0-1542280757 (Pubitemid 8350723)
71. Gerald D., Berra E., Frapart Y. M., Chan D. A., Giaccia A. J., Mansuy D., Pouysségur J., Yaniv M., Mechta-Grigoriou F., JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 2004 118 6 781 794 2-s2.0-4544346656 10.1016/j.cell.2004.08.025 (Pubitemid 39221736)
72. Guzy R. D., Schumacker P. T., Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Experimental Physiology 2006 91 5 807 819 2-s2.0-33747596652 10.1113/expphysiol.2006.033506 (Pubitemid 44266577)
73. Bell E. L., Klimova T. A., Eisenbart J., Moraes C. T., Murphy M. P., Budinger G. R. S., Chandel N. S., The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. Journal of Cell Biology 2007 177 6 1029 1036 2-s2.0-34250745912 10.1083/jcb.200609074 (Pubitemid 46955707)
74. Chandel N. S., Maltepe E., Goldwasser E., Mathieu C. E., Simon M. C., Schumacker P. T., Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proceedings of the National Academy of Sciences of the United States of America 1998 95 20 11715 11720 2-s2.0-0032578458 10.1073/pnas.95.20. 11715 (Pubitemid 28460480)
75. Görlach A., Berchner-Pfannschmidt U., Wotzlaw C., Cool R. H., Fandrey J., Acker H., Jungermann K., Kietzmann T., Reactive oxygen species modulate HIF-I mediated PAI-I expression: involvement of the GTPase RacI. Thrombosis and Haemostasis 2003 89 5 926 935 2-s2.0-0037954222 (Pubitemid 36603435)
76. Isaacs J. S., Jung Y. J., Mimnaugh E. G., Martinez A., Cuttitta F., Neckers L. M., Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. Journal of Biological Chemistry 2002 277 33 29936 29944 2-s2.0-0037119415
77. Oh S. H., Woo J. K., Yazici Y. D., Myers J. N., Kim W. Y., Jin Q., Hong S. S., Park H. J., Suh Y. G., Kim K. W., Hong W. K., Lee H. Y., Structural basis for depletion of heat shock protein 90 client proteins by deguelin. Journal of the National Cancer Institute 2007 99 12 949 961 2-s2.0-34347256360 10.1093/jnci/djm007 (Pubitemid 47073501)
78. Hagen T., Taylor C. T., Lam F., Moncada S., Redistribution of intracellular Oxygen in hypoxia by Nitric Oxide: effect on HIF1 α Science 2003 302 5652 1975 1978 2-s2.0-0348134741 10.1126/science.1088805 (Pubitemid 37523507)
79. Liu Y., Christou H., Morita T., Laughner E., Semenza G. L., Kourembanas S., Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer. Journal of Biological Chemistry 1998 273 24 15257 15262 2-s2.0-0032511014 10.1074/jbc.273.24.15257 (Pubitemid 28272827)
80. Huang L. E., Willmore W. G., Gu J., Goldberg M. A., Bunn H. F., Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide: implications for oxygen sensing and signaling. Journal of Biological Chemistry 1999 274 13 9038 9044 2-s2.0-0033605676 10.1074/jbc.274.13.9038 (Pubitemid 29164709)
81. Brüne B., Zhou J., Nitric oxide and superoxide: interference with hypoxic signaling. Cardiovascular Research 2007 75 2 275 282 2-s2.0-34250751339 10.1016/j.cardiores.2007.03.005 (Pubitemid 46961919)
82. Deshane J., Chen S., Caballero S., Grochot-Przeczek A., Was H., Li Calzi S., Lach R., Hock T. D., Chen B., Hill-Kapturczak N., Siegal G. P., Dulak J., Jozkowicz A., Grant M. B., Agarwal A., Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism. Journal of Experimental Medicine 2007 204 3 605 618 2-s2.0-33947386667 10.1084/jem.20061609 (Pubitemid 46457083)
83. Hiasa K. I., Ishibashi M., Ohtani K., Inoue S., Zhao Q., Kitamoto S., Sata M., Ichiki T., Takeshita A., Egashira K., Gene transfer of stromal cell-derived factor-1 α enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovascularization. Circulation 2004 109 20 2454 2461 2-s2.0-2542464782 10.1161/01.CIR.0000128213. 96779.61 (Pubitemid 38679567)
84. Urao N., Inomata H., Razvi M., Kim H. W., Wary K., McKinney R., Fukai T., Ushio-Fukai M., Role of nox2-based NADPH 0xidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia. Circulation Research 2008 103 2 212 220 2-s2.0-48849116997 10.1161/CIRCRESAHA. 108.176230
