Cortical rotation and messenger RNA localization in Xenopus axis formation

Wiley Interdisciplinary Reviews: Developmental Biology

Volumn 1, Issue 3, 2012, Pages 371-388

  Houston, Douglas W ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; CYCLINE; DICKKOPF 1 PROTEIN; DISHEVELLED 2; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYMPHOID ENHANCER FACTOR 1; MATURATION PROMOTING FACTOR; MESSENGER RNA; MOLECULAR MOTOR; PERILIPIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR 3; WNT PROTEIN; WNT11 PROTEIN; WNT5A PROTEIN;

AXIS; BLASTULA; CELLULAR DISTRIBUTION; CYTOPLASM; EMBRYO DEVELOPMENT; GENE EXPRESSION; HUMAN; MICROTUBULE ASSEMBLY; MUSCULOSKELETAL DEVELOPMENT; NONHUMAN; OOCYTE; POLARIZATION; REVIEW; ROTATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; XENOPUS;

ANIMALS; BODY PATTERNING; MICROTUBULES; OVUM; RNA TRANSPORT; RNA, MESSENGER; WNT SIGNALING PATHWAY; XENOPUS;

EID: 84866051280     PISSN: 17597684     EISSN: 17597692     Source Type: Journal    
DOI: 10.1002/wdev.29     Document Type: Review

References (150)

1. Spemann H. Entwicklungsphysiologische Studien am Tritonei. A Entwm 1903, 16:551-631.
2. Ancel P, Vintemberger P. Recherches sur le determinisme de la symmetrie bilaterale dans l'oeuf des Amphibiens. Bull Biol Fr Belg 1948(suppl) 31:1-182.
3. Clavert J. Symmetrization of the egg in vertebrates. Adv Morphol 1962, 2:27-60.
4. Elinson RP, Holowacz T. Specifying the dorsoanterior axis in frogs: 70 years since Spemann and Mangold. Curr Top Dev Biol 1995, 30:253-285.
5. Gerhart J, Danilchik M, Doniach T, Roberts S, Rowning B, Stewart R. Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development. Development 1989, 107(suppl):37-51.
6. Larabell CA, Torres M, Rowning BA, Yost C, Miller JR, Wu M, Kimelman D, Moon RT. Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in β-catenin that are modulated by the Wnt signaling pathway. J Cell Biol 1997, 136:1123-1136.
7. Schneider S, Steinbeisser H, Warga RM, Hausen P. β-Catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. Mech Dev 1996, 57:191-198.
8. Heasman J. Patterning the early Xenopus embryo. Development 2006, 133:1205-1217.
9. Ho RK. Axis formation in the embryo of the zebrafish, Brachydanio rerio. Semin Dev Biol 1992, 3:53-64.
10. Schier AF, Talbot WS. Molecular genetics of axis formation in zebrafish. Annu Rev Genet 2005, 39:561-613.
11. Roeser T, Stein S, Kessel M. Nuclear β-catenin and the development of bilateral symmetry in normal and LiCl-exposed chick embryos. Development 1999, 126:2955-2965.
12. Marikawa Y. Wnt/β-catenin signaling and body plan formation in mouse embryos. Semin Cell Dev Biol 2006, 17:175-184.
13. Weaver C, Kimelman D. Move it or lose it: axis specification in Xenopus. Development 2004, 131: 3491-3499.
14. Moon RT, Kimelman D. From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus. Bioessays 1998, 20:536-545.
15. Marrari Y, Clarke EJ, Rouvière C, Houliston E. Analysis of microtubule movement on isolated Xenopus egg cortices provides evidence that the cortical rotation involves dynein as well as kinesin related proteins and is regulated by local microtubule polymerisation. Dev Biol 2003, 257:55-70.
16. Vincent JP, Oster GF, Gerhart JC. Kinematics of gray crescent formation in Xenopus eggs: the displacement of subcortical cytoplasm relative to the egg surface. Dev Biol 1986, 113:484-500.
17. Elinson RP, Rowning B. A transient array of parallel microtubules in frog eggs: potential tracks for a cytoplasmic rotation that specifies the dorso-ventral axis. Dev Biol 1988, 128:185-197.
18. Houliston E, Elinson RP. Evidence for the involvement of microtubules, ER, and kinesin in the cortical rotation of fertilized frog eggs. J Cell Biol 1991, 114:1017-1028.
