The non-provitamin A carotenoid, lutein, inhibits NF-κB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-κB-inducing kinase pathways: Role of H2O2 in NF-κB activation

Free Radical Biology and Medicine

Volumn 45, Issue 6, 2008, Pages 885-896

  Kim, Ji Hee ^a   Na, Hee Jun ^a   Kim, Chun Ki ^a   Kim, Ji Yoon ^a   Ha, Kwon Soo ^a   Lee, Hansoo ^b   Chung, Hun Taeg ^c   Kwon, Ho Jeong ^d   Kwon, Young Guen ^d   Kim, Young Myeong ^a  

^a Kangwon National University College of Medicine   (South Korea)

^b Kangwon National University   (South Korea)

^c Wonkwang University   (South Korea)

^d Yonsei University   (South Korea)

Author keywords

NADPH oxidase; NF B; Nitric oxide; Reactive oxygen species

Indexed keywords

APOCYNIN; ASTAXANTHIN; BETA CAROTENE; CYCLOOXYGENASE 2; HYDROGEN PEROXIDE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN INDUCING KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; XANTHOPHYLL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; GENE ACTIVITY; GENE EXPRESSION REGULATION; INFLAMMATION; INTRACELLULAR TRANSPORT; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BASE SEQUENCE; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; GENE EXPRESSION REGULATION; HYDROGEN PEROXIDE; LUTEIN; MACROPHAGES, PERITONEAL; MICE; NF-KAPPA B; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

MUS;

EID: 54949129134     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.06.019     Document Type: Article

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