85. Zhang J., Piantadosi C. A., Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain. Journal of Clinical Investigation 1992 90 4 1193 1199 2-s2.0-0026462769
86. Cantley L. C., The phosphoinositide 3-kinase pathway. Science 2002 296 5573 1655 1657 2-s2.0-0037205048 10.1126/science.296.5573.1655 (Pubitemid 34579158)
87. Piantadosi C. A., Suliman H. B., Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. Journal of Biological Chemistry 2006 281 1 324 333 2-s2.0-33644852502 10.1074/jbc. M508805200 (Pubitemid 43671192)
88. Meissner M., Stein M., Urbich C., Reisinger K., Suske G., Staels B., Kaufmann R., Gille J., PPAR α activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation. Circulation Research 2004 94 3 324 332 2-s2.0-1242297567 10.1161/01.RES.0000113781.08139.81 (Pubitemid 38240723)
89. Piqueras L., Reynolds A. R., Hodivala-Dilke K. M., Alfranca A., Redondo J. M., Hatae T., Tanabe T., Warner T. D., Bishop-Bailey D., Activation of PPAR β / δ induces endothelial cell proliferation and angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 1 63 69 2-s2.0-33846577833 10.1161/01.ATV.0000250972.83623.61 (Pubitemid 46370477)
90. Fraisl P., Mazzone M., Schmidt T., Carmeliet P., Regulation of angiogenesis by Oxygen and metabolism. Developmental Cell 2009 16 2 167 179 2-s2.0-59649112848 10.1016/j.devcel.2009.01.003
91. Yamakawa K., Hosoi M., Koyama H., Tanaka S., Fukumoto S., Morii H., Nishizawa Y., Peroxisome proliferator-activated receptor- γ agonists increase vascular endothelial growth factor expression in human vascular smooth muscle cells. Biochemical and Biophysical Research Communications 2000 271 3 571 574 2-s2.0-0034685660 10.1006/bbrc.2000.2665 (Pubitemid 30444669)
92. Biscetti F., Gaetani E., Flex A., Aprahamian T., Hopkins T., Straface G., Pecorini G., Stigliano E., Smith R. C., Angelini F., Castellot J. J., Pola R., Selective activation of peroxisome proliferator-activated receptor (PPAR) α and PPAR γ induces neoangiogenesis through a vascular endothelial growth factor-dependent mechanism. Diabetes 2008 57 5 1394 1404 2-s2.0-47349117843 10.2337/db07-0765
93. Okada M., Yan S. F., Pinsky D. J., Peroxisome proliferator-activated receptor- γ (PPAR- γ) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets. The FASEB Journal 2002 16 14 1861 1868 2-s2.0-0036901274 10.1096/fj.02-0503com (Pubitemid 35462604)
94. Jiang C., Ting A. T., Seed B., PPAR- γ agonists inhibit production of monocyte inflammatory cytokines. Nature 1998 391 6662 82 86 2-s2.0-0031888958 10.1038/34184 (Pubitemid 28079219)
95. Simonin M. A., Bordji K., Boyault S., Bianchi A., Gouze E., Bécuwe P., Dauça M., Netter P., Terlain B., PPAR- γ ligands modulate effects of LPS in stimulated rat synovial fibroblasts. American Journal of Physiology 2002 282 1 C125 C133 2-s2.0-0036072894 (Pubitemid 34662559)
96. +-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism 2001 50 1 3 11 2-s2.0-0035180319 10.1053/meta.2001.19415 (Pubitemid 32058541)
97. Polikandriotis J. A., Mazzella L. J., Rupnow H. L., Hart C. M., Peroxisome proliferator-activated receptor γ ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor γ -dependent mechanisms. Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 9 1810 1816 2-s2.0-24144448954 10.1161/01.ATV. 0000177805.65864.d4 (Pubitemid 41243447)
98. Krönke G., Kadl A., Ikonomu E., Blüml S., Fürnkranz A., Sarembock I. J., Bochkov V. N., Exner M., Binder B. R., Leitinger N., Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors. Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 6 1276 1282 2-s2.0-34249297995 10.1161/ATVBAHA.107.142638 (Pubitemid 46809415)
99. Ouchi N., Shibata R., Walsh K., AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circulation Research 2005 96 8 838 846 2-s2.0-18044393806 10.1161/01.RES.0000163633.10240.3b (Pubitemid 40604967)
100. Ndisang J. F., Lane N., Jadhav A., Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes. American Journal of Physiology 2009 296 5 E1029 E1041 2-s2.0-66149135526 10.1152/ajpendo.90241.2008