19. Schroeder MM, Gard DL. Organization and regulation of cortical microtubules during the first cell cycle of Xenopus eggs. Development 1992, 114:699-709.
20. Manes ME, Elinson RP, Barbieri FD. Formation of the amphibian grey crescent: effects of colchicine and cytochalasin B. Wilhelm Roux's Arch Dev Biol 1978, 185:99-104.
21. Manes ME, Elinson RP. Ultraviolet light inhibits grey crescent formation on the frog egg. Wilhelm Roux's Arch Dev Biol 1980, 189:73-76.
22. Scharf SR, Gerhart JC. Axis determination in eggs of Xenopus laevis: a critical period before first cleavage, identified by the common effects of cold, pressure and ultraviolet irradiation. Dev Biol 1983, 99:75-87.
23. Rowning BA, Wells J, Wu M, Gerhart JC, Moon RT, Larabell CA. Microtubule-mediated transport of organelles and localization of β-catenin to the future dorsal side of Xenopus eggs. Proc Natl Acad Sci U S A 1997, 94:1224-1229.
24. Miller JR, Rowning BA, Larabell CA, Yang-Snyder JA, Bates RL, Moon RT. Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation. J Cell Biol 1999, 146:427-437.
25. Weaver C, Farr GH III, Pan W, Rowning BA, Wang J, Mao J, Wu D, Li L, Larabell CA, Kimelman D. GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs. Development 2003, 130:5425-5436.
26. Scharf SR, Rowning B, Wu M, Gerhart JC. Hyperdorsoanterior embryos from Xenopus eggs treated with D2O. Dev Biol 1989, 134:175-188.
27. Scharf SR, Gerhart JC. Determination of the dorsal-ventral axis in eggs of Xenopus laevis: complete rescue of UV-impaired eggs by oblique orientation before first cleavage. Dev Biol 1980, 79:181-198.
28. Zisckind N, Elinson R. Gavity and microtubules in dorsoventral polarization of the Xenopus egg. Develop Growth & Differ 1990, 32:575-581.
29. Vincent JP, Scharf SR, Gerhart JC. Subcortical rotation in Xenopus eggs: a preliminary study of its mechanochemical basis. Cell Motil Cytoskeleton 1987, 8:143-154.
30. Marrari Y, Terasaki M, Arrowsmith V, Houliston E. Local inhibition of cortical rotation in Xenopus eggs by an anti-KRP antibody. Dev Biol 2000, 224:250-262.
31. Robb DL, Heasman J, Raats J, Wylie C. A kinesin-like protein is required for germ plasm aggregation in Xenopus. Cell 1996, 87:823-831.
32. Marrari Y, Rouvière C, Houliston E. Complementary roles for dynein and kinesins in the Xenopus egg cortical rotation. Dev Biol 2004, 271:38-48.
33. Hirokawa N, Niwa S, Tanaka Y. Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. Neuron 2010, 68:610-638.
34. Houliston E, Elinson RP. Patterns of microtubule polymerization relating to cortical rotation in Xenopus laevis eggs. Development 1991, 112:107-117.
35. Elinson R, Palecek J. Independence of two microtubule systems in fertilized frog eggs: the sperm aster and the vegetal parallel array. Roux's Arch Dev Biol 1993, 202:224-232.
36. Brown EE, Margelot KM, Danilchik MV. Provisional bilateral symmetry in Xenopus eggs is established during maturation. Zygote 1994, 2:213-220.
37. Terasaki M, Chen LB, Fujiwara K. Microtubules and the endoplasmic reticulum are highly interdependent structures. J Cell Biol 1986, 103:1557-1568.
38. Waterman-Storer CM, Salmon ED. Endoplasmic reticulum membrane tubules are distributed by microtubules in living cells using three distinct mechanisms. Curr Biol 1998, 8:798-806.
39. Larabell CA, Rowning BA, Wells J, Wu M, Gerhart JC. Confocal microscopy analysis of living Xenopus eggs and the mechanism of cortical rotation. Development 1996, 122:1281-1289.
40. Fujisue M, Kobayakawa Y, Yamana K. Occurrence of dorsal axis-inducing activity around the vegetal pole of an uncleaved Xenopus egg and displacement to the equatorial region by cortical rotation. Development 1993, 118:163-170.
41. Holowacz T, Elinson RP. Cortical cytoplasm, which induces dorsal axis formation in Xenopus, is inactivated by UV irradiation of the oocyte. Development 1993, 119:277-285.
