Apple peel flavonoid- and triterpene-enriched extracts differentially affect cholesterol homeostasis in hamsters

Journal of Functional Foods

Volumn 4, Issue 4, 2012, Pages 963-971

  Thilakarathna, Surangi H ^a   Wang, Yanwen ^b   Rupasinghe, H P Vasantha ^a   Ghanam, Khadija ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Apple peel extracts; Cholesterol; Flavonoids; Hamster; Oxidative stress; Triterpenes

Indexed keywords

CRICETINAE; MALUS X DOMESTICA; MESOCRICETUS AURATUS;

EID: 84866152769     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2012.07.004     Document Type: Article

References (43)

1. Allouche Y., Beltrán G., Gaforio J.J., Uceda M., Mesa M.D. Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids. Food and Chemical Toxicology 2010, 10.1016/j.fct.2010.07.022.
2. American Heart Association Heart disease and stroke statistics - 2012 update: A report from the American Heart Association. Circulation 2012, 125:e2-e220. 10.1161/CIR.0b013e31823ac046.
3. American Heart Association. (2004). Statistical fact sheet: International cardiovascular disease statistics. American Heart Association, Available online at: Accessed on 26th November 2011. http://www.sld.cu/galerias/pdf/servicios/hta/international_cardiovascular_disease_statistics.pdf.
4. Akazome N.Y., Kanda T., Ohtake Y., Shimasaki H., Kobayashi T. Apple polyphenols influence cholesterol metabolism in healthy subjects with relatively high body mass index. Journal of Oleo Science 2007, 56:417-428.
5. Aprikian O., Busserolles J., Manach C., Mazur A., Morand C., Davicco M.-J., Besson C., Rayssiguier Y., Rémésy C., Demigne C. Lyophillyzed apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese Zucker rats. The Journal of Nutrition 2002, 132:1969-1976.
6. Auger C., Teissedre P.L., Gérain P., Lequeux N., Bornet A., Serisier S., Besançon P., Caporiccio B., Cristol J.P., Rouanet J.M. Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation. Journal of Agricultural and Food Chemistry 2005, 53:2015-2021.
7. Azuma K., Ippoushi K., Terao J. Evaluation of tolerable levels of dietary quercetin for exerting its antioxidative effect in high cholesterol-fed rats. Food and Chemical Toxicology 2010, 48:1117-1122.
8. Balakumar P., Sharma R., Singh M. Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in the rat. Pharmacological Research 2008, 58:356-363.
9. Barter P. The inflammation: Lipoprotein cycle. Atherosclerosis Supplements 2005, 6:15-20.
10. Bera T.K., De D., Chatterjee K., Ali K.M., Ghosh D. Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats. International Journal of Ayurveda Research 2010, 1:18-24.
11. Bhardwaj S.S., Chalasani N. Lipid-lowering agents that cause drug-induced hepatotoxicity. Clinics in Liver Disease 2007, 11(3):597-613.
12. Boyer J., Liu R.H. Apple phytochemicals and their health benefits. Nutrition Journal 2004, 3:5.
13. Brody T. Lipids. Nutritional biochemistry 1999, 326-344. Academic Press, San Diego, New York, Boston, London, Sydney, Tokyo, Toronto, USA.
14. -/- mice. Arteriosclerosis, Thrombosis and Vascular Biology 2008, 28:272-277.
15. He X., Liu R.H. Phytochemicals of apple peels: Isolation, structure elucidation, and their antiproliferative and antioxidant activities. Journal of Agricultural and Food Chemistry 2008, 56:9905-9910.
16. Huber G.M., Rupasinghe H.P.V. Phenolic profile and antioxidant properties of apple skin extracts. Journal of Food Science 2009, 74:693-700.
17. Huber G.M., Rupasinghe H.P.V., Shahidi F. Inhibition of oxidation of omega-3 polyunsaturated fatty acids and fish oil by quercetin glycosides. Food Chemistry 2009, 117:290-295.
18. Jia X., Chen Y., Zidichouski J., Zhang J., Sun C., Wang Y. Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats. Atherosclerosis 2008, 201:101-107.
19. Jialal I., Devaraj S. The role of oxidized low density lipoprotein in atherogenesis. Journal of Nutrition 1996, 126:1053S-1057S.
20. Kamada C., da Silva E., Ohnishi-Kameyama M., Moon J., Tero J. Attenuation of lipid peroxidation and hyperlipidemia by quercetin glucoside in the aorta of high cholesterol-fed rabbit. Free Radical Research 2005, 39:185-194.