101. Ndisang J. F., Jadhav A., Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes. American Journal of Physiology 2009 296 4 E829 E841 2-s2.0-65649110522 10.1152/ajpendo.90783.2008
102. + metabolism and SIRT1 activity. Nature 2009 458 7241 1056 1060 2-s2.0-67349276169 10.1038/nature07813
103. Papaiahgari S., Zhang Q., Kleeberger S. R., Cho H. Y., Reddy S. P., Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-P13K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells. Antioxidants and Redox Signaling 2006 8 1-2 43 52 2-s2.0-33644649422 10.1089/ars.2006.8.43 (Pubitemid 43324529)
104. Chang S. H., Garcia J., Melendez J. A., Kilberg M. S., Agarwal A., Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain. Biochemical Journal 2003 371 3 877 885 2-s2.0-0037907756 10.1042/BJ20021731 (Pubitemid 36578886)
105. Higashi Y., Noma K., Yoshizumi M., Kihara Y., Endothelial function and oxidative stress in cardiovascular diseases. Circulation Journal 2009 73 3 411 418 2-s2.0-62649123264 10.1253/circj.CJ-08-1102
106. Wegiel B., Gallo D. J., Raman K. G., Karlsson J. M., Ozanich B., Chin B. Y., Tzeng E., Ahmad S., Ahmed A., Baty C. J., Otterbein L. E., Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury. Circulation 2010 121 4 537 548 2-s2.0-76349103022 10.1161/CIRCULATIONAHA.109.887695
107. Chen B., Guo L., Fan C., Bolisetty S., Joseph R., Wright M. M., Agarwal A., George J. F., Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation. American Journal of Pathology 2009 175 1 422 429 2-s2.0-67649947461 10.2353/ajpath.2009.081033
108. Chauveau C., Bouchet D., Roussel J. C., Mathieu P., Braudeau C., Renaudin K., Tesson L., Soulillou J. P., Iyer S., Buelow R., Anegon I., Gene transfer of heme oxygenase-1 and carbon monoxide delivery inhibit chronic rejection. American Journal of Transplantation 2002 2 7 581 592 2-s2.0-0036705418 10.1034/j.1600-6143.2002.20702.x (Pubitemid 36306849)
109. Schillinger M., Exner M., Minar E., Mlekusch W., Müllner M., Mannhalter C., Bach F. H., Wagner O., Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor. Journal of the American College of Cardiology 2004 43 6 950 957 2-s2.0-1542499475 10.1016/j.jacc.2003.09.058 (Pubitemid 38352971)
110. Ullrich R., Exner M., Schillinger M., Zuckermann A., Raith M., Dunkler D., Horvat R., Grimm M., Wagner O., Microsatellite polymorphism in the heme oxygenase-1 gene promoter and cardiac allograft vasculopathy. Journal of Heart and Lung Transplantation 2005 24 10 1600 1605 2-s2.0-25844515239 10.1016/j.healun.2004.11.009 (Pubitemid 41396459)
111. Otterbein L. E., Zuckerbraun B. S., Haga M., Liu F., Song R., Usheva A., Stachulak C., Bodyak N., Neal Smith R., Csizmadia E., Tyagi S., Akamatsu Y., Flavell R. J., Billiar T. R., Tzeng E., Bach F. H., Choi A. M. K., Soares M. P., Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nature Medicine 2003 9 2 183 190 2-s2.0-0344284580 10.1038/nm817 (Pubitemid 36227720)
112. Deng Y. M., Wu B. J., Witting P. K., Stocker R., Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1. Circulation 2004 110 13 1855 1860 2-s2.0-4644290036 10.1161/01.CIR.0000142610. 10530.25 (Pubitemid 39299229)
113. Zuckerbraun B. S., Beek Y. C., Wegiel B., Billiar T. R., Czsimadia E., Rao J., Shimoda L., Ifedigbo E., Kanno S., Otterbein L. E., Carbon monoxide reverses established pulmonary hypertension. Journal of Experimental Medicine 2006 203 9 2109 2119 2-s2.0-33748455321 10.1084/jem.20052267 (Pubitemid 44352232)
114. Soares M. P., Seldon M. P., Gregoire I. P., Vassilevskaia T., Berberat P. O., Yu J., Tsui T. Y., Bach F. H., Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation. Journal of Immunology 2004 172 6 3553 3563 2-s2.0-1542724430 (Pubitemid 38337936)
115. Sun B., Zou X., Chen Y., Zhang P., Shi G., Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC. International Journal of Biological Sciences 2008 4 5 270 278 2-s2.0-50249117105