42. Yuge M, Kobayakawa Y, Fujisue M, Yamana K. A cytoplasmic determinant for dorsal axis formation in an early embryo of Xenopus laevis. Development 1990, 110:1051-1056.
43. Kageura H. Activation of dorsal development by contact between the cortical dorsal determinant and the equatorial core cytoplasm in eggs of Xenopus laevis. Development 1997, 124:1543-1551.
44. Kikkawa M, Takano K, Shinagawa A. Location and behavior of dorsal determinants during first cell cycle in Xenopus eggs. Development 1996, 122: 3687-3696.
45. Sakai M. The vegetal determinants required for the Spemann organizer move equatorially during the first cell cycle. Development 1996, 122:2207-2214.
46. Elinson RP, Pasceri P. Two UV-sensitive targets in dorsoanterior specification of frog embryos. Development 1989, 106:511-518.
47. Holwill S, Heasman J, Crawley C, Wylie CC. Axis and germ line deficiencies caused by u.v irradiation of Xenopus oocytes cultured in vitro. Development 1987, 100:735-743.
48. Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, Asashima M, Wylie CC, Lin X, Heasman J. Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell 2005, 120:857-871.
49. Kofron M, Birsoy B, Houston D, Tao Q, Wylie C, Heasman J. Wnt11/β-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin. Development 2007, 134:503-513.
50. Cha SW, Tadjuidje E, Tao Q, Wylie C, Heasman J. Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation. Development 2008, 135:3719-3729.
51. Sumanas S, Strege P, Heasman J, Ekker SC. The putative wnt receptor Xenopus frizzled-7 functions upstream of β-catenin in vertebrate dorsoventral mesoderm patterning. Development 2000, 127: 1981-1990.
52. Newport J, Kirschner M. A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription. Cell 1982, 30:687-696.
53. Yost C, Farr GH III, Pierce SB, Ferkey DM, Chen MM, Kimelman D. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell 1998, 93:1031-1041.
54. Kofron M, Klein P, Zhang F, Houston D, Schaible K, Wylie CC, Heasman J. The role of maternal axin in patterning the Xenopus embryo. Dev Biol 2001, 237:183-201.
55. Liao G, Tao Q, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsieh JC, Wylie C, Heasman J, Kuan CY. Jun NH2-terminal kinase (JNK) prevents nuclear β-catenin accumulation and regulates axis formation in Xenopus embryos. PNAS 2006, 103:16313-16318.
56. Tadjuidje E, Cha S-W, Louza M, Wylie C, Heasman J. The functions of maternal Dishevelled 2 and 3 in the early Xenopus embryo. Dev Dyn 2011.
57. Chan AP, Kloc M, Larabell CA, LeGros M, Etkin LD. The maternally localized RNA fatvg is required for cortical rotation and germ cell formation. Mech Dev 2007, 124:350-363.
58. Yang J, Wu J, Tan C, Klein PS. PP2A:B56ε{lunate} is required for Wnt/β-catenin signaling during embryonic development. Development 2003, 130:5569-5578.
59. Cuykendall TN, Houston D. Vegetally localized Xenopus trim36 regulates cortical rotation and dorsal axis formation. Development 2009, 136:3057-3065.
60. Davidson G, Shen J, Huang Y-L, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M, Niehrs C. Cell cycle control of wnt receptor activation. Dev Cell 2009, 17:788-799.
61. Heasman J, Crawford A, Goldstone K, Garner-Hamrick P, Gumbiner B, McCrea P, Kintner C, Noro CY, Wylie C. Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell 1994, 79:791-803.
62. Heasman J, Kofron M, Wylie C. β-Catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach. Dev Biol 2000, 222:124-134.
63. Houston DW, Kofron M, Resnik E, Langland R, Destree O, Wylie C, Heasman J. Repression of organizer genes in dorsal and ventral Xenopus cells mediated by maternal XTcf3. Development 2002, 129:4015-4025.
64. Belenkaya TY, Han C, Standley HJ, Lin X, Houston DW, Heasman J, Lin X. pygopus encodes a nuclear protein essential for wingless/Wnt signaling. Development 2002, 129:4089-4101.
65. Standley HJ, Destree O, Kofron M, Wylie C, Heasman J. Maternal XTcf1 and XTcf4 have distinct roles in regulating Wnt target genes. Dev Biol 2006, 289:318-328.
