Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ

Biological and Pharmaceutical Bulletin

Volumn 29, Issue 2, 2006, Pages 382-384

  Woo, Song Lee ^a   Im, Kyung Ran ^a,b   Park, Yong Dae ^a,b   Sung, Nack Do ^b   Jeong, Tae Sook ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Acyl CoA; Atherosclerosis; Cholesterol acytransferase (ACAT); Lycopus lucidus; Pentacyclic triterpene

Indexed keywords

BETULIC ACID; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE 1; CHOLESTEROL ACYLTRANSFERASE 2; OLEANOLIC ACID; OLEIC ACID; TRITERPENE; UNCLASSIFIED DRUG; URSOLIC ACID;

ANIMAL CELL; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; FRACTIONATION; IC 50; LYCOPUS; LYCOPUS LUCIDUS; NONHUMAN; PLANT LEAF; SPECTROSCOPY;

EID: 32044433519     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.29.382     Document Type: Article

References (17)

1. Anderson R. A., Joyce C., Davis M., Reagan J. W., Clark M., Shelness G. S., Rudel L. L., J. Biol. Chem., 273, 26747-26754 (1998).
2. Cases S., Novak S., Zheng Y.-W., Myers H. M., Lear S. R., Sande E., Welch C. B., Lusis A. J., Spancer T. A., Krouse B. R., Erickson S. K., Farese R. V., Jr., J. Biol. Chem., 273, 26755-26764 (1998).
3. Joyce C. W., Shelness G. S., Davis M. A., Lee R. G., Skinner K., Anderson R. A., Rudel L. L., Mol. Biol. Cell, 11, 3675-3687 (2000).
4. Rudel L. L., Lee R. G., Cockman T. L., Curr. Opin. Lipidol., 12, 121-127 (2001).
5. Lee W. S., Lee D. W., Baek Y. I., An S. J., Cho K. H., Choi Y. K., Kim H. J., Park H. Y., Bae K. H., Jeong T. S., Bioorg. Med. Chem. Lett., 14, 3109-3112 (2004).
6. Jeong T. S., Kim K. S., Yu H., Kim M. J., Cho K. H., Choi Y. K., Kim H. J., Park H. Y., Lee W. S., Bioorg. Med. Chem. Lett., 15, 385-388 (2005).
7. Malik A., Yuldashev M. P., Chem. Nat. Compd., 38, 104-105 (2002) and references cited therein.
8. Hwang B. Y., Chai H. B., Kardono L. B. S., Riswan S., Farnsworth N. R., Cordell G. A., Pezzuto J. M., Kinghorn A. D., Phytochemistry, 62, 197-201 (2003).
9. Toshio J. T., Morikawa T., Toguchida I., Ando S., Matsuda H., Yoshikawa M., Bioorg. Med. Chem., 10, 4005-4012 (2002).
10. Singh G. B., Singh S., Bani S., Gupta B. D., Banerjee S. K., J. Pharm. Pharmacol., 44, 456-458 (1992).
11. Jeong T. S., Hwang E. I., Lee H. B., Lee E. S., Kim Y. K., Min B. S., Bae K. H., Bok S. H., Kim S. U., Planta Med., 65, 261-263 (1999) and references cited therein.
12. Ikuta A., Itokawa H., Phytochemistry, 27, 2813-2815 (1988).
13. Sang S., Lapsley K., Rosen R. T., Ho C. T., J. Agric. Food Chem., 50, 607-609 (2002).
14. Cho K. H., An S., Lee W. S., Paik Y. K., Kim Y. K., Jeong T. S., Biochem. Biophys. Res. Commun., 309, 864-872 (2003).
15. Jeong T. S., Kim S. U., Son K. H., Kwon B. M., Kim Y. K., Choi M. U., Bok S. H., J. Antibiot., 48, 751-756 (1995).
16. Lada A. T., Davis M., Kent C., Chapman J., Tomoda H., Omura S., Rudel L. L., J. Lipid Res., 45, 378-386 (2004).
17. Tabas I., Chen L.-L., Clader J. W., McPhail A. T., Burnett A. A., Bartner P., Das P. R., Pramanik B. N., Puar M. S., Feinmark S. J., Zipkin R. E., Boykow G. B., Vita G., Tall A. R., J. Biol. Chem., 265, 8042-8051 (1990).