116. Kim J. H., Choi Y. K., Lee K. S., Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA. Free Radical Biology & Medicine 2012 53 3 629 640 10.1016/j.freeradbiomed. 2012.04.019
117. 2 in NF- κ B activation. Free Radical Biology and Medicine 2008 45 6 885 896 2-s2.0-54949129134 10.1016/j.freeradbiomed.2008.06.019
118. Zhang G., Ghosh S., Toll-like receptor-mediated NF- κ B activation: a phylogenetically conserved paradigm in innate immunity. Journal of Clinical Investigation 2001 107 1 13 19 2-s2.0-0035164415 (Pubitemid 32047406)
119. Jamaluddin M., Wang S., Boldogh I., Tian B., Brasier A. R., TNF- α -induced NF- κ B/RelA Ser276 phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway. Cellular Signalling 2007 19 7 1419 1433 2-s2.0-34249289745 10.1016/j.cellsig.2007.01.020 (Pubitemid 46818908)
120. Karin M., The beginning of the end: I κ B kinase (IKK) and NF- κ B activation. Journal of Biological Chemistry 1999 274 39 27339 27342 2-s2.0-0033600604 10.1074/jbc.274.39.27339 (Pubitemid 29457970)
121. Wang X. M., Kim H. P., Nakahira K., Ryter S. W., Choi A. M. K., The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. Journal of Immunology 2009 182 6 3809 3818 2-s2.0-65449130775 10.4049/jimmunol.0712437
122. Lee G., Na H. J., Namkoong S., Jeong Kwon H., Han S., Ha K. S., Kwon Y. G., Lee H., Kim Y. M., 4-O-methylgallic acid down-regulates endothelial adhesion molecule expression by inhibiting NF- κ B-DNA-binding activity. European Journal of Pharmacology 2006 551 13 143 151 2-s2.0-33750479072 10.1016/j.ejphar.2006.08.061 (Pubitemid 44648048)
123. Wagner K. R., Sharp F. R., Ardizzone T. D., Lu A., Clark J. F., Heme and iron metabolism: role in cerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism 2003 23 6 629 652 2-s2.0-0038119644 (Pubitemid 36713668)
124. Alayash A. I., Patel R. P., Cashon R. E., Redox reactions of hemoglobin and myoglobin: biological and toxicological implications. Antioxidants and Redox Signaling 2001 3 2 313 327 2-s2.0-0035001778 (Pubitemid 32473345)
125. Wang J., Zhuang H., Doré S., Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage. Neurobiology of Disease 2006 22 3 473 476 2-s2.0-33744938138 10.1016/j.nbd.2005.12.009 (Pubitemid 43842118)
126. Chen-Roetling J., Regan R. F., Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin. Biochemical and Biophysical Research Communications 2006 350 1 233 237 2-s2.0-33749080071 10.1016/j.bbrc.2006.09.036 (Pubitemid 44466598)
127. Chen-Roetling J., Benvenisti-Zarom L., Regan R. F., Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to heme-mediated oxidative injury. Journal of Neuroscience Research 2005 82 6 802 810 2-s2.0-28544449134 10.1002/jnr.20681 (Pubitemid 41746493)
128. Benvenisti-Zarom L., Regan R. F., Astrocyte-specific heme oxygenase-1 hyperexpression attenuates heme-mediated oxidative injury. Neurobiology of Disease 2007 26 3 688 695 2-s2.0-34248674094 10.1016/j.nbd.2007.03.006 (Pubitemid 46766635)
129. Qu Y., Chen-Roetling J., Benvenisti-Zarom L., Regan R. F., Attenuation of oxidative injury after induction of experimental intracerebral hemorrhage in heme oxygenase-2 knockout mice. Journal of Neurosurgery 2007 106 3 428 435 2-s2.0-33847633987 10.3171/jns.2007.106.3.428 (Pubitemid 46354296)
130. Regan R. F., Chen J., Benvenisti-Zarom L., Heme oxygenase-2 gene deletion attenuates oxidative stress in neurons exposed to extracellular hemin. BMC Neuroscience 2004 5, article 34 2-s2.0-12944252179 10.1186/1471-2202-5-34 (Pubitemid 40177047)
131. Rogers B., Yakopson V., Teng Z. P., Guo Y., Regan R. F., Heme oxygenase-2 knockout neurons are less vulnerable to hemoglobin toxicity. Free Radical Biology and Medicine 2003 35 8 872 881 2-s2.0-0141749478 10.1016/S0891-5849(03) 00431-3 (Pubitemid 37211441)
132. Panahian N., Yoshiura M., Maines M. D., Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. Journal of Neurochemistry 1999 72 3 1187 1203 2-s2.0-0032972686 (Pubitemid 29085035)
133. Ahmad A. S., Zhuang H., Doré S., Heme oxygenase-1 protects brain from acute excitotoxicity. Neuroscience 2006 141 4 1703 1708 2-s2.0-33747232569 10.1016/j.neuroscience.2006.05.035