66. Kennedy MW, Cha S-W, Tadjuidje E, Andrews PG, Heasman J, Kao KR. A co-dependent requirement of xBcl9 and Pygopus for embryonic body axis development in Xenopus. Dev Dyn 2010, 239:271-283.
67. Blythe SA, Cha S-W, Tadjuidje E, Heasman J, Klein PS. β-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev Cell 2010, 19:220-231.
68. Kessel RG, Subtelny S. Alteration of annulate lamellae in the in vitro progesterone-treated, full-grown Rana pipiens oocyte. J Exp Zool 1981, 217:119-135.
69. Klymkowsky MW, Maynell LA, Polson AG. Polar asymmetry in the organization of the cortical cytokeratin system of Xenopus laevis oocytes and embryos. Development 1987, 100:543-557.
70. Colman A, Jones EA, Heasman J. Meiotic maturation in Xenopus oocytes: a link between the cessation of protein secretion and the polarized disappearance of Golgi apparati. J Cell Biol 1985, 101:313-318.
71. Weeks DL, Melton DA. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-β. Cell 1987, 51:861-867.
72. Forristall C, Pondel M, Chen L, King ML. Patterns of localization and cytoskeletal association of two vegetally localized RNAs, Vg1 and Xcat-2. Development 1995, 121:201-208.
73. Hainski AM, Moody SA. Xenopus maternal RNAs from a dorsal animal blastomere induce a secondary axis in host embryos. Development 1992, 116:347-355.
74. Nieuwkoop PD. Origin and establishment of embryonic polar axes in amphibian development. Curr Top Dev Biol 1977, 11:115-132.
75. Danilchik MV, Denegre JM. Deep cytoplasmic rearrangements during early development in Xenopus laevis. Development 1991, 111:845-856.
76. McMahon AP, Moon RT. Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. Cell 1989, 58:1075-1084.
77. Xanthos JB, Kofron M, Tao Q, Schaible K, Wylie C, Heasman J. The roles of three signaling pathways in the formation and function of the Spemann Organizer. Development 2002, 129:4027-4043.
78. MacDonald BT, Tamai K, He X. Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009, 17:9-26.
79. Angers S, Moon RT. Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 2009, 10:468-477.
80. Amit S, Hatzubai A, Birman Y, Andersen JS, Ben-Shushan E, Mann M, Ben-Neriah Y, Alkalay I. Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev 2002, 16:1066-1076.
81. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X. Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 2002, 108:837-847.
82. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. β-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997, 16:3797-3804.
83. Taelman VF, Dobrowolski R, Plouhinec J-L, Fuentealba LC, Vorwald PP, Gumper I, Sabatini DD, De Robertis EM. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell 2010, 143:1136-1148.
84. Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, Roose J, Destrée O, Clevers H. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell 1996, 86:391-399.
85. Brunner E, Peter O, Schweizer L, Basler K. pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature 1997, 385:829-833.
86. Kao K, Elinson RP. Lithium-induced respecification of pattern in Xenopus laevis embryos. Nature 1986, 322:371-373.
87. Yang J, Tan C, Darken RS, Wilson PA, Klein PS. β-Catenin/Tcf-regulated transcription prior to the midblastula transition. Development 2002, 129: 5743-5752.
88. Ku M, Melton DA. Xwnt-11: a maternally expressed Xenopus wnt gene. Development 1993, 119:1161-1173.
89. Du SJ, Purcell SM, Christian JL, McGrew LL, Moon RT. Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol Cell Biol 1995, 15:2625-2634.
90. Tada M, Smith JC. Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development 2000, 127:2227-2238.
91. Heisenberg CP, Tada M, Rauch GJ, Saude L, Concha ML, Geisler R, Stemple DL, Smith JC, Wilson SW. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature 2000, 405:76-81.
92. Cha S, Tadjuidje E, White J, Wells J, Mayhew C, Wylie CC, Heasman J. Wnt11/5a complex formation caused by tyrosine sulfation increases canonical signaling activity. Curr Biol 2009, 19:1573-1580.
93. Lee E, Salic A, Kruger R, Heinrich R, Kirschner M. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol 2003, 1:E10.
94. Schroeder KE, Condic ML, Eisenberg LM, Yost HJ. Spatially regulated translation in embryos: asymmetric expression of maternal Wnt-11 along the dorsal-ventral axis in Xenopus. Dev Biol 1999, 214: 288-297.