21. Kawai Y., Nishikawa T., Shiba Y., Saito S., Murota K., Shibata N., Kobayashi M., Kanayama M., Uchida K., Terao J. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: Implication in the anti-atherosclerotic mechanism of dietary flavonoids. The Journal of Biological Chemistry 2008, 283:9424-9434.
22. Lam C.K., Zhang Z., Yu H., Tsang S.Y., Huang Y., Chen Z.Y. Apple polyphenols inhibit plasma CETP activity and reduce the ratio of non-HDL to HDL cholesterol. Molecular Nutrition and Food Research 2008, 52:950-958.
23. Lee W.S., Im K.M., Park Y., Sung D., Jeong T. Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ. Biological and Pharmacological Bulletin 2006, 29:382-384.
24. Leontowicz H., Leontowicz M., Gorinstein S., Martin-Belloso O., Trakhtenberg S. Apple peels and pulp as a source of bioactive compounds and their influence on digestibility and lipid profile in normal and atherogenic rats. Medycyna Weterynaryjna 2007, 63:1434-1436.
25. Lin L.Y., Peng C.C., Yang Y.L., Peng R.Y. Optimization of bioactive compounds in buckwheat sprouts and their effect on blood cholesterol in hamsters. Journal of Agricultural and Food Chemistry 2008, 56:1216-1223.
26. Lotito S., Frei B. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon?. Free Radical Biology and Medicine 2006, 41:1727-1746.
27. O'Neill F.H., Patel D.D., Knight B.L., Neuwirth C.K., Bourbon M., Soutar A.K., Taylor G.W., Thompson G.R., Naoumova R.P. Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. Arteriosclerosis, Thrombosis and Vascular Biology 2001, 21(5):832-837.
28. Osada K., Suzuki T., Kawakami Y., Senda M., Kasai A., Sami M., Ohta Y., Kanda T., Ikeda M. Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol. Lipids 2006, 41:133-139.
29. Rosa D.P., Bona S., Simonetto D., Zettler C., Marroni C.A., Marroni N.P. Melatonin protects the liver and erythrocytes against oxidative stress in cirrhotic rats. Experimental Gastroenterology 2010, 47:72-78.
30. Ross R. Atherosclerosis: A defense mechanism gone awry. American Journal of Pathology 1993, 143:987-1002.
31. Rupasinghe H.P.V., Erkan N., Yasmin A. Antioxidant protection of eicosapentaenoic acid and fish oil oxidation by polyphenolic-enriched apple peel extract. Journal of Agricultural and Food Chemistry 2010, 58:1233-1239.
32. Rupasinghe H.P.V., Wang L., Huber G.M., Pitts N.L. Effect of baking on dietary fibre and phenolics of muffins incorporated with apple peel powder. Food Chemistry 2008, 107:1217-1224.
33. Somova L.I., Shode F.O., Ramnanan P., Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies Africana leaves. Journal of Ethnopharmacology 2003, 84:299-305.
34. Stocker R., Keaney J.F. Role of oxidative modifications in atherosclerosis. Physiological Reviews 2004, 84:1381-1478.
35. Sudhahar V., Kumar S.A., Sudharsan P.T., Varalakshmi P. Protective effect of lupeol and its ester on cardiac abnormalities in experimental hypercholesterolemia. Vascular Pharmacology 2007, 46:412-418.
36. Tak P.P., Firestein G.S. NF-κB: A key role in inflammatory diseases. Journal of Clinical Investigation 2001, 107:7-11.
37. Thilakarathna, S. H. (2010). Inhibition of LDL oxidation in vitro and regulation of cholesterol metabolism in hamsters by apple peel bioactives. M.Sc. Thesis. Dalhousie University, Halifax, NS, Canada.
38. Thilakarathna S.H., Rupasinghe H.P.V. Anti-atherosclerotic effects of fruit bioactive compounds: A review of current scientific evidence. Canadian Journal of Plant Science 2012, 92:407-419.
39. Vinson J.A., Mandarano M.A., Shuta D.L., Bagchi M., Bagchi D. Beneficial effects of a novel IH636 grape seed proanthocyanidin extract and a niacin-bound chromium in a hamster atherosclerosis model. Molecular and Cellular Biochemistry 2002, 240:99-103.
40. Wang Y.W., Jones P.J.H., Pischel I., Fairow C. Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters. Lipids 2003, 38:165-170.
41. Wang Y., Jia X., Ghanam K., Beaupaire C., Zidichouski J., Miller L. Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters. Atheroclerosis 2010, 209:111-117.
42. Zhang Q., Chang Z., Wang Q. Ursane triterpenoids inhibit atherosclerosis and xanthoma in LDL receptor knockout mice. Cardiovascular Drugs and Therapy 2006, 20:349-357.
43. Zhang Z., Chang Q., Zhu M., Huang Y., Ho W.K., Chen Z. Characterization of antioxidants present in hawthorn fruits. The Journal of Nutritional Biochemistry 2001, 12:144-152.