134. Chen K., Gunter K., Maines M. D., Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. Journal of Neurochemistry 2000 75 1 304 313 2-s2.0-0034046911 10.1046/j.1471-4159.2000.0750304.x (Pubitemid 30418197)
135. Parfenova H., Basuroy S., Bhattacharya S., Tcheranova D., Qu Y., Regan R. F., Leffler C. W., Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection. American Journal of Physiology 2006 290 5 C1399 C1410 2-s2.0-33646436473 10.1152/ajpcell.00386.2005
136. Scapagnini G., D'Agata V., Calabrese V., Pascale A., Colombrita C., Alkon D., Cavallaro S., Gene expression profiles of heme oxygenase isoforms in the rat brain. Brain Research 2002 954 1 51 59 2-s2.0-0036839590 10.1016/S0006-8993(02)03338-3 (Pubitemid 35223440)
137. Chang E. F., Wong R. J., Vreman H. J., Igarashi T., Galo E., Sharp F. R., Stevenson D. K., Noble-Haeusslein L. J., Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. Journal of Neuroscience 2003 23 9 3689 3696 2-s2.0-0038206550 (Pubitemid 36958477)
138. Wang J., Doré S., Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage. Neuroscience 2008 155 4 1133 1141 2-s2.0-50249135422 10.1016/j.neuroscience.2008.07.004
139. Nelson C. W., Wei E. P., Povlishock J. T., Kontos H. A., Moskowitz M. A., Oxygen radicals in cerebral ischemia. American Journal of Physiology 1992 263 5, part 2 H1356 H1362 2-s2.0-0026443488
140. Gürsoy-Özdemir Y., Can A., Dalkara T., Reperfusion-induced oxidative/nitrativie injury to neurovascular unit after focal cerebral ischemia. Stroke 2004 35 6 1449 1453 2-s2.0-2542551340 10.1161/01.STR.0000126044.83777.f4 (Pubitemid 38697474)
141. Calabrese V., Giuffrida Stella A. M., Butterfield D. A., Scapagnini G., Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance. Antioxidants and Redox Signaling 2004 6 5 895 913 2-s2.0-4544327666 10.1089/ars.2004.6.895 (Pubitemid 39237943)
142. Kim H. P., Wang X., Zhang J., Suh G. Y., Benjamin I. J., Ryter S. W., Choi A. M. K., Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 β MAPK and heat shock factor-1. Journal of Immunology 2005 175 4 2622 2629 2-s2.0-23444437384 (Pubitemid 41113876)
143. Biermann J., Lagrèze W. A., Dimitriu C., Stoykow C., Goebel U., Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury. Investigative Ophthalmology and Visual Science 2010 51 7 3784 3791 2-s2.0-77955915244 10.1167/iovs.09-4894
144. Zhang X., Shan P., Alam J., Davis R. J., Flavell R. A., Lee P. J., Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38 α mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. Journal of Biological Chemistry 2003 278 24 22061 22070 2-s2.0-0038158280 10.1074/jbc.M301858200 (Pubitemid 36792616)
145. Almeida S. S., Queiroga C. S., Sousa M. F., Alves P. M., Paraaaa H. L. Vieira., Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes: role of BCL-2. Journal of Biological Chemistry 2012 287 14 10761 10770
146. Stein A. B., Bolli R., Dawn B., Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium. Journal of Molecular and Cellular Cardiology 2012 52 1 228 236
147. Bauer I., Pannen B. H., Bench-to-bedside review: carbon monoxidefrom mitochondrial poisoning to therapeutic use. Critical Care 2009 13 4 220 2-s2.0-75549091881
148. Motterlini R., Clark J. E., Foresti R., Sarathchandra P., Mann B. E., Green C. J., Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circulation Research 2002 90 2 E17 E24 2-s2.0-0037622140
149. Motterlini R., Mann B. E., Johnson T. R., Clark J. E., Foresti R., Green C. J., Bioactivity and pharmacological actions of carbon monoxide-releasing molecules. Current Pharmaceutical Design 2003 9 30 2525 2539 2-s2.0-0141919529 10.2174/1381612033453785 (Pubitemid 37236371)
150. Clark J. E., Naughton P., Shurey S., Green C. J., Johnson T. R., Mann B. E., Foresti R., Motterlini R., Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circulation Research 2003 93 2 e2 e8 2-s2.0-0041733077