95. Gradl D, Kuhl M, Wedlich D. Keeping a close eye on Wnt-1/wg signaling in Xenopus. Mech Dev 1999, 86:3-15.
96. Houston DW, Wylie C. Cloning and expression of Xenopus Lrp5 and Lrp6 genes. Mech Dev 2002, 117:337-342.
97. Westfall TA, Brimeyer R, Twedt J, Gladon J, Olberding A, Furutani-Seiki M, Slusarski DC. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity. J Cell Biol 2003, 162:889-898.
98. Saneyoshi T, Kume S, Amasaki Y, Mikoshiba K. The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature 2002, 417:295-299.
99. Marikawa Y, Elinson RP. Relationship of vegetal cortical dorsal factors in the Xenopus egg with the Wnt/β-catenin signaling pathway. Mech Dev 1999, 89:93-102.
100. Sokol SY. Analysis of Dishevelled signalling pathways during Xenopus development. Curr Biol 1996, 6:1456-1467.
101. Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 1998, 391:357-362.
102. Leyns L, Bouwmeester T, Kim S, Piccolo S, De Robertis E. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell 1997, 88:747-756.
103. Wang S, Krinks M, Lin K, Luyten F, Moos M. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell 1997, 88:757-766.
104. Vleminckx K, Wong E, Guger K, Rubinfeld B, Polakis P, Gumbiner BM. Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis. J Cell Biol 1997, 136:411-420.
105. Farr GH III, Ferkey DM, Yost C, Pierce SB, Weaver C, Kimelman D. Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol 2000, 148:691-702.
106. Takacs CM, Baird JR, Hughes EG, Kent SS, Benchabane H, Paik R, Ahmed Y. Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli. Science 2008, 319:333-336.
107. Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation. Cur Biol 2001, 11:44-49.
108. Nakamura M, Zhou XZ, Lu KP. Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. Curr Biol 2001, 11: 1062-1067.
109. Dominguez I, Green JB. Dorsal downregulation of GSK3β by a non-Wnt-like mechanism is an early molecular consequence of cortical rotation in early Xenopus embryos. Development 2000, 127:861-868.
110. Cook D, Fry MJ, Hughes K, Sumathipala R, Woodgett JR, Dale TC. Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. EMBO J 1996, 15:4526-4536.
111. Li L, Yuan H, Weaver CD, Mao J, Farr GH III, Sussman DJ, Jonkers J, Kimelman D, Wu D. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J 1999, 18:4233-4240.
112. Salic A, Lee E, Mayer L, Kirschner MW. Control of β-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell 2000, 5:523-532.
113. Capelluto DG, Kutateladze TG, Habas R, Finkielstein CV, He X, Overduin M. The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. Nature 2002, 419:726-729.
114. Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, Niehrs C. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 2007, 316:1619-1622.
115. Schwarz-Romond T, Merrifield C, Nichols BJ, Bienz M. The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. J Cell Sci 2005, 118:5269-5277.
116. van Amerongen R, Nawijn M, Franca-Koh J, Zevenhoven J, van der Gulden H, Jonkers J, Berns A. Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev 2005, 19:425-430.
117. Van Amerongen R, Nawijn M, Lambooij J, Proost N, Jonkers J, Berns A. Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways. Oncogene 2010, 29:93-104.
118. Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev 2008, 22:3050-3063.
119. Heasman J, Quarmby J, Wylie CC. The mitochondrial cloud of Xenopus oocytes: the source of germinal granule material. Dev Biol 1984, 105:458-469.
120. Dumont J. Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J Morphol 1972, 136:153-179.
121. Billett FS, Adam E. The structure of the mitochondrial cloud of Xenopus laevis oocytes. J Embryol Exp Morphol 1976, 36:697-710.
122. King ML, Messitt TJ, Mowry KL. Putting RNAs in the right place at the right time: RNA localization in the frog oocyte. Biol Cell 2005, 97:19-33.
123. Houston DW, Zhang J, Maines JZ, Wasserman SA, King ML. A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule. Development 1998, 125:171-180.
124. Horvay K, Claussen M, Katzer M, Landgrebe J, Pieler T. Xenopus Dead end mRNA is a localized maternal determinant that serves a conserved function in germ cell development. Dev Biol 2006, 291:1-11.
125. Deshler JO, Highett MI, Schnapp BJ. Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum. Science 1997, 276:1128-1131.
126. Yisraeli JK, Sokol S, Melton DA. A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA. Development 1990, 108:289-298.
127. Kloc M, Zearfoss NR, Etkin LD. Mechanisms of subcellular mRNA localization. Cell 2002, 108:533-544.
128. Cote CA, Gautreau D, Denegre JM, Kress TL, Terry NA, Mowry KL. A Xenopus protein related to hnRNP I has a role in cytoplasmic RNA localization. Mol Cell 1999, 4:431-437.
129. Yoon YJ, Mowry KL. Xenopus Staufen is a component of a ribonucleoprotein complex containing Vg1 RNA and kinesin. Development 2004, 131:3035-3045.
130. Pfeiffer DC, Gard DL. Microtubules in Xenopus oocytes are oriented with their minus-ends towards the cortex. Cell Motil Cytoskeleton 1999, 44:34-43.
131. Messitt TJ, Gagnon JA, Kreiling JA, Pratt CA, Yoon YJ, Mowry KL. Multiple kinesin motors coordinate cytoplasmic RNA transport on a subpopulation of microtubules in Xenopus oocytes. Dev Cell 2008, 15:426-436.
132. Chan AP, Kloc M, Etkin LD. fatvg encodes a new localized RNA that uses a 25-nucleotide element (FVLE1) to localize to the vegetal cortex of Xenopus oocytes. Development 1999, 126:4943-4953.
133. Walther TC, Farese RV. The life of lipid droplets. Biochim Biophys Acta 2009, 1791:459-466.
134. Welte MA, Cermelli S, Griner J, Viera A, Guo Y, Kim D-H, Gindhart JG, Gross SP. Regulation of lipid-droplet transport by the perilipin homolog LSD2. Curr Biol 2005, 15:1266-1275.
135. Cuykendall TN, Houston DW. Identification of germ plasm-associated transcripts by microarray analysis of Xenopus vegetal cortex RNA. Dev Dyn 2010, 239:1838-1848.
136. Trockenbacher A, Suckow V, Foerster J, Winter J, Krauss S, Ropers HH, Schneider R, Schweiger S. MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation. Nat Genet 2001, 29:287-294.
137. Short KM, Cox TC. Subclassification of the RBCC/ TRIM superfamily reveals a novel motif necessary for microtubule binding. J Biol Chem 2006, 281: 8970-8980.
138. Murti KG, Smith HT, Fried VA. Ubiquitin is a component of the microtubule network. PNAS 1988, 85:3019-3023.
139. Darras S, Marikawa Y, Elinson RP, Lemaire P. Animal and vegetal pole cells of early Xenopus embryos respond differently to maternal dorsal determinants: implications for the patterning of the organiser. Development 1997, 124:4275-4286.
140. Medina A, Wendler SR, Steinbeisser H. Cortical rotation is required for the correct spatial expression of nr3, sia and gsc in Xenopus embryos. Int J Dev Biol 1997, 41:741-745.
141. Strähle U, Jesuthasan S. Ultraviolet irradiation impairs epiboly in zebrafish embryos: evidence for a microtubule-dependent mechanism of epiboly. Development 1993, 119:909-919.
142. Abraham V, Miller A, Fluck R. Microtubule arrays during ooplasmic segregation in the medaka fish egg (Oryzias latipes). Biol Bull 1995, 188:136-145.
143. Webb T, Kowalski W, Fluck R. Microtubule-based movements during ooplasmic segregation in the medaka fish egg (Oryzias latipes). Biol Bull 1995, 188:146-156.
144. Jesuthasan S, Stähle U. Dynamic microtubules and specification of the zebrafish embryonic axis. Curr Biol 1997, 7:31-42.
145. Trimble L, Fluck R. Indicators of the dorsoventral axis in medaka (Oryzias latipes) zygotes. Fish Biol J 1995, 7:37-41.
146. Nojima H, Rothhämel S, Shimizu T, Kim C-H, Yonemura S, Marlow FL, Hibi M. Syntabulin, a motor protein linker, controls dorsal determination. Development 2010, 137:923-933.
147. Su Q, Cai Q, Gerwin C, Smith CL, Sheng Z-H. Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons. Nat Cell Biol 2004, 6:941-953.
148. Kemp C, Willems E, Abdo S, Lambiv L, Leyns L. Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. Dev Dyn 2005, 233: 1064-1075.
149. Croce JC, McClay DR. The canonical Wnt pathway in embryonic axis polarity. Semin Cell Dev Biol 2006, 17:168-174.
150. Nishida H. Specification of embryonic axis and mosaic development in ascidians. Dev Dyn 2005, 233:1177-1193.